Research Topics
Genomes and Genes
| Xavier Sastre-GarauSummaryAffiliation: Institut Curie Country: France Publications
| Collaborators
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Detail Information
Publications
Inflammatory myofibroblastic tumour (inflammatory pseudotumour) of the breast. Clinicopathological and genetic analysis of a case with evidence for clonalityXavier Sastre-Garau
Department of Pathology, Institut Curie, Paris, France
J Pathol 196:97-102. 2002..2p22.2), +7, del(9)(p23), +19. Including the present observation, a 9p deletion has now been found in three cases of IMT. These observations show that IMT may be a clonal neoplasm, even in sites different from deep soft tissues...- Two types of squamous cell carcinoma of the palatine tonsil characterized by distinct etiology, molecular features and outcomeLamia Charfi
Department of Tumor Biology, Institut Curie 26 rue d Ulm 75248 Paris Cedex 05, France
Cancer Lett 260:72-8. 2008..023). HPV status remained a significant prognostic factor in multivariate analysis. Tonsillar SCC can thus be divided in HPV positive and negative subgroups with different oncogenesis and response to treatment... 
Transcription analysis in the MeLiM swine model identifies RACK1 as a potential marker of malignancy for human melanocytic proliferationGiorgia Egidy
INRA, UMR955 Génétique Moléculaire et Cellulaire Laboratoire conventionné CEA n degree 17 Ecole Nationale Vétérinaire d Alfort, 7 Avenue du General de Gaulle, Maisons Alfort, F 94704 France
Mol Cancer 7:34. 2008..However, most of them eventually spontaneously regress. Our purpose was to investigate whether the MeLiM model could reveal markers of malignancy in human melanocytic proliferations...
[Merkel cell carcinoma revisited: a new example of viro-induced human tumour]X Sastre-Garau
Service de Pathologie, Departement de Biologie des Tumeurs, Institut Curie, 26, rue d Ulm, 75248 Paris Cedex 05, France
Pathol Biol (Paris) 59:127-30. 2011..The distinct molecular viral signature in every case of MCC represents an original tool for the follow-up of the disease. New therapeutic perspectives are to be drawn using this model...- Regression of low-grade cervical intraepithelial neoplasia in patients with HLA-DRB1*13 genotypeXavier Sastre-Garau
Department of Pathology, Institut Curie, 26 Rue d Ulm, 75231 Paris Cedex, France
Obstet Gynecol 104:751-5. 2004..To test this hypothesis, we designed a prospective study of low-grade CIN (CIN1) and analyzed the probability of regression of these lesions according to HLA-DR and HPV status... - Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesisXavier Sastre-Garau
Department of Pathology, Institut Curie, Paris, France
J Pathol 218:48-56. 2009..This information will help the development of novel approaches for the assessment and therapy of MCC and biologically related tumours... - Increased cell size and Akt activation in HER-2/neu-overexpressing invasive ductal carcinoma of the breastX Sastre-Garau
Department of Pathology, CNRS UMR144, Institut Curie, Paris, France
Histopathology 45:142-7. 2004..Akt has been found to be involved in the HER-2/neu signal transduction pathway and Akt activation has been associated with increased cell size in various models... - A genomic and transcriptomic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancerJean Philippe Meyniel
Department of Translational Research, Institut Curie, 26 Rue d Ulm, 75248 Paris, Cedex 05, France
BMC Cancer 10:222. 2010..The purpose of the present work was to develop genomic and transcriptomic tools to further refine the pathological diagnosis of ovarian tumors after a previous history of breast cancer... - Frequent genomic structural alterations at HPV insertion sites in cervical carcinomaMartine Peter
Department of Tumour Biology, Institut Curie, F 75248 Paris, France
J Pathol 221:320-30. 2010..Structural alterations of the host genome are frequently observed at the integration site of HPV DNA in cervical cancer and may act in oncogenesis... - Establishment and characterization of a panel of human uveal melanoma xenografts derived from primary and/or metastatic tumorsFariba Nemati
Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, Paris, France
Clin Cancer Res 16:2352-62. 2010..The aim of this study was to develop and characterize a panel of human uveal melanoma xenografts transplanted into immunodeficient mice... - A prognostic DNA signature for T1T2 node-negative breast cancer patientsEleonore Gravier
Department of Translational Research, Institut Curie, 26 Rue d Ulm, Paris, France
