M J Schlumberger

Summary

Affiliation: Institut Gustave Roussy
Country: France

Publications

  1. ncbi request reprint Is stimulation of thyroglobulin (Tg) useful in low-risk patients with thyroid carcinoma and undetectable Tg on thyroxin and negative neck ultrasound?
    Martin Schlumberger
    Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Clin Endocrinol (Oxf) 62:119-20. 2005
  2. ncbi request reprint Prognostic factors for persistent or recurrent disease of papillary thyroid carcinoma with neck lymph node metastases and/or tumor extension beyond the thyroid capsule at initial diagnosis
    Sophie Leboulleux
    Department of Nuclear Medicine and Endocrine Tumors, Institut National de la Santé et de la Recherche Médicale U605, Institut Gustave Roussy, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    J Clin Endocrinol Metab 90:5723-9. 2005
  3. pmc Long-term outcome of medullary thyroid carcinoma in patients with normal postoperative medical imaging
    G Pellegriti
    , Institut Gustave Roussy, Villejuif, France
    Br J Cancer 88:1537-42. 2003
  4. ncbi request reprint Target therapies for radioiodine refractory advanced thyroid tumors
    M Schlumberger
    Department of Nuclear Medicine and Endocrine Oncology, Centre de Référence Tumeurs Réfractaires de la Thyroïde, Institut Gustave Roussy and University Paris Sud, Villejuif, France
    J Endocrinol Invest 35:40-4. 2012
  5. pmc Kinase inhibitors for advanced medullary thyroid carcinoma
    Martin Schlumberger
    Centre de Référence Tumeurs Réfractaires de la Thyroïde, Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, University Paris Sud XI, Villejuif, France
    Clinics (Sao Paulo) 67:125-9. 2012
  6. doi request reprint Strategies of radioiodine ablation in patients with low-risk thyroid cancer
    Martin Schlumberger
    Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy and University Paris Sud, Villejuif, France
    N Engl J Med 366:1663-73. 2012
  7. pmc Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation?
    Eusebio Chiefari
    Department of Clinical Sciences, University of Roma La Sapienza, Roma, Italy
    BMC Cancer 2:35. 2002
  8. ncbi request reprint Follow-up and management of differentiated thyroid carcinoma: a European perspective in clinical practice
    Martin Schlumberger
    service de Medicine Nucleaire, Institut Gustave Roussy, 94805 Villejuif, France
    Eur J Endocrinol 151:539-48. 2004
  9. doi request reprint Clinical trials for progressive differentiated thyroid cancer: patient selection, study design, and recent advances
    Martin Schlumberger
    Department of Nuclear Medicine and Endocrine Oncology, Referral Center for Refractory Thyroid Tumors, Institut National du Cancer, Institut Gustave Roussy, Villejuif, France
    Thyroid 19:1393-400. 2009
  10. doi request reprint [Management of refractory thyroid cancers]
    M Schlumberger
    Service de médecine nucléaire et d oncologie endocrinienne, Université Paris Sud et Institut Gustave Roussy, Villejuif Cedex, France
    Ann Endocrinol (Paris) 72:149-57. 2011

Detail Information

Publications88

  1. ncbi request reprint Is stimulation of thyroglobulin (Tg) useful in low-risk patients with thyroid carcinoma and undetectable Tg on thyroxin and negative neck ultrasound?
    Martin Schlumberger
    Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Clin Endocrinol (Oxf) 62:119-20. 2005
  2. ncbi request reprint Prognostic factors for persistent or recurrent disease of papillary thyroid carcinoma with neck lymph node metastases and/or tumor extension beyond the thyroid capsule at initial diagnosis
    Sophie Leboulleux
    Department of Nuclear Medicine and Endocrine Tumors, Institut National de la Santé et de la Recherche Médicale U605, Institut Gustave Roussy, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    J Clin Endocrinol Metab 90:5723-9. 2005
    ..Initial treatment, performed at the Institut Gustave Roussy between 1987 and 1997, included in all patients a total thyroidectomy with central and ipsilateral en bloc neck dissection followed by radioactive iodine ablation...
  3. pmc Long-term outcome of medullary thyroid carcinoma in patients with normal postoperative medical imaging
    G Pellegriti
    , Institut Gustave Roussy, Villejuif, France
    Br J Cancer 88:1537-42. 2003
    ..01). These results show that postoperative CT level and tumour extension are critical prognostic factors for the identification of patients at a high risk of relapse...
  4. ncbi request reprint Target therapies for radioiodine refractory advanced thyroid tumors
    M Schlumberger
    Department of Nuclear Medicine and Endocrine Oncology, Centre de Référence Tumeurs Réfractaires de la Thyroïde, Institut Gustave Roussy and University Paris Sud, Villejuif, France
    J Endocrinol Invest 35:40-4. 2012
    ..They are mainly represented by protein kinase inhibitor molecules that should be proposed to advanced and progressive 131I refractory thyroid cancer patients by enrolling them in clinical trials or by the "off label" use of the drug...
