Eva Pebay-Peyroula

Summary

Affiliation: Institut de Biologie Structurale
Country: France

Publications

  1. ncbi request reprint Early structural rearrangements in the photocycle of an integral membrane sensory receptor
    Karl Edman
    Department of Molecular Biotechnology, Chalmers University of Technology, Box 462, S 40530 Gothenburg, Sweden
    Structure 10:473-82. 2002
  2. ncbi request reprint High-resolution structures and dynamics of membrane protein--lipid complexes: a critique
    E Pebay-Peyroula
    IBS, UMR 5075 CEA CNRS UJF, F 38027 Grenoble Cedex 1, France
    Curr Opin Struct Biol 11:427-32. 2001
  3. ncbi request reprint Nucleotide exchange in mitochondria: insight at a molecular level
    Eva Pebay-Peyroula
    Institut de Biologie Structurale, UMR 5075 CEA CNRS Université Joseph Fourier, 41 rue Jules Horowitz, F 38027 Grenoble Cedex 1, France
    Curr Opin Struct Biol 14:420-5. 2004
  4. ncbi request reprint Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
    Eva Pebay-Peyroula
    Institut de Biologie Structurale, UMR 5075 CEA CNRS Université Joseph Fourier, 41 rue Jules Horowitz, F 38027, Grenoble Cedex 1, France
    Nature 426:39-44. 2003
  5. ncbi request reprint Crystal structure of a novel tetrameric complex of agonist-bound ligand-binding domain of Biomphalaria glabrata retinoid X receptor
    Arjan de Groot
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Institut de Biologie Structurale Jean Pierre Ebel UMR 5075, CEA CNRS UJF, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    J Mol Biol 354:841-53. 2005
  6. ncbi request reprint Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domains
    Claire Massenet
    Institut de Biologie Structurale, UMR 5075 CEA CNRS Université Joseph Fourier, Laboratoire des Proteines Membranaires, 41 Rue Jules Horowitz 38027 Grenoble cedex 1, France
    J Biol Chem 280:13752-61. 2005
  7. doi request reprint Assaying the proton transport and regulation of UCP1 using solid supported membranes
    Iulia Blesneac
    Institut de Biologie Structurale, Université Grenoble 1, 38027 Grenoble Cedex 1, France
    Eur Biophys J 41:675-9. 2012
  8. doi request reprint Expression of a chloroplast ATP/ADP transporter in E. coli membranes: behind the Mistic strategy
    Aurelien Deniaud
    CEA, Institut de Biologie Structurale Jean Pierre Ebel, 41 rue Jules Horowitz, F 38027 Grenoble, France
    Biochim Biophys Acta 1808:2059-66. 2011
  9. ncbi request reprint Contamination from an affinity column: an encounter with a new villain in the world of membrane-protein crystallization
    Pankaj Panwar
    CEA, Institut de Biologie Structurale Jean Pierre Ebel, 41 rue Jules Horowitz, 38027 Grenoble, France
    Acta Crystallogr D Biol Crystallogr 68:1272-7. 2012
  10. ncbi request reprint Structural basis for sensory rhodopsin function
    Eva Pebay-Peyroula
    Institut de Biologie Structurale, UMR5075, CEA CNRS Université Joseph Fourier, 41 rue Jules Horowitz, Grenoble, France
    Biochim Biophys Acta 1565:196-205. 2002

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Early structural rearrangements in the photocycle of an integral membrane sensory receptor
    Karl Edman
    Department of Molecular Biotechnology, Chalmers University of Technology, Box 462, S 40530 Gothenburg, Sweden
    Structure 10:473-82. 2002
    ..Comparison with the early structural rearrangements of bacteriorhodopsin illustrates how modifications in the retinal binding pocket of pSRII allow subtle differences in the early relaxation of photoisomerized retinal...