Genes Chromosomes Cancer 49:1125-34. 2010..34; 95% confidence interval 1.01-11.02; P = 4.78 × 10(-2), Wald test). This study shows that tumor DNA contains important prognostic information that may help to predict metastasis in T1T2N0 tumors of the breast... - Expression of DNA repair proteins, MSH2, MLH1 and MGMT in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients' survivalStamatios Theocharis
Department of Pathology, Head and Neck Surgery, Institut Curie, Paris, France
J Oral Pathol Med 40:218-26. 2011..The present study aimed to evaluate the clinical significance of DNA repair proteins, MSH2, MLH1 and MGMT in mobile tongue squamous cell carcinoma (SCC)... - No evidence of human papillomavirus DNA sequences in invasive breast carcinomaPatricia De Cremoux
Department of Tumour Biology, Institut Curie, 26, rue d Ulm, 75248, Paris Cedex 05, France
Breast Cancer Res Treat 109:55-8. 2008..No HPV-DNA sequences were detected in our series of 50 samples. These data argue against the role of oncogenic HPV in the pathogenesis of breast cancer... - Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinomaChristophe Rosty
, Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France
Oncogene 24:7094-104. 2005..HPV expression level may thus provide a biological marker useful for prognosis assessment and specific therapy of the disease... - Respective prognostic value of genomic grade and histological proliferation markers in early stage (pN0) breast carcinomaFabien Reyal
Departement de Chirurgie, Institut Curie, Paris, France
PLoS ONE 7:e35184. 2012..Since most of the genes included in the GG are involved in cell proliferation, we performed a retrospective study to compare the prognostic value of GG, Mitotic Index and Ki67 score... - The molecular subtype classification is a determinant of sentinel node positivity in early breast carcinomaFabien Reyal
Department of Surgery, Institut Curie, Paris, France
PLoS ONE 6:e20297. 2011..The aim of our work was to decipher the interaction between this classification and the probability of a positive sentinel node biopsy... - Quantitative FISH analysis on interphase nuclei may improve diagnosis of DNA diploid breast cancersKhuong Truong
Cytogénétique Moléculaire et Oncologie, Unité Mixte de Recherche 147, Centre National de Recherche Scientifique Institut Curie, Paris, France
Diagn Cytopathol 26:213-6. 2002..In addition, the data also indicates that early breast tumors may have different genetic origins, which is important in the comprehension of tumor malignancy in early stages, especially for preinvasive lesions... - Phyllodes tumors of the breast segregate in two groups according to genetic criteriaMarick Lae
Departement de Biologie des Tumeurs, Service de Pathologie, Institut Curie Hôpital, Paris, France
Mod Pathol 20:435-44. 2007..Helpful additional pathological criteria for differentiating the two genetic groups of phyllodes tumors are the nuclear size and the mitotic rate... - KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcomeSandy Azoulay
Department of Pathology, Institut Curie, Paris Cedex, France
Mod Pathol 18:1623-31. 2005..This highly specific immunophenotype could be useful to differentiate adenoid cystic carcinoma of the breast from other subtypes of breast carcinoma such as cribriform carcinoma... - Disseminated tumor cells of breast cancer patients: a strong prognostic factor for distant and local relapseFrançois Clément Bidard
Department of Medical Oncology, Institut Curie, Paris, France
Clin Cancer Res 14:3306-11. 2008..Clinical significance of disseminated tumor cells (DTC) in bone marrow of early breast cancer patients has been reported, but improvements in detection methods are needed... - Lobular invasive carcinoma of the breast is a molecular entity distinct from luminal invasive ductal carcinomaNadège Gruel
Institut Curie, Translational Research Department, Paris, France
Eur J Cancer 46:2399-407. 2010..These molecular specificities should help with the identification of new therapeutic targets for ILC patients... - Secretory breast carcinomas with ETV6-NTRK3 fusion gene belong to the basal-like carcinoma spectrumMarick Lae
Service de Pathologie, Section Médicale, Institut Curie, Paris Cedex, France
Mod Pathol 22:291-8. 2009..These results support the hypothesis that secretory breast carcinomas have immunohistochemical and genetic features that distinguish them from other basal-like tumors of the breast... - A transcriptome signature of endothelial lymphatic cells coexists with the chronic oxidative stress signature in radiation-induced post-radiotherapy breast angiosarcomasNabila Sandra Hadj-Hamou
Institut Curie, Centre de Recherche, UMR3244, 26 Rue d Ulm Paris Cedex 5 F 75248, France
Carcinogenesis 33:1399-405. 2012..In contrast, MYC amplification, which is observed in all radiation-induced tumors but also at a low rate in primary tumors, was not a marker of the radiation tumorigenesis... 
