Olivier Schwartz

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Inhibition of human immunodeficiency virus type 1 Env-mediated fusion by DC-SIGN
    Cinzia Nobile
    Virus and Immunity Group, URA CNRS 1930, Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 77:5313-23. 2003
  2. pmc Covert human immunodeficiency virus replication in dendritic cells and in DC-SIGN-expressing cells promotes long-term transmission to lymphocytes
    Cinzia Nobile
    Institut Pasteur, Groupe Virus et Immunité, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 79:5386-99. 2005
  3. pmc SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells
    Benjamin Descours
    Institut de Genetique Humaine, CNRS UPR1142, Laboratoires de Virologie Moléculaire, Montpellier, France
    Retrovirology 9:87. 2012
  4. pmc Generation and characterization of a stable cell population releasing fluorescent HIV-1-based Virus Like Particles in an inducible way
    Claudia Muratori
    National AIDS Center, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    BMC Biotechnol 6:52. 2006
  5. doi request reprint Biology and pathogenesis of chikungunya virus
    Olivier Schwartz
    Institut Pasteur, 28 rue du Dr Roux, Paris 75724 Cedex 15, France
    Nat Rev Microbiol 8:491-500. 2010
  6. ncbi request reprint Cell of the month. Dendritic cell sensing a lymphocyte
    Olivier Schwartz
    Virus and Immunity Group, Institut Pasteur, Paris, France
    Nat Rev Mol Cell Biol 5:175. 2004
  7. pmc The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells
    Nicoletta Casartelli
    Unité Virus et Immunite, Institut Pasteur, 75724 Paris Cedex 15, France
    J Exp Med 207:39-49. 2010
  8. pmc Tetherin restricts productive HIV-1 cell-to-cell transmission
    Nicoletta Casartelli
    Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France
    PLoS Pathog 6:e1000955. 2010
  9. pmc DC-SIGN facilitates fusion of dendritic cells with human T-cell leukemia virus type 1-infected cells
    Pierre Emmanuel Ceccaldi
    Unité Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris Cedex 15, France
    J Virol 80:4771-80. 2006
  10. pmc Pediatric measles vaccine expressing a dengue antigen induces durable serotype-specific neutralizing antibodies to dengue virus
    Samantha Brandler
    Viral Genomics and Vaccination Laboratory, Institut Pasteur, CNRS URA3015, Paris, France
    PLoS Negl Trop Dis 1:e96. 2007

Detail Information

Publications68

  1. pmc Inhibition of human immunodeficiency virus type 1 Env-mediated fusion by DC-SIGN
    Cinzia Nobile
    Virus and Immunity Group, URA CNRS 1930, Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 77:5313-23. 2003
    ..DC-SIGN facilitates capture and accumulation of viral particles in a vesicular compartment and inhibits viral fusion. Competition between CD4 and DC-SIGN for Env binding likely affects virus access to the cytosol and syncytium formation...
  2. pmc Covert human immunodeficiency virus replication in dendritic cells and in DC-SIGN-expressing cells promotes long-term transmission to lymphocytes
    Cinzia Nobile
    Institut Pasteur, Groupe Virus et Immunité, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 79:5386-99. 2005
    ..The cell-type-dependent activity of DC-SIGN reflects the ability of HIV to replicate covertly in some cells, and not in others...
  3. pmc SAMHD1 restricts HIV-1 reverse transcription in quiescent CD4(+) T-cells
    Benjamin Descours
    Institut de Genetique Humaine, CNRS UPR1142, Laboratoires de Virologie Moléculaire, Montpellier, France
    Retrovirology 9:87. 2012
    ..Quiescent CD4+ T lymphocytes are highly refractory to HIV-1 infection due to a block at reverse transcription...