  2. ncbi request reprint High-resolution structures and dynamics of membrane protein--lipid complexes: a critique
    E Pebay-Peyroula
    IBS, UMR 5075 CEA CNRS UJF, F 38027 Grenoble Cedex 1, France
    Curr Opin Struct Biol 11:427-32. 2001
    ..As dynamic methods indicate high exchange rates, the interpretation of structural data requires a detailed knowledge of the specificity, affinity and cooperativity of lipid binding...
  3. ncbi request reprint Nucleotide exchange in mitochondria: insight at a molecular level
    Eva Pebay-Peyroula
    Institut de Biologie Structurale, UMR 5075 CEA CNRS Université Joseph Fourier, 41 rue Jules Horowitz, F 38027 Grenoble Cedex 1, France
    Curr Opin Struct Biol 14:420-5. 2004
    ..The analysis of residues located in the cavity hints at the mechanism of binding of adenine nucleotides. Additionally, the presence of conserved proline residues in three sharply kinked helices suggests a translocation mechanism...
  4. ncbi request reprint Structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside
    Eva Pebay-Peyroula
    Institut de Biologie Structurale, UMR 5075 CEA CNRS Université Joseph Fourier, 41 rue Jules Horowitz, F 38027, Grenoble Cedex 1, France
    Nature 426:39-44. 2003
    ..Our structure, together with earlier biochemical results, suggests that transport substrates bind to the bottom of the cavity and that translocation results from a transient transition from a 'pit' to a 'channel' conformation...
  5. ncbi request reprint Crystal structure of a novel tetrameric complex of agonist-bound ligand-binding domain of Biomphalaria glabrata retinoid X receptor
    Arjan de Groot
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Institut de Biologie Structurale Jean Pierre Ebel UMR 5075, CEA CNRS UJF, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    J Mol Biol 354:841-53. 2005
    ..This novel holo-tetramer configuration may have a biological role in activating genes whose promoters are poorly recognised by dimers but much more efficiently by the corresponding tetramers...
  6. ncbi request reprint Effects of p47phox C terminus phosphorylations on binding interactions with p40phox and p67phox. Structural and functional comparison of p40phox and p67phox SH3 domains
    Claire Massenet
    Institut de Biologie Structurale, UMR 5075 CEA CNRS Université Joseph Fourier, Laboratoire des Proteines Membranaires, 41 Rue Jules Horowitz 38027 Grenoble cedex 1, France
    J Biol Chem 280:13752-61. 2005
    ..Other mechanisms than a phosphorylation induced switch between the two SH3 must therefore take place for NADPH oxidase activation cascade to start...
  7. doi request reprint Assaying the proton transport and regulation of UCP1 using solid supported membranes
    Iulia Blesneac
    Institut de Biologie Structurale, Université Grenoble 1, 38027 Grenoble Cedex 1, France
    Eur Biophys J 41:675-9. 2012
    ....
  8. doi request reprint Expression of a chloroplast ATP/ADP transporter in E. coli membranes: behind the Mistic strategy
    Aurelien Deniaud
    CEA, Institut de Biologie Structurale Jean Pierre Ebel, 41 rue Jules Horowitz, F 38027 Grenoble, France
    Biochim Biophys Acta 1808:2059-66. 2011
    ..Therefore, considering the higher quantity of purified NTT1 mature form obtained via the Mistic fusion approach, this is a valuable strategy for obtaining quantities of pure and active proteins that are adequate for structural studies...
  9. ncbi request reprint Contamination from an affinity column: an encounter with a new villain in the world of membrane-protein crystallization
    Pankaj Panwar
    CEA, Institut de Biologie Structurale Jean Pierre Ebel, 41 rue Jules Horowitz, 38027 Grenoble, France
    Acta Crystallogr D Biol Crystallogr 68:1272-7. 2012
    ..The small crystals of contaminant protein led to the structure at 1.9 Å resolution of Strep-Tactin in complex with desthiobiotin...