Identification of typical medullary breast carcinoma as a genomic sub-group of basal-like carcinomas, a heterogeneous new molecular entityAnne Vincent-Salomon
Department of Tumor Biology, Institut Curie, Paris Cedex 05, France
Breast Cancer Res 9:R24. 2007..The present study was therefore designed to identify phenotypic and genetic alterations that distinguish MBCs from basal-like carcinomas (BLC)...- Metallothionein expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patient survivalStamatios Theocharis
Department of Pathology, Head and Neck Surgery, Institut Curie, Paris, France
Histopathology 59:514-25. 2011..The aim of the present study was to evaluate the clinical significance of MT expression in mobile tongue squamous cell carcinoma (SCC)... - X inactive-specific transcript RNA coating and genetic instability of the X chromosome in BRCA1 breast tumorsAnne Vincent-Salomon
Institut Curie, Centre de Recherche, Paris, France
Cancer Res 67:5134-40. 2007..Finally, we also show the necessity for combined global and single-cell approaches in the assessment of tumors with such a high degree of heterogeneity... - Different outcome of invasive cervical cancer associated with high-risk versus intermediate-risk HPV genotypePatricia De Cremoux
Department of Tumour Biology, Institut Curie, Paris, France
Int J Cancer 124:778-82. 2009..One third of invasive carcinoma were not associated with HPV 16/18, indicating that the screening for cervical neoplasia should be maintained after prophylactic vaccination against these HPV genotypes... - Distinct merkel cell polyomavirus molecular features in tumour and non tumour specimens from patients with merkel cell carcinomaHélène C Laude
Universite Paris Descartes, EA1833, Paris, France
PLoS Pathog 6:e1001076. 2010..We conclude that MCPyV molecular features in primary MCC tumour and PBMC may help to predict the course of the disease... - Proliferation markers predictive of the pathological response and disease outcome of patients with breast carcinomas treated by anthracycline-based preoperative chemotherapyAnne Vincent-Salomon
Department of Pathology, Institut Curie, Paris, France
Eur J Cancer 40:1502-8. 2004..The sequential analysis of MI in breast cancers treated by preoperative CT thus provides a surrogate for predicting long-term outcome... - Integrated genomic and transcriptomic analysis of ductal carcinoma in situ of the breastAnne Vincent-Salomon
Institut Curie, Department of Tumor Biology, Paris, France
Clin Cancer Res 14:1956-65. 2008..To gain insight into genomic and transcriptomic subtypes of ductal carcinomas in situ of the breast (DCIS)... - Lobular phenotype related to occult-metastatic spread in axillary sentinel node and/or bone marrow in breast carcinomaAnne Vincent-Salomon
Department of Pathology, Institut Curie, 75005 Paris Cedex, France
Eur J Cancer 45:1979-86. 2009.... - High Ki67 expression is a risk marker of invasive relapse for classical lobular carcinoma in situ patientsAnne Vincent-Salomon
Department of Tumor Biology, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
Breast 21:380-3. 2012..Our aim was to evaluate the risk of relapse for lobular carcinoma in situ (LCIS) patients, diagnosed on mammography performed for microcalcifications and according to proliferation assessed by Ki67 staining... - RCAS1 expression in mobile tongue squamous cell carcinoma: an immunohistochemical studyStamatios Theocharis
Department of Pathology, Head and Neck Surgery, Institute Curie, Paris, France
Med Sci Monit 17:BR228-234. 2011..The present study aimed to evaluate the clinical significance of RCAS1 expression in mobile tongue squamous cell carcinoma (SCC)... - High PTP4A3 phosphatase expression correlates with metastatic risk in uveal melanoma patientsCecile Laurent
Institut Curie, Paris, France
