Guy Franck Richard

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. doi request reprint Highly Specific Contractions of a Single CAG/CTG Trinucleotide Repeat by TALEN in Yeast
    Guy Franck Richard
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, Département Génomes and Génétique, Paris, France Sorbonne Universités, UPMC Univ Paris 6, IFD, Paris, France CNRS, UMR3525, Paris, France
    PLoS ONE 9:e95611. 2014
  2. pmc Comparative genomics and molecular dynamics of DNA repeats in eukaryotes
    Guy Franck Richard
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS, URA2171, Universite Pierre et Marie Curie, UFR927, 25 rue du Dr Roux, F 75015, Paris, France
    Microbiol Mol Biol Rev 72:686-727. 2008
  3. ncbi request reprint Molecular evolution of minisatellites in hemiascomycetous yeasts
    Guy Franck Richard
    Unité de Génétique Moléculaire des Levures, Universite Pierre et Marie Curie, Institut Pasteur, 75724 Paris Cedex 15, France
    Mol Biol Evol 23:189-202. 2006
  4. pmc Mini- and microsatellite expansions: the recombination connection
    G F Richard
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS, Paris, France
    EMBO Rep 1:122-6. 2000
  5. ncbi request reprint Contractions and expansions of CAG/CTG trinucleotide repeats occur during ectopic gene conversion in yeast, by a MUS81-independent mechanism
    Guy Franck Richard
    Unité de Génétique Moléculaire des Levures URA 2171 CNRS and UFR 927 Univ Pierre et Marie Curie, Department Structure and Dynamics of Genomes, Institut Pasteur, 75724 Paris Cedex 15, France
    J Mol Biol 326:769-82. 2003
  6. pmc Dynamic evolution of megasatellites in yeasts
    Thomas Rolland
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, Department Genomes and Genetics, Paris, France
    Nucleic Acids Res 38:4731-9. 2010
  7. pmc Transcription and nuclear transport of CAG/CTG trinucleotide repeats in yeast
    Emmanuelle Fabre
    Unité de Génétique Moléculaire des Levures URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nucleic Acids Res 30:3540-7. 2002
  8. ncbi request reprint Analysis of microsatellites in 13 hemiascomycetous yeast species: mechanisms involved in genome dynamics
    Alain Malpertuy
    Unité de Génétique Moléculaire des Levures URA 2171 CNRS, UFR 927 Université Pierre et Marie Curie, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Mol Evol 56:730-41. 2003
  9. doi request reprint Megasatellites: a new class of large tandem repeats discovered in the pathogenic yeast Candida glabrata
    Agnès Thierry
    Unité de Génétique Moléculaire des Levures, Institut Pasteur, CNRS URA2171, Université Pierre et Marie Curie UFR 927, 25 rue du Dr Roux, 75015, Paris, France
    Cell Mol Life Sci 67:671-6. 2010
  10. ncbi request reprint Comparative genomics of hemiascomycete yeasts: genes involved in DNA replication, repair, and recombination
    Guy Franck Richard
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS, UFR 927 Université Pierre et Marie Curie, Institut Pasteur, Paris Cedex, France
    Mol Biol Evol 22:1011-23. 2005