  4. pmc Generation and characterization of a stable cell population releasing fluorescent HIV-1-based Virus Like Particles in an inducible way
    Claudia Muratori
    National AIDS Center, Istituto Superiore di Sanita, Viale Regina Elena, 299, 00161 Rome, Italy
    BMC Biotechnol 6:52. 2006
    ..We sought to overcome such a limitation by using a cell line releasing HIV-1 particles in an inducible way, and by exploiting the ability of a HIV-1 Nef mutant to be incorporated in virions at quite high levels...
  5. doi request reprint Biology and pathogenesis of chikungunya virus
    Olivier Schwartz
    Institut Pasteur, 28 rue du Dr Roux, Paris 75724 Cedex 15, France
    Nat Rev Microbiol 8:491-500. 2010
    ..This Review highlights some of the most recent advances in our understanding of the biology of CHIKV and its interactions with the host...
  6. ncbi request reprint Cell of the month. Dendritic cell sensing a lymphocyte
    Olivier Schwartz
    Virus and Immunity Group, Institut Pasteur, Paris, France
    Nat Rev Mol Cell Biol 5:175. 2004
  7. pmc The antiviral factor APOBEC3G improves CTL recognition of cultured HIV-infected T cells
    Nicoletta Casartelli
    Unité Virus et Immunite, Institut Pasteur, 75724 Paris Cedex 15, France
    J Exp Med 207:39-49. 2010
    ..Our results reveal a novel function for A3G, acting not only as an intrinsic antiviral factor but also as an inducer of the adaptive immune system...
  8. pmc Tetherin restricts productive HIV-1 cell-to-cell transmission
    Nicoletta Casartelli
    Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France
    PLoS Pathog 6:e1000955. 2010
    ..Tetherin, by imprinting virions in donor cells, is the first example of a surface restriction factor limiting viral cell-to-cell spread...
  9. pmc DC-SIGN facilitates fusion of dendritic cells with human T-cell leukemia virus type 1-infected cells
    Pierre Emmanuel Ceccaldi
    Unité Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris Cedex 15, France
    J Virol 80:4771-80. 2006
    ..Altogether, our results indicate that DC-SIGN facilitates HTLV-1 infection and fusion of DCs through an ICAM-dependent mechanism...
  10. pmc Pediatric measles vaccine expressing a dengue antigen induces durable serotype-specific neutralizing antibodies to dengue virus
    Samantha Brandler
    Viral Genomics and Vaccination Laboratory, Institut Pasteur, CNRS URA3015, Paris, France
    PLoS Negl Trop Dis 1:e96. 2007
    ..The protective efficacy of this vaccine should be studied in non-human primates. A combined measles-dengue vaccine might provide a one-shot approach to immunize children against both diseases where they co-exist...
  11. ncbi request reprint DC-SIGN promotes exogenous MHC-I-restricted HIV-1 antigen presentation
    Arnaud Moris
    Groupe Virus et Immunité, URA CNRS 1930, Institut Pasteur, Paris, France
    Blood 103:2648-54. 2004
    ..Altogether, our results highlight new aspects of DC-SIGN interactions with HIV-1. The lectin does not significantly protect captured virions against degradation and promotes MHC-I exogenous presentation of HIV-1 antigens...
  12. pmc Simultaneous cell-to-cell transmission of human immunodeficiency virus to multiple targets through polysynapses
    Dominika Rudnicka
    Department of Virology, Virus and Immunity Unit, Institut Pasteur, URA CNRS 3015, Paris Cedex 15, France
    J Virol 83:6234-46. 2009
    ..In HIV-infected individuals, these structures, by promoting concomitant infection of multiple targets in the vicinity of infected cells, may facilitate exponential viral growth and escape from immune responses...
  13. pmc Inefficient human immunodeficiency virus replication in mobile lymphocytes
    Marion Sourisseau
    Groupe Virus et Immunité, URA CNRS 1930, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 81:1000-12. 2007
    ..Altogether, these results indicate that cell-to-cell transfer is the predominant mode of HIV spread and help to explain why this virus replicates so efficiently in lymphoid organs...
