Philippe Saas

Summary

Affiliation: Institut de Veille Sanitaire
Country: France

Publications

  1. ncbi request reprint Intravenous infusion of apoptotic cells simultaneously with allogeneic hematopoietic grafts alters anti-donor humoral immune responses
    Sylvain Perruche
    Unité mixte EFS Université EA2284 Inserm U645, IFR 133, 25020 Besançon, France
    Am J Transplant 4:1361-5. 2004
  2. doi request reprint Phosphatidylserine-expressing cell by-products in transfusion: A pro-inflammatory or an anti-inflammatory effect?
    P Saas
    INSERM, UMR1098, BP 1937, 25020 Besançon cedex, France
    Transfus Clin Biol 19:90-7. 2012
  3. pmc Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?
    Sylvain Perruche
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Convent Drive, Bethesda, MD 20892, USA
    Arthritis Res Ther 11:R104. 2009
  4. pmc Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity
    Eric Toussirot
    Department of Rheumatology, University Hospital Jean Minjoz, Boulevard Fleming, Besancon Cedex, France
    Arthritis Res Ther 11:R101. 2009
  5. pmc Mediators involved in the immunomodulatory effects of apoptotic cells
    Philippe Saas
    INSERM U645, University of Besancon, Etablissement Français du Sang Bourgogne Franche Comté, 1 boulevard A Fleming, F 25020 Besançon, France
    Transplantation 84:S31-4. 2007
  6. ncbi request reprint [Towards the use of intravenous apoptotic leukocyte infusion as a cell-based therapy approach?]
    P Saas
    INSERM, UMR 645, EFS Bourgogne Franche Comte, Universite de Franche Comte, IFR 133 BP 1937, 1, boulevard A Fleming, 25020 Besançon cedex, France
    Transfus Clin Biol 15:98-108. 2008
  7. ncbi request reprint [Immune monitoring of kidney transplant recipients: can markers predictive of over-immunosuppression be identified?]
    P Saas
    Inserm UMR645, 1, boulevard Alexander Fleming, B P 1937, 25020 Besançon cedex, France
    Ann Pharm Fr 66:115-21. 2008
  8. ncbi request reprint Cell-based therapy approaches using dying cells: from tumour immunotherapy to transplantation tolerance induction
    Philippe Saas
    INSERM E0119 UPRES EA2284, Etablissement Fran ais du Sang de Bourgogne Franche Comt, 1 boulevard A Fleming, BP1937, F 25020 Besan on, France
    Expert Opin Biol Ther 2:249-63. 2002
  9. ncbi request reprint Dendritic cells: to where do they lead?
    Philippe Saas
    INSERM E0119 UPRES EA2284, EFS Bourgogne Franche Comte, 25020 Besançon, France
    Transplantation 73:S12-5. 2002
  10. doi request reprint Intravenous apoptotic cell infusion as a cell-based therapy toward improving hematopoietic cell transplantation outcome
    Philippe Saas
    Inserm UMR645, Besancon, France
    Ann N Y Acad Sci 1209:118-26. 2010

Detail Information

Publications68

  1. ncbi request reprint Intravenous infusion of apoptotic cells simultaneously with allogeneic hematopoietic grafts alters anti-donor humoral immune responses
    Sylvain Perruche
    Unité mixte EFS Université EA2284 Inserm U645, IFR 133, 25020 Besançon, France
    Am J Transplant 4:1361-5. 2004
    ..Further studies will determine whether apoptotic cell infusion, in addition to hematopoietic graft facilitation might also contribute to preventing deleterious Ab-mediated allo-responses in various transplantation settings...
  2. doi request reprint Phosphatidylserine-expressing cell by-products in transfusion: A pro-inflammatory or an anti-inflammatory effect?
    P Saas
    INSERM, UMR1098, BP 1937, 25020 Besançon cedex, France
    Transfus Clin Biol 19:90-7. 2012
    ..Then, we discuss how these phosphatidylserine-expressing cell by-products may influence transfusion...
  3. pmc Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy?
    Sylvain Perruche
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Convent Drive, Bethesda, MD 20892, USA
    Arthritis Res Ther 11:R104. 2009
    ..Therefore we evaluated the potential of apoptotic cell injection to influence the course of inflammation in SCW-induced arthritis in rats...
