P Sansonetti

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint Molecular and cellular mechanisms of invasion of the intestinal barrier by enteric pathogens. The paradigm of Shigella
    P J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, INSERM U 389, Institut Pasteur, Paris, France
    Folia Microbiol (Praha) 43:239-46. 1998
  2. doi request reprint Host-bacteria homeostasis in the healthy and inflamed gut
    Philippe J Sansonetti
    Department of Cell Biology and Infection, Institut Pasteur, Paris, France
    Curr Opin Gastroenterol 24:435-9. 2008
  3. ncbi request reprint Microbes and microbial toxins: paradigms for microbial-mucosal interactions III. Shigellosis: from symptoms to molecular pathogenesis
    P J Sansonetti
    Unité de Pathogénie Microbienne Moléculaire et Unité Institut National de la Santé et de la Recherche Médicale 389, Institut Pasteur, 75724 Paris Cedex 15, France
    Am J Physiol Gastrointest Liver Physiol 280:G319-23. 2001
  4. pmc Host-pathogen interactions: the seduction of molecular cross talk
    P Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, Paris, France
    Gut 50:III2-8. 2002
  5. ncbi request reprint Debugging how bacteria manipulate the immune response
    Philippe J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris, Cedex 15, France
    Immunity 26:149-61. 2007
  6. doi request reprint Learning tolerance while fighting ignorance
    Philippe J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, 75724 Paris Cedex 15, France Microbiologie et Maladies Infectieuses, College de France, 75231 Paris Cedex 05, France
    Cell 138:416-20. 2009
  7. ncbi request reprint Rupture of the intestinal epithelial barrier and mucosal invasion by Shigella flexneri
    P J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Sante et de la Recherche Medicale, Institut Pasteur, Paris, France
    Clin Infect Dis 28:466-75. 1999
  8. ncbi request reprint Molecular bases of epithelial cell invasion by Shigella flexneri
    P J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, INSERM U 389, Institut Pasteur, Paris, France
    Antonie Van Leeuwenhoek 74:191-7. 1998
  9. pmc Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis
    P J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, F 75724 Paris Cedex 15, France
    Infect Immun 67:1471-80. 1999
  10. ncbi request reprint War and peace at mucosal surfaces
    Philippe J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, U389 INSERM and Howard Hughes Medical Institute, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Nat Rev Immunol 4:953-64. 2004

Detail Information

Publications77

  1. ncbi request reprint Molecular and cellular mechanisms of invasion of the intestinal barrier by enteric pathogens. The paradigm of Shigella
    P J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, INSERM U 389, Institut Pasteur, Paris, France
    Folia Microbiol (Praha) 43:239-46. 1998
    ..These data can now be used to understand the mechanisms of mucosal protection against bacillary dysentery...
  2. doi request reprint Host-bacteria homeostasis in the healthy and inflamed gut
    Philippe J Sansonetti
    Department of Cell Biology and Infection, Institut Pasteur, Paris, France
    Curr Opin Gastroenterol 24:435-9. 2008
    ..This review attempts to delineate the (sometimes thin) border between these two situations that are at the heart of understanding gut homeostasis and its possible rupture...
  3. ncbi request reprint Microbes and microbial toxins: paradigms for microbial-mucosal interactions III. Shigellosis: from symptoms to molecular pathogenesis
    P J Sansonetti
    Unité de Pathogénie Microbienne Moléculaire et Unité Institut National de la Santé et de la Recherche Médicale 389, Institut Pasteur, 75724 Paris Cedex 15, France
    Am J Physiol Gastrointest Liver Physiol 280:G319-23. 2001
    ..Subsequent apoptotic killing of macrophages in a caspase 1-dependent process causes the release of IL-1beta and IL-18, which accounts for the initial steps of inflammation...
