A Scalbert

Summary

Affiliation: Institut National de la Recherche Agronomique
Country: France

Publications

  1. ncbi [Food and cancer: state of the art about the protective effect of fruits and vegetables]
    Mariette Gerber
    INSERM CRLC, Groupe d Epidémiologie Métabolique, Val d Aurelle, 34298 Montpellier Cedex 05
    Bull Cancer 89:293-312. 2002
  2. ncbi Polyphenols and prevention of cardiovascular diseases
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    Curr Opin Lipidol 16:77-84. 2005
  3. ncbi Dietary polyphenols and the prevention of diseases
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Centre de Recherche de Clermont Ferrand Theix, St Genes Champanelle, France
    Crit Rev Food Sci Nutr 45:287-306. 2005
  4. ncbi Proanthocyanidins and human health: systemic effects and local effects in the gut
    A Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments INRA, Saint Genes Champanelle, France
    Biofactors 13:115-20. 2000
  5. ncbi Polyphenols: antioxidants and beyond
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, Institut National de la Recherche Agronomique, Saint Genes Champanelle, France
    Am J Clin Nutr 81:215S-217S. 2005
  6. ncbi Absorption and metabolism of polyphenols in the gut and impact on health
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Biomed Pharmacother 56:276-82. 2002
  7. pmc Phenol-Explorer: an online comprehensive database on polyphenol contents in foods
    V Neveu
    UMR 1019 Unite de Nutrition Humaine, INRA, Centre de Recherche de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    Database (Oxford) 2010:bap024. 2010
  8. ncbi Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial Caco-2 cells
    S Deprez
    Laboratoire de Chimie Biologique, INRA, Institut National Agronomique Paris-Grignon (INA-PG, Thiverval-Grignon, France
    Antioxid Redox Signal 3:957-67. 2001
  9. doi Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice
    A Mauray
    Unité de Nutrition Humaine UMR1019, INRA, Centre de Recherche de Clermont Ferrand Theix, Groupe Micronutriments, Métabolisme et Santé MiMeS, 63122 Saint Genes Champanelle, France
    Nutr Metab Cardiovasc Dis 22:72-80. 2012
  10. ncbi Flavanone metabolism in healthy and tumor-bearing rats
    M Silberberg
    Unité des Maladies Métaboliques et Micronutriments, INRA, Centre de Recherche de Clermont Ferrant Theix, 63122 Saint Genes Champanelle, France
    Biomed Pharmacother 60:529-35. 2006

Collaborators

Detail Information

Publications45

  1. ncbi [Food and cancer: state of the art about the protective effect of fruits and vegetables]
    Mariette Gerber
    INSERM CRLC, Groupe d Epidémiologie Métabolique, Val d Aurelle, 34298 Montpellier Cedex 05
    Bull Cancer 89:293-312. 2002
    ....
  2. ncbi Polyphenols and prevention of cardiovascular diseases
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    Curr Opin Lipidol 16:77-84. 2005
    ..This paper reviews the recent studies on the prevention of cardiovascular diseases by polyphenols, focusing on human studies...
  3. ncbi Dietary polyphenols and the prevention of diseases
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Centre de Recherche de Clermont Ferrand Theix, St Genes Champanelle, France
    Crit Rev Food Sci Nutr 45:287-306. 2005
    ..More human studies are needed to provide clear evidence of their health protective effects and to better evaluate the risks possibly resulting from too high a polyphenol consumption...
  4. ncbi Proanthocyanidins and human health: systemic effects and local effects in the gut
    A Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments INRA, Saint Genes Champanelle, France
    Biofactors 13:115-20. 2000
    ..The nutritional significance of proanthocyanidins is discussed in relation to their physico-chemical properties and bioavailability...
  5. ncbi Polyphenols: antioxidants and beyond
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, Institut National de la Recherche Agronomique, Saint Genes Champanelle, France
    Am J Clin Nutr 81:215S-217S. 2005
    ....