  14. doi request reprint Chikungunya-induced cell death is limited by ER and oxidative stress-induced autophagy
    Pierre Emmanuel Joubert
    Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, Paris, France
    Autophagy 8:1261-3. 2012
    ....
  15. pmc HIV-1 Nef inhibits ruffles, induces filopodia, and modulates migration of infected lymphocytes
    Cinzia Nobile
    Virus and Immunity Unit, Department of Virology, Institut Pasteur, URA CNRS 3015, 28 rue du Dr Roux, Paris Cedex 15, France
    J Virol 84:2282-93. 2010
    ..Therefore, Nef induces complex effects on the lymphocyte actin cytoskeleton and cellular morphology, which likely impacts the capacity of infected cells to circulate and to encounter and communicate with bystander cells...
  16. pmc Partial inhibition of human immunodeficiency virus replication by type I interferons: impact of cell-to-cell viral transfer
    Daniela Vendrame
    Institut Pasteur, Virus and Immunity Unit, CNRS URA 3015, 25 28 Rue du Dr Roux, 75724 Paris, France
    J Virol 83:10527-37. 2009
    ..They help explain the incomplete protection by naturally secreted IFN during HIV infection and the unsatisfactory outcome of IFN treatment in HIV-infected patients...
  17. pmc Type I IFN controls chikungunya virus via its action on nonhematopoietic cells
    Clementine Schilte
    Department of Immunology, Unité Immunobiologie des Cellules Dendritiques, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Exp Med 207:429-42. 2010
    ..This study defines an essential role for type I IFN, produced via cooperation between multiple host sensors and acting directly on nonhematopoietic cells, in the control of CHIKV...
  18. pmc ZAP-70 kinase regulates HIV cell-to-cell spread and virological synapse formation
    Nathalie Sol-Foulon
    Groupe Virus et Immunité, Institut Pasteur, CNRS URA1930, France
    EMBO J 26:516-26. 2007
    ..These results bring novel insights into the links that exist between T-cell activation and HIV spread, and suggest that HIV usurps components of the immunological synapse machinery to ensure its own spread through cell-to-cell contacts...
  19. pmc Restriction of foamy viruses by APOBEC cytidine deaminases
    Frédéric Delebecque
    Virus and Immunity Group, URA CNRS 1930, Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 80:605-14. 2006
    ..In infected hosts, the persistence strategy employed by FV might be based on low levels of replication, as well as avoidance of cells expressing large amounts of active cytidine deaminases...
  20. doi request reprint Transcytosis of HTLV-1 across a tight human epithelial barrier and infection of subepithelial dendritic cells
    Sandra Martin-Latil
    Unité Epidémiologie et Physiopathologie des Virus Oncogènes, URA Centre National de la Recherche Scientifique 3015, Institut Pasteur, Paris, France
    Blood 120:572-80. 2012
    ..The present study provides the first data pertaining to the mode of HTLV-1 transport across a tight epithelial barrier, as can occur during mother-to-child HTLV-1 transmission during breastfeeding...
  21. pmc Preclinical studies of a modified vaccinia virus Ankara-based HIV candidate vaccine: antigen presentation and antiviral effect
    Samantha Brandler
    Unité Virus et Immunite, Institut Pasteur, URA CNRS 3015, Paris, France
    J Virol 84:5314-28. 2010
    ..Deciphering the immune responses to MVA in culture experiments will help in the design of innovative vaccine strategies...
  22. ncbi request reprint Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse
    Maria Isabel Thoulouze
    Unite de Biologie Cellulaire des Lymphocytes, Centre National de la Recherche Scientifique Unité de Recherche Associée 1930, Institut Pasteur, 25 28 rue Dr Roux, 75724 Paris Cedex 15, France
    Immunity 24:547-61. 2006
    ..Alteration of endocytic and signaling networks at the immunological synapse likely impacts the function and fate of HIV-1-infected cells...