  10. ncbi request reprint Structural basis for sensory rhodopsin function
    Eva Pebay-Peyroula
    Institut de Biologie Structurale, UMR5075, CEA CNRS Université Joseph Fourier, 41 rue Jules Horowitz, Grenoble, France
    Biochim Biophys Acta 1565:196-205. 2002
    ..Future investigations using time-resolved crystallography, structural dynamics, and computational studies will provide the basis to unveil the molecular mechanisms of sensory receptors-mediated transmembrane signaling...
  11. doi request reprint Impaired transport of nucleotides in a mitochondrial carrier explains severe human genetic diseases
    Stephanie Ravaud
    Université Grenoble, IBS, Institut de Biologie Structurale, Grenoble, France
    ACS Chem Biol 7:1164-9. 2012
    ....
  12. doi request reprint Production of UCP1 a membrane protein from the inner mitochondrial membrane using the cell free expression system in the presence of a fluorinated surfactant
    Iulia Blesneac
    Université Grenoble 1, Institut de Biologie Structurale, Grenoble Cedex 1, France
    Biochim Biophys Acta 1818:798-805. 2012
    ..Further biochemical and biophysical analysis such as size exclusion chromatography, circular dichroism and thermal stability, of the purified protein showed that the protein is non-aggregated, monodisperse and well-folded...
  13. doi request reprint Mitochondrial bovine ADP/ATP carrier in detergent is predominantly monomeric but also forms multimeric species
    Hugues Nury
    CEA, DSV, and CNRS and Universite Joseph Fourier, Institut de Biologie Structurale, 41 rue Jules Horowitz, F 38027, Grenoble, France
    Biochemistry 47:12319-31. 2008
    ....
  14. ncbi request reprint Crystal structure of the oxidized form of the periplasmic mercury-binding protein MerP from Ralstonia metallidurans CH34
    Laurence Serre
    Institut de Biologie Structurale, UMR 5075 CNRS CEA UJF IBS LPM, 41 Avenue Jules Horowitz, 38027 Grenoble Cedex 01, France
    J Mol Biol 339:161-71. 2004
    ..We propose a possible mechanism of mercury transfer between two CXXC motifs based on a transient bi-coordinated mercury intermediate...
  15. ncbi request reprint Detection and characterization of merohedral twinning in two protein crystals: bacteriorhodopsin and p67(phox)
    Antoine Royant
    Institut de Biologie Structurale, CEA CNRS Université Joseph Fourier UMR5075, 41 rue Jules Horowitz, F 38027 Grenoble Cedex 1, France
    Acta Crystallogr D Biol Crystallogr 58:784-91. 2002
    ..Second-, third- and fourth-order moments of the intensity distribution are useful indicators for evaluating the twinning precisely in order to correct the intensities or to screen rapidly for non-twinned crystals...
  16. ncbi request reprint Heavy-atom derivatives in lipidic cubic phases: results on hen egg-white lysozyme tetragonal derivative crystals with Gd-HPDO3A complex
    Eric Girard
    Institut de Biologie Structurale J P Ebel CEA CNRS UJF, UMR 5075, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    Acta Crystallogr D Biol Crystallogr 60:1506-8. 2004
    ..Further studies with membrane proteins that are known to crystallize in lipidic cubic phases will be undertaken with Gd-HPDO3A and other Gd complexes to test whether derivative crystals with high Gd-site occupancies can be obtained...
  17. ncbi request reprint Drosophila nuclear receptor E75 is a thiolate hemoprotein
    Eve de Rosny
    CEA, CNRS, UJF, UMR 5075, Institut de Biologie Structurale Jean Pierre Ebel, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France
    Biochemistry 45:9727-34. 2006
    ..The other iron coordination pairs are discussed. We conclude that E75 is a new example of a thiolate hemoprotein and that it may be involved in hormone synthesis regulation...