  4. pmc Increased production of soluble CTLA-4 in patients with spondylarthropathies correlates with disease activity
    Eric Toussirot
    Department of Rheumatology, University Hospital Jean Minjoz, Boulevard Fleming, Besancon Cedex, France
    Arthritis Res Ther 11:R101. 2009
    ..Here, we evaluated circulating levels of sCTLA-4 as a marker of immune dysregulation in SpA. Intracellular CTLA-4 and levels of CTLA-4 transcript expression in peripheral blood lymphocytes (PBL) were also studied...
  5. pmc Mediators involved in the immunomodulatory effects of apoptotic cells
    Philippe Saas
    INSERM U645, University of Besancon, Etablissement Français du Sang Bourgogne Franche Comté, 1 boulevard A Fleming, F 25020 Besançon, France
    Transplantation 84:S31-4. 2007
    ..e., TGF-beta) or immunomodulatory cells ("alternatively-activated" macrophages, certain dendritic cell subsets, or regulatory T cells) in a physiological manner by using apoptotic cell infusion can be a promising way to induce tolerance...
  6. ncbi request reprint [Towards the use of intravenous apoptotic leukocyte infusion as a cell-based therapy approach?]
    P Saas
    INSERM, UMR 645, EFS Bourgogne Franche Comte, Universite de Franche Comte, IFR 133 BP 1937, 1, boulevard A Fleming, 25020 Besançon cedex, France
    Transfus Clin Biol 15:98-108. 2008
    ..Here, we review the different factors and cells implicated in the immunomodulatory properties of apoptotic cells. Then, we discuss the potential significance of such observations in transfusion practice...
  7. ncbi request reprint [Immune monitoring of kidney transplant recipients: can markers predictive of over-immunosuppression be identified?]
    P Saas
    Inserm UMR645, 1, boulevard Alexander Fleming, B P 1937, 25020 Besançon cedex, France
    Ann Pharm Fr 66:115-21. 2008
    ..Identification of gene polymorphisms or factors associated with complications after transplantation may help physicians to determine high-risk recipient profiles and optimize pre- and post-transplantation treatment strategies...
  8. ncbi request reprint Cell-based therapy approaches using dying cells: from tumour immunotherapy to transplantation tolerance induction
    Philippe Saas
    INSERM E0119 UPRES EA2284, Etablissement Fran ais du Sang de Bourgogne Franche Comt, 1 boulevard A Fleming, BP1937, F 25020 Besan on, France
    Expert Opin Biol Ther 2:249-63. 2002
    ..In conclusion, this review will suggest appropriate conditions to efficiently and safely use apoptotic cells as a new cell therapy product...
  9. ncbi request reprint Dendritic cells: to where do they lead?
    Philippe Saas
    INSERM E0119 UPRES EA2284, EFS Bourgogne Franche Comte, 25020 Besançon, France
    Transplantation 73:S12-5. 2002
    ..Each hypothesis is illustrated with examples in the field of transplantation. Lastly, the criteria necessary for proposing tolerogenic dendritic cells to promote engraftment and long-term allograft survival are discussed...
  10. doi request reprint Intravenous apoptotic cell infusion as a cell-based therapy toward improving hematopoietic cell transplantation outcome
    Philippe Saas
    Inserm UMR645, Besancon, France
    Ann N Y Acad Sci 1209:118-26. 2010
    ..Here, we review the different mechanisms and the potential beneficial effects associated with the immunomodulatory properties of apoptotic cells in the AHCT setting...
  11. ncbi request reprint Role of STAT3 in CD4+CD25+FOXP3+ regulatory lymphocyte generation: implications in graft-versus-host disease and antitumor immunity
    Jean René Pallandre
    Institut National de la Santé et de la Recherche Médicale U645, EFS Bourgogne Franche Comte, University of Franche Comte, Besancon, France
    J Immunol 179:7593-604. 2007
    ..STAT3 modulation should be taken into account when assessing how regulatory T cells contribute to inflammatory diseases and tumor immunosurveillance...
  12. pmc Association of mixed hematopoietic chimerism with elevated circulating autoantibodies and chronic graft-versus-host disease occurrence
    Sylvain Perruche
    INSERM U645, University of Franche Comte, EFSB FC, IFR133, Besancon, France
    Transplantation 81:573-82. 2006
    ..Here we evaluated the relation between chimerism state after reduced-intensity conditioning transplantation (RICT), autoantibody production, and chronic GVHD (cGVHD)-related pathology...
