Asier Saez-Cirion

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection
    Camille Lécuroux
    INSERM, U1012, Le Kremlin Bicetre, France
    PLoS ONE 8:e59767. 2013
  2. pmc Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
    Asier Saez-Cirion
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    PLoS Pathog 9:e1003211. 2013
  3. pmc Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers
    Asier Saez-Cirion
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    Blood 118:955-64. 2011
  4. ncbi request reprint Ex vivo T cell-based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responses
    Asier Saez-Cirion
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France
    Nat Protoc 5:1033-41. 2010
  5. pmc HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
    Asier Saez-Cirion
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 75725 Paris, France
    Proc Natl Acad Sci U S A 104:6776-81. 2007
  6. ncbi request reprint Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers
    Camille Lécuroux
    INSERM U1012, Le Kremlin Bicetre, France
    J Virol 88:176-87. 2014
  7. pmc CD4 dynamics over a 15 year-period among HIV controllers enrolled in the ANRS French observatory
    Faroudy Boufassa
    INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Epidemiology of HIV and STI Team, Le Kremlin Bicetre, France
    PLoS ONE 6:e18726. 2011
  8. ncbi request reprint Potential Role for HIV-Specific CD38-/HLA-DR+ CD8+ T Cells in Viral Suppression and Cytotoxicity in HIV Controllers
    Stéphane Hua
    INSERM U1012, Le Kremlin Bicetre, France Université Paris Sud 11, Le Kremlin Bicetre, France
    PLoS ONE 9:e101920. 2014
  9. ncbi request reprint HIV controllers: how do they tame the virus?
    Asier Saez-Cirion
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 25 rue du Dr Roux, 75725 Paris Cedex 15, France
    Trends Immunol 28:532-40. 2007
  10. doi request reprint Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses
    Asier Saez-Cirion
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    J Immunol 182:7828-37. 2009