  18. ncbi request reprint Determining membrane protein structures: still a challenge!
    Jean Jacques Lacapere
    INSERM, U773, Centre de Recherche Biomedicale Bichat Beaujon CRB3, Faculte de Medecine X Bichat, Universite Paris 7, BP 416, F 75018, Paris, France
    Trends Biochem Sci 32:259-70. 2007
    ..Progress in this field will improve knowledge of ligand-induced activation and inhibition of membrane proteins in addition to aiding the design of membrane-protein-targeted drugs...
  19. ncbi request reprint Valine 181 is critical for the nucleotide exchange activity of human mitochondrial ADP/ATP carriers in yeast
    Carine De Marcos Lousa
    Laboratoire de Physiologie Moléculaire et Cellulaire, IBGC CNRS, UMR 5095, 1 rue Camille Saint Saens, 33077 Bordeaux Cedex, France
    Biochemistry 44:4342-8. 2005
    ..These results are discussed in the light of the bovine Ancp structure, that shares more than 90% amino acid identity with Hancps, and its interaction with the lipid environment...
  20. ncbi request reprint Crystallization of the bovine ADP/ATP carrier is critically dependent upon the detergent-to-protein ratio
    Cécile Dahout-Gonzalez
    Laboratoire de Biochimie et Biophysique des Systemes Integres, UMR 5092 CEA CNRS Université Joseph Fourier, Departement de Reponse et Dynamique Cellulaires, CEA Grenoble, 17 Avenue des Martyrs, F 38054 Grenoble Cedex 9, France
    Acta Crystallogr D Biol Crystallogr 59:2353-5. 2003
    ..High-quality crystals were only obtained when excess detergent was removed to reach a controlled detergent-to-protein ratio...
  21. ncbi request reprint Deformation of helix C in the low temperature L-intermediate of bacteriorhodopsin
    Karl Edman
    Department of Chemistry and Bioscience, Chalmers University of Technology, Box 462, S 40530 Gothenburg, Sweden
    J Biol Chem 279:2147-58. 2004
    ..Implications regarding the structural mechanism for proton pumping by bacteriorhodopsin are discussed...
  22. ncbi request reprint X-ray spectroscopy and X-ray diffraction at wavelengths near the K-absorption edge of phosphorus
    Valerie Biou
    Laboratoire d Enzymologie et de Biochimie Structurales CNRS, Avenue de la Terrasse, 91198 Gif sur Yvette Cedex, France
    J Synchrotron Radiat 12:402-9. 2005
    ..Various techniques of crystal mounting were attempted. In addition, fluorescence measurements on a solution of threonine synthase appear to hint at a change of the phosphate environment of the cofactor upon activator binding...
  23. ncbi request reprint Structural and mechanistic insight from high resolution structures of archaeal rhodopsins
    Ehud M Landau
    Membrane Protein Laboratory, Sealy Center for Structural Biology, and Department of Physiology and Biophysics, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555 0437, USA
    FEBS Lett 555:51-6. 2003
    ..Fundamental principles of energy transduction and sensory reception in the archaeal rhodopsins, which may have relevance to other systems, are discussed...
  24. pmc Electron microscopic evidence for nucleation and growth of 3D acetylcholine receptor microcrystals in structured lipid-detergent matrices
    Yoav Paas
    Recepteurs et Cognition, Unité de Recherche Associée 2182, Centre National de la Recherche Scientifique, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 100:11309-14. 2003
    ..The latter are stable in detergent-containing aqueous solutions and can currently be used for seeding and epitaxial growth, en route to crystals of appropriate dimensions for x-ray diffraction studies...
  25. ncbi request reprint Bacteriorhodopsin: a high-resolution structural view of vectorial proton transport
    Richard Neutze
    Department of Molecular Biotechnology, Chalmers University of Technology, Box 462, Goteborg, Sweden
    Biochim Biophys Acta 1565:144-67. 2002
    ....