  6. ncbi Absorption and metabolism of polyphenols in the gut and impact on health
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Biomed Pharmacother 56:276-82. 2002
    ..Alternatively, some health effects of polyphenols may not require their absorption through the gut barrier. Their role as iron chelators in the gut lumen is briefly discussed...
  7. pmc Phenol-Explorer: an online comprehensive database on polyphenol contents in foods
    V Neveu
    UMR 1019 Unite de Nutrition Humaine, INRA, Centre de Recherche de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    Database (Oxford) 2010:bap024. 2010
    ..It should help researchers to better understand the role of phytochemicals in the technical and nutritional quality of food, and food manufacturers to develop tailor-made healthy foods. Database URL: http://www.phenol-explorer.eu...
  8. ncbi Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial Caco-2 cells
    S Deprez
    Laboratoire de Chimie Biologique, INRA, Institut National Agronomique Paris-Grignon (INA-PG, Thiverval-Grignon, France
    Antioxid Redox Signal 3:957-67. 2001
    ..PAs, particularly the most astringent PA polymer, were also adsorbed on the epithelial cells. These results suggest that PA dimers and trimers could be absorbed in vivo and that polymer bioavailability is limited to the gut lumen...
  9. doi Bilberry anthocyanin-rich extract alters expression of genes related to atherosclerosis development in aorta of apo E-deficient mice
    A Mauray
    Unité de Nutrition Humaine UMR1019, INRA, Centre de Recherche de Clermont Ferrand Theix, Groupe Micronutriments, Métabolisme et Santé MiMeS, 63122 Saint Genes Champanelle, France
    Nutr Metab Cardiovasc Dis 22:72-80. 2012
    ..These results provide a global integrated view of the mechanisms involved in the preventive action of bilberry anthocyanin-rich extract against atherosclerosis...
  10. ncbi Flavanone metabolism in healthy and tumor-bearing rats
    M Silberberg
    Unité des Maladies Métaboliques et Micronutriments, INRA, Centre de Recherche de Clermont Ferrant Theix, 63122 Saint Genes Champanelle, France
    Biomed Pharmacother 60:529-35. 2006
    ..The lower concentration of flavanones in the TuB rats suggests that disease and more particularly cancer, may affect the bioavailability of flavonoids...
  11. ncbi Contribution of genomics to the understanding of physiological functions
    J F Hocquette
    INRA, UR1213, Recherche sur les Herbivores, Theix, 63122 Saint Genes Champanelle, France
    J Physiol Pharmacol 60:5-16. 2009
    ..Physiological models with invalidated or over-expressed genes will be precious tools to check these new biological discoveries...
  12. doi Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database
    J Perez-Jimenez
    Clermont Universite, Universite d Auvergne, Unite de Nutrition Humaine, Saint Genes Champanelle, France
    Eur J Clin Nutr 64:S112-20. 2010
    ..These data, scattered in several hundred publications, have been compiled in the Phenol-Explorer database. The aim of this paper is to identify the 100 richest dietary sources of polyphenols using this database...
  13. ncbi Catechin is metabolized by both the small intestine and liver of rats
    J L Donovan
    , INRA, , France
    J Nutr 131:1753-7. 2001
    ..The data further demonstrate the role of the rat small intestine in the glucuronidation and methylation of flavonoids as well as the role of the liver in sulfation, methylation and biliary excretion...
  14. ncbi Chlorogenic acid is absorbed in its intact form in the stomach of rats
    Sophie Lafay
    Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    J Nutr 136:1192-7. 2006
    ..No other metabolites could be detected by HPLC-electrospray ionization-MS-MS. These results show for the first time that chlorogenic acid is quickly absorbed in the rat stomach in its intact form...
  15. ncbi Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats
    Sophie Lafay
    Unite de Nutrition Humaine, Institut National de la Recherche Agronomique, Centre de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    Br J Nutr 96:39-46. 2006
    ..In contrast to numerous flavonoids, absorbed phenolic acids are poorly excreted in the bile or gut lumen. Their bioavailability therefore appears to be governed largely by their uptake into the gut mucosa...