  13. doi request reprint Thymic function, anti-thymocytes globulins, and cancer after renal transplantation
    Didier Ducloux
    INSERM, UMR645, Besancon, F 25020, France
    Transpl Immunol 25:56-60. 2011
    ..Here, we examined whether pre-transplant thymic function estimated by TREC levels is predictive of cancer occurrence following ATG treatment...
  14. ncbi request reprint Urinary cytotoxic molecular markers for a noninvasive diagnosis in acute renal transplant rejection
    Maria Yannaraki
    INSERM U645, Besancon, France
    Transpl Int 19:759-68. 2006
    ..P, GB and Fas-L gene expression in urine specimens were upregulated in AR episodes but also in UTI, CMV infection and DGF. Therefore, this technique would appear to be of limited clinical value as a noninvasive method of diagnosing AR...
  15. doi request reprint Cytomegalovirus exposure and cardiovascular disease in kidney transplant recipients
    Cécile Courivaud
    UMR1098, INSERM, Besancon, France
    J Infect Dis 207:1569-75. 2013
    ..62 [95% CI, .91-3.05]; P = .098). Both pretransplantation CMV exposure and posttransplantation CMV replication contribute to the increased risk of cardiovascular disease in transplant recipients...
  16. ncbi request reprint Natural killer cells prevent CD28-mediated Foxp3 transcription in CD4+CD25- T lymphocytes
    Emilie Brillard
    INSERM U645, University of Franche Comte, EFS Bourgogne Franche Comte, Besancon, France
    Exp Hematol 35:416-25. 2007
    ..Because natural killer cells (NK) are critical for efficient cytotoxic T-cell priming and TH1 polarization, we investigated their role in Foxp3 induction in CD4(+) T lymphocytes...
  17. doi request reprint Cytomegalovirus exposure, immune exhaustion and cancer occurrence in renal transplant recipients
    Cécile Courivaud
    INSERM, UMR645, Besancon, France
    Transpl Int 25:948-55. 2012
    ..9 ± 8%; P < 0.0001), whereas CD8+CD57+IL2- cells were more frequent in CMV-exposed patients. Our results highly suggest that CMV increases the risk of cancer after transplantation...
  18. doi request reprint TGF-beta-exposed plasmacytoid dendritic cells participate in Th17 commitment
    Francis Bonnefoy
    INSERM, Unité Mixte de Recherche 645, F 25020 Besançon Cedex, France
    J Immunol 186:6157-64. 2011
    ..Such findings have implications in the pathogenesis of autoimmune diseases or immune responses against mucosal extracellular pathogens...
  19. pmc Prolonged CD4 T cell lymphopenia increases morbidity and mortality after renal transplantation
    Didier Ducloux
    Institut National de la Sante et de la Recherche Medicale, UMR645, Besancon, France
    J Am Soc Nephrol 21:868-75. 2010
    ..Determination of pretransplantation thymic function may identify patients at higher risk for CD4 T cell lymphopenia and posttransplantation morbidity, including cancer and infections...
  20. ncbi request reprint A single intravenous infusion of apoptotic cells, an alternative cell-based therapy approach facilitating hematopoietic cell engraftment, did not induce autoimmunity
    Sylvain Perruche
    INSERM E0119, Etablissement Français du Sang Bourgogne Franche Comté, MEN EA2284, Universite de Franche Comte, Besancon, France
    J Hematother Stem Cell Res 12:451-9. 2003
    ..Overall, these results show no specific toxicity of a single infusion of apoptotic cells administrated simultaneously to BM and may also shed light on factors influencing the immunogenic properties of apoptotic cells...
  21. doi request reprint Lymphocyte subsets in renal transplant recipients with de novo genitourinary malignancies
    Guillaume Guichard
    Department of Urology and Renal Transplantation, University Hospital, Besancon, France
    Urol Int 80:257-63. 2008
    ..We previously reported that CD4 lymphocytopenia is associated with a high incidence of skin cancer in RTR. Here, we investigate whether persistent CD4 T cell lymphopenia is associated with GUT occurrence...
  22. ncbi request reprint Preventive effect of ultraviolet radiation on murine chronic sclerodermatous graft-versus-host disease
    Isabelle Mermet
    Service de Dermatologie, Université et Centre Hospitalier Universitaire de Franche Comté, Besancon, France
    Transplantation 84:1696-700. 2007
    ..We conclude that UVB irradiation of recipient before or after transplantation has a preventive effect on cutaneous Scl GVHD and may represent an effective strategy for prevention of Scl GVHD...