Collaborators

Detail Information

Publications26

  1. pmc CD8 T-cells from most HIV-infected patients lack ex vivo HIV-suppressive capacity during acute and early infection
    Camille Lécuroux
    INSERM, U1012, Le Kremlin Bicetre, France
    PLoS ONE 8:e59767. 2013
    ..This indicates that the superior HIV-suppressive capacity of CD8+ T-cells from HIV controllers is not a general characteristic of the HIV-specific CD8+ T cell response in primary HIV infection...
  2. pmc Post-treatment HIV-1 controllers with a long-term virological remission after the interruption of early initiated antiretroviral therapy ANRS VISCONTI Study
    Asier Saez-Cirion
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    PLoS Pathog 9:e1003211. 2013
    ..Our results show that early and prolonged cART may allow some individuals with a rather unfavorable background to achieve long-term infection control and may have important implications in the search for a functional HIV cure...
  3. pmc Restriction of HIV-1 replication in macrophages and CD4+ T cells from HIV controllers
    Asier Saez-Cirion
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    Blood 118:955-64. 2011
    ..These results point to a contribution of intrinsic cell resistance to the control of infection and the containment of viral reservoir in HICs...
  4. ncbi request reprint Ex vivo T cell-based HIV suppression assay to evaluate HIV-specific CD8+ T-cell responses
    Asier Saez-Cirion
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France
    Nat Protoc 5:1033-41. 2010
    ..We also depict the conditions of a rapid assay on the basis of flow cytometry analysis of intracellular HIV-Gag products. These procedures take 14-17 d when the p24 ELISA assay is used, or 6 d with the intracellular Gag assay...
  5. pmc HIV controllers exhibit potent CD8 T cell capacity to suppress HIV infection ex vivo and peculiar cytotoxic T lymphocyte activation phenotype
    Asier Saez-Cirion
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 75725 Paris, France
    Proc Natl Acad Sci U S A 104:6776-81. 2007
    ..This constitutive antiviral capacity of CD8(+) T cells could account for the control of viral replication in HIC...
  6. ncbi request reprint Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers
    Camille Lécuroux
    INSERM U1012, Le Kremlin Bicetre, France
    J Virol 88:176-87. 2014
    ..In conclusion, both HLA-B*57 and the amount of ultrasensitive viral load seem to play a role in HIV-specific CD8(+) T cell responses in HIC. ..
  7. pmc CD4 dynamics over a 15 year-period among HIV controllers enrolled in the ANRS French observatory
    Faroudy Boufassa
    INSERM, CESP Centre for research in Epidemiology and Population Health, U1018, Epidemiology of HIV and STI Team, Le Kremlin Bicetre, France
    PLoS ONE 6:e18726. 2011
    ..There are few large published studies of HIV controllers with long-term undetectable viral load (VL). We describe the characteristics and outcomes of 81 French HIV controllers...
  8. ncbi request reprint Potential Role for HIV-Specific CD38-/HLA-DR+ CD8+ T Cells in Viral Suppression and Cytotoxicity in HIV Controllers
    Stéphane Hua
    INSERM U1012, Le Kremlin Bicetre, France Université Paris Sud 11, Le Kremlin Bicetre, France
    PLoS ONE 9:e101920. 2014
    ..HIV controllers (HIC) are rare HIV-1-infected patients who exhibit spontaneous viral control. HIC have high frequency of CD38-/HLA-DR+ HIV-specific CD8+ T cells. Here we examined the role of this subset in HIC status...
  9. ncbi request reprint HIV controllers: how do they tame the virus?
    Asier Saez-Cirion
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 25 rue du Dr Roux, 75725 Paris Cedex 15, France
    Trends Immunol 28:532-40. 2007
    ..In this review, we examine recent findings from these studies...
  10. doi request reprint Heterogeneity in HIV suppression by CD8 T cells from HIV controllers: association with Gag-specific CD8 T cell responses
    Asier Saez-Cirion
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    J Immunol 182:7828-37. 2009
    ..These results, on the one hand, suggest the importance of Gag responses in the antiviral potency of CD8(+) T cells from HICs and, on the other hand, propose that other host mechanisms may contribute to restraining HIV infection in HICs...
  11. pmc The engagement of activating FcgammaRs inhibits primate lentivirus replication in human macrophages
    Annie David
    Unité de Régulations des Infections Rétrovirales, Institut Pasteur, 25 rue du Docteur Roux, 75726 Paris Cedex 15, France
    J Immunol 177:6291-300. 2006
    ..We found that FcgammaR-dependent activation of MDMs also inhibits the replication of HIV-2, SIVmac, and SIVagm, suggesting a common control mechanism for primate immunodeficiency lentiviruses in activated macrophages...
  12. pmc Persistent resistance to HIV-1 infection in CD4 T cells from exposed uninfected Vietnamese individuals is mediated by entry and post-entry blocks
    Asier Saez-Cirion
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France
    Retrovirology 3:81. 2006
    ..Here, we further characterized the restriction of viral replication in CD4 T cells from five EUs and assessed its persistence in serial samples...
  13. doi request reprint NKG2D expression on HIV-specific CD8+ T cells is reduced in viremic HIV-1-infected patients but maintained in HIV controllers
    Camille Lécuroux
    INSERM, U1012, Le Kremlin Bicetre, France
    J Acquir Immune Defic Syndr 62:17-20. 2013
    ..The maintenance of NKG2D expression on CD8 T cells in HIV controllers may contribute to better cell function...
  14. doi request reprint Elevated IP10 levels are associated with immune activation and low CD4⁺ T-cell counts in HIV controller patients
    Nicolas Noel
