Dimitrios A Skoufias

Summary

Affiliation: Institut de Biologie Structurale
Country: France

Publications

  1. ncbi request reprint Is there a "G spot" in sister chromatid cohesion resolution?
    Dimitrios A Skoufias
    Institut de Biologie Structurale, UMR5075, Grenoble, France
    Cell Cycle 10:2835. 2011
  2. pmc Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed
    Dimitrios A Skoufias
    Institut de Biologie Structurale Jean Pierre Ebel, Atomic Energy Commission Centre National de la Recherche Scientifique, 38027 Grenoble, Cedex 1, France
    J Cell Biol 179:671-85. 2007
  3. pmc Molecular distinctions between Aurora A and B: a single residue change transforms Aurora A into correctly localized and functional Aurora B
    Fabienne Hans
    Institut National de la Sante et de la Recherche Medicale, Universite Joseph Fourier Grenoble 1, Grenoble, France
    Mol Biol Cell 20:3491-502. 2009
  4. doi request reprint Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5
    Salvatore DeBonis
    Institut de Biologie Structurale, 41, rue Jules Horowitz, 38027 Grenoble Cedex 01, France
    J Med Chem 51:1115-25. 2008
  5. ncbi request reprint Screening for inhibitors of microtubule-associated motor proteins
    Frank Kozielski
    Institut de Biologie Structurale, CEA CNRS UJF, Grenoble, France
    Methods Mol Med 137:189-207. 2007
  6. ncbi request reprint SMC5 and MMS21 are required for chromosome cohesion and mitotic progression
    Susanne Behlke-Steinert
    Institut de Biologie Structurale CEA, CNRS, UJF, Grenoble, France
    Cell Cycle 8:2211-8. 2009
  7. doi request reprint Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines
    Sergey Tcherniuk
    Institut de Biologie Structurale, CEA CNRS UJF J P Ebel, Laboratoire des Protéines du Cytosquelette 41 rue Jules Horowitz, 38027 Grenoble Cedex 01, France
    Biochem Pharmacol 79:864-72. 2010
  8. ncbi request reprint In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities
    Salvatore DeBonis
    Institut de Biologie Structurale, 41, rue Jules Horowitz, 38027 Grenoble Cedex 01, France
    Mol Cancer Ther 3:1079-90. 2004
  9. ncbi request reprint Analysis of the spindle-assembly checkpoint in HeLa cells
    Paul R Andreassen
    Institut de Biologie Structurale, J P Ebel CEA CNRS UJF, Grenoble, France
    Methods Mol Biol 281:213-25. 2004
  10. pmc Structural basis of cytotoxicity mediated by the type III secretion toxin ExoU from Pseudomonas aeruginosa
    Claire Gendrin
    Bacterial Pathogenesis Group, Institut de Biologie Structurale IBS, Universite Grenoble I, Grenoble, France
    PLoS Pathog 8:e1002637. 2012

Collaborators

  • Robert L Margolis
  • Andrea Dessen
  • Benoit Joseph
  • Susanne Behlke-Steinert
  • Sylvie Elsen
  • Frank Kozielski
  • Salvatore DeBonis
  • Claire Gendrin
  • Sergey Tcherniuk
  • Fabienne Hans
  • Paul R Andreassen
  • Ina Attree
  • Philippe Huber
  • Carlos Contreras-Martel
  • David Lemaire
  • Stéphanie Bouillot
  • Robert van Lis
  • Stefan Dimitrov
  • Rose Laure Indorato
  • Bernard Marquet
  • Christian Laggner
  • François Liger
  • Roman Lopez
  • Gautier Robin
  • Luc Lebeau
  • Richard H Wade