  23. pmc Endothelial cell-derived microparticles induce plasmacytoid dendritic cell maturation: potential implications in inflammatory diseases
    Fanny Angelot
    Inserm UMR645, University of Franche Comte, EFS Bourgogne Franche Comte, IFR133, Besancon, France
    Haematologica 94:1502-12. 2009
    ..The aim of our study was to determine whether interactions between endothelial microparticles and plasmacytoid dendritic cells could contribute to such pathologies...
  24. doi request reprint Influence of fractalkine receptor gene polymorphisms V249I-T280M on cancer occurrence after renal transplantation
    Cécile Courivaud
    INSERM, UMR645, Universite de Franche Comte, Etablissement Français du Sang, IFR133, Besancon, France
    Transplantation 95:728-32. 2013
    ..We hypothesized that a renal transplant recipient (RTR) carrying the homozygous I249M280 genotype could experience more cancer due to lower CX3CL1-dependent antitumorigenic effects...
  25. doi request reprint Intracytoplasmic detection of TCL1--but not ILT7-by flow cytometry is useful for blastic plasmacytoid dendritic cell leukemia diagnosis
    Fanny Angelot-Delettre
    Etablissement Français du Sang Bourgogne Franche Comté, Laboratoire d hématologie immunologie biologie moléculaire, Besançon F 25020, France
    Cytometry A 81:718-24. 2012
    ..Thus, intracellular TCL1 detection should be included in acute leukemia diagnosis panels used in hematology laboratories. © 2012 International Society for Advancement of Cytometry...
  26. ncbi request reprint Human leukocyte antigen-G5 secretion by human mesenchymal stem cells is required to suppress T lymphocyte and natural killer function and to induce CD4+CD25highFOXP3+ regulatory T cells
    Zohair Selmani
    Institut National de la Santé et de la Recherche Médicale U645, IFR 133, Universite de Franche Comte, Etablissement Français du Sang Bourgogne Franche Comté, Besancon, France
    Stem Cells 26:212-22. 2008
    ..Our results provide evidence that HLA-G5 secreted by MSCs is critical to the suppressive functions of MSCs and should contribute to improving clinical therapeutic trials that use MSCs to prevent GvHD...
  27. ncbi request reprint A single-platform approach using flow cytometry and microbeads to evaluate immune reconstitution in mice after bone marrow transplantation
    Sylvain Perruche
    Unité mixte EFS Université EA2284 Inserm U645, IFR133, Laboratoire d Immunologie, Etablissement Français du Sang Bourgogne Franche Comté, INSERM U645, 1 boulevard A Fleming, BP1937, F 25020 Besançon, France
    J Immunol Methods 294:53-66. 2004
    ....
  28. doi request reprint The COX-2 gene promoter polymorphism -765 delays CD4 T-cell reconstitution after lymphocyte depletion with antithymocyte globulins
    Cécile Courivaud
    INSERM, UMR645, Besancon, F 25020 France
    Hum Immunol 72:1060-3. 2011
    ..COX-2 gene promoter polymorphism at position -765 (G → C) is associated with persistent CD4 T-cell lymphopenia after ATG in RTR. This effect is likely to be mediated by the actions of PGE(2) on thymus function and viability...
  29. ncbi request reprint IL-6 promoter polymorphism -174 is associated with new-onset diabetes after transplantation
    Jamal Bamoulid
    INSERM, U645, University Besançon, and IFR133, Besancon, France
    J Am Soc Nephrol 17:2333-40. 2006
    ..These results highly suggest that IL-6 production capacity influences the development of NODAT and that diabetes-inducing drug administration should be limited in overweight patients who carry the GG genotype...
  30. doi request reprint Extended diagnostic criteria for plasmacytoid dendritic cell leukaemia
    Francine Garnache-Ottou
    Inserm UMR645, Université of Franche Comté, Etablissement Français du Sang Bourgogne Franche Comté, 1 boulevard A Fleming, Besancon, France
    Br J Haematol 145:624-36. 2009
    ..Atypical pDCL can be also identified this way and non-pDC acute leukaemia excluded: this scoring strategy is useful for diagnosing pDCL and apDCL...
  31. ncbi request reprint Relevance of Toll-like receptor-4 polymorphisms in renal transplantation
    Didier Ducloux
    Department of Nephrology, Dialysis, and Renal Transplantation, CHU Saint Jacques, Besancon, France
    Kidney Int 67:2454-61. 2005
    ..We assessed the impact of the two TLR4 variants on the risk of severe infection, the incidence of acute rejection, and the occurrence of atherosclerotic complications in renal transplant recipients (RTR)...