Cancer Res 71:666-74. 2011..Our findings suggest that PTP4A3 or its cellular substrates could constitute attractive therapeutic targets to treat metastatic uveal melanomas... - Uveal melanoma: management and outcome of patients with extraocular spreadCaren Bellmann
Institut Curie, Ophthalmology Department, 26, rue d Ulm, Paris 75005, France
Br J Ophthalmol 94:569-74. 2010..CONCLUSIONS Tumour recurrence rates and survival rates were not adversely affected in patients receiving conservative eye treatment. This may thus represent a therapeutic option in certain patients with extraocular spread... - Fine-needle aspiration as a diagnostic technique in 50 cases of primary Ewing sarcoma/peripheral neuroectodermal tumor. Institut Curie's experienceJerzy Klijanienko
Department of Tumor Biology, Institut Curie, Paris, France
Diagn Cytopathol 40:19-25. 2012..In conclusion, FNA assisted by genomic techniques is powerful methods to accurate diagnose ES/PNET... - Clinical and biological characteristics of cervical neoplasias with FGFR3 mutationChristophe Rosty
Departement de Pathologie, Institut Curie, Section Médicale, 26 Rue d Ulm, 75248 Paris Cedex 05, France
Mol Cancer 4:15. 2005..To further analyze the role of FGFR3 in cervical tumor progression, we extended our study to screen a total of 75 invasive tumors and 80 cervical intraepithelial neoplasias (40 low-grade and 40 high-grade lesions)... - miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress responseBogdan Mateescu
Stress and Cancer Laboratory, Institut Curie, Paris, France
Nat Med 17:1627-35. 2011..In addition, although oxidative stress promotes tumor growth, it also sensitizes tumors to treatment, which could account for the limited success of antioxidants in clinical trials... - Diagnostic and prognostic information obtained on fine-needle aspirates of primary neuroblastic tumors: Proposal for a cytology prognostic scoreJerzy Klijanienko
Department of Pathology, Institut Curie, Paris, France
Cancer Cytopathol 119:411-23. 2011..The use of cytological material for diagnosis and prognosis in patients with neuroblastic tumors is poorly described in the literature... - A transcriptome signature distinguished sporadic from postradiotherapy radiation-induced sarcomasNabila Sandra Hadj-Hamou
Institut Curie, Centre de Recherche, UMR3244, 26 Rue d Ulm, Paris Cedex 5 F 75248, France
Carcinogenesis 32:929-34. 2011..The functions of the genes of the signature suggest that RI sarcomas were subject to chronic oxidative stress probably due to mitochondrial dysfunction... - Modulation of tumor growth by inhibitory Fc(gamma) receptor expressed by human melanoma cellsLydie Cassard
Unité d Immunologie Cellulaire et Clinique, Institut National de la Santé et de la Recherche Médicale INSERM U 255 and Université Pierre et Marie Curie Paris VI, Centre de Recherches Biomedicales des Cordeliers, Paris, France
J Clin Invest 110:1549-57. 2002..Therefore, Fc(gamma)R expression on human tumors may be one component of the efficacy of antibody-mediated therapies, and Fc(gamma)R-positive tumors could be the most sensitive candidates for such treatments... - [Lobular neoplasia]Brigitte Sigal-Zafrani
Institut Curie, 26 Rue d Ulm, 75005 Paris
Ann Pathol 23:547-53. 2003..Mass screening is challenging the current opinion that lobular disease cannot be detected by mammography. This raises the problem of the optimal management of patients with lobular neoplasia on needle core biopsies... - Time to metastatic relapse and breast cancer cells dissemination in bone marrow at metastatic relapseFrançois Clément Bidard
Department of Medical Oncology, Institut Curie, 26 Rue d Ulm, 75005, Paris, France
Clin Exp Metastasis 25:871-5. 2008..Dissemination of DTC in other host organ and/or epithelial-mesenchymal transition from cytokeratin-positive to cytokeratin-negative DTC may explain this observation... - Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancerArmelle Corpet