  4. pmc Host-pathogen interactions: the seduction of molecular cross talk
    P Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, Paris, France
    Gut 50:III2-8. 2002
    ..Finally, a variety of strategies also exist to deal with other components of the epithelial barrier, such as macrophages. Pro-phagocytic, anti-phagocytic, and pro-apoptotic processes appear to be of particular importance...
  5. ncbi request reprint Debugging how bacteria manipulate the immune response
    Philippe J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris, Cedex 15, France
    Immunity 26:149-61. 2007
    ....
  6. doi request reprint Learning tolerance while fighting ignorance
    Philippe J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, 75724 Paris Cedex 15, France Microbiologie et Maladies Infectieuses, College de France, 75231 Paris Cedex 05, France
    Cell 138:416-20. 2009
    ..It is becoming clear that the host immune system must reach a delicate balance between destroying dangerous bacterial pathogens while preserving the beneficial gut microbiota...
  7. ncbi request reprint Rupture of the intestinal epithelial barrier and mucosal invasion by Shigella flexneri
    P J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Sante et de la Recherche Medicale, Institut Pasteur, Paris, France
    Clin Infect Dis 28:466-75. 1999
    ..Once they are intracellular, bacteria multiply within the cytoplasm and move from cell to cell by an actin-dependent process...
  8. ncbi request reprint Molecular bases of epithelial cell invasion by Shigella flexneri
    P J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, INSERM U 389, Institut Pasteur, Paris, France
    Antonie Van Leeuwenhoek 74:191-7. 1998
    ..Bacteria then lyse the two membranes, reach the cytoplasmic compartment again, and resume actin-driven movement...
  9. pmc Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis
    P J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, F 75724 Paris Cedex 15, France
    Infect Immun 67:1471-80. 1999
    ..By mediating eradication of bacteria at their epithelial entry site, although at the cost of severe epithelial destruction, IL-8 therefore appears to be a key chemokine in the control of bacterial translocation...
  10. ncbi request reprint War and peace at mucosal surfaces
    Philippe J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, U389 INSERM and Howard Hughes Medical Institute, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Nat Rev Immunol 4:953-64. 2004
    ..This review discusses the mechanisms for establishing and controlling the 'dialogue' between unresponsiveness and initiation of active immune defences in the gut. Si vis pacem, para bellum. (If you wish for peace, prepare for war.)...
  11. ncbi request reprint The innate signaling of dangers and the dangers of innate signaling
    Philippe J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, Unité INSERM 786, and the Howard Hughes Medical Institute International Program, Institut Pasteur, 75724 Paris, France
    Nat Immunol 7:1237-42. 2006
    ..A growing number of non-Toll-like innate immune receptors is recognized as part of this surveillance network...
  12. pmc Infection of rabbit Peyer's patches by Shigella flexneri: effect of adhesive or invasive bacterial phenotypes on follicle-associated epithelium
    P J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, U389 INSERM, Institut Pasteur, Paris
    Infect Immun 64:2752-64. 1996
    ..These experiments demonstrate that various remodeling patterns may occur in Peyer's patches in response to bacterial pathogens, depending on the virulence phenotype expressed by the pathogenic strain...
  13. ncbi request reprint The bacterial weaponry: lessons from Shigella
    Philippe J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, and Howard Hughes Medical Institute, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Ann N Y Acad Sci 1072:307-12. 2006
    ....
  14. pmc Shigellosis: an old disease in new clothes?
    Philippe J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, Unité INSERM 786, Institut Pasteur, Paris, France
    PLoS Med 3:e354. 2006
  15. ncbi request reprint Phagocytosis of bacterial pathogens: implications in the host response
    P Sansonetti
    Unité de Pathogénie Microbienne Moléculaire et Unité INSERM 389, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Semin Immunol 13:381-90. 2001
    ..We have taken enteroinvasive micro-organisms such as Yersinia, Shigella and Salmonella as a paradigm of the significance of phagocytosis/antiphagocytosis in the development of an infection and on the elicitation of the host response...
