Xavier Sastre-Garau

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. ncbi request reprint Inflammatory myofibroblastic tumour (inflammatory pseudotumour) of the breast. Clinicopathological and genetic analysis of a case with evidence for clonality
    Xavier Sastre-Garau
    Department of Pathology, Institut Curie, Paris, France
    J Pathol 196:97-102. 2002
  2. ncbi request reprint Two types of squamous cell carcinoma of the palatine tonsil characterized by distinct etiology, molecular features and outcome
    Lamia Charfi
    Department of Tumor Biology, Institut Curie 26 rue d Ulm 75248 Paris Cedex 05, France
    Cancer Lett 260:72-8. 2008
  3. pmc Long-term prognostic performance of Ki67 rate in early stage, pT1-pT2, pN0, invasive breast carcinoma
    Fabien Reyal
    Department of Surgery, Institut Curie, Paris, France
    PLoS ONE 8:e55901. 2013
  4. pmc Respective prognostic value of genomic grade and histological proliferation markers in early stage (pN0) breast carcinoma
    Fabien Reyal
    Departement de Chirurgie, Institut Curie, Paris, France
    PLoS ONE 7:e35184. 2012
  5. pmc Transcription analysis in the MeLiM swine model identifies RACK1 as a potential marker of malignancy for human melanocytic proliferation
    Giorgia Egidy
    INRA, UMR955 Génétique Moléculaire et Cellulaire Laboratoire conventionné CEA n degree 17 Ecole Nationale Vétérinaire d Alfort, 7 Avenue du General de Gaulle, Maisons Alfort, F 94704 France
    Mol Cancer 7:34. 2008
  6. doi request reprint [Merkel cell carcinoma revisited: a new example of viro-induced human tumour]
    X Sastre-Garau
    Service de Pathologie, Departement de Biologie des Tumeurs, Institut Curie, 26, rue d Ulm, 75248 Paris Cedex 05, France
    Pathol Biol (Paris) 59:127-30. 2011
  7. ncbi request reprint Regression of low-grade cervical intraepithelial neoplasia in patients with HLA-DRB1*13 genotype
    Xavier Sastre-Garau
    Department of Pathology, Institut Curie, 26 Rue d Ulm, 75231 Paris Cedex, France
    Obstet Gynecol 104:751-5. 2004
  8. ncbi request reprint Increased cell size and Akt activation in HER-2/neu-overexpressing invasive ductal carcinoma of the breast
    X Sastre-Garau
    Department of Pathology, CNRS UMR144, Institut Curie, Paris, France
    Histopathology 45:142-7. 2004
  9. doi request reprint Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis
    Xavier Sastre-Garau
    Department of Pathology, Institut Curie, Paris, France
    J Pathol 218:48-56. 2009
  10. pmc A genomic and transcriptomic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer
    Jean Philippe Meyniel
    Department of Translational Research, Institut Curie, 26 Rue d Ulm, 75248 Paris, Cedex 05, France
    BMC Cancer 10:222. 2010

Detail Information

Publications90

  1. ncbi request reprint Inflammatory myofibroblastic tumour (inflammatory pseudotumour) of the breast. Clinicopathological and genetic analysis of a case with evidence for clonality
    Xavier Sastre-Garau
    Department of Pathology, Institut Curie, Paris, France
    J Pathol 196:97-102. 2002
    ..2p22.2), +7, del(9)(p23), +19. Including the present observation, a 9p deletion has now been found in three cases of IMT. These observations show that IMT may be a clonal neoplasm, even in sites different from deep soft tissues...
  2. ncbi request reprint Two types of squamous cell carcinoma of the palatine tonsil characterized by distinct etiology, molecular features and outcome
    Lamia Charfi
    Department of Tumor Biology, Institut Curie 26 rue d Ulm 75248 Paris Cedex 05, France
    Cancer Lett 260:72-8. 2008
    ..023). HPV status remained a significant prognostic factor in multivariate analysis. Tonsillar SCC can thus be divided in HPV positive and negative subgroups with different oncogenesis and response to treatment...
  3. pmc Long-term prognostic performance of Ki67 rate in early stage, pT1-pT2, pN0, invasive breast carcinoma
    Fabien Reyal
    Department of Surgery, Institut Curie, Paris, France
    PLoS ONE 8:e55901. 2013
    ..The present study aims to validate Ki67 as prognostic factor in a large cohort of early-stage (pT1-pT2, pN0) breast cancer patients...
  4. pmc Respective prognostic value of genomic grade and histological proliferation markers in early stage (pN0) breast carcinoma
    Fabien Reyal
    Departement de Chirurgie, Institut Curie, Paris, France
    PLoS ONE 7:e35184. 2012
    ..Since most of the genes included in the GG are involved in cell proliferation, we performed a retrospective study to compare the prognostic value of GG, Mitotic Index and Ki67 score...
  5. pmc Transcription analysis in the MeLiM swine model identifies RACK1 as a potential marker of malignancy for human melanocytic proliferation
    Giorgia Egidy
    INRA, UMR955 Génétique Moléculaire et Cellulaire Laboratoire conventionné CEA n degree 17 Ecole Nationale Vétérinaire d Alfort, 7 Avenue du General de Gaulle, Maisons Alfort, F 94704 France
    Mol Cancer 7:34. 2008
    ..However, most of them eventually spontaneously regress. Our purpose was to investigate whether the MeLiM model could reveal markers of malignancy in human melanocytic proliferations...