Institut Curie, UMR218, Nuclear Dynamics and Genome Plasticity, Paris, France
EMBO J 30:480-93. 2011..We discuss the implications of these results for breast cancer diagnosis and prognosis... - Giant basal cell carcinoma with regional lymph node and distant lung metastasisSaud Aldhaban
Service de Dermatologie, Hopital Cochin, Universite Paris Descartes, Paris, France
Eur J Dermatol 21:972-5. 2011..As the lesion remained solitary but had increased in size five months later, the patient finally accepted a surgical resection. A right upper-lobe pneumonectomy was performed and pathologic examination confirmed the metastasis as a MBCC... - Pre-operative Concomitant Radio-chemotherapy in Bulky Carcinoma of the Cervix: A Single Institution StudyAnne de la Rochefordiere
Radiation Oncology, for Gynaecology Study Group of the Institut Curie, Paris, France
Clin Med Oncol 2:227-36. 2008..To evaluate the treatment results of patients (pts) with FIGO stage IB2, IIA, IIB cervical carcinoma (CC) treated with pre-operative radio-chemotherapy, followed by extended radical hysterectomy... - Macroscopic quality control improves the reliability of blue dye-only sentinel lymph node biopsy in breast cancerClaude Nos
Department of Surgery, Institut Curie, Paris, France
Ann Surg Oncol 10:525-30. 2003..At the Institut Curie, to reduce the false-negative rate, we have developed a histological quality control of the SLN performed by blue dye alone, which consists of verification of the SLN blue stain by the pathologist... - Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with BRCA1/2 InactivationTatiana Popova
Authors Affiliations Centre de Recherche, INSERM U830, Departments of Tumor Biology, Translational Department, and Radiotherapy, Institut Curie, Sorbonne Paris Cité, University Paris Descartes, Paris and Institut Bergonié, Bordeaux, France
Cancer Res 72:5454-62. 2012..This assay may ease the challenge of selecting patients for genetic testing or recruitment to clinical trials of novel emerging therapies that target DNA repair deficiencies in cancer. Cancer Res; 72(21); 5454-62. ©2012 AACR... - FAK and Src expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survivalStamatios Theocharis
Department of Pathology, Institut Curie, Paris, France
J Cancer Res Clin Oncol 138:1369-77. 2012..The present study aimed to evaluate the clinical significance of FAK and Src protein expression in mobile tongue squamous cell carcinoma (SCC)... - PHOX2B immunolabeling: a novel tool for the diagnosis of undifferentiated neuroblastomas among childhood small round blue-cell tumorsFranck Bielle
APHP, Hopital Robert Debre, Service de Pathologie, Paris, France
Am J Surg Pathol 36:1141-9. 2012..Finally, we showed that PHOX2B immunohistochemical analysis improves the diagnosis of undifferentiated neuroblastoma with high specificity and sensitivity... - In vivo efficacy of photodynamic therapy in three new xenograft models of human retinoblastomaIsabelle Aerts
INSERM U 612, Centre de Recherche, Institut Curie, 26 Rue d Ulm, 75 248 Paris cedex 05, France
Photodiagnosis Photodyn Ther 7:275-83. 2010..Photodynamic therapy represents a nonmutagenic therapeutic approach, and may reduce the incidence of secondary tumors. To study the in vivo efficacy of photodynamic therapy, human retinoblastoma xenografts were established in nude mice... - Long peptide vaccination can lead to lethality through CD4+ T cell-mediated cytokine stormHiroshi Kitamura
Laboratoire d Immunologie, Institut Curie, Paris, France
J Immunol 185:892-901. 2010.... - Cyto-histological correlations in primary, recurrent and metastatic rhabdomyosarcoma: the institut Curie's experienceJerzy Klijanienko
Department of Tumor Biology, Institut Curie, Paris, France