  5. pmc Kinase inhibitors for advanced medullary thyroid carcinoma
    Martin Schlumberger
    Centre de Référence Tumeurs Réfractaires de la Thyroïde, Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, University Paris Sud XI, Villejuif, France
    Clinics (Sao Paulo) 67:125-9. 2012
    ..In patients with progressive disease, treatment with kinase inhibitors should be offered...
  6. doi request reprint Strategies of radioiodine ablation in patients with low-risk thyroid cancer
    Martin Schlumberger
    Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy and University Paris Sud, Villejuif, France
    N Engl J Med 366:1663-73. 2012
    ..The administration of the smallest possible amount of radioiodine would improve care...
  7. pmc Increased expression of AP2 and Sp1 transcription factors in human thyroid tumors: a role in NIS expression regulation?
    Eusebio Chiefari
    Department of Clinical Sciences, University of Roma La Sapienza, Roma, Italy
    BMC Cancer 2:35. 2002
    ..In the majority of thyroid cancers, however, iodide uptake is reduced, probably as a result of decreased NIS protein expression...
  8. ncbi request reprint Follow-up and management of differentiated thyroid carcinoma: a European perspective in clinical practice
    Martin Schlumberger
    service de Medicine Nucleaire, Institut Gustave Roussy, 94805 Villejuif, France
    Eur J Endocrinol 151:539-48. 2004
    ..We also offer expanded and additional comments on various issues in the management of DTC...
  9. doi request reprint Clinical trials for progressive differentiated thyroid cancer: patient selection, study design, and recent advances
    Martin Schlumberger
    Department of Nuclear Medicine and Endocrine Oncology, Referral Center for Refractory Thyroid Tumors, Institut National du Cancer, Institut Gustave Roussy, Villejuif, France
    Thyroid 19:1393-400. 2009
    ..In those with progressive disease, treatment with kinase inhibitors should be offered preferably in the context of a prospective trial...
  10. doi request reprint [Management of refractory thyroid cancers]
    M Schlumberger
    Service de médecine nucléaire et d oncologie endocrinienne, Université Paris Sud et Institut Gustave Roussy, Villejuif Cedex, France
    Ann Endocrinol (Paris) 72:149-57. 2011
    ..These inhibitors are effective in differentiated and medullary thyroid cancers, and induce a partial response or a long-term stabilisation in more than half of patients...
  11. ncbi request reprint [Papillary and follicular thyroid carcinoma]
    M Schlumberger
    Service de Medecine Nucleaire, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Ann Endocrinol (Paris) 68:120-8. 2007
    ..In the other patients, other tests may be indicated, starting with the administration of a large activity of radioiodine. In these patients, serum TSH should be decreased to a low level...
  12. ncbi request reprint Follow-up of low-risk patients with differentiated thyroid carcinoma: a European perspective
    Martin Schlumberger
    Institut Gustave Roussy, Villejuif, France
    Eur J Endocrinol 150:105-12. 2004
    ..We sought to develop an improved protocol for the follow-up of low-risk patients with DTC based on the findings of recent studies...
  13. ncbi request reprint Diagnostic follow-up of well-differentiated thyroid carcinoma: historical perspective and current status
    M J Schlumberger
    Nuclear Medicine and Endocrine Tumours, Institut Gustave Roussy and Université Paris Sud, Villejuif, France
    J Endocrinol Invest 22:3-7. 1999
    ..Continued work in these three areas and in new areas will allow the thyroidology community to build on, and patients to benefit from recent progress...
  14. ncbi request reprint How the availability of recombinant human TSH has changed the management of patients who have thyroid cancer
    Martin Schlumberger
    University Paris Sud, Paris, France
    Nat Clin Pract Endocrinol Metab 3:641-50. 2007
    ....
  15. ncbi request reprint Comparison of seven serum thyroglobulin assays in the follow-up of papillary and follicular thyroid cancer patients
    M Schlumberger
    Institut Gustave Roussy, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    J Clin Endocrinol Metab 92:2487-95. 2007
    ..Serum thyroglobulin (Tg) is the marker of differentiated thyroid cancer after initial treatment and TSH stimulation increases its sensitivity for the diagnosis of recurrent disease...
  16. doi request reprint Approach to the patient with advanced differentiated thyroid cancer
    M Schlumberger
    Department of Nuclear Medicine and Endocrine Oncology, Centre de Référence Tumeurs Réfractaires de la Thyroïde, Institut Gustave Roussy and University Paris Sud XI, 94800 Villejuif, France
    Eur J Endocrinol 166:5-11. 2012
    ..Encouraging results have been obtained with the use of kinase inhibitors that should be offered as first-line treatment, preferably in the context of a prospective trial...
  17. ncbi request reprint Clinical use of recombinant human TSH in thyroid cancer patients
    M Schlumberger
    Department of Nuclear Medicine and Endocrine Tumors, Institut Gustave Roussy, 94805 Villejuif, Cedex France
    Eur J Endocrinol 143:557-63. 2000
    ..Its clinical efficiency for the detection of persistent and recurrent disease is similar to that of thyroid hormone withdrawal. The main purpose for its use is to avoid hypothyroidism...