  6. doi request reprint [Merkel cell carcinoma revisited: a new example of viro-induced human tumour]
    X Sastre-Garau
    Service de Pathologie, Departement de Biologie des Tumeurs, Institut Curie, 26, rue d Ulm, 75248 Paris Cedex 05, France
    Pathol Biol (Paris) 59:127-30. 2011
    ..The distinct molecular viral signature in every case of MCC represents an original tool for the follow-up of the disease. New therapeutic perspectives are to be drawn using this model...
  7. ncbi request reprint Regression of low-grade cervical intraepithelial neoplasia in patients with HLA-DRB1*13 genotype
    Xavier Sastre-Garau
    Department of Pathology, Institut Curie, 26 Rue d Ulm, 75231 Paris Cedex, France
    Obstet Gynecol 104:751-5. 2004
    ..To test this hypothesis, we designed a prospective study of low-grade CIN (CIN1) and analyzed the probability of regression of these lesions according to HLA-DR and HPV status...
  8. ncbi request reprint Increased cell size and Akt activation in HER-2/neu-overexpressing invasive ductal carcinoma of the breast
    X Sastre-Garau
    Department of Pathology, CNRS UMR144, Institut Curie, Paris, France
    Histopathology 45:142-7. 2004
    ..Akt has been found to be involved in the HER-2/neu signal transduction pathway and Akt activation has been associated with increased cell size in various models...
  9. doi request reprint Merkel cell carcinoma of the skin: pathological and molecular evidence for a causative role of MCV in oncogenesis
    Xavier Sastre-Garau
    Department of Pathology, Institut Curie, Paris, France
    J Pathol 218:48-56. 2009
    ..This information will help the development of novel approaches for the assessment and therapy of MCC and biologically related tumours...
  10. pmc A genomic and transcriptomic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous history of breast cancer
    Jean Philippe Meyniel
    Department of Translational Research, Institut Curie, 26 Rue d Ulm, 75248 Paris, Cedex 05, France
    BMC Cancer 10:222. 2010
    ..The purpose of the present work was to develop genomic and transcriptomic tools to further refine the pathological diagnosis of ovarian tumors after a previous history of breast cancer...
  11. doi request reprint Establishment and characterization of a panel of human uveal melanoma xenografts derived from primary and/or metastatic tumors
    Fariba Nemati
    Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, Paris, France
    Clin Cancer Res 16:2352-62. 2010
    ..The aim of this study was to develop and characterize a panel of human uveal melanoma xenografts transplanted into immunodeficient mice...
  12. ncbi request reprint Frequent genomic structural alterations at HPV insertion sites in cervical carcinoma
    Martine Peter
    Department of Tumour Biology, Institut Curie, F 75248 Paris, France
    J Pathol 221:320-30. 2010
    ..Structural alterations of the host genome are frequently observed at the integration site of HPV DNA in cervical cancer and may act in oncogenesis...
  13. doi request reprint A prognostic DNA signature for T1T2 node-negative breast cancer patients
    Eleonore Gravier
    Department of Translational Research, Institut Curie, 26 Rue d Ulm, Paris, France
    Genes Chromosomes Cancer 49:1125-34. 2010
    ..34; 95% confidence interval 1.01-11.02; P = 4.78 × 10(-2), Wald test). This study shows that tumor DNA contains important prognostic information that may help to predict metastasis in T1T2N0 tumors of the breast...
  14. doi request reprint Different outcome of invasive cervical cancer associated with high-risk versus intermediate-risk HPV genotype
    Patricia De Cremoux
    Department of Tumour Biology, Institut Curie, Paris, France
    Int J Cancer 124:778-82. 2009
    ..One third of invasive carcinoma were not associated with HPV 16/18, indicating that the screening for cervical neoplasia should be maintained after prophylactic vaccination against these HPV genotypes...
  15. doi request reprint Secretory breast carcinomas with ETV6-NTRK3 fusion gene belong to the basal-like carcinoma spectrum
    Marick Lae
    Service de Pathologie, Section Médicale, Institut Curie, Paris Cedex, France
    Mod Pathol 22:291-8. 2009
    ..These results support the hypothesis that secretory breast carcinomas have immunohistochemical and genetic features that distinguish them from other basal-like tumors of the breast...
  16. ncbi request reprint Histone deacetylase-1 and -2 expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival
    Stamatios Theocharis
    Department of Pathology, Head and Neck Surgery, Institut Curie, Paris, France
    J Oral Pathol Med 40:706-14. 2011
    ..The aim of the present study was to evaluate the clinical significance of HDAC-1 and -2 protein expression in mobile tongue squamous cell carcinoma (SCC)...
  17. doi request reprint Disseminated tumor cells of breast cancer patients: a strong prognostic factor for distant and local relapse
    François Clément Bidard
    Department of Medical Oncology, Institut Curie, Paris, France
    Clin Cancer Res 14:3306-11. 2008
    ..Clinical significance of disseminated tumor cells (DTC) in bone marrow of early breast cancer patients has been reported, but improvements in detection methods are needed...