Diagn Cytopathol 35:482-7. 2007..9% vs. 6.7%), mitotic figures (57.1% vs. 18.9%), and cyto-nuclear atypia (77.1% vs. 43.2%). Inversely, spindle-shaped cells were more frequently seen in nonalveolar versus alveolar RMSs (37.8% vs. 20.9%)... - Heterochromatin protein 1alpha: a hallmark of cell proliferation relevant to clinical oncologyLeanne de Koning
Laboratory of Nuclear Dynamics and Genome Plasticity UMR218, Institut Curie CNRS UPMC, 26 Rue d Ulm, 75248 Paris Cedex 05, France
EMBO Mol Med 1:178-91. 2009..The overexpression of HP1alpha constitutes a new example of a potential epigenetic contribution to tumourigenesis that is of clinical interest for cancer prognosis... - Overexpression/amplification of HER-2/neu is uncommon in invasive carcinoma of the uterine cervixChristophe Rosty
, Institut Curie, , Paris, France
Int J Gynecol Pathol 23:13-7. 2004..Overexpression/amplification of HER-2/neu is uncommon in invasive cervical carcinoma, suggesting that there is little indication for using anti-p185c-erbB2 therapy in the treatment of these patients... - Histological margin assessment for breast ductal carcinoma in situ: precision and implicationsBrigitte Sigal-Zafrani
Department of Pathology, Institut Curie, 26 Rue d Ulm, 75248 Paris, France
Mod Pathol 17:81-8. 2004..A standard for margin status reporting and pathological processing of screen-detected DCIS in situ lesions will help in the interpretation of data from different institutions... - Genomic profiling and identification of high-risk uveal melanoma by array CGH analysis of primary tumors and liver metastasesJulien Trolet
Department of Bioinformatics, Institut Curie, Paris, France
Invest Ophthalmol Vis Sci 50:2572-80. 2009..The purpose of this study was to analyze genomic profiles in a large series of ocular tumors and liver metastases and design a genome-based classifier for metastatic risk assessment... - Human papillomavirus mutational insertion: specific marker of circulating tumor DNA in cervical cancer patientsMaura Campitelli
Department of Radiation Oncology, Institut Curie, Hospital, Paris, France
PLoS ONE 7:e43393. 2012..To determine whether the sequence of the cell-viral junction could be used in clinical practice as a specific marker of ctDNA, we analyzed a series of cervical cancer patient serums... - Non-sentinel lymph node metastasis prediction in breast cancer with metastatic sentinel lymph node: impact of molecular subtypes classificationFabien Reyal
Department of Surgery, Institut Curie, Paris, France
PLoS ONE 7:e47390. 2012.... - Efficiency of the hybrid capture 2 HPV DNA test in cervical cancer screening. A study by the French Society of Clinical CytologyPatricia De Cremoux
Department of Tumor Biology, Institut Curie, Paris, France
Am J Clin Pathol 120:492-9. 2003..89%) and 135 samples (7.56%), respectively. Although HC2 can be considered a reliable and sensitive test for HPV DNA detection, we do not advocate its use for large-scale screening for cervical neoplasia... - Radiation-induced sarcomas after radiotherapy for breast carcinoma: a large-scale single-institution reviewYoulia M Kirova
Department of Radiation Oncology, Institut Curie, Paris, France
Cancer 104:856-63. 2005..Sarcomas are a rare complication of radiotherapy for breast carcinoma and patients have a poor prognosis. The incidence, histology, and management of patients with sarcomas were reviewed in the current study... - Antibody-dependent cell cytotoxicity synapses form in mice during tumor-specific antibody immunotherapyPascale Hubert
Institut Curie, Hopital, Departement de Biologie des Tumeurs, Paris, France
Cancer Res 71:5134-43. 2011..These results show that in vivo ADCC mediated by macrophages and neutrophils during tumor rejection by Chi-Tn mAb involves a novel type of multifocal immune synapse between effectors of innate immunity and tumor cells... - Specific TP53 mutation pattern in radiation-induced sarcomasNathalie Gonin-Laurent