  18. doi request reprint [Refractory thyroid cancers]
    Martin Schlumberger
    Institut Gustave Roussy, Universite Paris Sud, Service de médecine nucléaire et d oncologie endocrinienne, 94805 Villejuif Cedex, France
    Presse Med 40:1189-98. 2011
    ..Their toxicity is significant and these treatments should be given only to selected patients with locally advanced or metastatic disease, with progression or with clinical symptoms...
  19. ncbi request reprint New therapeutic approaches to treat medullary thyroid carcinoma
    Martin Schlumberger
    University Paris Sud 11, Paris, France
    Nat Clin Pract Endocrinol Metab 4:22-32. 2008
    ..Although RET mutations are common in hereditary MTC and can occur in some cases of sporadic MTC, knowledge of other molecular defects associated with the development of MTC should reveal new targets for therapy...
  20. ncbi request reprint The role of recombinant thyroid-stimulating hormone (rhTSH) in the detection and management of well-differentiated thyroid carcinoma: a roundtable discussion
    M J Schlumberger
    Nuclear Medicine and Endocrine Tumours, Institut Gustave Roussy, Villejuif, France
    J Endocrinol Invest 22:35-41. 1999
    ..Clinical studies are underway to confirm the preliminary promise of rhTSH as an adjunct to radioablation of normal or neoplastic thyroid tissue, with emphasis on the therapeutic setting...
  21. ncbi request reprint Defects in iodide metabolism in thyroid cancer and implications for the follow-up and treatment of patients
    Martin Schlumberger
    Oncology at University Paris Sud, Paris, France
    Nat Clin Pract Endocrinol Metab 3:260-9. 2007
    ..Novel strategies are currently being explored to restore iodine uptake in cancer cells that are unable to concentrate radioiodine...
  22. ncbi request reprint Imaging medullary thyroid carcinoma with persistent elevated calcitonin levels
    Anne Laure Giraudet
    Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    J Clin Endocrinol Metab 92:4185-90. 2007
    ..Because calcitonin level remains elevated after initial treatment in many medullary thyroid carcinoma (MTC) patients without evidence of disease in the usual imaging work-up, there is a need to define optimal imaging procedures...
  23. ncbi request reprint Radioiodine therapy for papillary and follicular thyroid carcinoma
    Michele Klain
    Department of Nuclear Medicine and Commissariat à l Energie Atomique LRC 29V, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Eur J Nucl Med Mol Imaging 29:S479-85. 2002
    ..It should be used selectively, i.e. only in those patients for whom a clinical benefit may be expected...
  24. doi request reprint Histologic results of para-aortic lymphadenectomy in patients treated for stage IB2/II cervical cancer with negative [18F]fluorodeoxyglucose positron emission tomography scans in the para-aortic area
    Mathias Boughanim
    Department of Surgery, Institut Gustave Roussy, and University Paris Sud, Villejuif, France
    J Clin Oncol 26:2558-61. 2008
    ....
  25. ncbi request reprint Rationale for central and bilateral lymph node dissection in sporadic and hereditary medullary thyroid cancer
    Claudia Scollo
    Nuclear Medicine, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    J Clin Endocrinol Metab 88:2070-5. 2003
    ....
  26. doi request reprint Prophylactic lymph node dissection for papillary thyroid cancer less than 2 cm: implications for radioiodine treatment
    Stephane Bonnet
    Department of Oncologic Surgery, Institut Gustave Roussy, Villejuif Cedex, France
    J Clin Endocrinol Metab 94:1162-7. 2009
    ..The aim was to determine the effect of lymph node (LN) staging on the indication for treatment with radioiodine...
  27. ncbi request reprint Neck recurrence from thyroid carcinoma: serum thyroglobulin and high-dose total body scan are not reliable criteria for cure after radioiodine treatment
    Anne Bachelot
    Department of Nuclear Medicine and Endocrine Tumours, Institut Gustave Roussy, Villejuif Cedex, France
    Clin Endocrinol (Oxf) 62:376-9. 2005
    ....
  28. doi request reprint Transarterial chemoembolization of liver metastases from well differentiated gastroenteropancreatic endocrine tumors with doxorubicin-eluting beads: preliminary results
    Thierry de Baere
    Department of Interventional Radiology, Institut Gustave Roussy, rue Camille Desmoulins, Villejuif 94805, France
    J Vasc Interv Radiol 19:855-61. 2008
    ..To evaluate the feasibility, safety, and efficacy of transarterial chemoembolization (TACE) of progressive liver metastases from well differentiated gastroenteropancreatic endocrine (GEP) tumors with drug-eluting beads (DEBs)...
  29. ncbi request reprint Correlation between [18f]fluorodeoxyglucose positron-emission tomography scan and histology of pelvic nodes in early-stage cervical cancer
    Enrica Bentivegna
    Department of Surgery, Gustave Roussy Institute University Paris Sud, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Anticancer Res 30:1029-32. 2010
    ....