  32. ncbi request reprint [Tolerance in transplantation: potential contribution of haematopoietic transplantation and cell therapy]
    Francois Kleinclauss
    Laboratoire de Thérapeutique Immuno moléculaire, INSERM E 0119 UPRES EA 2284, Etablissement Français du Sang Bourgogne Franche Comté, Besancon, France
    Prog Urol 13:1406-14. 2003
    ..This approach can be particularly useful in combined haematopoietic stem cell and organ transplantation in order to induce a state of macro-chimerism...
  33. ncbi request reprint Can tolerogenic dendritic cells help to modulate allo-immune responses in the setting of hematopoietic cell transplantation?
    Stephanie Fresnay
    INSERM E0119, Etablissement Français du Sang Bourgogne Franche Comté, MEN EA2284, Universite de Franche Comte, Besancon, France
    Transpl Immunol 11:259-66. 2003
    ..Here, we propose that DC blocked in an immature stage, using immunosuppressive agents, or lymphoid DC can be adequate candidates to control the alloreactive conflict post-allograft...
  34. ncbi request reprint Polybrene and interleukin-4: two opposing factors for retroviral transduction of bone-marrow-derived dendritic cells
    Stephanie Fresnay
    Etablissement Français du Sang de Bourgogne Franche Comté, INSERM E0119, UPRES MEN2284, Universite de Franche Comte, F 25020 Besançon Cedex, France
    J Gene Med 4:601-12. 2002
    ..The goal of this study was to infect DCs in an immature state in order to take advantage of their proliferating and tolerogenic potential...
  35. pmc No evidence of association between NOD2/CARD15 gene polymorphism and atherosclerotic events after renal transplantation
    Cécile Courivaud
    INSERM, U645, Besancon, France
    Transplantation 81:1212-5. 2006
    ..No correlation was observed between NOD2 gene polymorphism and the occurrence of AE after renal transplantation. NOD2 gene polymorphism thus does not appear to influence cardiovascular complications in RTR...
  36. pmc The interleukin-6 gene promoter polymorphism -174 and atherosclerotic events in overweight transplanted patients
    Jamal Bamoulid
    INSERM, UMR645, 25020 Besançon, France
    J Transplant 2011:803429. 2011
    ..92-9.33], P = .069 in the prospective cohort). All these data are consistent with a role for both genetic and environmental determinants of inflammation (white adipose tissue mass) in the development of AE in renal transplanted patients...
  37. ncbi request reprint B Cell allogeneic responses after hematopoietic cell transplantation: is it time to address this issue?
    Sylvain Perruche
    INSERM, U645, Besancon, France
    Transplantation 79:S37-9. 2005
    ..We also describe the control of antidonor alloresponses by intravenous simultaneous infusion of apoptotic cells with allogeneic hematopoietic grafts...
  38. ncbi request reprint How should chimerism be decoded?
    Christophe Ferrand
    INSERM E0119 UPRES EA2284, Etablissement Français du Sang Bourgogne Franche Comté, Universite de Franche Comte, Besancon, France
    Transplantation 75:50S-54S. 2003
    ..Finally, the authors suggest how these methods may help to improve the understanding of microchimerism in solid organ transplantation...
  39. ncbi request reprint Administration of donor apoptotic cells: an alternative cell-based therapy to induce tolerance?
    Francois Kleinclauss
    INSERM E0119 UPRES EA2284, Etablissement Français du Sang Bourgogne Franche Comté, Universite de Franche Comte, Besancon, France
    Transplantation 75:43S-45S. 2003
    ..The authors discuss how intravenous apoptotic cell infusion may influence the outcome of combined transplantation. This may prove to be an interesting approach for future development in cell therapy...
  40. ncbi request reprint Increased levels of circulating microparticles are associated with increased procoagulant activity in patients with cutaneous malignant melanoma
    Claire Laresche
    Service de Dermatologie, Centre Hospitalier Universitaire Jean Minjoz, Besancon, France
    J Invest Dermatol 134:176-82. 2014
    ..In addition, we observed an inverse correlation between PMPs, AV(+)MPs, and clotting times. Our data suggest that MPs are involved in the progression of melanoma and may be associated to melanoma-associated thrombogenesis. ..