Detail Information

Publications18

  1. doi request reprint Highly Specific Contractions of a Single CAG/CTG Trinucleotide Repeat by TALEN in Yeast
    Guy Franck Richard
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, Département Génomes and Génétique, Paris, France Sorbonne Universités, UPMC Univ Paris 6, IFD, Paris, France CNRS, UMR3525, Paris, France
    PLoS ONE 9:e95611. 2014
    ..It is the first demonstration that induction of a TALEN in an eukaryotic cell leads to shortening of trinucleotide repeat tracts to lengths below pathological thresholds in humans, with 100% efficacy and very high specificity. ..
  2. pmc Comparative genomics and molecular dynamics of DNA repeats in eukaryotes
    Guy Franck Richard
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS, URA2171, Universite Pierre et Marie Curie, UFR927, 25 rue du Dr Roux, F 75015, Paris, France
    Microbiol Mol Biol Rev 72:686-727. 2008
    ....
  3. ncbi request reprint Molecular evolution of minisatellites in hemiascomycetous yeasts
    Guy Franck Richard
    Unité de Génétique Moléculaire des Levures, Universite Pierre et Marie Curie, Institut Pasteur, 75724 Paris Cedex 15, France
    Mol Biol Evol 23:189-202. 2006
    ....
  4. pmc Mini- and microsatellite expansions: the recombination connection
    G F Richard
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS, Paris, France
    EMBO Rep 1:122-6. 2000
    ..We will review data connecting tandem repeat rearrangements and recombination in humans and in eukaryotic model organisms, and discuss the possible role of recombination in trinucleotide repeat expansions in human neurological disorders...
  5. ncbi request reprint Contractions and expansions of CAG/CTG trinucleotide repeats occur during ectopic gene conversion in yeast, by a MUS81-independent mechanism
    Guy Franck Richard
    Unité de Génétique Moléculaire des Levures URA 2171 CNRS and UFR 927 Univ Pierre et Marie Curie, Department Structure and Dynamics of Genomes, Institut Pasteur, 75724 Paris Cedex 15, France
    J Mol Biol 326:769-82. 2003
    ..We concluded that trinucleotide repeat rearrangements occur frequently during ectopic but not during allelic recombination, by a mechanism that does not require crossover formation...
  6. pmc Dynamic evolution of megasatellites in yeasts
    Thomas Rolland
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, Department Genomes and Genetics, Paris, France
    Nucleic Acids Res 38:4731-9. 2010
    ..These mechanisms actively cooperate to create new megasatellites, that may play an important role in the adaptation of Candida glabrata to its human host...
  7. pmc Transcription and nuclear transport of CAG/CTG trinucleotide repeats in yeast
    Emmanuelle Fabre
    Unité de Génétique Moléculaire des Levures URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nucleic Acids Res 30:3540-7. 2002
    ..CAG- or CUG-containing transcripts show a non-homogeneous cellular localization. We propose that long mRNAs result from transcription slippage, and discuss the possible implications for human diseases...
  8. ncbi request reprint Analysis of microsatellites in 13 hemiascomycetous yeast species: mechanisms involved in genome dynamics
    Alain Malpertuy
    Unité de Génétique Moléculaire des Levures URA 2171 CNRS, UFR 927 Université Pierre et Marie Curie, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Mol Evol 56:730-41. 2003
    ....
  9. doi request reprint Megasatellites: a new class of large tandem repeats discovered in the pathogenic yeast Candida glabrata
    Agnès Thierry
    Unité de Génétique Moléculaire des Levures, Institut Pasteur, CNRS URA2171, Université Pierre et Marie Curie UFR 927, 25 rue du Dr Roux, 75015, Paris, France
    Cell Mol Life Sci 67:671-6. 2010
    ..Their putative role in promoting genome rearrangements by interfering with DNA replication will also be discussed...
  10. ncbi request reprint Comparative genomics of hemiascomycete yeasts: genes involved in DNA replication, repair, and recombination
    Guy Franck Richard
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS, UFR 927 Université Pierre et Marie Curie, Institut Pasteur, Paris Cedex, France
    Mol Biol Evol 22:1011-23. 2005
    ..lactis. Phylogenetic analyses show that the duplicated SGS1 gene evolved faster than the original gene, probably leading to a specialization of function of the duplicated copy...
  11. pmc Detection and characterization of megasatellites in orthologous and nonorthologous genes of 21 fungal genomes
    Fredj Tekaia
    Unité de Génétique Moléculaire des Levures, Département Génomes and Génétique, Institut Pasteur, Paris, France
    Eukaryot Cell 12:794-803. 2013
    ..Altogether, these results suggest that megasatellites are created and lost during evolution of fungal genomes, probably sharing similar functions, although their primary sequences are not necessarily conserved...
  12. doi request reprint SRS2 and SGS1 prevent chromosomal breaks and stabilize triplet repeats by restraining recombination
    Alix Kerrest
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS, URA2171, Universite Pierre et Marie Curie, UFR 927, 25 rue du Dr Roux, F 75015 Paris, France
    Nat Struct Mol Biol 16:159-67. 2009
    ..In the absence of Srs2 or Sgs1, DNA damage accumulates and is processed by homologous recombination, triggering repeat rearrangements...
  13. pmc Megasatellites: a peculiar class of giant minisatellites in genes involved in cell adhesion and pathogenicity in Candida glabrata
    Agnès Thierry
    Institut Pasteur, Unité de Génétique Moléculaire des Levures, CNRS, URA2171, F 75015 Paris, France
    Nucleic Acids Res 36:5970-82. 2008
    ..Most of the time, these minisatellites are not conserved between C. glabrata and S. cerevisiae, although their host genes are well conserved, raising the question of an active mechanism creating minisatellites de novo in hemiascomycetes...
  14. ncbi request reprint Genome evolution in yeasts
    Bernard Dujon
    Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie
    Nature 430:35-44. 2004
    ....
  15. pmc Large-scale exploration of growth inhibition caused by overexpression of genomic fragments in Saccharomyces cerevisiae
    Jeanne Boyer
    Unité de Génétique Moléculaire des Levures, URA2171 CNRS and UFR 927 Université Pierre et Marie Curie, Paris Cedex 15, France
    Genome Biol 5:R72. 2004
    ....
  16. ncbi request reprint The spirochetal chpK-chromosomal toxin-antitoxin locus induces growth inhibition of yeast and mycobacteria
    Mathieu Picardeau
    Unité de bactériologie moléculaire et médicale, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris15, France
    FEMS Microbiol Lett 229:277-81. 2003
    ..These results show that ChpK possesses a broad activity against both prokaryotes and eukaryotes, suggesting that the cellular target of the toxin is conserved in these organisms...
  17. ncbi request reprint Genetic network interactions among replication, repair and nuclear pore deficiencies in yeast
    Sophie Loeillet
    Institut Curie, Section de Recherche, UMR144 Centre National de la Recherche Scientifique, Génétique Moléculaire de la Recombinaison, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    DNA Repair (Amst) 4:459-68. 2005
    ..Altogether, these data suggest that the pathological interactions between the rad27Delta and specific nupDelta mutations result from the accumulation of unrepaired DNA damages...
  18. pmc Saccharomyces cerevisiae donor preference during mating-type switching is dependent on chromosome architecture and organization
    Eric Coïc
    Department of Biology and Rosenstiel Center, Brandeis University, Waltham, Massachusetts 02254 9110, USA
    Genetics 173:1197-206. 2006
    ..We propose that RE's targets are anchor sites that tether chromosome III-L in MATalpha cells thus reducing its mobility in the nucleus...