Detail Information

Publications10

  1. ncbi request reprint Is there a "G spot" in sister chromatid cohesion resolution?
    Dimitrios A Skoufias
    Institut de Biologie Structurale, UMR5075, Grenoble, France
    Cell Cycle 10:2835. 2011
  2. pmc Mitosis persists in the absence of Cdk1 activity when proteolysis or protein phosphatase activity is suppressed
    Dimitrios A Skoufias
    Institut de Biologie Structurale Jean Pierre Ebel, Atomic Energy Commission Centre National de la Recherche Scientifique, 38027 Grenoble, Cedex 1, France
    J Cell Biol 179:671-85. 2007
    ..Furthermore, the degradation of a protein other than cyclin B1 is essential to activate a phosphatase that, in turn, enables mitotic exit...
  3. pmc Molecular distinctions between Aurora A and B: a single residue change transforms Aurora A into correctly localized and functional Aurora B
    Fabienne Hans
    Institut National de la Sante et de la Recherche Medicale, Universite Joseph Fourier Grenoble 1, Grenoble, France
    Mol Biol Cell 20:3491-502. 2009
    ..An Aurora A-Delta120 N-terminal truncation construct reinforces Aurora A similarity to Aurora B, because it does not associate with centrosomes but instead associates with kinetochores...
  4. doi request reprint Structure-activity relationship of S-trityl-L-cysteine analogues as inhibitors of the human mitotic kinesin Eg5
    Salvatore DeBonis
    Institut de Biologie Structurale, 41, rue Jules Horowitz, 38027 Grenoble Cedex 01, France
    J Med Chem 51:1115-25. 2008
    ..The most effective compounds investigated with substitutions at the para-position of one phenyl ring have an estimated K i (app) of 100 nM in vitro and induce mitotic arrest with an EC 50 of 200 nM...
  5. ncbi request reprint Screening for inhibitors of microtubule-associated motor proteins
    Frank Kozielski
    Institut de Biologie Structurale, CEA CNRS UJF, Grenoble, France
    Methods Mol Med 137:189-207. 2007
    ....
  6. ncbi request reprint SMC5 and MMS21 are required for chromosome cohesion and mitotic progression
    Susanne Behlke-Steinert
    Institut de Biologie Structurale CEA, CNRS, UJF, Grenoble, France
    Cell Cycle 8:2211-8. 2009
    ..Our results thus establish that SMC5 is crucial for mitotic progression and maintenance of sister chromatid cohesion during mitosis, and that this role of SMC5 seems to be independent of the SMC5/6 complex...
  7. doi request reprint Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines
    Sergey Tcherniuk
    Institut de Biologie Structurale, CEA CNRS UJF J P Ebel, Laboratoire des Protéines du Cytosquelette 41 rue Jules Horowitz, 38027 Grenoble Cedex 01, France
    Biochem Pharmacol 79:864-72. 2010
    ..These data also suggest a possible mechanism by which drug resistance may occur in tumors treated with agents targeting Eg5...
  8. ncbi request reprint In vitro screening for inhibitors of the human mitotic kinesin Eg5 with antimitotic and antitumor activities
    Salvatore DeBonis
    Institut de Biologie Structurale, 41, rue Jules Horowitz, 38027 Grenoble Cedex 01, France
    Mol Cancer Ther 3:1079-90. 2004
    ....
  9. ncbi request reprint Analysis of the spindle-assembly checkpoint in HeLa cells
    Paul R Andreassen
    Institut de Biologie Structurale, J P Ebel CEA CNRS UJF, Grenoble, France
    Methods Mol Biol 281:213-25. 2004
    ..We also describe a bi-parameter flow cytometric assay, using either MPM-2 or anti-phospho-(Ser10)-histone H3 antibodies, for quantitating mitotic cells...
  10. pmc Structural basis of cytotoxicity mediated by the type III secretion toxin ExoU from Pseudomonas aeruginosa
    Claire Gendrin
    Bacterial Pathogenesis Group, Institut de Biologie Structurale IBS, Universite Grenoble I, Grenoble, France
    PLoS Pathog 8:e1002637. 2012
    ..This could reflect an attempt of the infected cell to target ExoU for degradation in order to protect itself from its aggressive cytotoxic action...