Michael J Plevin

Summary

Affiliation: Institut de Biologie Structurale
Country: France

Publications

  1. doi A simple biosynthetic method for stereospecific resonance assignment of prochiral methyl groups in proteins
    Michael J Plevin
    CEA, Institut de Biologie Structurale Jean Pierre Ebel, Grenoble, France
    J Biomol NMR 49:61-7. 2011
  2. pmc Parallel screening and optimization of protein constructs for structural studies
    Rodolfo M Rasia
    Institut de Biologie Structurale Jean Pierre Ebel, Centre National de la Recherche Scientifique, Universite Joseph Fourier, Grenoble, France
    Protein Sci 18:434-9. 2009
  3. doi Direct detection of CH/pi interactions in proteins
    Michael J Plevin
    CEA, Institut de Biologie Structurale Jean Pierre Ebel, Grenoble, France
    Nat Chem 2:466-71. 2010
  4. doi Characterization of a conserved "threonine clasp" in CAP-Gly domains: role of a functionally critical OH/pi interaction in protein recognition
    Michael J Plevin
    Division of Signaling Biology, Ontario Cancer Institute, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada
    J Am Chem Soc 130:14918-9. 2008
  5. doi Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53
    Feng Wang
    Division of Signaling Biology, Ontario Cancer Institute, Toronto, Ontario, Canada M5G 2M9
    J Mol Biol 384:590-603. 2008
  6. doi Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry
    Peter B Stathopulos
    Division of Signaling Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Toronto, Ontario M5G 1L7, Canada
    Cell 135:110-22. 2008
  7. doi An optimized isotopic labelling strategy of isoleucine-γ2 methyl groups for solution NMR studies of high molecular weight proteins
    Isabel Ayala
    CNRS, Institut de Biologie Structurale, Grenoble, France
    Chem Commun (Camb) 48:1434-6. 2012
  8. ncbi Stored Ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region: An initiation mechanism for capacitive Ca2+ entry
    Peter B Stathopulos
    Division of Signaling Biology and Department of Medical Biophysics, Ontario Cancer Institute and University of Toronto, Toronto M5G 1L7, Ontario, Canada
    J Biol Chem 281:35855-62. 2006
  9. ncbi CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1
    Ikuko Hayashi
    Division of Signaling Biology, Ontario Cancer Institute, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada
    Nat Struct Mol Biol 14:980-1. 2007
  10. pmc The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domain
    Michael J Plevin
    Division of Signaling Biology, Ontario Cancer Institute, University Health Network, Canada
    Proc Natl Acad Sci U S A 103:10242-7. 2006