  41. ncbi request reprint A skin substitute based on human amniotic membrane
    Hélène Tauzin
    UMR 1098, SFR FED 4234, University of Franche Comte, 25000, Besancon, France
    Cell Tissue Bank 15:257-65. 2014
    ..As re-epithelialization is an important step for ulcer closure, a model of epidermized HAM could be used to speed up the healing of such wounds...
  42. pmc Polyclonal antithymocyte globulin and cardiovascular disease in kidney transplant recipients
    Didier Ducloux
    Integrated Center for Research in Inflammatory Diseases UMR1098, French Institute of Health and Medical Research, University Hospital Federation, Besancon, France French Federal Research Institute for Engineering for Cellular and Tissue Biology IFR133, University of Franche Comte, Besancon, France Department of Nephrology, Dialysis, and Renal Transplantation, University Hospital of Besancon, Besancon, France Clinical Investigation Centre Integrated Biotherapeutics CIC BT 506, University Hospital of Besancon, Besancon, France and
    J Am Soc Nephrol 25:1349-56. 2014
    ..70; P=0.01). In conclusion, ATG associated with both immune activation and post-transplant CVEs in this cohort. Further studies should precisely determine whether ATG-induced immune activation is the causal link between ATG and CVEs...
  43. ncbi request reprint Plasmacytoid dendritic cell leukaemia/lymphoma: towards a well defined entity?
    Francine Garnache-Ottou
    EFS BFC, Haematology and Immunology Laboratory, Besancon, France
    Br J Haematol 136:539-48. 2007
    ..g. T-cell leukaemia 1)--blood dendritic cell antigen-2 and high levels of CD123 expression as potential markers. In addition, we propose a multidisciplinary approach including several fields of haematology to improve pDCL diagnosis...
  44. doi request reprint CD304 is preferentially expressed on a subset of B-lineage acute lymphoblastic leukemia and represents a novel marker for minimal residual disease detection by flow cytometry
    Françoise Solly
    Etablissement Français du Sang Bourgogne Franche Comté, Laboratoire d hématologie immunologie biologie moléculaire, Besancon, France
    Cytometry A 81:17-24. 2012
    ..Finally, CD304 was repeatedly expressed in patients with TEL-AML1 gene rearrangement, which warrants further investigation on its potential relevance as a prognosis marker or therapeutic target...
  45. ncbi request reprint Expression of the myeloid-associated marker CD33 is not an exclusive factor for leukemic plasmacytoid dendritic cells
    Francine Garnache-Ottou
    Etablissement Français du Sang Bourgogne Franche Comté, Unité mixte EFS Université EA2284 Inserm U645, IFR133, Besancon, France
    Blood 105:1256-64. 2005
    ....
  46. ncbi request reprint [Allogeneic adoptive immunotherapy]
    P Tiberghien
    Inserm EPI 0119 Upres EA 2284, Etablissement Français du Sang Bourgogne Franche Comté, Universite de Franche Comte, 1, Boulevard Alexandre Fleming, BP 1937, 25020 cedex, Besancon, France
    Transfus Clin Biol 10:170-4. 2003
    ..Such a transplant modality is now perceived has a very efficient form of adoptive allogeneic immunotherapy unfortunately associated with significant toxicity...
  47. doi request reprint Characterization of peripheral blood stem cell grafts mobilized by granulocyte colony-stimulating factor and plerixafor compared with granulocyte colony-stimulating factor alone
    Beatrice Gaugler
    EFS Bourgogne Franche Comte, Besancon, France
    Cytotherapy 15:861-8. 2013
    ....
  48. ncbi request reprint Immune regulation and transplantation: an exciting challenge
    Philippe Saas
    INSERM E0119 UPRES EA2284, Etablissement Français du Sang Bourgogne Franche Comté, Universite de Franche Comte, Besancon, France
    Transplantation 77:S38-40. 2004
  49. ncbi request reprint Increased presence of anti-HLA antibodies early after allogeneic granulocyte colony-stimulating factor-mobilized peripheral blood hematopoietic stem cell transplantation compared with bone marrow transplantation
    Valérie Lapierre
    Unité de Thérapie Tissulaire, Cellulaire et Génique, INSERM E 0119 UPRES EA 2284, Etablissement Français du Sang Bourgogne Franche Comté, Besancon, France
    Blood 100:1484-9. 2002
    ..02). In conclusion, this study strongly suggests that G-CSF-mobilized PBHSCT results in an increased incidence of circulating anti-HLA Abs and further confirms that the use of such a graft alters alloimmune Ab responses...