  30. ncbi request reprint Combined treatment of anaplastic thyroid carcinoma with surgery, chemotherapy, and hyperfractionated accelerated external radiotherapy
    Renaud de Crevoisier
    Department of Radiation Oncology, Institut Gustave Roussy, Villejuif, France
    Int J Radiat Oncol Biol Phys 60:1137-43. 2004
    ..To analyze a prospective protocol combining surgery, chemotherapy (CT), and hyperfractionated accelerated radiotherapy (RT) in anaplastic thyroid carcinoma...
  31. doi request reprint 131I effective half-life and dosimetry in thyroid cancer patients
    Hervé Remy
    Department of Nuclear Medicine, Institut Gustave Roussy, Villejuif, France
    J Nucl Med 49:1445-50. 2008
    ..There are still some uncertainties concerning parameters that may influence the effective half-life of (131)I and the absorbed doses by extrathyroidal organs...
  32. ncbi request reprint The role of PET in follow-up of patients treated for differentiated epithelial thyroid cancers
    Sophie Leboulleux
    Department of Nuclear Medicine and Endocrine Tumors at the Institut Gustave Roussy, Villejuif, France
    Nat Clin Pract Endocrinol Metab 3:112-21. 2007
    ..In patients with metastatic disease, PET can help to identify patients needing closer follow-up...
  33. doi request reprint Prognostic factors influencing survival from metastatic (stage IV) gastroenteropancreatic well-differentiated endocrine carcinoma
    Cosimo Durante
    Service de Médecine Nucléaire et de Cancérologie Endocrinienne, Institut Gustave Roussy, Universite Paris XI, 94805 Villejuif Cedex, France
    Endocr Relat Cancer 16:585-97. 2009
    ..This study enables the stratification of metastatic GEP WDEC patients into distinct risk groups. These risk categories can be used to tailor therapeutic approaches and also to design and interpret clinical trials...
  34. ncbi request reprint Functional characterization of human thyroid tissue with immunohistochemistry
    Antongiulio Faggiano
    Department of Pathology, Commissariat à l Energie Atomique LRC29V, Institut Gustave Roussy, University Paris Sud, Villejuif Cedex, France
    Thyroid 17:203-11. 2007
    ....
  35. doi request reprint Charcoal suspension tattoo localization for differentiated thyroid cancer recurrence
    Dana M Hartl
    Department of Otolaryngology Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France
    Ann Surg Oncol 16:2602-8. 2009
    ..Intraoperative localization of these small foci in previously dissected necks is a surgical challenge. We describe a new technique for ultrasound-guided tattooing to facilitate excision...
  36. ncbi request reprint Ultrasound criteria of malignancy for cervical lymph nodes in patients followed up for differentiated thyroid cancer
    Sophie Leboulleux
    Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    J Clin Endocrinol Metab 92:3590-4. 2007
    ..Neck ultrasonography (US) has become a keystone in the follow-up of patients with differentiated thyroid cancer...
  37. ncbi request reprint Characteristics of follicular cell-derived thyroid carcinomas occurring after external radiation exposure: results of a case control study nested in a cohort
    Carole Rubino
    Unit of Cancer Epidemiology, National Institute of Health and Medical Research U521 INSERM, Villejuif, France
    Thyroid 12:299-304. 2002
    ..1-6.5), and conversely the frequency of follicular histology was similar in male cases and in male controls (OR = 0.3, 95% CI: 0.1-1.4). The risks of recurrence and of thyroid cancer related death were similar in cases and in controls...
  38. ncbi request reprint The risk of multiple primary breast and thyroid carcinomas
    Elisabeth Adjadj
    Unit of Cancer Epidemiology, National Institute of Health and Medical Research, Gustave Roussy Institute, Villejuif, France
    Cancer 98:1309-17. 2003
    ....
  39. doi request reprint High rate of multifocality and occult lymph node metastases in papillary thyroid carcinoma arising in thyroglossal duct cysts
    Dana M Hartl
    Department of Otolaryngology Head and Neck Surgery, Institut Gustave Roussy, Villejuif, France
    Ann Surg Oncol 16:2595-601. 2009
    ..The incidence of cancer in thyroglossal duct cysts (TDC) is low and management is controversial. The objective was to report the rate of multifocality, lymph node metastases, and long-term results for TDC carcinomas in adults...
  40. ncbi request reprint Detection of liver metastases from endocrine tumors: a prospective comparison of somatostatin receptor scintigraphy, computed tomography, and magnetic resonance imaging
    Clarisse Dromain
    Department of Radiology, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    J Clin Oncol 23:70-8. 2005
    ..To define predictive factors for "high-sensitivity SRS."..
  41. doi request reprint Performance of (18)fluorodeoxyglucose-positron emission tomography and somatostatin receptor scintigraphy for high Ki67 (≥10%) well-differentiated endocrine carcinoma staging
    Ronan Abgral
    Department of Nuclear Medicine, University Hospital of Brest, 29200 Brest, France
    J Clin Endocrinol Metab 96:665-71. 2011
    ....