  23. pmc Innate sensing of HIV-infected cells
    Alice Lepelley
    Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France
    PLoS Pathog 7:e1001284. 2011
    ..Characterization of the mechanisms of innate recognition of HIV-infected cells allows a better understanding of the pathogenic and exacerbated immunologic events associated with HIV infection...
  24. pmc HIV-1 Nef promotes the localization of Gag to the cell membrane and facilitates viral cell-to-cell transfer
    Marine Malbec
    Departement de Virologie, Institut Pasteur, Unité Virus et Immunite, 28 rue du Docteur Roux, Paris F 75015, France
    Retrovirology 10:80. 2013
    ..Whether Nef modulates Gag and/or GagPol localization and assembly at the membrane and facilitates viral cell-to-cell transfer has not been extensively characterized so far...
  25. ncbi request reprint HIV-1 Nef-induced upregulation of DC-SIGN in dendritic cells promotes lymphocyte clustering and viral spread
    Nathalie Sol-Foulon
    Unité Rétrovirus et Transfert Génétique, URA CNRS 1930, Institut Pasteur, 28 rue du Docteur Roux, 75724 Cedex 15, Paris, France
    Immunity 16:145-55. 2002
    ..These results provide new insights into how HIV-1 spreads from DCs to T lymphocytes and manipulates immune responses. They help explain how Nef may act as a virulence factor in vivo...
  26. pmc Characterization of reemerging chikungunya virus
    Marion Sourisseau
    Department of Virology, Unité Virus et Immunite, Institut Pasteur, Paris, France
    PLoS Pathog 3:e89. 2007
    ..CHIKV was highly sensitive to the antiviral activity of type I and II interferons. These results provide a general insight into the interaction between CHIKV and its mammalian host...
  27. pmc SAMHD1 restricts HIV-1 cell-to-cell transmission and limits immune detection in monocyte-derived dendritic cells
    Isabel Puigdomènech
    Institut Pasteur, Unité Virus et Immunite, Departement de Virologie, and CNRS, URA3015, Paris, France
    J Virol 87:2846-56. 2013
    ..Therefore, SAMHD1, by controlling the sensitivity of MDDCs to HIV-1 infection during intercellular contacts, impacts their ability to sense the virus and to trigger an innate immune response...
  28. doi request reprint Cutting edge: independent roles for IRF-3 and IRF-7 in hematopoietic and nonhematopoietic cells during host response to Chikungunya infection
    Clementine Schilte
    Unité d Immunobiologie des Cellules Dendritiques, Departement d Immunologie, Institut Pasteur, Paris 75724, France
    J Immunol 188:2967-71. 2012
    ..These results highlight the interplay between nonimmune and immune cells during Chikungunya virus infection and suggest an important role for nonhematopoietic cells as a critical source of IFN-α/β...
  29. pmc DC-SIGN from African green monkeys is expressed in lymph nodes and mediates infection in trans of simian immunodeficiency virus SIVagm
    Mickaël J Y Ploquin
    Unité de Biologie des Rétrovirus, Institut Pasteur, Paris, France
    J Virol 78:798-810. 2004
    ....
  30. doi request reprint Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles
    Zacarias Garcia
    Institut Pasteur, Dynamics of Immune Responses Unit, Paris, France
    Blood 120:4744-50. 2012
    ..Our results identify SCS macrophages as primary mediators of NK cell activation in response to lymph-borne viral particles suggesting that they act as early sensors of local infection or delivery of viral-based vaccines...
  31. pmc HIV cell-to-cell transmission requires the production of infectious virus particles and does not proceed through env-mediated fusion pores
    Blandine Monel
    INSERM U941, Hopital Saint Louis, Paris, France
    J Virol 86:3924-33. 2012
    ..The increased efficiency of this infection route may thus be attributed to the high local concentrations of virus particles at sites of cellular contacts rather than to a qualitatively different transmission process...