Collaborators

Detail Information

Publications17

  1. doi A simple biosynthetic method for stereospecific resonance assignment of prochiral methyl groups in proteins
    Michael J Plevin
    CEA, Institut de Biologie Structurale Jean Pierre Ebel, Grenoble, France
    J Biomol NMR 49:61-7. 2011
    ..This new strategy thus represents an economically-attractive, robust alternative for obtaining isotopically-encoded stereospecific NMR assignments of prochiral methyl groups...
  2. pmc Parallel screening and optimization of protein constructs for structural studies
    Rodolfo M Rasia
    Institut de Biologie Structurale Jean Pierre Ebel, Centre National de la Recherche Scientifique, Universite Joseph Fourier, Grenoble, France
    Protein Sci 18:434-9. 2009
    ..Our approach, which is equally applicable for manual or automated implementation, offers an efficient way to identify and optimize protein constructs for NMR or X-ray crystallographic investigations...
  3. doi Direct detection of CH/pi interactions in proteins
    Michael J Plevin
    CEA, Institut de Biologie Structurale Jean Pierre Ebel, Grenoble, France
    Nat Chem 2:466-71. 2010
    ....
  4. doi Characterization of a conserved "threonine clasp" in CAP-Gly domains: role of a functionally critical OH/pi interaction in protein recognition
    Michael J Plevin
    Division of Signaling Biology, Ontario Cancer Institute, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada
    J Am Chem Soc 130:14918-9. 2008
    ..The OH/pi interaction is part of a TxFxxxxW motif that comprises a conserved "threonine clasp" that defines function in CAP-Gly domains...
  5. doi Biochemical and structural characterization of an intramolecular interaction in FOXO3a and its binding with p53
    Feng Wang
    Division of Signaling Biology, Ontario Cancer Institute, Toronto, Ontario, Canada M5G 2M9
    J Mol Biol 384:590-603. 2008
    ..We also show that p53 disrupts the intramolecular interaction between FH and CR3. These results provide evidence for interplay of the FH and CR3 domains in association with p53...
  6. doi Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry
    Peter B Stathopulos
    Division of Signaling Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Toronto, Ontario M5G 1L7, Canada
    Cell 135:110-22. 2008
    ..We provide atomic resolution insight into the molecular basis for STIM1-mediated SOCE initiation and show that the folded/unfolded state of the Ca2+-sensing region of STIM is crucial to SOCE regulation...
  7. doi An optimized isotopic labelling strategy of isoleucine-γ2 methyl groups for solution NMR studies of high molecular weight proteins
    Isabel Ayala
    CNRS, Institut de Biologie Structurale, Grenoble, France
    Chem Commun (Camb) 48:1434-6. 2012
    ..The (2)H, (13)C-pattern of the biosynthetic precursor has been designed to optimize magnetization transfer, in large proteins, between these important structural probes and their corresponding backbone nuclei...
  8. ncbi Stored Ca2+ depletion-induced oligomerization of stromal interaction molecule 1 (STIM1) via the EF-SAM region: An initiation mechanism for capacitive Ca2+ entry
    Peter B Stathopulos
    Division of Signaling Biology and Department of Medical Biophysics, Ontario Cancer Institute and University of Toronto, Toronto M5G 1L7, Ontario, Canada
    J Biol Chem 281:35855-62. 2006
    ..The low Ca2+ affinity of EF-SAM is reconciled with the confirmed role of STIM1 as an ER Ca2+ sensor...
  9. ncbi CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1
    Ikuko Hayashi
    Division of Signaling Biology, Ontario Cancer Institute, University of Toronto, 101 College Street, Toronto, Ontario, M5G 1L7, Canada
    Nat Struct Mol Biol 14:980-1. 2007
    ..Our data thus demonstrate that regulation of microtubule dynamics by plus end-tracking proteins (+TIPs) occurs through direct competition between homologous binding interfaces...
  10. pmc The acute myeloid leukemia fusion protein AML1-ETO targets E proteins via a paired amphipathic helix-like TBP-associated factor homology domain
    Michael J Plevin
    Division of Signaling Biology, Ontario Cancer Institute, University Health Network, Canada
    Proc Natl Acad Sci U S A 103:10242-7. 2006
    ..Together, these findings imply that a cofactor exchange mechanism, analogous to that described for E protein inhibition, may represent a common mode of action for ETO...
  11. doi A systematic mutagenesis-driven strategy for site-resolved NMR studies of supramolecular assemblies
    Carlos Amero
    Institut de Biologie Structurale Jean Pierre Ebel, CNRS, Grenoble, France
    J Biomol NMR 50:229-36. 2011
    ..The utility of this general and straightforward strategy is demonstrated through the characterization of intermolecular interactions involving a 468-kDa multimeric aminopeptidase, PhTET2...
  12. doi Characterization of the intrinsic and TSC2-GAP-regulated GTPase activity of Rheb by real-time NMR
    Christopher B Marshall
    Division of Signaling Biology, Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada M5G 2M9
    Sci Signal 2:ra3. 2009
    ..Most, but not all, of the disease-associated GTPase-activating protein (GAP) domain mutants of TSC2 that we examined affected its enzymatic activity. This method can now be applied to study the function and regulation of other GTPases...
  13. doi Backbone resonance assignments of the micro-RNA precursor binding region of human TRBP
    Matthieu P M H Benoit
    Institut de Biologie Structurale Jean Pierre Ebel, CEA, 41, rue Jules Horowitz, 38027 Grenoble, France
    Biomol NMR Assign 7:229-33. 2013
    ..TRBP contains 3 double-stranded RNA binding domains the first two of which have been shown to interact with miRNA precursors. Here we present the backbone resonance assignments and secondary structure of residues 19-228 of human TRBP2. ..
  14. pmc Crystal structure of type I ryanodine receptor amino-terminal beta-trefoil domain reveals a disease-associated mutation "hot spot" loop
    Fernando J Amador
    Division of Signaling Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 101 College Street, Toronto, ON, Canada M5G 1L7
    Proc Natl Acad Sci U S A 106:11040-4. 2009
    ....
  15. pmc The RNA-binding region of human TRBP interacts with microRNA precursors through two independent domains
    Matthieu P M H Benoit
    CEA, Institut de Biologie Structurale Jean Pierre Ebel, Grenoble, France
    Nucleic Acids Res 41:4241-52. 2013
    ..These data suggest that TRBP could play a role before and after processing of pre-miRNAs by Dicer...
  16. doi iHADAMAC: a complementary tool for sequential resonance assignment of globular and highly disordered proteins
    Sophie Feuerstein
    Institut de Biologie Structurale, Université Grenoble 1, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    J Magn Reson 214:329-34. 2012
    ....
  17. ncbi The LxxLL motif: a multifunctional binding sequence in transcriptional regulation
    Michael J Plevin
    Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario M5G 2M9, Canada
    Trends Biochem Sci 30:66-9. 2005
    ..Several recently reported 3D structures of protein-LxxLL motif complexes and an intriguing novel interaction implicated in leukaemia have further highlighted the diversity and regulatory importance of this seemingly simple motif...