  50. ncbi request reprint Administration of herpes simplex-thymidine kinase-expressing donor T cells with a T-cell-depleted allogeneic marrow graft
    P Tiberghien
    Etablissement Français du Sang, Bourgogne Franche Comté, and Service d Anatomie Pathologique and Service d Hématologie, Centre Hospitolier Universitoire CHU Besançon, Besancon, France
    Blood 97:63-72. 2001
    ..Such findings open the way to the infusion of higher numbers of gene-modified donor T cells to enhance post-BMT immune competence while preserving GCV-sensitive alloreactivity...
  51. doi request reprint Development and characterization of a human dermal equivalent with physiological mechanical properties
    Gwenaël Rolin
    Inserm UMR 645 Engineering and Cutaneous Biology Team, Besancon, France
    Skin Res Technol 18:251-8. 2012
    ..Indeed, human skin is naturally under tension. Taking into account these features, the purpose of this work was to obtain a cellularized dermal equivalent (CDE), composed of collagen and dermal fibroblasts...
  52. doi request reprint [Genetic polymorphisms: how to interpret studies?]
    Cécile Courivaud
    INSERM UMR 645, Etablissement Français du Sang Bourgogne Franche Comté, Universite de Franche Comte, Besancon, France
    Nephrol Ther 8:141-5. 2012
    ..Conflicting results between similar studies have contributed to seriously distrust the validity of this approach. This review emphasizes on intrinsic properties of SNP and methodological prerequisites for such studies...
  53. ncbi request reprint Exposure to exogenous DNA can modify the sensitivity of the Fas apoptotic pathway
    Marcelo De Carvalho Bittencourt
    Etablissement Français du Sang de Bourgogne Franche Comté, INSERM E0119 UPRES EA2284, Universite de Franche Comte, F 25020 Besançon Cedex, France
    J Gene Med 4:14-24. 2002
    ..These modifications can alter the immunogenicity and/or the susceptibility of the target cell to apoptosis and may produce unwanted consequences in vivo...
  54. ncbi request reprint CD4 cell lymphopenia and atherosclerosis in renal transplant recipients
    Didier Ducloux
    Department of Nephrology, Saint Jacques Hospital, Besancon, France
    J Am Soc Nephrol 14:767-72. 2003
    ....
  55. ncbi request reprint Enhanced activation of B cells in a granulocyte colony-stimulating factor-mobilized peripheral blood stem cell graft
    H Tayebi
    , INSERM, E-0119, UPRES EA-2284, , , France
    Br J Haematol 114:698-700. 2001
    ....
  56. ncbi request reprint Effect of granulocyte colony-stimulating factor mobilization on phenotypical and functional properties of immune cells
    H Tayebi
    , Bd Alexandre Fleming, , France
    Exp Hematol 29:458-70. 2001
    ..Our data demonstrate in a randomized setting that quantitative as well as qualitative differences exist between a bone marrow and a peripheral blood stem cell graft, whose ability to produce type 1 and type 2 cytokines is impaired...
  57. doi request reprint Preferential splenic CD8(+) T-cell activation in rituximab-nonresponder patients with immune thrombocytopenia
    Sylvain Audia
    Centre de Recherche, National de la Santé et de la Recherche Médicale 1098, University of Franche Comte, Besancon, France
    Blood 122:2477-86. 2013
    ..Altogether, these results demonstrate for the first time an activation of splenic CD8(+) T cells in ITP patients who did not respond to RTX and suggest their involvement in platelet destruction in these patients. ..
  58. doi request reprint Th1 and Th17 lymphocytes expressing CD161 are implicated in giant cell arteritis and polymyalgia rheumatica pathogenesis
    Maxime Samson
    Université de Bourgogne and CHU Dijon le Bocage, Dijon, France
    Arthritis Rheum 64:3788-98. 2012
    ..The objective of this study was to decipher the role of the major CD4+ T cell subsets in GCA and its rheumatologic form, polymyalgia rheumatica (PMR)...
  59. pmc Intravenous apoptotic spleen cell infusion induces a TGF-beta-dependent regulatory T-cell expansion
    F Kleinclauss
    INSERM U645, 1 Bd A Fleming, Besançon F 25020, France
    Cell Death Differ 13:41-52. 2006
    ..This novel association between apoptosis and regulatory T-cell expansion may also contribute to preventing deleterious autoimmune responses during normal turnover...