  42. ncbi request reprint Liver resection (and associated extrahepatic resections) for metastatic well-differentiated endocrine tumors: a 15-year single center prospective study
    Dominique Elias
    Department of Surgical Oncology, Comprehensive Cancer Center, Institut Gustave Roussy, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Surgery 133:375-82. 2003
    ..However, surveillance alone yields only a 22% 5-year survival when metastases occur. The aim of this study was to determine the results of hepatic and extra hepatic resections and to clarify the indications of surgery...
  43. ncbi request reprint Trans-catheter arterial chemoembolization as first-line treatment for hepatic metastases from endocrine tumors
    Alain Roche
    Service de Radiologie Interventionnelle, Institut Gustave Roussy, rue Camille Desmoulins 39, 94805 Villejuif Cedex, France
    Eur Radiol 13:136-40. 2003
    ..Long-term palliation is possible in unresectable liver metastases from digestive neuroendocrine tumors with a few sessions of TACE as first-line and eventually exclusive treatment...
  44. ncbi request reprint Clinical review: Current concepts in the management of unilateral recurrent laryngeal nerve paralysis after thyroid surgery
    Dana M Hartl
    Department of Otolaryngology and Head and Neck Surgery, Institut Gustave Roussy, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    J Clin Endocrinol Metab 90:3084-8. 2005
    ..This study was designed to provide an update on the pathophysiological concepts and patient management in a common complication of thyroid surgery, unilateral recurrent laryngeal nerve paralysis (URLNP)...
  45. ncbi request reprint Prospective study of bone marrow infiltration in aggressive lymphoma by three independent methods: whole-body MRI, PET/CT and bone marrow biopsy
    Vincent Ribrag
    Department of Medicine, Institut Gustave Roussy, Villejuif, France
    Eur J Radiol 66:325-31. 2008
    ..The aim of this study was to compare the performance of BMB, whole-body MRI and PET/CT for evaluation of BM infiltration...
  46. doi request reprint Functional consequences of dual oxidase-thyroperoxidase interaction at the plasma membrane
    Rodrigo Soares Fortunato
    Instituto de Biofisica Carlos Chagas Filho, CCS Bloc G Cidade Universitaria, Rio de Janeiro, Brazil
    J Clin Endocrinol Metab 95:5403-11. 2010
    ..Both enzymes are colocalized and associated, but the consequences of this interaction remain obscure...
  47. ncbi request reprint [Treatment strategy of neuroendocrine tumors]
    Michel Ducreux
    Unité de gastroentérologie Institut Gustave Roussy 94805 Villejuif
    Rev Prat 52:290-6. 2002
    ..Gastrinoma and other pancreatic tumours arising in the context of multiple endocrine neoplasia type I disease need a specific therapeutic strategy...
  48. ncbi request reprint Differential expression of galectin-3 in medullary thyroid carcinoma and C-cell hyperplasia
    Antongiulio Faggiano
    Department of Pathology, Commissariat à l Energie Atomique LRC29V, Institut Gustave Roussy, F 94805 Villejuif Cedex, France
    Clin Endocrinol (Oxf) 57:813-9. 2002
    ..The reliability of this marker in the differential diagnosis between medullary thyroid carcinoma and C-cell hyperplasia was studied by immunohistochemistry...
  49. doi request reprint Phase II study of plitidepsin 3-hour infusion every 2 weeks in patients with unresectable advanced medullary thyroid carcinoma
    Eric Baudin
    Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, Villejuif, France
    Am J Clin Oncol 33:83-8. 2010
    ..v.) infusion every 2 weeks in patients with unresectable advanced medullary thyroid carcinoma (MTC)...
  50. ncbi request reprint Relationship between tumor burden and serum thyroglobulin level in patients with papillary and follicular thyroid carcinoma
    Anne Bachelot
    Institut Gustave Roussy, Villejuif, France
    Thyroid 12:707-11. 2002
    ..Nevertheless, undetectable serum Tg should not be considered as a reliable criteria to exclude a minimal tumor burden in patients who have already been treated with (131)I...
  51. doi request reprint Serum thyroglobulin determination in thyroid cancer patients
    Zelia Francis
    Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, University Paris Sud XI, rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Best Pract Res Clin Endocrinol Metab 22:1039-46. 2008
    ..Modern methods with an improved functional sensitivity may facilitate its use during follow-up...
  52. ncbi request reprint Radiation exposure and familial aggregation of cancers as risk factors for colorectal cancer after radioiodine treatment for thyroid carcinoma
    Carole Rubino
    National Institute of Public Health and Medical Research, INSERM, Unit 605, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France
    Int J Radiat Oncol Biol Phys 62:1084-9. 2005
    ..The aim of this study in thyroid cancer patients was to evaluate the role of familial factors in the risk of colorectal cancer and their potential interaction with radioiodine exposure...