  32. pmc A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76
    Vincenzo Di Bartolo
    Molecular Immunology Unit, Centre National de la Recherche Scientifique CNRS URA 1961, Institut Pasteur, 75724 Paris, Cedex 15, France
    J Exp Med 204:681-91. 2007
    ..These data reveal a novel negative feedback loop involving HPK-1-dependent serine phosphorylation of SLP-76 and 14-3-3 protein recruitment, which tunes T cell activation...
  33. ncbi request reprint The effects of HIV-1 Nef on CD4 surface expression and viral infectivity in lymphoid cells are independent of rafts
    Nathalie Sol-Foulon
    Virus and Immunity Group, URA CNRS 1930, Paris, France
    J Biol Chem 279:31398-408. 2004
    ..Altogether, these results strongly suggest that rafts are not a key element involved in the effects of Nef on trafficking of cellular proteins and on viral replication...
  34. ncbi request reprint Dendritic cells and HIV-specific CD4+ T cells: HIV antigen presentation, T-cell activation, and viral transfer
    Arnaud Moris
    Groupe Virus et Immunité, Unité de Recherche Associée URA Centre National de la Recherche Scientifique CNRS 1930, Paris, France
    Blood 108:1643-51. 2006
    ..Our results unravel the mechanisms of MHC-II-restricted HIV antigen presentation by DCs and describe how HIV gains access to the very cells designed by the immune system to counteract this pathogen...
  35. ncbi request reprint The Siva protein is a novel intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T-lymphoid cells
    Bénédicte Py
    Institut Cochin, CNRS UMR 8104, Universite Paris Descartes, 27 rue du Faubourg Saint Jacques, 75014, Paris, France
    Apoptosis 12:1879-92. 2007
    ..Altogether, these results suggest that Siva-1 might participate in the CD4-initiated signaling apoptotic pathway induced by the HIV-1 envelope in T-lymphoid cells...
  36. pmc Hyperthermia stimulates HIV-1 replication
    Ferdinand Roesch
    Institut Pasteur, Unité Virus et Immunite, Departement de Virologie, Paris, France
    PLoS Pathog 8:e1002792. 2012
    ..Altogether, our results indicate that fever may directly stimulate HIV-1 replication, in a process involving Hsp90 and facilitation of Tat-mediated LTR activity...
  37. pmc CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope
    Sylvain Cardinaud
    INSERM, UMR S945, Université Pierre et Marie Curie UPMC, Paris, France
    PLoS Pathog 7:e1002049. 2011
    ..Our results strongly suggest that HIV-1 escapes CTL surveillance by introducing mutations leading to HIV ARF-epitope destruction by proteasomes...
  38. pmc Innate sensing of foamy viruses by human hematopoietic cells
    Rejane Rua
    Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France
    J Virol 86:909-18. 2012
    ..Therefore, FV are potent inducers of type I IFN by pDCs and by PBMCs. This previously underestimated activation of the innate immune response may be involved in the control of viral replication in humans...
  39. pmc Chikungunya virus-induced autophagy delays caspase-dependent cell death
    Pierre Emmanuel Joubert
    Unité Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, Paris, France
    J Exp Med 209:1029-47. 2012
    ..Our study suggests that inducers of autophagy may limit the pathogenesis of acute Chikungunya disease...
  40. ncbi request reprint Antigen crosspresentation by human plasmacytoid dendritic cells
    Guillaume Hoeffel
    Departement d Immunologie, Institut Cochin, Paris, F 75014, France
    Immunity 27:481-92. 2007
    ....
  41. doi request reprint Live attenuated measles vaccine expressing HIV-1 Gag virus like particles covered with gp160DeltaV1V2 is strongly immunogenic
    Mathilde Guerbois
    Laboratoire de Génomique Virale et Vaccination, CNRS URA 3015, Institut Pasteur, Paris Cedex 15, France
    Virology 388:191-203. 2009
    ..This candidate vaccine will be next tested in non-human primates. As a pediatric vaccine, it might protect children and adolescents simultaneously from measles and HIV...