  18. ncbi request reprint No evidence of human papillomavirus DNA sequences in invasive breast carcinoma
    Patricia De Cremoux
    Department of Tumour Biology, Institut Curie, 26, rue d Ulm, 75248, Paris Cedex 05, France
    Breast Cancer Res Treat 109:55-8. 2008
    ..No HPV-DNA sequences were detected in our series of 50 samples. These data argue against the role of oncogenic HPV in the pathogenesis of breast cancer...
  19. doi request reprint Expression of DNA repair proteins, MSH2, MLH1 and MGMT in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients' survival
    Stamatios Theocharis
    Department of Pathology, Head and Neck Surgery, Institut Curie, Paris, France
    J Oral Pathol Med 40:218-26. 2011
    ..The present study aimed to evaluate the clinical significance of DNA repair proteins, MSH2, MLH1 and MGMT in mobile tongue squamous cell carcinoma (SCC)...
  20. ncbi request reprint Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma
    Christophe Rosty
    Departement de Biologie des Tumeurs, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Oncogene 24:7094-104. 2005
    ..HPV expression level may thus provide a biological marker useful for prognosis assessment and specific therapy of the disease...
  21. doi request reprint Patient-derived xenografts recapitulate molecular features of human uveal melanomas
    Cecile Laurent
    Institut Curie, Paris, France
    Mol Oncol 7:625-36. 2013
    ..These models therefore constitute valuable preclinical tool for drug screening in UM...
  22. ncbi request reprint Quantitative FISH analysis on interphase nuclei may improve diagnosis of DNA diploid breast cancers
    Khuong Truong
    Cytogénétique Moléculaire et Oncologie, Unité Mixte de Recherche 147, Centre National de Recherche Scientifique Institut Curie, Paris, France
    Diagn Cytopathol 26:213-6. 2002
    ..In addition, the data also indicates that early breast tumors may have different genetic origins, which is important in the comprehension of tumor malignancy in early stages, especially for preinvasive lesions...
  23. pmc The molecular subtype classification is a determinant of sentinel node positivity in early breast carcinoma
    Fabien Reyal
    Department of Surgery, Institut Curie, Paris, France
    PLoS ONE 6:e20297. 2011
    ..The aim of our work was to decipher the interaction between this classification and the probability of a positive sentinel node biopsy...
  24. ncbi request reprint Phyllodes tumors of the breast segregate in two groups according to genetic criteria
    Marick Lae
    Departement de Biologie des Tumeurs, Service de Pathologie, Institut Curie Hôpital, Paris, France
    Mod Pathol 20:435-44. 2007
    ..Helpful additional pathological criteria for differentiating the two genetic groups of phyllodes tumors are the nuclear size and the mitotic rate...
  25. ncbi request reprint Lobular phenotype related to occult-metastatic spread in axillary sentinel node and/or bone marrow in breast carcinoma
    Anne Vincent-Salomon
    Department of Pathology, Institut Curie, 75005 Paris Cedex, France
    Eur J Cancer 45:1979-86. 2009
    ....
  26. pmc Genomic instability: a stronger prognostic marker than proliferation for early stage luminal breast carcinomas
    Anne Vincent-Salomon
    Department of Tumor Biology, Institut Curie, Paris, France INSERM U830, Institut Curie, Paris, France
    PLoS ONE 8:e76496. 2013
    ..The accurate prognosis definition to tailor treatment for early luminal invasive breast carcinoma patients remains challenging...
  27. doi request reprint Integrated genomic and transcriptomic analysis of ductal carcinoma in situ of the breast
    Anne Vincent-Salomon
    Institut Curie, Department of Tumor Biology, Paris, France
    Clin Cancer Res 14:1956-65. 2008
    ..To gain insight into genomic and transcriptomic subtypes of ductal carcinomas in situ of the breast (DCIS)...
  28. doi request reprint Lobular invasive carcinoma of the breast is a molecular entity distinct from luminal invasive ductal carcinoma
    Nadège Gruel
    Institut Curie, Translational Research Department, Paris, France
    Eur J Cancer 46:2399-407. 2010
    ..These molecular specificities should help with the identification of new therapeutic targets for ILC patients...
  29. doi request reprint High Ki67 expression is a risk marker of invasive relapse for classical lobular carcinoma in situ patients
    Anne Vincent-Salomon
    Department of Tumor Biology, Institut Curie, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Breast 21:380-3. 2012
    ..Our aim was to evaluate the risk of relapse for lobular carcinoma in situ (LCIS) patients, diagnosed on mammography performed for microcalcifications and according to proliferation assessed by Ki67 staining...
  30. ncbi request reprint Proliferation markers predictive of the pathological response and disease outcome of patients with breast carcinomas treated by anthracycline-based preoperative chemotherapy
    Anne Vincent-Salomon
    Department of Pathology, Institut Curie, Paris, France
    Eur J Cancer 40:1502-8. 2004
    ..The sequential analysis of MI in breast cancers treated by preoperative CT thus provides a surrogate for predicting long-term outcome...
  31. doi request reprint Loss of heterozygosity at 13q13 and 14q32 predicts BRCA2 inactivation in luminal breast carcinomas
    Nicolas Pécuchet
    Institut Curie, Centre de Recherche, Paris, France INSERM U830, Paris, France Department of Tumor Biology, Institut Curie, Paris, France
    Int J Cancer 133:2834-42. 2013
    ..7-33.5) in the whole series. In conclusion, the simplified BRCA2 classifier based on the co-occurrence of LOH at 13q13 and 14q32 could provide an indication to test for BRCA2 mutation in patients with ER-positive IDC. ..