  16. ncbi Polyphenol levels in human urine after intake of six different polyphenol-rich beverages
    Hideyuki Ito
    Unite des Maladies Metaboliques et Micronutrients, INRA, 63122 Saint Genes Champanelle, France
    Br J Nutr 94:500-9. 2005
    ..Levels of urinary excretion suggest that chlorogenic acid, gallic acid, epicatechin, naringenin or hesperetin could be used as specific biomarkers to evaluate the consumption of coffee, wine, tea or cocoa, and citrus juices respectively...
  17. ncbi Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods
    Louise I Mennen
    UMR INSERM U557 INRA CNAM, ISTNA CNAM, 5 rue du Vertbois, 75003 Paris, France
    Br J Nutr 96:191-8. 2006
    ..37-0.54, P < 0.001). The present results suggest that several polyphenols measured in a spot urine sample can be used as biomarkers of polyphenol-rich food intake...
  18. ncbi Daily polyphenol intake in France from fruit and vegetables
    Pierre Brat
    Université Méditerranée Aix Marseille 2, Faculte de Medecine, IPHM IFR 125, Marseille, F 13385 France
    J Nutr 136:2368-73. 2006
    ....
  19. ncbi Whole-grain and refined wheat flours show distinct metabolic profiles in rats as assessed by a 1H NMR-based metabonomic approach
    Anthony Fardet
    UMR 1019 Unite de Nutrition Humaine, Institute National de la Recherche Agronomique, Centre de Recherche de Clermont Ferrand Theix, F 63122 St Genes Champanelle, France
    J Nutr 137:923-9. 2007
    ..These suggest that the WGF diet improved the redox and lipid status...
  20. ncbi Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats
    Catherine Felgines
    université Clermont 1, UFR Pharmacie, Laboratoire de Pharmacognosie, 28 Place Henri Dunant, BP 38, F 63001 Clermont Ferrand Cedex 1, France
    Br J Nutr 98:1126-31. 2007
    ..Pg 3-glc was thus glucuronidated to a larger extent than cyanidin 3-glucoside. These results highlight the influence of the aglycone structure on anthocyanin metabolism...
  21. doi Apple polyphenols and fibers attenuate atherosclerosis in apolipoprotein E-deficient mice
    Sylvain Auclair
    Unite de Nutrition Humaine, UMR1019, INRA, Centre de Recherche de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    J Agric Food Chem 56:5558-63. 2008
    ..On the basis of the results, we hypothesize that apple fibers and polyphenols may play a role in preventing atherosclerosis disease by decreasing uric acid plasma level...
  22. ncbi Metabolomics provide new insight on the metabolism of dietary phytochemicals in rats
    Anthony Fardet
    Unite de Nutrition Humaine, Institut National de la Recherche Agronomique, Centre de Recherche de Clermont Ferrand Theix, F 63122 St Genes Champanelle, France
    J Nutr 138:1282-7. 2008
    ..This study shows that metabolomics allows the identification of new metabolites of phytochemicals and can be used to distinguish individuals fed different phytochemical-containing foods...
  23. doi Orally administered isoflavones are present as glucuronides in the human prostate
    Laurent Guy
    CHU Clermont Ferrand, Service Urologie, Clermont Ferrand, France
    Nutr Cancer 60:461-8. 2008
    ..Isoflavone mechanisms of action should thus be investigated in in vitro cell studies using physiological conditions, intracellular concentrations below 5 nmol/g and no intracellular deconjugation of the monoglucuronide metabolites...
  24. doi Influence of glucose on cyanidin 3-glucoside absorption in rats
    Catherine Felgines
    Laboratoire de Pharmacognosie, Univ Clermont 1, UFR Pharmacie, Clermont Ferrand, France
    Mol Nutr Food Res 52:959-64. 2008
    ..01) suggesting that the red orange extract contained other components that were able to interfere with Cy 3-glc intestinal absorption. This study has thus shown that glucose did not interfere with anthocyanin glucoside absorption...