  42. pmc Neonatal plasmacytoid dendritic cells (pDCs) display subset variation but can elicit potent anti-viral innate responses
    Xiaoming Zhang
    Régulation Immunitaire et Vaccinologie, Institut Pasteur, Paris, France
    PLoS ONE 8:e52003. 2013
    ..Therefore, neonatal pDCs clearly display variation in phenotype and subset composition, but without major consequences for their antiviral responses...
  43. pmc Identification of cryptic MHC I-restricted epitopes encoded by HIV-1 alternative reading frames
    Sylvain Cardinaud
    Unité Cellulaire Antivirale, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Exp Med 199:1053-63. 2004
    ..This should be taken into account when designing vaccine strategies aimed at activating these responses...
  44. doi request reprint HIV escape from natural killer cytotoxicity: nef inhibits NKp44L expression on CD4+ T cells
    Hugues Fausther-Bovendo
    INSERM UMR945, Hopital Pitie Salpetriere, Paris, France
    AIDS 23:1077-87. 2009
    ..NKp44LCD4 T cells are highly sensitive to the NK lysis activity. In contrast, HIV-infected CD4 T cells are resistant to NK killing, suggesting that HIV-1 developed strategies to avoid detection by the host cell immunity...
  45. ncbi request reprint DC-SIGN and L-SIGN are high affinity binding receptors for hepatitis C virus glycoprotein E2
    Pierre Yves Lozach
    Unite d Immunologie Virale, Institut Pasteur, 28, rue du Dr Roux, 75015 Paris, France
    J Biol Chem 278:20358-66. 2003
    ..High affinity interaction of viral glycoproteins with oligomeric lectins might represent a strategy by which HCV targets to and concentrates in the liver and infects dendritic cells...
  46. doi request reprint Restricting HIV the SAMHD1 way: through nucleotide starvation
    Diana Ayinde
    Institut Pasteur, Unité Virus et Immunite, Departement de Virologie, Centre National de la Recherche Scientifique, Unité de Recherche Associée 3015, Paris, France
    Nat Rev Microbiol 10:675-80. 2012
    ..In this Progress article, we describe how SAMHD1 regulates the pool of intracellular nucleotides to control HIV replication and the innate immune response...
  47. pmc DC-SIGN induction in alveolar macrophages defines privileged target host cells for mycobacteria in patients with tuberculosis
    Ludovic Tailleux
    Institut Pasteur, Unite de Genetique Mycobacterienne, Paris, France
    PLoS Med 2:e381. 2005
    ....
  48. pmc Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish
    Nuno Palha
    Institut Pasteur, Macrophages et Développement de l Immunité, Department of Developmental and Stem Cells Biology, Paris, France CNRS URA2578, Paris, France Université Pierre et Marie Curie, Paris, France
    PLoS Pathog 9:e1003619. 2013
    ..Altogether, our results show that the zebrafish represents a novel valuable model to dynamically visualize replication, pathogenesis and host responses to a human virus. ..
  49. pmc Human muscle satellite cells as targets of Chikungunya virus infection
    Simona Ozden
    Unité Epidémiologie et Physiopathologie des Virus Oncogènes CNRS URA1930, Institut Pasteur, Paris, France
    PLoS ONE 2:e527. 2007
    ..7% of cases. Since the cellular targets of CHIK virus in humans are unknown, we studied the pathogenic events and targets of CHIK infection in skeletal muscle...
  50. pmc A new role for the HTLV-1 p8 protein: increasing intercellular conduits and viral cell-to-cell transmission
    Marine Malbec
    Virus and Immunity Unit, Institut Pasteur, URA CNRS 3015, 28 rue du Dr Roux, 75724 Paris, France
    Viruses 3:254-9. 2011
    ..So far, only synapses and biofilms have been described for HTLV-1 transmission. Recently, Van Prooyen et al. [1] identified an additional mode of HTLV-1 transmission through cellular conduits induced by the viral accessory protein p8...