  32. doi request reprint A transcriptome signature of endothelial lymphatic cells coexists with the chronic oxidative stress signature in radiation-induced post-radiotherapy breast angiosarcomas
    Nabila Sandra Hadj-Hamou
    Institut Curie, Centre de Recherche, UMR3244, 26 Rue d Ulm Paris Cedex 5 F 75248, France
    Carcinogenesis 33:1399-405. 2012
    ..In contrast, MYC amplification, which is observed in all radiation-induced tumors but also at a low rate in primary tumors, was not a marker of the radiation tumorigenesis...
  33. doi request reprint Metallothionein expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patient survival
    Stamatios Theocharis
    Department of Pathology, Head and Neck Surgery, Institut Curie, Paris, France
    Histopathology 59:514-25. 2011
    ..The aim of the present study was to evaluate the clinical significance of MT expression in mobile tongue squamous cell carcinoma (SCC)...
  34. pmc Distinct merkel cell polyomavirus molecular features in tumour and non tumour specimens from patients with merkel cell carcinoma
    Hélène C Laude
    Universite Paris Descartes, EA1833, Paris, France
    PLoS Pathog 6:e1001076. 2010
    ..We conclude that MCPyV molecular features in primary MCC tumour and PBMC may help to predict the course of the disease...
  35. doi request reprint Time to metastatic relapse and breast cancer cells dissemination in bone marrow at metastatic relapse
    François Clément Bidard
    Department of Medical Oncology, Institut Curie, 26 Rue d Ulm, 75005, Paris, France
    Clin Exp Metastasis 25:871-5. 2008
    ..Dissemination of DTC in other host organ and/or epithelial-mesenchymal transition from cytokeratin-positive to cytokeratin-negative DTC may explain this observation...
  36. ncbi request reprint Urokinase-type plasminogen activator and plasminogen-activator-inhibitor type 1 predict metastases in good prognosis breast cancer patients
    Patricia De Cremoux
    Departement de Biologie des Tumeurs, Institut Curie, 26 Rue d Ulm, 75231 Paris Cedex, France
    Anticancer Res 29:1475-82. 2009
    ..This retrospective analysis was designed to confirm the predictive role of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type I (PAI-1) in the outcome of early stage, node-negative breast cancer patients...
  37. pmc Clinical and biological characteristics of cervical neoplasias with FGFR3 mutation
    Christophe Rosty
    Departement de Pathologie, Institut Curie, Section Médicale, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Mol Cancer 4:15. 2005
    ..To further analyze the role of FGFR3 in cervical tumor progression, we extended our study to screen a total of 75 invasive tumors and 80 cervical intraepithelial neoplasias (40 low-grade and 40 high-grade lesions)...
  38. ncbi request reprint X inactive-specific transcript RNA coating and genetic instability of the X chromosome in BRCA1 breast tumors
    Anne Vincent-Salomon
    Institut Curie, Centre de Recherche, Paris, France
    Cancer Res 67:5134-40. 2007
    ..Finally, we also show the necessity for combined global and single-cell approaches in the assessment of tumors with such a high degree of heterogeneity...
  39. pmc Identification of typical medullary breast carcinoma as a genomic sub-group of basal-like carcinomas, a heterogeneous new molecular entity
    Anne Vincent-Salomon
    Department of Tumor Biology, Institut Curie, Paris Cedex 05, France
    Breast Cancer Res 9:R24. 2007
    ..The present study was therefore designed to identify phenotypic and genetic alterations that distinguish MBCs from basal-like carcinomas (BLC)...
  40. ncbi request reprint KIT is highly expressed in adenoid cystic carcinoma of the breast, a basal-like carcinoma associated with a favorable outcome
    Sandy Azoulay
    Department of Pathology, Institut Curie, Paris Cedex, France
    Mod Pathol 18:1623-31. 2005
    ..This highly specific immunophenotype could be useful to differentiate adenoid cystic carcinoma of the breast from other subtypes of breast carcinoma such as cribriform carcinoma...
  41. doi request reprint Uveal melanoma: management and outcome of patients with extraocular spread
    Caren Bellmann
    Institut Curie, Ophthalmology Department, 26, rue d Ulm, Paris 75005, France
    Br J Ophthalmol 94:569-74. 2010
    ..CONCLUSIONS Tumour recurrence rates and survival rates were not adversely affected in patients receiving conservative eye treatment. This may thus represent a therapeutic option in certain patients with extraocular spread...
  42. doi request reprint High PTP4A3 phosphatase expression correlates with metastatic risk in uveal melanoma patients
    Cecile Laurent
    Institut Curie, Paris, France
    Cancer Res 71:666-74. 2011
    ..Our findings suggest that PTP4A3 or its cellular substrates could constitute attractive therapeutic targets to treat metastatic uveal melanomas...
  43. pmc RCAS1 expression in mobile tongue squamous cell carcinoma: an immunohistochemical study
    Stamatios Theocharis
    Department of Pathology, Head and Neck Surgery, Institute Curie, Paris, France
    Med Sci Monit 17:BR228-234. 2011
    ..The present study aimed to evaluate the clinical significance of RCAS1 expression in mobile tongue squamous cell carcinoma (SCC)...