UMR7147 Institut Curie CNRS UPMC, CEA LRC38, Paris, France
Carcinogenesis 27:1266-72. 2006..The lack of hyper-reactivity of CpG dinucleotides and the presence of recurrent sites of mutation at codons 135 and 237 seem also to be specific for radiation tumorigenesis... - Fine-needle aspiration in myxofibrosarcoma: experience of Institut CuriePierre Colin
Department of Pathology, Institut Curie, Paris 75248, France
Diagn Cytopathol 38:343-6. 2010..The cytological misdiagnosis is of limited clinical consequence because FNA findings suggestive of a myxoid tumor will be indicative for a surgical removal followed by the histopathological analysis... - Chromosomal instability in near-diploid colorectal cancer: a link between numbers and structureMartine Muleris
French National Institute for Health and Medical Research INSERM, UMRS_762, Centre de Recherche CDR Saint Antoine, Paris, France
PLoS ONE 3:e1632. 2008.... - Oxidative stress promotes myofibroblast differentiation and tumour spreadingAurore Toullec
Laboratory of Stress and Cancer, INSERM U830, Institut Curie, 75248 Paris Cedex 05, France
EMBO Mol Med 2:211-30. 2010..Collectively, our data uncover a new mechanism by which oxidative stress increases the migratory properties of stromal fibroblasts, which in turn potentiate tumour dissemination... - Visualizing chromosomes as transcriptome correlation maps: evidence of chromosomal domains containing co-expressed genes--a study of 130 invasive ductal breast carcinomasFabien Reyal
, Centre National de la Recherche Scientifique, Paris, France
Cancer Res 65:1376-83. 2005..Transcription correlation maps are a new way of visualizing transcriptome data. They will help to identify new genes involved in tumor progression and new mechanisms of gene regulation in tumors... - Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humansArmelle Logie
UMR 144, Centre National de la Recherche Scientifique, Section de Recherche, Institut Curie, Paris, France
Hum Mol Genet 14:1153-60. 2005..Our findings directly implicate FGFR3 activation as a major cause of benign epidermal tumors in humans... - Genomic organization of amplified MYC genes suggests distinct mechanisms of amplification in tumorigenesisJohn Herrick
, , Institut Pasteur, Paris, France
Cancer Res 65:1174-9. 2005..Interestingly, different amplification patterns seem to be correlated with the disease outcome, thus providing new insights into HPV-related cancer development and tumor progression... - High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumorsElodie Manie
Institut Curie, Centre de Recherche, Paris, France
Cancer Res 69:663-71. 2009..In conclusion, TP53 mutation is highly recurrent in BLCs independently of BRCA1 status, but not a common feature of BRCA1 luminal tumors... - Selective expression of inhibitory Fcgamma receptor by metastatic melanoma impairs tumor susceptibility to IgG-dependent cellular responseLydie Cassard
INSERM, U872, Microenvironnement immunitaire et tumeurs, Equipe 13, Centre de Recherche des Cordeliers, Paris, France
Int J Cancer 123:2832-9. 2008..Thus, our results identify FcgammaRIIB as a marker of human metastatic melanoma that impairs the tumor susceptibility to FcgammaR-dependent innate effector responses... - Histological detection of minimal metastatic involvement in axillary sentinel nodes: a rational basis for a sensitive methodology usable in daily practicePaul Freneaux
Department of Pathology, Institut Curie, Paris, France
Mod Pathol 15:641-6. 2002..The clinical significance of occult metastases in SN needs to be specified by long-term follow-up analysis... - Relevance of CT and MRI in retinoblastoma for the diagnosis of postlaminar invasion with normal-size optic nerve: a retrospective study of 150 patients with histological comparisonHervé J Brisse
Department of Radiology, Institute Curie, 26 Rue d Ulm, Paris 75005, France