  51. ncbi request reprint Extensive editing of a small fraction of human T-cell leukemia virus type 1 genomes by four APOBEC3 cytidine deaminases
    Renaud Mahieux
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Gen Virol 86:2489-94. 2005
    ..Thus, although HTLV-1 DNA can indeed be edited by at least four APOBEC3 cytidine deaminases in vitro, they are conspicuously absent in vivo...
  52. pmc HIV-1 Virological Synapse: Live Imaging of Transmission
    Jerome Feldmann
    Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, 28 rue du Dr Roux, 75724 Paris, France
    Viruses 2:1666-80. 2010
    ..This review will recapitulate current knowledge with a particular emphasis on the questions live microscopy has raised...
  53. ncbi request reprint HIV-1 buds and accumulates in "nonacidic" endosomes of macrophages
    Mabel Jouve
    Institut Curie, INSERM U653, 26 rue d Ulm 75248 Paris Cedex 05, France
    Cell Host Microbe 2:85-95. 2007
    ..Thus, HIV-1 has developed a strategy for survival within infected macrophages involving prevention of acidification within a devoted endocytic virus assembly compartment...
  54. pmc Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue viruses
    Erika Navarro-Sanchez
    Interactions Moléculaires Flavivirus Hôtes, 25 rue du Dr Roux, 75724 Paris, France
    EMBO Rep 4:723-8. 2003
    ..Mosquito-cell-derived DVs may have differential infectivity for DC-SIGN-expressing cells. We suggest that the differential use of DC-SIGN by viral envelope glycoproteins may account for the immunopathogenesis of DVs...
  55. pmc The core lipopolysaccharide of Escherichia coli is a ligand for the dendritic-cell-specific intercellular adhesion molecule nonintegrin CD209 receptor
    John Klena
    School of Molecular Biosciences, Washington State University, Pullman, Washington, USA
    J Bacteriol 187:1710-5. 2005
    ..coli in part by interacting with the complete core region of the LPS molecule. These results provide a mechanism for how O antigen acts as an antiphagocytic factor...
  56. ncbi request reprint Functional characterization of HIV-1 Nef mutants in the context of viral infection
    Oliver T Fackler
    Department of Virology, University of Heidelberg, INF 324, D 69120 Heidelberg, Germany
    Virology 351:322-39. 2006
    ..The results emphasize that multiple activities govern Nef's effects on HIV replication and argue against a role of virion incorporation for Nef's activity as pathogenicity factor...
  57. pmc Deciphering the molecular bases of Mycobacterium tuberculosis binding to the lectin DC-SIGN reveals an underestimated complexity
    Sylvain Pitarque
    Institut de Pharmacologie et de Biologie Structurale, Département Mécanismes Moléculaires des Infections Mycobactériennes, CNRS UMR 5089, 205 route de Narbonne, 31077 Toulouse Cedex 4, France
    Biochem J 392:615-24. 2005
    ..tuberculosis binding to DC-SIGN is more complicated than previously thought and provides further insight into the mechanisms of M. tuberculosis recognition by the immune system...
  58. pmc Human dendritic cell-specific intercellular adhesion molecule-grabbing nonintegrin (CD209) is a receptor for Yersinia pestis that promotes phagocytosis by dendritic cells
    Pei Zhang
    Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago UIC, 1601 Parkview Avenue, Rockford, IL 61107, USA
    Infect Immun 76:2070-9. 2008
    ..pestis and human DCs can be reduced by a combination treatment with anti-CD209 and anti-CD207 antibodies. This study shows that human DC-SIGN is a receptor for Y. pestis that promotes phagocytosis by DCs in vitro...
