Felix A Rey

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc The disulfide bonds in glycoprotein E2 of hepatitis C virus reveal the tertiary organization of the molecule
    Thomas Krey
    Institut Pasteur, CNRS URA3015, Unité de Virologie Structurale, Paris, France
    PLoS Pathog 6:e1000762. 2010
  2. pmc Molecular gymnastics at the herpesvirus surface
    Felix A Rey
    Unité de Virologie Structurale and Centre National de la Recherche Scientifique, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    EMBO Rep 7:1000-5. 2006
  3. doi request reprint Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography
    James E Voss
    Institut Pasteur, Departement de Virologie, Unité de Virologie Structurale, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nature 468:709-12. 2010
  4. doi request reprint Crystal structure of the pestivirus envelope glycoprotein E(rns) and mechanistic analysis of its ribonuclease activity
    Thomas Krey
    Unité de Virologie Structurale, Institut Pasteur, 75015 Paris, France
    Structure 20:862-73. 2012
  5. doi request reprint Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody
    Joseph J B Cockburn
    Unité de Virologie Structurale, Departement de Virologie, Institut Pasteur, 75724 Paris Cedex 15, France
    Structure 20:303-14. 2012
  6. doi request reprint Functional and evolutionary insight from the crystal structure of rubella virus protein E1
    Rebecca M DuBois
    Institut Pasteur, Departement de Virologie, Unité de Virologie Structurale and CNRS URA 3015, F 75724 Paris Cedex 15, France
    Nature 493:552-6. 2013
  7. pmc X-ray structure of the arenavirus glycoprotein GP2 in its postfusion hairpin conformation
    Sebastien Igonet
    Departement de Virologie, Unité de Virologie Structurale, Institut Pasteur, F 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 108:19967-72. 2011
  8. pmc Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape
    Thomas Krey
    Institut Pasteur, Unité de Virologie Structurale, Departement Virologie, Paris, France
    PLoS Pathog 9:e1003364. 2013
  9. pmc High-level secretion of recombinant monomeric murine and human single-chain Fv antibodies from Drosophila S2 cells
    Allissia A Gilmartin
    Départment de Virologie, Institut Pasteur, Unité de Virologie Structurale, CNRS URA 3015, Paris, France
    Protein Eng Des Sel 25:59-66. 2012
  10. pmc Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody
    Marija Backovic
    Institut Pasteur, Departement de Virologie, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 107:22635-40. 2010

Collaborators

  • Hugues Bedouelle
  • Marija Backovic
  • Till Rümenapf
  • Enrico A Stura
  • Marc Jamin
  • Daniel X Johansson
  • David Bhella
  • Patrick England
  • Florence Cordier
  • Bruno Eschli
  • CHING JUH LAI
  • Ana P Goncalvez
  • Leonid V Chernomordik
  • Philippe Dussart
  • Francois Bontems
  • Nicolas Wolff
  • Thomas C Mettenleiter
  • Thomas Krey
  • Marie Christine Vaney
  • Stephane Duquerroy
  • Joseph J B Cockburn
  • Gerard Bricogne
  • Clemens Vonrhein
  • Carlos M Kikuti
  • Laurence Damier-Piolle
  • Rajiv G Tawar
  • Jimena Pérez-Vargas
  • Rebecca M DuBois
  • Ahmed Haouz
  • M Erika Navarro Sanchez
  • Allissia A Gilmartin
  • Mats A A Persson
  • Sebastien Igonet
  • Nicolas Babault
  • Fasseli Coulibaly
  • James E Voss
  • Bernard Delmas
  • Hadas Raveh-Barak
  • Benjamin Podbilewicz
  • Ori Avinoam
  • Clari Valansi
  • M Alejandra Tortorici
  • Steven K H Foung
  • Zhen Yong Keck
  • Annalisa Meola
  • Giovanna Barba-Spaeth
  • Rana Al Kurdi
  • Nickolas Fretes
  • Lark L Coffey
  • Fernando Arenzana Seisdedos
  • Elena Zaitseva
  • Benjamin Lamp
  • Agathe Urvoas
  • Isabelle Staropoli
  • Hans Hengartner
  • Joseph Cockburn
  • Mireille Lafage
  • Monique Lafon
  • Henri Buc
  • Christophe Prehaud
  • Muriel Delepierre
  • Clemens Vonhrein
  • Elodie Crublet
  • Christophe Chevalier
  • Bruno Baron
  • Andrew Thompson
  • Annette Martin
  • Christine Girard-Blanc
  • Jacques d'Alayer
  • Bruno Robert
  • Aure Saulnier
  • Isabelle Petitpas
  • Celine Henry
  • Sonia Libersou
  • Bruno Da Costa
  • Jorge Navaza
  • Jean Lepault
  • Kirsty MacLellan
  • Armelle Vigouroux
  • Nathalie Castagné
  • Jean François Eléouët
  • Paloma F Varela