  16. ncbi request reprint Blockade of CD14 increases Shigella-mediated invasion and tissue destruction
    C Wenneras
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Sante et de la Recherche Medicale, Unité 389, Institut Pasteur, Paris, France
    J Immunol 164:3214-21. 2000
    ..Moreover, in vitro blockade of CD14 did not impede bactericidal activity. Thus, anti-CD14 treatment interfered with host defense mechanisms involved with removal/eradication of Shigella...
  17. pmc The secretion of the Shigella flexneri Ipa invasins is activated by epithelial cells and controlled by IpaB and IpaD
    R Menard
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, Paris, France
    EMBO J 13:5293-302. 1994
    ..We propose that IpaB and IpaD, by interacting in the secretion apparatus, modulate secretion...
  18. ncbi request reprint Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Paris Cedex 15, France
    J Biol Chem 278:8869-72. 2003
    ..Additionally, the characterization of Nod2 as the first pathogen-recognition molecule that detects MDP will help to unravel the well known biological activities of this immunomodulatory compound...
  19. ncbi request reprint CD44 binds to the Shigella IpaB protein and participates in bacterial invasion of epithelial cells
    A Skoudy
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Paris, France
    Cell Microbiol 2:19-33. 2000
    ..The IpaB-CD44 interaction appears to be required for Shigella invasion by initiating the early steps of the entry process...
  20. ncbi request reprint Nod1 detects a unique muropeptide from gram-negative bacterial peptidoglycan
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28, rue du Dr Roux, 75724Paris Cedex 15, France
    Science 300:1584-7. 2003
    ..Moreover, we show that in epithelial cells (which represent the first line of defense against invasive pathogens), Nod1is indispensable for intracellular Gram-negative bacterial sensing...
  21. ncbi request reprint Blockade of CD14 aggravates experimental shigellosis
    C Wenneras
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, Paris, France
    J Endotoxin Res 7:442-6. 2001
    ..In contrast, higher quantities of TNF-alpha were observed in the CD14-blocked group. To conclude, anti-CD14 treatment had a detrimental effect on the capacity of Shigella-infected animals to clear the infection...
  22. pmc The tripartite type III secreton of Shigella flexneri inserts IpaB and IpaC into host membranes
    A Blocker
    Unité de Pathogénie Microbienne Moléculaire INSERM U389, Institut Pasteur, 75724 Paris Cedex 15, France
    J Cell Biol 147:683-93. 1999
    ..Secreton morphology did not change upon activation of secretion. In mutants of some genes encoding the secretion machinery the organelle was absent, whereas ipaB and ipaC mutants displayed normal secretons...
  23. ncbi request reprint Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells
    Meng Tsung Tien
    Pathogénie Microbienne Moléculaire Unit, Institut National de la Sante et de la Recherche Medicale U389, Paris, France
    J Immunol 176:1228-37. 2006
    ..casei treatment. Thus, L. casei has developed a sophisticated means to maintain intestinal homeostasis through a process that involves manipulation of the ubiquitin/proteasome pathway upstream of I-kappaBalpha...
  24. ncbi request reprint Shigella interaction with intestinal epithelial cells determines the innate immune response in shigellosis
    M Isabel Fernandez
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, Rue du Dr Roux 28, F 75724 Paris 15, France
    Int J Med Microbiol 293:55-67. 2003
    ....
  25. ncbi request reprint The pattern-recognition molecule Nod1 is localized at the plasma membrane at sites of bacterial interaction
    Thomas A Kufer
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, France, and Unité INSERM 786, Institut Pasteur, France
    Cell Microbiol 10:477-86. 2008
    ..Our data provide evidence that membrane association is linked to Nod1 function and, in view of recent findings on Nod2, that this may be a common feature of NLR family members...