  44. ncbi request reprint Overexpression/amplification of HER-2/neu is uncommon in invasive carcinoma of the uterine cervix
    Christophe Rosty
    Departement de Pathologie, Institut Curie, Section Médicale, Paris, France
    Int J Gynecol Pathol 23:13-7. 2004
    ..Overexpression/amplification of HER-2/neu is uncommon in invasive cervical carcinoma, suggesting that there is little indication for using anti-p185c-erbB2 therapy in the treatment of these patients...
  45. pmc Non-sentinel lymph node metastasis prediction in breast cancer with metastatic sentinel lymph node: impact of molecular subtypes classification
    Fabien Reyal
    Department of Surgery, Institut Curie, Paris, France
    PLoS ONE 7:e47390. 2012
    ....
  46. doi request reprint Fine-needle aspiration as a diagnostic technique in 50 cases of primary Ewing sarcoma/peripheral neuroectodermal tumor. Institut Curie's experience
    Jerzy Klijanienko
    Department of Tumor Biology, Institut Curie, Paris, France
    Diagn Cytopathol 40:19-25. 2012
    ..In conclusion, FNA assisted by genomic techniques is powerful methods to accurate diagnose ES/PNET...
  47. doi request reprint Diagnostic and prognostic information obtained on fine-needle aspirates of primary neuroblastic tumors: Proposal for a cytology prognostic score
    Jerzy Klijanienko
    Department of Pathology, Institut Curie, Paris, France
    Cancer Cytopathol 119:411-23. 2011
    ..The use of cytological material for diagnosis and prognosis in patients with neuroblastic tumors is poorly described in the literature...
  48. doi request reprint miR-141 and miR-200a act on ovarian tumorigenesis by controlling oxidative stress response
    Bogdan Mateescu
    Stress and Cancer Laboratory, Institut Curie, Paris, France
    Nat Med 17:1627-35. 2011
    ..In addition, although oxidative stress promotes tumor growth, it also sensitizes tumors to treatment, which could account for the limited success of antioxidants in clinical trials...
  49. pmc A transcriptome signature distinguished sporadic from postradiotherapy radiation-induced sarcomas
    Nabila Sandra Hadj-Hamou
    Institut Curie, Centre de Recherche, UMR3244, 26 Rue d Ulm, Paris Cedex 5 F 75248, France
    Carcinogenesis 32:929-34. 2011
    ..The functions of the genes of the signature suggest that RI sarcomas were subject to chronic oxidative stress probably due to mitochondrial dysfunction...
  50. pmc Asf1b, the necessary Asf1 isoform for proliferation, is predictive of outcome in breast cancer
    Armelle Corpet
    Institut Curie, UMR218, Nuclear Dynamics and Genome Plasticity, Paris, France
    EMBO J 30:480-93. 2011
    ..We discuss the implications of these results for breast cancer diagnosis and prognosis...
  51. ncbi request reprint [Lobular neoplasia]
    Brigitte Sigal-Zafrani
    Institut Curie, 26 Rue d Ulm, 75005 Paris
    Ann Pathol 23:547-53. 2003
    ..Mass screening is challenging the current opinion that lobular disease cannot be detected by mammography. This raises the problem of the optimal management of patients with lobular neoplasia on needle core biopsies...
  52. pmc Modulation of tumor growth by inhibitory Fc(gamma) receptor expressed by human melanoma cells
    Lydie Cassard
    Unité d Immunologie Cellulaire et Clinique, Institut National de la Santé et de la Recherche Médicale INSERM U 255 and Université Pierre et Marie Curie Paris VI, Centre de Recherches Biomedicales des Cordeliers, Paris, France
    J Clin Invest 110:1549-57. 2002
    ..Therefore, Fc(gamma)R expression on human tumors may be one component of the efficacy of antibody-mediated therapies, and Fc(gamma)R-positive tumors could be the most sensitive candidates for such treatments...
  53. pmc Human papillomavirus mutational insertion: specific marker of circulating tumor DNA in cervical cancer patients
    Maura Campitelli
    Department of Radiation Oncology, Institut Curie, Hospital, Paris, France
    PLoS ONE 7:e43393. 2012
    ..To determine whether the sequence of the cell-viral junction could be used in clinical practice as a specific marker of ctDNA, we analyzed a series of cervical cancer patient serums...
  54. pmc Pre-operative Concomitant Radio-chemotherapy in Bulky Carcinoma of the Cervix: A Single Institution Study
    Anne de la Rochefordiere
    Radiation Oncology, for Gynaecology Study Group of the Institut Curie, Paris, France
    Clin Med Oncol 2:227-36. 2008
    ..To evaluate the treatment results of patients (pts) with FIGO stage IB2, IIA, IIB cervical carcinoma (CC) treated with pre-operative radio-chemotherapy, followed by extended radical hysterectomy...