  53. doi request reprint Thyroid adenomas and carcinomas following radiotherapy for a hemangioma during infancy
    Nadia Haddy
    INSERM, U605, Villejuif, France
    Radiother Oncol 93:377-82. 2009
    ..This paper presents the incidence of differentiated thyroid adenomas and carcinomas after radiotherapy in this cohort...
  54. ncbi request reprint Transposition of the thyroid iodide uptake and organification system in nonthyroid tumor cells by adenoviral vector-mediated gene transfers
    Anne Boland
    UMR 1582 CNRS IGR Aventis, Institut Gustave Roussy, Villejuif, France
    Thyroid 12:19-26. 2002
    ..However, the levels of iodide organification obtained were too low to significantly increase the iodide retention time in the target cells...
  55. doi request reprint Expression of cell cycle biomarkers and telomere length in papillary thyroid carcinoma: a comparative study between radiation-associated and spontaneous cancers
    Mihaela Achille
    Laboratoire de Radiobiologie et Oncologie, DSV DRR Commissariat à l Energie Atomique, Villejuif, France
    Am J Clin Oncol 32:1-8. 2009
    ..To better define the biologic profile of radiation-induced and sporadic PTC, we compared in these two groups of PTC the expression of cell cycle regulatory proteins and telomere length...
  56. ncbi request reprint Prognostic parameters of metastatic adrenocortical carcinoma
    Guillaume Assie
    Service de Médecine Nucléaire et de Cancérologie Endocrinienne, Institut Gustave Roussy, Universite Paris XI, 94800 Villejuif, France
    J Clin Endocrinol Metab 92:148-54. 2007
    ..Prognostic parameters of metastatic adrenocortical carcinoma (ACC) are poorly characterized...
  57. doi request reprint Prognostic markers of survival after combined mitotane- and platinum-based chemotherapy in metastatic adrenocortical carcinoma
    Pasqualino Malandrino
    Service de Médecine Nucléaire et de Cancérologie Endocrinienne, Institut Gustave Roussy, Universite Paris XI, 39 rue Camille Desmoulins, Villejuif Cedex, France
    Endocr Relat Cancer 17:797-807. 2010
    ..03 and <0.001). Our study suggests a prognostic role for mitotane therapy and objective response to platinum-based chemotherapy...
  58. doi request reprint Therapeutic administration of 131I for differentiated thyroid cancer: radiation dose to ovaries and outcome of pregnancies
    Jerome Philippe Garsi
    INSERM U605, Villejuif, France
    J Nucl Med 49:845-52. 2008
    ....
  59. doi request reprint Progression of medullary thyroid carcinoma: assessment with calcitonin and carcinoembryonic antigen doubling times
    Anne Laure Giraudet
    Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy and University Paris Sud, 94805 Villejuif Cedex, France
    Eur J Endocrinol 158:239-46. 2008
    ..The progression of medullary thyroid cancer is difficult to assess with imaging modalities; we studied the interest of calcitonin and carcinoembryonic antigen (CEA) doubling times and of Ki-67 labeling and mitotic index (MI)...
  60. ncbi request reprint PAX8 and peroxisome proliferator-activated receptor gamma 1 gene expression status in benign and malignant thyroid tissues
    Ludovic Lacroix
    CNRS UMR 8125 Commissariat a l Energie Atomique, LRC29V, and Department of Clinical Biology, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    Eur J Endocrinol 151:367-74. 2004
    ....
  61. ncbi request reprint Pulmonary and extrapulmonary poorly differentiated large cell neuroendocrine carcinomas: diagnostic and prognostic features
    Antongiulio Faggiano
    Department of Nuclear Medicine and Endocrinological Oncology, Gustave Roussy Institute, Villejuif, France
    Cancer 110:265-74. 2007
    ..The objective of this study was to investigate the epidemiology, clinical presentation, prognostic factors, and molecular pathways of patients with poorly differentiated LCNEC...
  62. ncbi request reprint Poorly differentiated follicular thyroid carcinoma: prognostic factors and relevance of histological classification
    Melania Pulcrano
    Nuclear Medicine and Endocrine Oncology, Commissariat à l Energie Atomique LRC29V, Institut Gustave Roussy and University Paris Sud, Villejuif, France
    Thyroid 17:639-46. 2007
    ....
  63. ncbi request reprint Medullary thyroid carcinoma
    Sophie Leboulleux
    Institut Gustave Roussy, Villejuif, France
    Clin Endocrinol (Oxf) 61:299-310. 2004
    ..However, there is no effective treatment for distant metastases, and new therapeutic modalities are urgently needed...
  64. ncbi request reprint Age-dependent variation of follicular size and expression of iodine transporters in human thyroid tissue
    Antongiulio Faggiano
    Department of Nuclear Medicine, Commissariat a l Energie Atomique, Institut Gustave Roussy, 39 rue C Demoulins, 94805 Villejuif Cedex, France
    J Nucl Med 45:232-7. 2004
    ....