  26. pmc The Shigella flexneri effector OspG interferes with innate immune responses by targeting ubiquitin-conjugating enzymes
    Dong Wook Kim
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Sante et de la Recherche Medicale, Unité Mixte de Recherche 389, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    Proc Natl Acad Sci U S A 102:14046-51. 2005
    ..This finding indicates that OspG negatively controls the host innate response induced by S. flexneri upon invasion of the epithelium...
  27. pmc Identification of the cis-acting site involved in activation of promoters regulated by activity of the type III secretion apparatus in Shigella flexneri
    Maria Mavris
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 75724 Paris Cedex 15, France
    J Bacteriol 184:6751-9. 2002
    ..We also present evidence that at least one ipaH gene that is carried by the chromosome is controlled by MxiE and IpgC...
  28. ncbi request reprint Structure and composition of the Shigella flexneri "needle complex", a part of its type III secreton
    A Blocker
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 39:652-63. 2001
    ..As MxiH was present in NCs in large molar excess, we propose that it is the major needle component. MxiI may cap at the external needle tip...
  29. ncbi request reprint IL-8 is a key chemokine regulating neutrophil recruitment in a new mouse model of Shigella-induced colitis
    Monique Singer
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Sante et de la Recherche Medicale U389, Institut Pasteur, Paris, France
    J Immunol 173:4197-206. 2004
    ..This is a major step forward in the development of a murine model of bacillary dysentery...
  30. ncbi request reprint The development of a FACS-based strategy for the isolation of Shigella flexneri mutants that are deficient in intercellular spread
    M Rathman
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 35:974-90. 2000
    ....
  31. doi request reprint A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infection
    Armelle Phalipon
    Institut Pasteur, Unite de Pathogenie Microbienne Moleculaire, Paris, France
    J Immunol 182:2241-7. 2009
    ..This synthetic carbohydrate-based conjugate may be a candidate for a SF2a vaccine...
  32. ncbi request reprint Intracellular vs extracellular recognition of pathogens--common concepts in mammals and flies
    Stephen E Girardin
    Pathogénie Microbienne Moléculaire and Immunité Innée et Signalisation, Institut Pasteur, 28 rue du Dr Roux, 75724 Cedex 15, Paris, France
    Trends Microbiol 10:193-9. 2002
    ..The homology between TLRs and the Toll system in Drosophila suggests that conserved defense mechanisms are likely to be shared by diverse organisms...
  33. pmc Virulent Shigella flexneri subverts the host innate immune response through manipulation of antimicrobial peptide gene expression
    Brice Sperandio
    Unite de Pathogenie Microbienne Moleculaire, Département de Biologie Cellulaire et Infection, Institut Pasteur, 75724 Paris Cedex 15, France
    J Exp Med 205:1121-32. 2008
    ..Thus, S. flexneri has developed a dedicated strategy to weaken the innate immunity to manage its survival and colonization ability in the intestine...
  34. ncbi request reprint Roles for T and NK cells in the innate immune response to Shigella flexneri
    Karine Le-Barillec
    Unité des Cytokines et Développement Lymphoide, Institut National de la Sante et de la Recherche Medicale, Unité 668, Paris Cedex, France
    J Immunol 175:1735-40. 2005
    ..flexneri infection through amplification of an inflammatory response. This cellular lymphocyte redundancy assures IFN-gamma production, which is central to innate immunity against Shigella infection...
  35. ncbi request reprint Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium
    Hélène d'Hauteville
    Unité de Pathogénie Microbienne Moléculaire and Institut National de la Santé et de la Recherche Médicale, Unité 389, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Immunol 168:5240-51. 2002
    ....
  36. pmc Myosin II is involved in capping and uroid formation in the human pathogen Entamoeba histolytica
    P Arhets
    , , Paris, France
    Infect Immun 63:4358-67. 1995
    ....
  37. ncbi request reprint Identification of the critical residues involved in peptidoglycan detection by Nod1
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 280:38648-56. 2005
    ....