  55. ncbi request reprint Mature cytotoxic CD56(bright)/CD16(+) natural killer cells can infiltrate lymph nodes adjacent to metastatic melanoma
    Meriem Messaoudene
    Authors Affiliations Inserm U1016, CNRS UMR 8104, Institut Cochin APHP, Department of Dermatology, Hospital Cochin, University Paris Descartes APHP, Department of Dermatology APHP, Department of Surgery, Hospital Bichat, University Paris Diderot Surgery Department, Institut Curie, rue d Ulm Paris Hospital Foch, Suresnes Centre de Recherche des Cordeliers, 15 rue de l école de médecine and INSERM U1015 INSERM, Institut Gustave Roussy, Villejuif, Paris, France
    Cancer Res 74:81-92. 2014
    ..Taken together, the results offer evidence that adjuvant immunotherapy that targets NK cells in M-LN for activation may improve treatment of patients with sentinel lymph node-positive melanoma...
  56. doi request reprint Giant basal cell carcinoma with regional lymph node and distant lung metastasis
    Saud Aldhaban
    Service de Dermatologie, Hopital Cochin, Universite Paris Descartes, Paris, France
    Eur J Dermatol 21:972-5. 2011
    ..As the lesion remained solitary but had increased in size five months later, the patient finally accepted a surgical resection. A right upper-lobe pneumonectomy was performed and pathologic examination confirmed the metastasis as a MBCC...
  57. ncbi request reprint Macroscopic quality control improves the reliability of blue dye-only sentinel lymph node biopsy in breast cancer
    Claude Nos
    Department of Surgery, Institut Curie, Paris, France
    Ann Surg Oncol 10:525-30. 2003
    ..At the Institut Curie, to reduce the false-negative rate, we have developed a histological quality control of the SLN performed by blue dye alone, which consists of verification of the SLN blue stain by the pathologist...
  58. pmc Germline mutation in the RAD51B gene confers predisposition to breast cancer
    Lisa Golmard
    Institut Curie, Department of Tumour Biology, 26 Rue d Ulm, 75248, Paris, Cedex 05, France
    BMC Cancer 13:484. 2013
    ..The present study analysed the five RAD51 paralogs (RAD51B, RAD51C, RAD51D, XRCC2, XRCC3) to estimate their contribution to breast and ovarian cancer predisposition...
  59. ncbi request reprint Efficiency of the hybrid capture 2 HPV DNA test in cervical cancer screening. A study by the French Society of Clinical Cytology
    Patricia De Cremoux
    Department of Tumor Biology, Institut Curie, Paris, France
    Am J Clin Pathol 120:492-9. 2003
    ..89%) and 135 samples (7.56%), respectively. Although HC2 can be considered a reliable and sensitive test for HPV DNA detection, we do not advocate its use for large-scale screening for cervical neoplasia...
  60. doi request reprint Ploidy and large-scale genomic instability consistently identify basal-like breast carcinomas with BRCA1/2 inactivation
    Tatiana Popova
    Centre de Recherche, University Paris Descartes, Paris, France
    Cancer Res 72:5454-62. 2012
    ..This assay may ease the challenge of selecting patients for genetic testing or recruitment to clinical trials of novel emerging therapies that target DNA repair deficiencies in cancer...
  61. doi request reprint PHOX2B immunolabeling: a novel tool for the diagnosis of undifferentiated neuroblastomas among childhood small round blue-cell tumors
    Franck Bielle
    APHP, Hopital Robert Debre, Service de Pathologie, Paris, France
    Am J Surg Pathol 36:1141-9. 2012
    ..Finally, we showed that PHOX2B immunohistochemical analysis improves the diagnosis of undifferentiated neuroblastoma with high specificity and sensitivity...
  62. doi request reprint FAK and Src expression in mobile tongue squamous cell carcinoma: associations with clinicopathological parameters and patients survival
    Stamatios Theocharis
    Department of Pathology, Institut Curie, Paris, France
    J Cancer Res Clin Oncol 138:1369-77. 2012
    ..The present study aimed to evaluate the clinical significance of FAK and Src protein expression in mobile tongue squamous cell carcinoma (SCC)...
  63. ncbi request reprint Histological margin assessment for breast ductal carcinoma in situ: precision and implications
    Brigitte Sigal-Zafrani
    Department of Pathology, Institut Curie, 26 Rue d Ulm, 75248 Paris, France
    Mod Pathol 17:81-8. 2004
    ..A standard for margin status reporting and pathological processing of screen-detected DCIS in situ lesions will help in the interpretation of data from different institutions...
  64. ncbi request reprint Cyto-histological correlations in primary, recurrent and metastatic rhabdomyosarcoma: the institut Curie's experience
    Jerzy Klijanienko
    Department of Tumor Biology, Institut Curie, Paris, France
    Diagn Cytopathol 35:482-7. 2007
    ..9% vs. 6.7%), mitotic figures (57.1% vs. 18.9%), and cyto-nuclear atypia (77.1% vs. 43.2%). Inversely, spindle-shaped cells were more frequently seen in nonalveolar versus alveolar RMSs (37.8% vs. 20.9%)...
  65. doi request reprint In vivo efficacy of photodynamic therapy in three new xenograft models of human retinoblastoma
    Isabelle Aerts
    INSERM U 612, Centre de Recherche, Institut Curie, 26 Rue d Ulm, 75 248 Paris cedex 05, France
    Photodiagnosis Photodyn Ther 7:275-83. 2010
    ..Photodynamic therapy represents a nonmutagenic therapeutic approach, and may reduce the incidence of secondary tumors. To study the in vivo efficacy of photodynamic therapy, human retinoblastoma xenografts were established in nude mice...