Detail Information

Publications19

  1. pmc The disulfide bonds in glycoprotein E2 of hepatitis C virus reveal the tertiary organization of the molecule
    Thomas Krey
    Institut Pasteur, CNRS URA3015, Unité de Virologie Structurale, Paris, France
    PLoS Pathog 6:e1000762. 2010
    ....
  2. pmc Molecular gymnastics at the herpesvirus surface
    Felix A Rey
    Unité de Virologie Structurale and Centre National de la Recherche Scientifique, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    EMBO Rep 7:1000-5. 2006
    ....
  3. doi request reprint Glycoprotein organization of Chikungunya virus particles revealed by X-ray crystallography
    James E Voss
    Institut Pasteur, Departement de Virologie, Unité de Virologie Structurale, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nature 468:709-12. 2010
    ..3), this work also provides new insight into the acid-triggered conformational change on the virus particle and its inbuilt inhibition mechanism in the immature complex...
  4. doi request reprint Crystal structure of the pestivirus envelope glycoprotein E(rns) and mechanistic analysis of its ribonuclease activity
    Thomas Krey
    Unité de Virologie Structurale, Institut Pasteur, 75015 Paris, France
    Structure 20:862-73. 2012
    ....
  5. doi request reprint Mechanism of dengue virus broad cross-neutralization by a monoclonal antibody
    Joseph J B Cockburn
    Unité de Virologie Structurale, Departement de Virologie, Institut Pasteur, 75724 Paris Cedex 15, France
    Structure 20:303-14. 2012
    ..The structures also highlight the mechanism by which A-strand Mabs disrupt the architecture of the mature virion, inducing premature fusion loop exposure and concomitant particle inactivation...
  6. doi request reprint Functional and evolutionary insight from the crystal structure of rubella virus protein E1
    Rebecca M DuBois
    Institut Pasteur, Departement de Virologie, Unité de Virologie Structurale and CNRS URA 3015, F 75724 Paris Cedex 15, France
    Nature 493:552-6. 2013
    ..By contrast, in the absence of this constraint, the strictly human rubella virus seems to have drifted considerably into a unique niche as sole member of the Rubivirus genus...
  7. pmc X-ray structure of the arenavirus glycoprotein GP2 in its postfusion hairpin conformation
    Sebastien Igonet
    Departement de Virologie, Unité de Virologie Structurale, Institut Pasteur, F 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 108:19967-72. 2011
    ....
  8. pmc Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape
    Thomas Krey
    Institut Pasteur, Unité de Virologie Structurale, Departement Virologie, Paris, France
    PLoS Pathog 9:e1003364. 2013
    ..In summary, our results identify a critical structural motif at the E2 surface, which is essential for virus propagation and therefore represents an ideal candidate for structure-based immunogen design for vaccine development...
  9. pmc High-level secretion of recombinant monomeric murine and human single-chain Fv antibodies from Drosophila S2 cells
    Allissia A Gilmartin
    Départment de Virologie, Institut Pasteur, Unité de Virologie Structurale, CNRS URA 3015, Paris, France
    Protein Eng Des Sel 25:59-66. 2012
    ..Structural comparison with the Protein Data Bank revealed the typical spatial organization of V(H) and V(L) domains, further validating the here-reported expression system...
  10. pmc Structure of a core fragment of glycoprotein H from pseudorabies virus in complex with antibody
    Marija Backovic