  38. ncbi request reprint Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine
    Armelle Phalipon
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Santé et de la Recherche Médicale Unité 389
    J Immunol 176:1686-94. 2006
    ..A pentadecasaccharide representing three biological repeating units was identified as a potential candidate for further development of a chemically defined glycoconjugate vaccine against S. flexneri 2a infection...
  39. ncbi request reprint Magnetic resonance imaging of Klebsiella pneumoniae-induced pneumonia in mice
    Regis Tournebize
    Pathogénie Microbienne Moléculaire INSERM 389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Cell Microbiol 8:33-43. 2006
    ..MRI thus represents a powerful technique to study in vivo the interactions between a pathogen and its host in real time...
  40. pmc The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells
    Joelle Mounier
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, Paris, France
    PLoS Pathog 5:e1000271. 2009
    ..These results indicate that the IpaC effector domain determines Src-dependent actin polymerization and ruffle formation during bacterial invasion...
  41. ncbi request reprint An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses
    Laurence Arbibe
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, F75724 Paris Cedex 15, France
    Nat Immunol 8:47-56. 2007
    ..S. flexneri has thus evolved the capacity to precisely modulate host cell epigenetic 'information' as a strategy for repressing innate immunity...
  42. ncbi request reprint Capping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domain
    Nalini Ramarao
    Unite de Pathogenie Microbienne Moleculaire, INSERM U786, Institut Pasteur, 75724 Paris Cedex 15, France
    FEBS Lett 581:853-7. 2007
    ..These results suggest that IpaA regulates actin polymerisation/depolymerisation at sites of Shigella invasion by modulating the barbed end capping activity of vinculin...
  43. doi request reprint War and peace at the intestinal epithelial surface: an integrated view of bacterial commensalism versus bacterial pathogenicity
    Philippe J Sansonetti
    Pasteur Institute, Paris, France
    J Pediatr Gastroenterol Nutr 46:E6-7. 2008
  44. ncbi request reprint Maturation of paneth cells induces the refractory state of newborn mice to Shigella infection
    MARIA ISABEL FERNANDEZ
    Unite de Pathogenie Microbienne Moleculaire, Département de Biologie Cellulaire et Infection, Unité Institut National de la Santé et de la Recherche Médicale U786, Paris, France
    J Immunol 180:4924-30. 2008
    ....
  45. ncbi request reprint Shigella's ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival?
    Armelle Phalipon
    Unite de Pathogenie Microbienne Moleculaire, INSERM U786, Institut Pasteur 25, rue du Dr Roux, Paris, France
    Immunol Cell Biol 85:119-29. 2007
    ..The escape strategies, the possible direct effect of Shigella on B and T lymphocytes, their impact on the development of adaptive immunity, and how they may help explain the limited protection induced by natural infection are discussed...
  46. ncbi request reprint Epigenetic regulation of host response to LPS: causing tolerance while avoiding Toll errancy
    Laurence Arbibe
    Unité de Pathogénie Microbienne Moléculaire and Unité INSERM 786, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Cell Host Microbe 1:244-6. 2007
    ..In a recent paper, Foster et al. (2007) demonstrate that this subtle balance is established and imprinted via epigenetic regulation...
  47. ncbi request reprint Molecular and cellular bases of bacterial virulence: guessing the future episodes of an ongoing saga
    Philippe J Sansonetti
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, 25 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France
    Res Microbiol 159:59-61. 2008
  48. pmc Conversion of PtdIns(4,5)P(2) into PtdIns(5)P by the S.flexneri effector IpgD reorganizes host cell morphology
    Kirsten Niebuhr
    Pathogénie Microbienne Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO J 21:5069-78. 2002
    ..These data provide the molecular basis for a new mechanism employed by a pathogenic bacterium to promote membrane ruffling at the entry site...