  25. doi A liquid chromatography-quadrupole time-of-flight (LC-QTOF)-based metabolomic approach reveals new metabolic effects of catechin in rats fed high-fat diets
    Anthony Fardet
    UMR 1019, Unite de Nutrition Humaine, INRA, Centre de Recherche de Clermont Ferrand Theix, F 63122 S Genès Champanelle, France
    J Proteome Res 7:2388-98. 2008
    ..After catechin supplementation, the excretion of nicotinic acid was fully restored to the level found in the rats fed the low-fat diet. The physiological significance of these metabolic changes is discussed...
  26. ncbi Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism
    Mathieu Silberberg
    Laboratoire des Maladies Métaboliques et des Micronutriments, I N R A, Centre de Recherche de Clermont Ferrant Theix, 63122 Saint Genes Champanelle, France
    Life Sci 77:3156-67. 2005
    ....
  27. ncbi Caffeic acid inhibits oxidative Stress and reduces hypercholesterolemia induced by iron overload in rats
    Sophie Lafay
    Unité des Maladies Métaboliques and Micronutriments, INRA de Clermont Ferrand Theix, 63122 St Genes Champanelle, France
    Int J Vitam Nutr Res 75:119-25. 2005
    ..07 g/L to 0.82 g/L; p < 0.001). These results demonstrate the antioxidative capacity of caffeic acid, a highly bioavailable polyphenol, in an in vivo model of oxidative stress...
  28. ncbi Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract or the procyanidin dimer B3
    Jennifer L Donovan
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Br J Nutr 87:299-306. 2002
    ..Future research should focus on other procyanidin metabolites such as phenolic acids and on the effects of the unabsorbed oligomers and polymers on the human gastrointestinal tract...
  29. ncbi Mammalian lignan formation in rats fed a wheat bran diet
    Catherine Nicolle
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    J Agric Food Chem 50:6222-6. 2002
    ..These results show that the formation of lignans from wheat bran is influenced by the diet, possibly because of an adaptation of the colonic microflora...
  30. ncbi Cocoa procyanidins are stable during gastric transit in humans
    Laurent Y Rios
    Institute of Food Research, Norwich Research Park, Norwich, United Kingdom
    Am J Clin Nutr 76:1106-10. 2002
    ..Degradation of procyanidins under simulated gastric conditions at pH 2.0 has been reported in vitro...
  31. ncbi Microbial aromatic acid metabolites formed in the gut account for a major fraction of the polyphenols excreted in urine of rats fed red wine polyphenols
    Marie Paule Gonthier
    Unité des Maladies Métaboliques et Micronutriments, INRA Theix, 63122 Saint Genes Champanelle, France
    J Nutr 133:461-7. 2003
    ..More attention should be given in the future to these microbial metabolites and their biological properties to help explain the health effects of polyphenols that are not easily absorbed through the gut barrier...
  32. ncbi Chocolate intake increases urinary excretion of polyphenol-derived phenolic acids in healthy human subjects
    Laurent Y Rios
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Am J Clin Nutr 77:912-8. 2003
    ..In vitro and in vivo studies using pure compounds as substrates suggest that proanthocyanidins and the related catechin monomers may be degraded into more bioavailable low-molecular-weight phenolic acids by the microflora in the colon...
  33. ncbi Novel liquid chromatography-electrospray ionization mass spectrometry method for the quantification in human urine of microbial aromatic acid metabolites derived from dietary polyphenols
    Marie Paule Gonthier
    Unité des Maladies Métaboliques et Micronutriments, INRA Theix, 63122, Saint Genes Champanelle, France
    J Chromatogr B Analyt Technol Biomed Life Sci 789:247-55. 2003
    ....
  34. ncbi Chlorogenic acid bioavailability largely depends on its metabolism by the gut microflora in rats
    Marie Paule Gonthier
    Unité des Maladies Métaboliques et Micronutriments, INRA Theix, 63122 Saint Genes Champanelle, France
    J Nutr 133:1853-9. 2003
    ..Their potential importance in explaining the biological effects of dietary polyphenols is emphasized...
  35. ncbi Metabolism of dietary procyanidins in rats
    Marie Paule Gonthier
    Unité des Maladies Métaboliques et Micronutriments, INRA Theix, Saint Genes Champanelle, France
    Free Radic Biol Med 35:837-44. 2003
    ..This will have to be considered to explain the health effects of procyanidins. The contribution of their microbial metabolites should also be further investigated...