  66. doi request reprint Genomic profiling and identification of high-risk uveal melanoma by array CGH analysis of primary tumors and liver metastases
    Julien Trolet
    Department of Bioinformatics, Institut Curie, Paris, France
    Invest Ophthalmol Vis Sci 50:2572-80. 2009
    ..The purpose of this study was to analyze genomic profiles in a large series of ocular tumors and liver metastases and design a genome-based classifier for metastatic risk assessment...
  67. doi request reprint Long peptide vaccination can lead to lethality through CD4+ T cell-mediated cytokine storm
    Hiroshi Kitamura
    Laboratoire d Immunologie, Institut Curie, Paris, France
    J Immunol 185:892-901. 2010
    ....
  68. pmc Heterochromatin protein 1alpha: a hallmark of cell proliferation relevant to clinical oncology
    Leanne de Koning
    Laboratory of Nuclear Dynamics and Genome Plasticity UMR218, Institut Curie CNRS UPMC, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    EMBO Mol Med 1:178-91. 2009
    ..The overexpression of HP1alpha constitutes a new example of a potential epigenetic contribution to tumourigenesis that is of clinical interest for cancer prognosis...
  69. doi request reprint Fine-needle aspiration in myxofibrosarcoma: experience of Institut Curie
    Pierre Colin
    Department of Pathology, Institut Curie, Paris 75248, France
    Diagn Cytopathol 38:343-6. 2010
    ..The cytological misdiagnosis is of limited clinical consequence because FNA findings suggestive of a myxoid tumor will be indicative for a surgical removal followed by the histopathological analysis...
  70. doi request reprint Antibody-dependent cell cytotoxicity synapses form in mice during tumor-specific antibody immunotherapy
    Pascale Hubert
    Institut Curie, Hopital, Departement de Biologie des Tumeurs, Paris, France
    Cancer Res 71:5134-43. 2011
    ..These results show that in vivo ADCC mediated by macrophages and neutrophils during tumor rejection by Chi-Tn mAb involves a novel type of multifocal immune synapse between effectors of innate immunity and tumor cells...
  71. ncbi request reprint Radiation-induced sarcomas after radiotherapy for breast carcinoma: a large-scale single-institution review
    Youlia M Kirova
    Department of Radiation Oncology, Institut Curie, Paris, France
    Cancer 104:856-63. 2005
    ..Sarcomas are a rare complication of radiotherapy for breast carcinoma and patients have a poor prognosis. The incidence, histology, and management of patients with sarcomas were reviewed in the current study...
  72. pmc Oxidative stress promotes myofibroblast differentiation and tumour spreading
    Aurore Toullec
    Laboratory of Stress and Cancer, INSERM U830, Institut Curie, 75248 Paris Cedex 05, France
    EMBO Mol Med 2:211-30. 2010
    ..Collectively, our data uncover a new mechanism by which oxidative stress increases the migratory properties of stromal fibroblasts, which in turn potentiate tumour dissemination...
  73. pmc Chromosomal instability in near-diploid colorectal cancer: a link between numbers and structure
    Martine Muleris
    French National Institute for Health and Medical Research INSERM, UMRS_762, Centre de Recherche CDR Saint Antoine, Paris, France
    PLoS ONE 3:e1632. 2008
    ....
  74. ncbi request reprint Specific TP53 mutation pattern in radiation-induced sarcomas
    Nathalie Gonin-Laurent
    UMR7147 Institut Curie CNRS UPMC, CEA LRC38, Paris, France
    Carcinogenesis 27:1266-72. 2006
    ..The lack of hyper-reactivity of CpG dinucleotides and the presence of recurrent sites of mutation at codons 135 and 237 seem also to be specific for radiation tumorigenesis...
  75. ncbi request reprint Histological detection of minimal metastatic involvement in axillary sentinel nodes: a rational basis for a sensitive methodology usable in daily practice
    Paul Freneaux
    Department of Pathology, Institut Curie, Paris, France
    Mod Pathol 15:641-6. 2002
    ..The clinical significance of occult metastases in SN needs to be specified by long-term follow-up analysis...
  76. ncbi request reprint Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans
    Armelle Logie
    UMR 144, Centre National de la Recherche Scientifique, Section de Recherche, Institut Curie, Paris, France
    Hum Mol Genet 14:1153-60. 2005
    ..Our findings directly implicate FGFR3 activation as a major cause of benign epidermal tumors in humans...
  77. ncbi request reprint Selective expression of inhibitory Fcgamma receptor by metastatic melanoma impairs tumor susceptibility to IgG-dependent cellular response
    Lydie Cassard
    INSERM, U872, Microenvironnement immunitaire et tumeurs, Equipe 13, Centre de Recherche des Cordeliers, Paris, France
    Int J Cancer 123:2832-9. 2008
    ..Thus, our results identify FcgammaRIIB as a marker of human metastatic melanoma that impairs the tumor susceptibility to FcgammaR-dependent innate effector responses...
  78. doi request reprint High frequency of TP53 mutation in BRCA1 and sporadic basal-like carcinomas but not in BRCA1 luminal breast tumors
    Elodie Manie
    Institut Curie, Centre de Recherche, Paris, France
    Cancer Res 69:663-71. 2009
    ..In conclusion, TP53 mutation is highly recurrent in BLCs independently of BRCA1 status, but not a common feature of BRCA1 luminal tumors...