  49. ncbi request reprint Secretory component: a new role in secretory IgA-mediated immune exclusion in vivo
    Armelle Phalipon
    Unite de Pathogenie Microbienne Moleculaire, INSERM U 389, France
    Immunity 17:107-15. 2002
    ..Therefore, binding of IgA(d/p) to SC during the course of SIgA-mediated mucosal response constitutes a crucial step in achieving efficient protection of the epithelial barrier by immune exclusion...
  50. ncbi request reprint Anti-inflammatory role for intracellular dimeric immunoglobulin a by neutralization of lipopolysaccharide in epithelial cells
    M Isabel Fernandez
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, 28 rue du Dr Roux, 75015, Paris, France
    Immunity 18:739-49. 2003
    ..Thus, intracellular neutralization by dIgA limits the acute local inflammation induced by proinflammatory pathogen-associated molecular patterns such as LPS...
  51. ncbi request reprint Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 278:41702-8. 2003
    ..By defining the PG structural requirements for Nod1 and Nod2 sensing, this study reveals how PG processing and modifications, either by host or bacterial enzymes, may affect innate immune responses...
  52. ncbi request reprint Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing
    Stephen E Girardin
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Paris, France
    Trends Immunol 24:652-8. 2003
    ..Together, studies on Nod2 (Card15) provide a conceptual link between inflammatory disorders, such as Crohn's disease and Blau syndrome, and bacterial sensing...
  53. ncbi request reprint Bacterial invasion: the paradigms of enteroinvasive pathogens
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, INSERM Unité 604, Département de Biologie Cellulaire et Infection, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    Science 304:242-8. 2004
    ..The mechanisms underlying bacterial entry, phagosome maturation, and dissemination reveal common strategies as well as unique tactics evolved by individual species to establish infection...
  54. pmc Cortactin and Crk cooperate to trigger actin polymerization during Shigella invasion of epithelial cells
    Laurence Bougnères
    Unite de Pathogenie Microbienne Moleculaire, INSERM U389, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Cell Biol 166:225-35. 2004
    ..These results point at a major role for a Crk-cortactin complex in actin polymerization downstream of tyrosine kinase signaling...
  55. ncbi request reprint Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island
    Jérôme Viala
    Groupe d Immunité Innée et Signalisation, Institut National de la Sante et de la Recherche Medicale U389, Institut Pasteur, Paris, France
    Nat Immunol 5:1166-74. 2004
    ..pylori than were wild-type mice. We propose that sensing of H. pylori by Nod1 represents a model for host recognition of noninvasive pathogens...
  56. ncbi request reprint Characterization of the interaction partners of secreted proteins and chaperones of Shigella flexneri
    A L Page
    , INSERM U389, Paris Cedex 15, France
    Mol Microbiol 42:1133-45. 2001
    ..Homotypic interactions were identified with the baits IpaA, IpaB and IpaC. Interactions between effectors and components of the TTS machinery were also selected that might give insights into regulation of the TTS process...
  57. ncbi request reprint Extracellular association and cytoplasmic partitioning of the IpaB and IpaC invasins of S. flexneri
    R Menard
    Unite de Pathogenie Microbienne Moleculaire, Paris, France
    Cell 79:515-25. 1994
    ..We propose that IpgC, which is not secreted and thus acts as a molecular chaperone, serves as a receptor that prevents premature oligomerization of IpaB and IpaC within the cytoplasm of Shigella cells...
  58. doi request reprint Vaccination against shigellosis: is it the path that is difficult or is it the difficult that is the path?
    Armelle Phalipon
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, 75724 Paris Cedex 15, France
    Microbes Infect 10:1057-62. 2008
    ..More basic research is also required to improve what we can still consider as first-generation vaccines, and to explore possible new paradigms including the search for cross-protective antigens...
  59. pmc Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin
    Joao Gamelas Magalhaes
    Unité de Pathogénie Microbienne Moléculaire INSERM U389, Paris, France
    EMBO Rep 6:1201-7. 2005
    ..This study thereby identifies Nod1 as the long sought after sensor of TCT in mammals...