    Institut Pasteur, Departement de Virologie, Unité de Virologie Structurale, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 107:22635-40. 2010
    ....
  11. doi request reprint Alphavirus structure: activation for entry at the target cell surface
    Marie Christine Vaney
    Institut Pasteur, Unité de Virologie Structurale, CNRS UMR 3569, Paris, France
    Curr Opin Virol 3:151-8. 2013
    ..The major outstanding questions in this area are also identified and discussed...
  12. doi request reprint Peptides targeting the PDZ domain of PTPN4 are efficient inducers of glioblastoma cell death
    Nicolas Babault
    Unité de Résonance Magnétique Nucléaire des Biomolécules, Departement de Biologie Structurale et Chimie, Institut Pasteur, F 75724 Paris, France
    Structure 19:1518-24. 2011
    ..These results allow us to propose a potential mechanism for the efficiency of peptides and provide a target and a robust framework for the design of new pro-death compounds...
  13. doi request reprint Structural basis of eukaryotic cell-cell fusion
    Jimena Pérez-Vargas
    Institut Pasteur, Unité de Virologie Structurale, 25 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France CNRS UMR 3569, 25 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France
    Cell 157:407-19. 2014
    ....
  14. pmc Structural insights into the neutralization mechanism of a higher primate antibody against dengue virus
    Joseph J B Cockburn
    Departement de Virologie, Institut Pasteur, Unité de Virologie Structurale, Paris, France
    EMBO J 31:767-79. 2012
    ..This study, thus, provides new information and tools for effective vaccine design to prevent dengue disease...
  15. doi request reprint Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus
    Rajiv G Tawar
    Institut Pasteur, Unité de Virologie Structurale, Département de Virologie and CNRS Unité de Recherche Associée URA 3015, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Science 326:1279-83. 2009
    ..Furthermore, the nucleoprotein structure highlights possible key sites for drug targeting...
  16. doi request reprint Class II enveloped viruses
    Marie Christine Vaney
    Institut Pasteur, Departement de Virologie, Unité de Virologie Structurale, F 75724 Paris Cedex 15, France
    Cell Microbiol 13:1451-9. 2011
    ....
  17. doi request reprint Virus entry: old viruses, new receptors
    Marija Backovic
    Institut Pasteur, Unité de Virologie Structurale, Département de Virologie and CNRS URA 3015, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Curr Opin Virol 2:4-13. 2012
    ....
  18. pmc The picobirnavirus crystal structure provides functional insights into virion assembly and cell entry
    Stephane Duquerroy
    Institut Pasteur, Unité de Virologie Structurale, Virology Department, CNRS URA 3015, Paris, France
    EMBO J 28:1655-65. 2009
    ..Our data also show that picobirnavirus particles are capable of disrupting biological membranes in vitro, indicating that its simple 120-subunits capsid has evolved animal cell invasion properties...
  19. pmc Crystal structure of an Aquabirnavirus particle: insights into antigenic diversity and virulence determinism
    Fasseli Coulibaly
    CNRS INRA UMR 2472 1157 and IFR 115, Laboratoire de Virologie Moleculaire et Structurale, 1 Avenue de la Terrasse, F 91198 Gif sur Yvette Cedex, France
    J Virol 84:1792-9. 2010
    ..Thus, in addition to revealing the viral antigenic determinants, the structure suggests that birnaviruses interact with different receptors for attachment and for cell internalization during entry...