Pediatr Radiol 37:649-56. 2007..Detection of optic nerve invasion is mandatory in children primarily enucleated for retinoblastoma to ensure a free resection margin... - Urokinase-type plasminogen activator and plasminogen-activator-inhibitor type 1 predict metastases in good prognosis breast cancer patientsPatricia De Cremoux
Departement de Biologie des Tumeurs, Institut Curie, 26 Rue d Ulm, 75231 Paris Cedex, France
Anticancer Res 29:1475-82. 2009..This retrospective analysis was designed to confirm the predictive role of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type I (PAI-1) in the outcome of early stage, node-negative breast cancer patients... - HER2 status in patients with breast carcinoma is not modified selectively by preoperative chemotherapy and is stable during the metastatic processAnne Vincent-Salomon
Department of Pathology, Institut Curie, Paris, France
Cancer 94:2169-73. 2002..In a few patients, a diminution in the level of HER2 expression was observed after CT or in secondary tumors. This may have been due to a transitory state of altered tumor cells or to the selection of HER2 negative tumor cells clones... - MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic dataMatthieu Bui Nguyen Binh
Department of Pathology at the Curie Institute, Paris, France
Am J Surg Pathol 29:1340-7. 2005..In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas... - Ductal breast carcinoma develops through different patterns of chromosomal evolutionRomain Molist
FRE 2584 CNRS, Institut Curie, Paris, France
Genes Chromosomes Cancer 43:147-54. 2005..Chromosomes 5, 7, 8, and 20 were the most frequently gained. Our findings support the evidence of a new pathway of chromosomal evolution in a small subset of ductal breast carcinomas characterized by numerical chromosome aberrations... - [Sclerosing angiomatoid nodular transformation of the spleen]Olfa Chouchane Mlik
Departement de Pathologie, Institut Curie, 26 Rue d Ulm, Paris Cedex 05, France
Ann Pathol 28:317-20. 2008..In this report, we discuss the pathology of this lesion and the differential diagnosis of SANT with other lesions such as hemangiomas, hamartomas and inflammatory pseudotumors... - UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 as a new immunohistochemical breast cancer markerNora Berois
, , Facultad de Medicina, , Montevideo, Uruguay
J Histochem Cytochem 54:317-28. 2006..Considering that an abnormal O-glycosylation greatly contributes to the phenotype and biology of breast cancer cells, ppGalNAc-T6 expression could provide new insights about breast cancer glycobiology... - Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumorsPascaline Tisserand
Laboratoire de Genotoxicololgie des Tumeurs Paris, France
Cancer Biol Ther 2:559-63. 2003..Medullary carcinoma of the breast should therefore be considered to be a unique entity defined by specific histologic and molecular traits... - [Standards, Options and Recommendations for the management of invasive cervical cancer patients (non metastastic)]Michel Resbeut
FNCLCC, Standards, Options, Recommandations, 101, rue de Tolbiac, 75654 Paris Cedex 13
Bull Cancer 90:333-46. 2003..Algorithms for the management of patients are also included... - [Malignant tumors of the penis in the Cameroons: epidemiological, clinical, pathological and therapeutical features.]M Sow
Ann Pathol 26:299-301. 2006 - A new model of patient tumor-derived breast cancer xenografts for preclinical assaysElisabetta Marangoni
U612 Institut National de la Sante et de la Recherche Medicale, Pharmacologie Préclinique Antitumorale, Paris Anatomie et Cytologie Pathologique, Hopital Trousseau, Tours, France
Clin Cancer Res 13:3989-98. 2007..To establish a panel of human breast cancer (HBC) xenografts in immunodeficient mice suitable for pharmacologic preclinical assays...