  60. pmc Cytoplasmic targeting of IpaC to the bacterial pole directs polar type III secretion in Shigella
    Valentin Jaumouillé
    Department of Cell Biology and Infections, Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, Paris, France
    EMBO J 27:447-57. 2008
    ..These results indicate that cytoplasmic polar localization directs secretion of IpaC at the pole of Shigella, and may represent a mandatory step for T3S...
  61. ncbi request reprint Type III secretion effectors of the IpaH family are E3 ubiquitin ligases
    John R Rohde
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris, Cedex 15, France
    Cell Host Microbe 1:77-83. 2007
    ..This study assigns a function for IpaH family members as E3 ubiquitin ligases...
  62. doi request reprint Phase 1 clinical trial of live attenuated Shigella dysenteriae type-1 DeltaicsA Deltaent Deltafep DeltastxA:HgR oral vaccine SC599 in healthy human adult volunteers
    Christine Sadorge
    Centre de Recherche Vaccinale et Biomédicale, Institut Pasteur, 75724 Paris Cedex 15, France
    Vaccine 26:978-87. 2008
    ..8, 26 and 8.5. Serum antibody responses were seen in three subjects. SC599 appears immunogenic with maximum tolerated dose greater than 10(8)CFU...
  63. ncbi request reprint The invasive phenotype of Shigella flexneri directs a distinct gene expression pattern in the human intestinal epithelial cell line Caco-2
    Thierry Pedron
    Unité de Pathogénie Microbienne Moléculaire et Unité INSERM 389, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Biol Chem 278:33878-86. 2003
    ..Dramatic increase in IL-8 gene transcription points to this chemokine as the major molecule orchestrating mucosal inflammation in shigellosis...
  64. ncbi request reprint Sensing of bacteria: NOD a lonely job
    Thomas A Kufer
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, F 75724 Paris Cedex 15, France
    Curr Opin Microbiol 10:62-9. 2007
    ..These reveal that the two sensing-systems are non-redundant in bacterial recognition and that their cross-talk plays an important role in immunological homeostasis...
  65. ncbi request reprint The small GTP-binding protein RacG regulates uroid formation in the protozoan parasite Entamoeba histolytica
    N Guillen
    Unite de Pathogenie Microbienne Moleculaire, Institut National de la Santé et de la Recherche Médicale U389 Institut Pasteur, France
    J Cell Sci 111:1729-39. 1998
    ..In addition, the number and localization of uroids were modified. These results suggest a role for EhRacG in amoebic morphogenesis and cytokinesis...
  66. ncbi request reprint Adherence modifies the regulation of gene expression induced by interleukin-10
    Anne France Petit-Bertron
    UP Cytokines and Inflammation, Institut Pasteur, 28 rue Dr Roux, 75015 Paris, France
    Cytokine 29:1-12. 2005
    ..Furthermore, the inhibition of the expression of SOCS1 by IL-10 in the absence of adherence, may explain its priming effects on a subsequent LPS stimulation that we previously described...
  67. pmc Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases
    Mathias Chamaillard
    Fondation Jean Dausset, Centre d Etude du Polymorphisme Humain, 27 rue Juliette Dodu, 75010 Paris, France
    Proc Natl Acad Sci U S A 100:3455-60. 2003
    ....
  68. ncbi request reprint Mucosal lymphoid infiltrate dominates colonic pathological changes in murine experimental shigellosis
    Maria Celeste Martino
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita La Sapienza, Rome, Italy
    J Infect Dis 192:136-48. 2005
    ..Because mice are naturally resistant to shigellosis, there is no mouse model that mimics human disease. We explore the susceptibility of intestinal flora-depleted mice to shigellosis after intragastric infection with Shigella strains...