    aINSERM U1012, Régulation de la réponse immune, infection VIH1 et autoimmunité, Université Paris Sud bAPHP, Service de Medecine Interne, Hôpitaux Universitaires Paris Sud cINSERM U1018, Centre de Recherche en Epidémiologie et Santé des Populations, Universite Paris Sud, Le Kremlin Bicêtre dInstitut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris eService de Microbiologie, CHU Carémeau fINSERM U1047, Centre National de Référence des Brucella L A, UFR de Médecine Université Montpellier 1, Nîmes gFaculté de Médecine Paris Sud XI, Le Kremlin Bicêtre hAPHP, Laboratoire de Virologie, CHU Necker, Paris, France
    AIDS 28:467-76. 2014
    ..The levels of inflammatory biomarkers in HICs and the biomarkers' relationships with immunologic and virologic status have yet to be fully characterized...
  15. pmc p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway
    Awatef Allouch
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 110:E3997-4006. 2013
    ..Our findings unravel a cellular pathway that restricts HIV-1 and other primate lentiviruses by affecting dNTP synthesis, thereby pointing to new potential cellular targets for anti-HIV therapeutic strategies. ..
  16. pmc Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity
    Jorge R Almeida
    Institut National de la Santé et de la Recherche Médicale Unité, Hopital Pitie Salpetriere, Universite Pierre et Marie Curie, Paris, France
    Blood 113:6351-60. 2009
    ....
  17. doi request reprint Will it be possible to live without antiretroviral therapy?
    Chiraz Hamimi
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    Curr Opin HIV AIDS 8:196-203. 2013
    ..We will consider recent insights into the mechanisms underlying control in these patients and how this has already encouraged the search for therapeutic approaches to induce a similar HIV functional cure in other patients...
  18. doi request reprint Natural resistance to HIV infection: lessons learned from HIV‐exposed uninfected individuals
    Gianfranco Pancino
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    J Infect Dis 202:S345-50. 2010
    ..These results support a contribution of innate responses to resistance against HIV‐1 infection. Scientific and ethical issues encountered during research in exposed uninfected subjects must be considered...
  19. doi request reprint The link between CD8⁺ T-cell antigen-sensitivity and HIV-suppressive capacity depends on HLA restriction, target epitope and viral isolate
    Anna Lissina
    aINSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie PARIS6, Hopital Pitie Salpetriere, Paris, France bInstitute of Infection and Immunity, Cardiff University School of Medicine, Heath Park, Cardiff, Wales, UK cInstitut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France Anna Lissina and Solène Fastenackels contributed equally to this writing of this work Current address Centro de Investigacion en Enfermedades Infecciosas, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico
    AIDS 28:477-86. 2014
    ....
  20. pmc High Antibody-Dependent Cellular Cytotoxicity Responses Are Correlated with Strong CD8 T Cell Viral Suppressive Activity but Not with B57 Status in HIV-1 Elite Controllers
    Olivier Lambotte
    INSERM, U1012, Bicetre, France AP HP, Department of Internal Medicine and Infectious Diseases, Bicetre Hospital, Bicetre, France University Paris Sud, Bicetre, France
    PLoS ONE 8:e74855. 2013
    ..0086). These data suggest a role for ADCC in immune control of HIV, especially in HLA B57 negative controllers. ..
  21. doi request reprint Blunted response to combination antiretroviral therapy in HIV elite controllers: an international HIV controller collaboration
    Faroudy Boufassa
    INSERM, CESP Centre for research in Epidemiology and Population Health, Epidemiology of HIV and STI Team, Le Kremlin Bicetre, France Univ Paris Sud, Le Kremlin Bicetre, France
    PLoS ONE 9:e85516. 2014
    ..Here we studied the CD4 T-cell count dynamics after cART initiation among 34 ECs followed in U.S. and European cohorts, by comparison with chronically viremic patients (VIRs)...
  22. doi request reprint Immunodominance of HLA-B27-restricted HIV KK10-specific CD8(+) T-cells is not related to naïve precursor frequency
    Maria Candela Iglesias
    INSERM UMR S 945, Infections and Immunity, Universite Pierre et Marie Curie Paris 6, Hopital Pitie Salpetriere, Paris, France
    Immunol Lett 149:119-22. 2013
    ..These data implicate alternative mechanisms in the relative protection conferred by CD8(+) T-cell responses to this epitope...
  23. pmc First Dominique Dormont International Conference on "Host-pathogen interactions in chronic infections - viral and host determinants of HCV, HCMV, and HIV infections"
    Elisabeth Menu
    Laboratoire de Biologie des Rétrovirus, Institut Pasteur, 75015 Paris, France
    Retrovirology 2:24. 2005
    ..The following is a summary of the scientific sessions of this meeting (http://www.congres-evenement.fr/ddormont)...
  24. doi request reprint HIV controllers: a genetically determined or inducible phenotype?
    Asier Saez-Cirion
    Institut Pasteur, Unité de Régulation des Infections Rétrovirales, Paris, France
    Immunol Rev 254:281-94. 2013
    ....
  25. ncbi request reprint Quantitative real-time analysis of HIV-1 gene expression dynamics in single living primary cells
    Asier Saez-Cirion
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, Paris, France
    Biotechnol J 1:682-9. 2006
    ....
  26. ncbi request reprint HIV cure research: advances and prospects
    Caroline P Passaes
    Unité de Régulation des Infections Rétrovirales, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France CEA, Division of Immuno Virology, iMETI DSV, 18 route du Panorama, 92265 Fontenay aux Roses, France Electronic address
    Virology 454:340-52. 2014
    ..This review discusses the most recent strategies that have been developed in the search for an HIV cure and to improve life quality of people living with HIV. ..