  59. pmc DC-SIGN is the major Mycobacterium tuberculosis receptor on human dendritic cells
    Ludovic Tailleux
    INSERM EMI 0013 Institut Universitaire d Hématologie, Assistance Publique Hopitaux de Paris, France
    J Exp Med 197:121-7. 2003
    ..Thus, as for human immunodeficiency virus (HIV), which is captured by the same receptor, DC-SIGN-mediated entry of M. tuberculosis in DCs in vivo is likely to influence bacterial persistence and host immunity...
  60. ncbi request reprint DC-SIGN (CD209) recognition of Neisseria gonorrhoeae is circumvented by lipooligosaccharide variation
    Pei Zhang
    Department of Biomedical Sciences, College of Medicine, University of Illinois at Chicago, USA
    J Leukoc Biol 79:731-8. 2006
    ..The experiments suggest that LOS variation may have evolved as a mechanism for GC to avoid phagocytosis by DCs...
  61. ncbi request reprint Activation of the lectin DC-SIGN induces an immature dendritic cell phenotype triggering Rho-GTPase activity required for HIV-1 replication
    Ashleigh Hodges
    Medical Research Council Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
    Nat Immunol 8:569-77. 2007
    ..Activation of LARG in DCs exposed to HIV was required for the formation of virus-T cell synapses. Thus, HIV sequestration by and stimulation of DC-SIGN helps HIV evade immune responses and spread to cells...
  62. doi request reprint HIV-1 Nef protein expression in human CD34+ progenitors impairs the differentiation of an early T/NK cell precursor
    Céline Dorival
    INSERM U 841, Faculte de Medecine, Creteil, France
    Virology 377:207-15. 2008
    ..Altogether, these data demonstrate that Nef interferes with the differentiation of a primitive lymphoid human precursor with a T/NK potential...
  63. pmc The human polycomb group EED protein interacts with the integrase of human immunodeficiency virus type 1
    Sebastien Violot
    Laboratoire de Virologie and Pathogénèse Virale, Faculté de médecine RTH Laennec, CNRS UMR 5537, France
    J Virol 77:12507-22. 2003
    ..i., suggesting the ocurrence of multiprotein complexes involving these three proteins at early steps of the HIV-1 virus life cycle. Such IEM patterns were not observed with a noninfectious, envelope deletion mutant of HIV-1...
  64. ncbi request reprint Modulation of the immunological synapse: a key to HIV-1 pathogenesis?
    Oliver T Fackler
    Oliver T Fackler is at the Department of Virology, University of Heidelberg, D 69120 Heidelberg, Germany
    Nat Rev Immunol 7:310-7. 2007
    ..We propose that modulating lymphocyte signalling, apoptosis and intracellular trafficking ensures efficient spread of the virus in the hostile environment of the immune system...
  65. ncbi request reprint Langerhans cells lap up HIV-1
    Olivier Schwartz
    Nat Med 13:245-6. 2007
  66. pmc Processing of the bovine spongiform encephalopathy-specific prion protein by dendritic cells
    Catherine Rybner-Barnier
    Neurovirologie et Régénération du Système Nerveux, Department de Neurosciences, Repliement et Modélisation des Protéines, Dpt Biologie Structurale et Chimie, Biologie des Régulations Immunaires, INSERM E352, 75015 Paris, France
    J Virol 80:4656-63. 2006
    ....
  67. pmc Dual inhibitory effects of APOBEC family proteins on retrotransposition of mammalian endogenous retroviruses
    Cécile Esnault
    Unité des rétrovirus endogènes et éléments rétroïdes des eucaryotes supérieurs, CNRS UMR 8122 Institut, Gustave Roussy, 94805 Villejuif, France
    Nucleic Acids Res 34:1522-31. 2006
    ..This dual, two-step effect likely participates in the efficient defense of the cell genome against invading endogenous retroelements...
  68. ncbi request reprint [HIV-1, a very Vif virus]
    Olivier Schwartz
    Med Sci (Paris) 20:139-41. 2004