  69. pmc PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection
    Caroline Pendaries
    INSERM Unité 563, CPTP, Département d Oncogenèse et Signalisation dans les Cellules Hématopoïétiques, Hopital Purpan, Toulouse, France
    EMBO J 25:1024-34. 2006
    ..Thus, S. flexneri parasitism is shedding light onto a new mechanism of PI 3-kinase/Akt activation via PtdIns5P production that plays an important role in host cell responses such as survival...
  70. ncbi request reprint The Salmonella typhimurium flagellar basal body protein FliE is required for flagellin production and to induce a proinflammatory response in epithelial cells
    Katharine A Reed
    Department of Pathology and Laboratory Medicine, Emory University, 615 Michael Street, Whitehead Research Building, Atlanta, GA 30322, USA
    J Biol Chem 277:13346-53. 2002
    ..typhimurium-induced proinflammatory responses through basolateral TLR5 and is consistent with the emerging model of S. typhimurium flagellin-induced inflammation...
  71. ncbi request reprint Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells
    Jonathan D Edgeworth
    Department of Infectious Diseases, St George s Hospital Medical School, London, GB
    Eur J Immunol 32:1464-71. 2002
    ..The rapid death of DC during the early stages of shigellosis is likely to have adverse consequences for generation of adaptive immunity...
  72. ncbi request reprint The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists
    Mihai G Netea
    Department of Internal Medicine, Radboud University Nijmegen Medical Center, The Netherlands
    J Biol Chem 280:35859-67. 2005
    ..Together, our results identified a cross-talk between the Nod1 and Nod2 pathways and suggested that down-regulation of Nod1/M-Tri(DAP) pathway may be associated with Crohn disease...
  73. pmc The contribution of accessory toxins of Vibrio cholerae O1 El Tor to the proinflammatory response in a murine pulmonary cholera model
    Karla Jean Fullner
    Departments of Microbiology Immunology, Feinberg School of Medicine, Northwestern University, 303 E Chicago Ave, Morton 6 626, Chicago, IL 60611, USA
    J Exp Med 195:1455-62. 2002
    ..Thus, the reduced virulence of KFV101 makes it a prototype for multi-toxin deleted vaccine strains that could be used for protection against V. cholerae without the adverse effects of the accessory cholera toxins...
  74. pmc Human monocytes kill Shigella flexneri but then die by apoptosis associated with suppression of proinflammatory cytokine production
    Lucy J Hathaway
    Department of Infectious Diseases, St George s Hospital Medical School, London SW17 ORE, United Kingdom
    Infect Immun 70:3833-42. 2002
    ..This delayed apoptosis may have important effects on the ordered initiation of the innate immune response, leading to the excessive inflammatory response characteristic of shigellosis...
  75. ncbi request reprint New animal model of shigellosis in the Guinea pig: its usefulness for protective efficacy studies
    Doo Hee Shim
    Mucosal Immunology Section, International Vaccine Institute, Seoul, Korea
    J Immunol 178:2476-82. 2007
    ..In the guinea pig, administration of Shigella by i.r. route induces acute inflammation, making this animal model useful for assessing the protective efficacy of Shigella vaccine candidates...
  76. doi request reprint NOD2: a potential target for regulating liver injury
    Mathilde Body-Malapel
    INSERM U795, Lille, France
    Lab Invest 88:318-27. 2008
    ..Taken together, our results indicate that NOD2 may represent a new therapeutic target in liver diseases...
  77. pmc Apoptosis in acute shigellosis is associated with increased production of Fas/Fas ligand, perforin, caspase-1, and caspase-3 but reduced production of Bcl-2 and interleukin-2
    Rubhana Raqib
    International Centre for Diarrhoeal Diseases Research, Bangladesh, Dhaka, Bangladesh
    Infect Immun 70:3199-207. 2002
    ..dysenteriae type 1 infection was associated with a significant up-regulation of Fas/Fas-L and perforin and granzyme A expression and a down-regulation of Bcl-2 and IL-2, which promote cell survival...