  79. ncbi request reprint Genomic organization of amplified MYC genes suggests distinct mechanisms of amplification in tumorigenesis
    John Herrick
    Unité Stabilité des Génomes, Département de Structure et Dynamique des Génomes, Institut Pasteur, Paris, France
    Cancer Res 65:1174-9. 2005
    ..Interestingly, different amplification patterns seem to be correlated with the disease outcome, thus providing new insights into HPV-related cancer development and tumor progression...
  80. ncbi request reprint Visualizing chromosomes as transcriptome correlation maps: evidence of chromosomal domains containing co-expressed genes--a study of 130 invasive ductal breast carcinomas
    Fabien Reyal
    Unite Mixte de Recherche 144, Centre National de la Recherche Scientifique, Paris, France
    Cancer Res 65:1376-83. 2005
    ..Transcription correlation maps are a new way of visualizing transcriptome data. They will help to identify new genes involved in tumor progression and new mechanisms of gene regulation in tumors...
  81. ncbi request reprint Relevance of CT and MRI in retinoblastoma for the diagnosis of postlaminar invasion with normal-size optic nerve: a retrospective study of 150 patients with histological comparison
    Hervé J Brisse
    Department of Radiology, Institute Curie, 26 Rue d Ulm, Paris 75005, France
    Pediatr Radiol 37:649-56. 2007
    ..Detection of optic nerve invasion is mandatory in children primarily enucleated for retinoblastoma to ensure a free resection margin...
  82. ncbi request reprint HER2 status in patients with breast carcinoma is not modified selectively by preoperative chemotherapy and is stable during the metastatic process
    Anne Vincent-Salomon
    Department of Pathology, Institut Curie, Paris, France
    Cancer 94:2169-73. 2002
    ..The objective of this study was to determine whether HER2 expression levels in breast carcinomas were modified by chemotherapy or during the metastatic process...
  83. ncbi request reprint MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data
    Matthieu Bui Nguyen Binh
    Department of Pathology at the Curie Institute, Paris, France
    Am J Surg Pathol 29:1340-7. 2005
    ..In conclusion, MDM2 and CDK4 immunostainings, which correlate with gene amplification, are helpful adjuncts to differentiate ALT-WDLPS from benign adipose tumors and to separate DDLPS from poorly differentiated sarcomas...
  84. ncbi request reprint Ductal breast carcinoma develops through different patterns of chromosomal evolution
    Romain Molist
    FRE 2584 CNRS, Institut Curie, Paris, France
    Genes Chromosomes Cancer 43:147-54. 2005
    ..Chromosomes 5, 7, 8, and 20 were the most frequently gained. Our findings support the evidence of a new pathway of chromosomal evolution in a small subset of ductal breast carcinomas characterized by numerical chromosome aberrations...
  85. doi request reprint [Sclerosing angiomatoid nodular transformation of the spleen]
    Olfa Chouchane Mlik
    Departement de Pathologie, Institut Curie, 26 Rue d Ulm, Paris Cedex 05, France
    Ann Pathol 28:317-20. 2008
    ..In this report, we discuss the pathology of this lesion and the differential diagnosis of SANT with other lesions such as hemangiomas, hamartomas and inflammatory pseudotumors...
  86. ncbi request reprint UDP-N-acetyl-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase-6 as a new immunohistochemical breast cancer marker
    Nora Berois
    Departamento de Bioquimica, Laboratorio de Oncología Básica, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay
    J Histochem Cytochem 54:317-28. 2006
    ..Considering that an abnormal O-glycosylation greatly contributes to the phenotype and biology of breast cancer cells, ppGalNAc-T6 expression could provide new insights about breast cancer glycobiology...
  87. ncbi request reprint Lack of HIN-1 methylation defines specific breast tumor subtypes including medullary carcinoma of the breast and BRCA1-linked tumors
    Pascaline Tisserand
    Laboratoire de Genotoxicololgie des Tumeurs Paris, France
    Cancer Biol Ther 2:559-63. 2003
    ..Medullary carcinoma of the breast should therefore be considered to be a unique entity defined by specific histologic and molecular traits...
  88. ncbi request reprint [Standards, Options and Recommendations for the management of invasive cervical cancer patients (non metastastic)]
    Michel Resbeut
    FNCLCC, Standards, Options, Recommandations, 101, rue de Tolbiac, 75654 Paris Cedex 13
    Bull Cancer 90:333-46. 2003
    ..The methodology is based on literature review and critical appraisal by a multidisciplinary group of experts, with feedback from specialists in cancer care delivery...
  89. ncbi request reprint [Malignant tumors of the penis in the Cameroons: epidemiological, clinical, pathological and therapeutical features]
    M Sow
    Ann Pathol 26:299-301. 2006
  90. ncbi request reprint A new model of patient tumor-derived breast cancer xenografts for preclinical assays
    Elisabetta Marangoni
    U612 Institut National de la Sante et de la Recherche Medicale, Pharmacologie Préclinique Antitumorale, Paris Anatomie et Cytologie Pathologique, Hopital Trousseau, Tours, France
    Clin Cancer Res 13:3989-98. 2007
    ..To establish a panel of human breast cancer (HBC) xenografts in immunodeficient mice suitable for pharmacologic preclinical assays...