  65. ncbi request reprint Follicular-cell derived thyroid cancer in children
    Sophie Leboulleux
    Service de Medecine Nucleaire, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France
    Eur J Cancer 40:1655-9. 2004
    ..Long term prognosis is favorable, but a few deaths have been reported some decades after initial treatment. Adverse prognostic indicators are younger age at discovery and presence of distant metastases...
  66. doi request reprint Aggressive inherited and sporadic medullary thyroid carcinomas display similar oncogenic pathways
    Nabahet Ameur
    CNRS FRE 2939, Institut de Cancerologie Gustave Roussy, Villejuif, France
    Endocr Relat Cancer 16:1261-72. 2009
    ..Using a MTC cell line, silencing of RET induced the inhibition of PTN gene expression. Overall, our results suggest that familial MTC and sporadic MTC could activate similar oncogenic pathways...
  67. ncbi request reprint Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters
    Ludovic Lacroix
    Department of Clinical Biology, Commissariat à l Energie Atomique LRC29V, Institut Gustave Roussy, 94805 Villejuif Cedex, France
    J Clin Endocrinol Metab 89:1423-8. 2004
    ..Expression of AIT protein was undetectable in most papillary carcinomas and was weak but detectable in most follicular carcinomas; it was negative in anaplastic carcinomas...
  68. ncbi request reprint Inheritable forms of medullary thyroid carcinoma
    Anne Bachelot
    Department of Nuclear Medicine and Endocrine Tumors, Institut Gustave Roussy, Villejuif, France
    Biochimie 84:61-6. 2002
    ..The identification of hereditary MTC has been facilitated in recent years by the direct analysis of the ret proto-oncogene...
  69. ncbi request reprint Familial medullary thyroid carcinoma: clinical variability and low aggressiveness associated with RET mutation at codon 804
    Francesca Lombardo
    Départment de Biologie Clinique and Service de Médecine Nucléaire, Institut Gustave Roussy, Villejuif, France
    J Clin Endocrinol Metab 87:1674-80. 2002
    ..Indeed, our data should be confirmed on a larger series of V804L carriers, but may offer a balanced strategy to keep under control and prevent development of the full disease phenotype...
  70. ncbi request reprint New therapeutic approaches for metastatic thyroid carcinoma
    Eric Baudin
    Department of Nuclear Medicine and Endocrine Oncology, Institut Gustave Roussy, and Faculté de Médecine Paris Sud, Villejuif, France
    Lancet Oncol 8:148-56. 2007
    ..However, the recent availability of molecularly targeted treatments has led to changes in the treatment strategy for DTC in patients with distant metastases, especially in those who are resistant to radioiodine treatment...
  71. ncbi request reprint Sodium/iodide symporter (NIS) gene expression is the limiting step for the onset of thyroid function in the human fetus
    Gabor Szinnai
    Faculty of Medicine René Descartes, Paris V, Site Necker, Institut National de la Santé et de la Recherche Médicale Equipe Mixte 0363, Pediatric Endocrine Unit, Assistance Publique Hopitaux de Paris AP HP, Hopital Necker Enfants Malades, Paris, France
    J Clin Endocrinol Metab 92:70-6. 2007
    ..Terminal differentiation of the human thyroid is characterized by the onset of follicle formation and thyroid hormone synthesis at 11 gestational weeks (GW)...
  72. ncbi request reprint Follicular cell-derived thyroid cancer in children
    Sophie Leboulleux
    Institut Gustave Roussy, Villejuif, France
    Horm Res 63:145-51. 2005
    ..The aim of initial treatment should be the total removal of neoplastic foci with a minimal morbidity. Some cancer-related deaths have been reported decades after initial treatment...
  73. ncbi request reprint HEX, PAX-8 and TTF-1 gene expression in human thyroid tissues: a comparative analysis with other genes involved in iodide metabolism
    Ludovic Lacroix
    Department of Clinical Biology, Institut Gustave Roussy and Commissariat à l Energie Atomique LRC 29V, Villejuif, France
    Clin Endocrinol (Oxf) 64:398-404. 2006
    ..The delineation of eventual correlations existing between the expression of transcription factors and of putative target genes in physiological and pathological conditions could be relevant to better understand tumorigenesis...
  74. ncbi request reprint Molecular epidemiology of thyroid cancer
    Martin Schlumberger
    Service de Medecine Nucleaire, Institut Gustave Roussy, 39 rue Camille Desmoulins, 94805 Villejuif, France
    Cancer Treat Res 122:107-20. 2004
  75. ncbi request reprint [Oncogenes and thyroid tumors]
    Ludovic Lacroix
    Institut Gustave Roussy, 94805 Villejuif Cedex
    Bull Cancer 92:37-43. 2005
    ..Follicular carcinomas are characterized by the presence of a RAS mutation or of a PAX8-PPARgamma rearrangement. Inactivating mutations of the p53 gene are found only in anaplastic thyroid carcinomas...