  60. doi request reprint Influence of cyclooxygenase-2 (COX-2) gene promoter polymorphism -765 on graft loss after renal transplantation
    C Courivaud
    INSERM, UMR645, F 25020, Besancon, France
    Am J Transplant 9:2752-7. 2009
    ..COX-2 gene promoter polymorphism at position -765 (G-->C) is associated with a higher rate of graft loss in RTRs. Such findings may be used to influence immunosuppressive strategies and optimize patient management...
  61. ncbi request reprint Distinct hematopoietic support by two human stromal cell lines
    C Loeuillet
    EFS de Bourgogne Franche Comté, Besancon, France
    Exp Hematol 29:736-45. 2001
    ..Here, we have characterized and studied the hematopoietic support for two cell lines corresponding to the promoters alpha-SM (alphaSM-56 line) and SV40 (SV40-56 line)...
  62. ncbi request reprint LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level
    Patrick Ducoroy
    Institut National de la Santé et de la Recherche Médicale INSERM U517, IFR 100, Faculties of Medicine and Pharmacy, Dijon, France
    Blood 101:194-201. 2003
    ..This original mechanism, together with LF 15-0195 efficacy in various disease models, makes this compound a promising immunosuppressive drug...
  63. ncbi request reprint [Allorecognition of the recipient after hematopoietic transplantation]
    Pierre Tiberghien
    Inserm E 0119 MEN EA 2284, EFS Bourgogne, Franche Comte, 1 bd Fleming, 25000 Besancon, France
    Bull Cancer 90:706-10. 2003
    ..A better understanding of the involved immune mechanisms, the development of novel immunomonitoring tools and cell engineering approaches should result in a significantly increased therapeutic index of allogeneic alloreactivity...
  64. doi request reprint CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells
    Sylvain Perruche
    Mucosal Immunology Unit, Oral Infection and Immunity Branch, National Institute of Dental and Craniofacial Research NIDCR, US National Institutes of Health NIH, 30 Convent Drive, Bethesda, Maryland 20892, USA
    Nat Med 14:528-35. 2008
    ..Thus, CD3-specific antibody-induced immune tolerance is associated with TGF-beta production in phagocytes involved in clearing apoptotic T cells, which suggests that apoptosis is linked to active suppression in immune tolerance...
  65. ncbi request reprint Immune modulation and microchimerism after unmodified versus leukoreduced allogeneic red blood cell transfusion in cancer patients: results of a randomized study
    Valérie Lapierre
    Unit of Transfusion Medicine and Hemovigilance, the Biostatistics and Epidemiology Service, the Department of Anesthesia and Reanimation, Gustave Roussy Cancer Institute, Villejuif, France
    Transfusion 47:1691-9. 2007
    ..Transfusion of red blood cells (RBCs) has been associated with immunomodulatory effects. Persistence of donor cells in the recipient may be contributive...
  66. ncbi request reprint Adipose tissue, serum adipokines, and ghrelin in patients with ankylosing spondylitis
    Eric Toussirot
    Department of Rheumatology, University Hospital Jean Minjoz, Bd Fleming, F 25030 Besancon, Cedex, France
    Metabolism 56:1383-9. 2007
    ..Leptin production was reduced in contrast with normal levels of adiponectin. These adipokine results, together with high serum ghrelin levels, may influence the inflammatory response in AS...
  67. ncbi request reprint Influence of ex vivo expansion and retrovirus-mediated gene transfer on primary T lymphocyte phenotype and functions
    Delphine Sauce
    Laboratoire de Thérapeutique Immuno moléculaire, INSERM E 0119, UPRES EA 2284, and Etablissement Français du Sang Bourgogne Franche Comté, Besançon 25000, France
    J Hematother Stem Cell Res 11:929-40. 2002
    ..Thus, future T cell expansion protocols should try to improve not only cell expansion or gene transfer efficiency, but also T cell functions...
  68. ncbi request reprint Bacterial extract (OM-89) specific and non specific immunomodulation in rheumatoid arthritis patients
    Eric Toussirot
    Department of Rheumatology, University Hospital Jean Minjoz, Bd Fleming, F 25030 Besancon Cedex, France
    Autoimmunity 39:299-306. 2006
    ..Our results suggest that OM-89 has immunomodulatory properties by inducing changes in PBMC cytokines release suggestive of an induced Tr1 response to OM-89...