Thierry Rose

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response
    Thierry Rose
    Département Infection et Epidémiologie, Institut Pasteur, Unité d Immunogénétique Cellulaire, Paris, France
    J Biol Chem 285:14898-908. 2010
  2. doi request reprint IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork
    Anne Hélène Pillet
    Institut Pasteur, Département Infection et Epidémiologie, Departement d Immunologie, Unité d Immunogénétique Cellulaire, Paris, France
    J Mol Biol 403:671-92. 2010
  3. pmc Membrane microdomains and cytoskeleton organization shape and regulate the IL-7 receptor signalosome in human CD4 T-cells
    Blanche Tamarit
    Institut Pasteur, Département Infection et Epidémiologie, Departement d Immunologie, Unité d Immunogénétique Cellulaire, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 288:8691-701. 2013
  4. doi request reprint Interleukin (IL)-2 and IL-15 have different effects on human natural killer lymphocytes
    Anne Hélène Pillet
    Institut Pasteur, Unité d Immunogénétique Cellulaire, Département d Infection et d Epidémiologie, Paris, France
    Hum Immunol 72:1013-7. 2011
  5. doi request reprint A programmed switch from IL-15- to IL-2-dependent activation in human NK cells
    Anne Hélène Pillet
    Départment d Infection et d Epidémiologie, Unité d Immunogénétique Cellulaire, Institut Pasteur, Paris, France
    J Immunol 182:6267-77. 2009
  6. doi request reprint Human IL-Rbeta chains form IL-2 binding homodimers
    Anne Hélène Pillet
    Unité d Immunogénétique Cellulaire, Département Infection et Epidémiologie, Institut Pasteur, Paris, France
    Eur Cytokine Netw 19:49-59. 2008
  7. doi request reprint Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients
    Thierry Rose
    Institut Pasteur, Unité d Immunogénétique Cellulaire, Paris France
    J Immunol 182:7389-97. 2009
  8. ncbi request reprint Structural analysis and modeling of a synthetic interleukin-2 mimetic and its interleukin-2Rbeta2 receptor
    Thierry Rose
    Departement de Biologie Structurale et Chimie, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 278:22868-76. 2003
  9. pmc A novel archaeal regulatory protein, Sta1, activates transcription from viral promoters
    Alexandra Kessler
    Unite de Biologie Moleculaire du Gene chez les Extremophiles, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Nucleic Acids Res 34:4837-45. 2006

Collaborators

Detail Information

Publications9

  1. pmc Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response
    Thierry Rose
    Département Infection et Epidémiologie, Institut Pasteur, Unité d Immunogénétique Cellulaire, Paris, France
    J Biol Chem 285:14898-908. 2010
    ..Thus, early events leading to IL-7 signal transduction involve its receptor compartmentalization into membrane nanodomains and cytoskeleton recruitment...
  2. doi request reprint IL-2 induces conformational changes in its preassembled receptor core, which then migrates in lipid raft and binds to the cytoskeleton meshwork
    Anne Hélène Pillet
    Institut Pasteur, Département Infection et Epidémiologie, Departement d Immunologie, Unité d Immunogénétique Cellulaire, Paris, France
    J Mol Biol 403:671-92. 2010
    ....
  3. pmc Membrane microdomains and cytoskeleton organization shape and regulate the IL-7 receptor signalosome in human CD4 T-cells
    Blanche Tamarit
    Institut Pasteur, Département Infection et Epidémiologie, Departement d Immunologie, Unité d Immunogénétique Cellulaire, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 288:8691-701. 2013
    ..Radial microtubules disappear 15 min later, while transversal microtubules, independent of phospho-STAT5 transport, begin to bud from the microtubule organization center...
  4. doi request reprint Interleukin (IL)-2 and IL-15 have different effects on human natural killer lymphocytes
    Anne Hélène Pillet
    Institut Pasteur, Unité d Immunogénétique Cellulaire, Département d Infection et d Epidémiologie, Paris, France
    Hum Immunol 72:1013-7. 2011
    ..By contrast, IL-2 induces the rapid disappearance of IL-2Rα and γ(c) chains when the gene transcription is downregulated, shutting down IL-2-responses as demonstrated by the absence of STAT5 phosphorylation and BCL2 expression...
  5. doi request reprint A programmed switch from IL-15- to IL-2-dependent activation in human NK cells
    Anne Hélène Pillet
    Départment d Infection et d Epidémiologie, Unité d Immunogénétique Cellulaire, Institut Pasteur, Paris, France
    J Immunol 182:6267-77. 2009
    ..Such a program may prevent excessive human NK cell activation by effectors of innate immunity and regulate the transition between the innate and adaptive stages of immune responses...
  6. doi request reprint Human IL-Rbeta chains form IL-2 binding homodimers
    Anne Hélène Pillet
    Unité d Immunogénétique Cellulaire, Département Infection et Epidémiologie, Institut Pasteur, Paris, France
    Eur Cytokine Netw 19:49-59. 2008
    ..IL-2Rbeta/IL-2Rbeta could represent either a decoy receptor or a new form of IL-2R involved in signaling when gammac expression is low...
  7. doi request reprint Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients
    Thierry Rose
    Institut Pasteur, Unité d Immunogénétique Cellulaire, Paris France
    J Immunol 182:7389-97. 2009
    ..0014) 2-fold decrease in plasma sIL-7Ralpha levels compared with those in control healthy individuals. Plasma IL-7 and sIL-7Ralpha levels did not show any obvious relationship...
  8. ncbi request reprint Structural analysis and modeling of a synthetic interleukin-2 mimetic and its interleukin-2Rbeta2 receptor
    Thierry Rose
    Departement de Biologie Structurale et Chimie, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 278:22868-76. 2003
    ....
  9. pmc A novel archaeal regulatory protein, Sta1, activates transcription from viral promoters
    Alexandra Kessler
    Unite de Biologie Moleculaire du Gene chez les Extremophiles, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Nucleic Acids Res 34:4837-45. 2006
    ..This strategy of the archaeal virus to co-opt a host cell regulator to promote transcription of its genes resembles eukaryal virus-host relationships...