  76. ncbi request reprint Serum thyroglobulin and 131I whole body scan after recombinant human TSH stimulation in the follow-up of low-risk patients with differentiated thyroid cancer
    Massimo Torlontano
    Unit of Endocrinology, Scientific Institute Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo, Foggia, Italy
    Eur J Endocrinol 148:19-24. 2003
    ..The aim of our study was to evaluate the diagnostic accuracy of (131)I-WBS and serum Tg measurement obtained after rhTSH stimulation and of neck ultrasonography in the first follow-up of DTC patients...
  77. pmc Expanding indications for recombinant human TSH in thyroid cancer
    Bryan R Haugen
    Thyroid 18:687-94. 2008
  78. ncbi request reprint Post-surgical use of radioiodine (131I) in patients with papillary and follicular thyroid cancer and the issue of remnant ablation: a consensus report
    Furio Pacini
    University of Siena, Siena, Italy
    Eur J Endocrinol 153:651-9. 2005
    ..To determine, based on published literature and expert clinical experience, current indications for the post-surgical administration of a large radioiodine activity in patients with differentiated thyroid cancer...
  79. ncbi request reprint Thyroid-hormone therapy and thyroid cancer: a reassessment
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, Naples, Italy
    Nat Clin Pract Endocrinol Metab 1:32-40. 2005
    ..5 mU/l). Only selected patients with high-risk papillary and follicular thyroid cancer require long-term TSH-suppressive doses of L-T(4). In these patients, careful monitoring is necessary to avoid undesirable effects on bone and heart...
  80. ncbi request reprint Distributing KI pills to minimize thyroid radiation exposure in case of a nuclear accident in France
    Bernard Le Guen
    Nat Clin Pract Endocrinol Metab 3:611. 2007
  81. ncbi request reprint European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium
    Furio Pacini
    Section of Endocrinology and Metabolism, University of Siena, Via Bracci, 53100 Siena, Italy
    Eur J Endocrinol 154:787-803. 2006
  82. ncbi request reprint Iodine biokinetics and dosimetry in radioiodine therapy of thyroid cancer: procedures and results of a prospective international controlled study of ablation after rhTSH or hormone withdrawal
    Heribert Hänscheid
    Klinik und Poliklinik fur Nuklearmedizin, Universitat Wurzburg, D 97080 Wurzburg, Germany
    J Nucl Med 47:648-54. 2006
    ..7 GBq (131)I in differentiated thyroid cancer after stimulation with recombinant human TSH (rhTSH) or by thyroid hormone withdrawal (THW) are presented...
  83. ncbi request reprint A comparison of short-term changes in health-related quality of life in thyroid carcinoma patients undergoing diagnostic evaluation with recombinant human thyrotropin compared with thyroid hormone withdrawal
    Pamela R Schroeder
    Johns Hopkins Medical Institutions, Division of Endocrinology and Metabolism, 1830 East Monument Street, Suite 333, Baltimore, Maryland 21287, USA
    J Clin Endocrinol Metab 91:878-84. 2006
    ..Levothyroxine (L-T4) withdrawal for thyroglobulin measurement and whole body scanning increases these tests' sensitivities but causes hypothyroidism. Recombinant human TSH (rhTSH) enables testing without L-T4 withdrawal...
  84. ncbi request reprint Stimulation of iodide uptake by human chorionic gonadotropin in FRTL-5 cells: effects on sodium/iodide symporter gene and protein expression
    Franco Arturi
    Dipartimento di Medicina Sperimentale e Clinica, Università di Catanzaro Magna Graecia, Catanzaro 88100, Italy
    Eur J Endocrinol 147:655-61. 2002
    ..Various clinical and experimental findings support the concept that human chorionic gonadotropin (hCG) can stimulate iodide uptake in thyroid cells...
  85. ncbi request reprint Regulation by human chorionic gonadotropin of sodium/iodide symporter gene expression in the JAr human choriocarcinoma cell line
    Franco Arturi
    Dipartimento di Medicina Sperimentale e Clinica, Universita di Catanzaro, Magna Graecia 88100 Catanzaro, Italy
    Endocrinology 143:2216-20. 2002
    ....
  86. ncbi request reprint Subclinical hyperthyroidism: clinical features and treatment options
    Bernadette Biondi
    Department of Clinical and Molecular Endocrinology and Oncology, University of Naples Federico II, 80131 Naples, Italy
    Eur J Endocrinol 152:1-9. 2005
    ..Subclinical hyperthyroidism and its related clinical manifestations are reversible and may be prevented by timely treatment...
  87. pmc Follicular thyroid tumors with the PAX8-PPARgamma1 rearrangement display characteristic genetic alterations
    Ludovic Lacroix
    Functional Genomic Unit, Institut Gustave Roussy, Villejuif Cedex, France
    Am J Pathol 167:223-31. 2005
    ..These data identify several differentially expressed genes, such as FGD3, that may serve as potential targets of PPARgamma and as members of novel molecular pathways involved in the development of thyroid carcinomas...
  88. doi request reprint Galectin-3 for indeterminate thyroid cytology
    Abir Al Ghuzlan
    Lancet Oncol 9:508-10. 2008