  36. ncbi Effect of carrot intake on cholesterol metabolism and on antioxidant status in cholesterol-fed rat
    Catherine Nicolle
    Unité des Maladies Métaboliques and Micronutriments, INRA Clermont Ferrand Theix, Saint Genes Champanelle, France
    Eur J Nutr 42:254-61. 2003
    ..Vegetables are major dietary sources of fibers and antioxidants such as carotenoids, polyphenols and vitamin C which contribute to explain their protective effects against cardiovascular diseases...
  37. ncbi Risks and safety of polyphenol consumption
    Louise I Mennen
    Unite Mixte de Recherche INSERM Unit 557 INRA Unit 1125, ISTNA CNAM, Paris, France
    Am J Clin Nutr 81:326S-329S. 2005
    ....
  38. ncbi Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Am J Clin Nutr 81:230S-242S. 2005
    ..Data are still too limited for assessment of hydroxycinnamic acids and other polyphenols. These data may be useful for the design and interpretation of intervention studies investigating the health effects of polyphenols...
  39. ncbi High-throughput profiling of dietary polyphenols and their metabolites by HPLC-ESI-MS-MS in human urine
    Hideyuki Ito
    Unite des Maladies Metaboliques et Micronutrients, INRA, 63122 Saint Genes Champanelle, France
    Biofactors 22:241-3. 2004
    ..It has been applied to human urine samples collected from volunteers after consumption of different polyphenol-rich beverages in controlled conditions...
  40. ncbi Polyphenols: food sources and bioavailability
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    Am J Clin Nutr 79:727-47. 2004
    ..A thorough knowledge of the bioavailability of the hundreds of dietary polyphenols will help us to identify those that are most likely to exert protective health effects...
  41. ncbi Dietary lignins are precursors of mammalian lignans in rats
    Aynun Nahar Begum
    Unite des Maladies Metaboliques et Micronutrients, INRA Theix, 63122 Saint Genes Champanelle, France
    J Nutr 134:120-7. 2004
    ..The detection of deuterated ENL by LC-tandem MS in urine (20 nmol/d) clearly confirms the conversion of lignin into mammalian lignans. More research is warranted to determine the bioavailability of lignins in the human diet...
  42. ncbi Strawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugates in humans
    Catherine Felgines
    Laboratoire de Pharmacognosie, Faculte de Pharmacie, 63001 Clermont Ferrand, France
    J Nutr 133:1296-301. 2003
    ..This study demonstrated that anthocyanins were glucuro- and sulfo-conjugated in humans and that the main metabolite of strawberry anthocyanins in human urine was a monoglucuronide of pelargonidin...
  43. doi Tissue distribution of isoflavones in ewes after consumption of red clover silage
    Mireia Urpi-Sarda
    Nutrition and Food Science Department, XaRTA, Pharmacy Faculty, University of Barcelona, 08028 Barcelona, Spain
    Arch Biochem Biophys 476:205-10. 2008
    ..Reproductive organs contained higher concentrations of isoflavones than heart, muscle, or thymus. Distribution of isoflavones in ewe tissues is unequal and may reflect specific impact in some target tissues...
  44. ncbi Flavonoids and heart health: proceedings of the ILSI North America Flavonoids Workshop, May 31-June 1, 2005, Washington, DC
    John W Erdman
    University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    J Nutr 137:718S-737S. 2007
    ..Data presented support the concept that certain flavonoids in the diet can be associated with significant health benefits, including heart health. Research gaps were identified to help advance the science...
  45. ncbi Influence of acute phytochemical intake on human urinary metabolomic profiles
    Marianne C Walsh
    Centre for Food and Health, School of Agriculture, Food Science and Veterinary Medicine, University College Dublin, Dublin 4, Ireland
    Am J Clin Nutr 86:1687-93. 2007
    ..Diversity in dietary intake contributes to variation in human metabolomic profiles and artifacts from acute dietary intake can affect metabolomics data...