Maria Carla Parrini

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. ncbi request reprint Spatiotemporal regulation of the Pak1 kinase
    M C Parrini
    Inserm U528, Institut Curie, Section de Recherche, 26 Rue d Ulm, 75005 Paris, France
    Biochem Soc Trans 33:646-8. 2005
  2. pmc Dissecting activation of the PAK1 kinase at protrusions in living cells
    Maria Carla Parrini
    Institut Curie, Centre de Recherche, Paris, France
    J Biol Chem 284:24133-43. 2009
  3. pmc SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility
    Maria Carla Parrini
    Institut Curie, Centre de Recherche, Paris F 75248, France
    Mol Cell 42:650-61. 2011
  4. doi request reprint Automated velocity mapping of migrating cell populations (AVeMap)
    Maxime Deforet
    Laboratoire Physico Chimie Curie, Unité Mixte de Recherche 168, Centre de Recherche, Institut Curie, Centre National de la Recherche Scientifique, et Université Pierre et Marie Curie, Paris, France
    Nat Methods 9:1081-3. 2012
  5. pmc RalB mobilizes the exocyst to drive cell migration
    Carine Rosse
    Institut Curie, Inserm U528, Transduction Networks Analysis Group, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Mol Cell Biol 26:727-34. 2006
  6. pmc Cell motility: The necessity of Rac1 GDP/GTP flux
    Maria Carla Parrini
    Institut Curie, Centre de Recherche, Inserm U830 Paris, France
    Commun Integr Biol 4:772-4. 2011
  7. ncbi request reprint Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
    M Lei
    Laboratory of Molecular Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Cell 102:387-97. 2000

Collaborators

  • Charles Yeaman
  • Philippe Chavrier
  • Kazuhiro Aoki
  • Maxime Deforet
  • Jacques Camonis
  • Carine Rosse
  • Laurence Petitjean
  • Marco Biondini
  • Pascal Silberzan
  • Axel Buguin
  • M Lei
  • Michael A White
  • Anastassia Hatzoglou
  • B J Mayer
  • M J Eck
  • W Meng
  • S C Harrison
  • W Lu

Detail Information

Publications7

  1. ncbi request reprint Spatiotemporal regulation of the Pak1 kinase
    M C Parrini
    Inserm U528, Institut Curie, Section de Recherche, 26 Rue d Ulm, 75005 Paris, France
    Biochem Soc Trans 33:646-8. 2005
    ..Cutting edge microscopy technologies on living cells are finally shedding light on the intricate spatiotemporal mechanisms regulating Pak1...
  2. pmc Dissecting activation of the PAK1 kinase at protrusions in living cells
    Maria Carla Parrini
    Institut Curie, Centre de Recherche, Paris, France
    J Biol Chem 284:24133-43. 2009
    ..This study leads to a model for the complex and accurate regulation of PAK1 kinase in vivo at cell protrusions...
  3. pmc SH3BP1, an exocyst-associated RhoGAP, inactivates Rac1 at the front to drive cell motility
    Maria Carla Parrini
    Institut Curie, Centre de Recherche, Paris F 75248, France
    Mol Cell 42:650-61. 2011
    ..Our finding that SH3BP1 downregulates Rac1 at the motile-cell front indicates that Rac1 inactivation in this location, as well as its activation by GEF proteins, is a fundamental requirement for cell motility...
  4. doi request reprint Automated velocity mapping of migrating cell populations (AVeMap)
    Maxime Deforet
    Laboratoire Physico Chimie Curie, Unité Mixte de Recherche 168, Centre de Recherche, Institut Curie, Centre National de la Recherche Scientifique, et Université Pierre et Marie Curie, Paris, France
    Nat Methods 9:1081-3. 2012
    ..This method allows for the computation of quantitative migration parameters via an extensive dynamic mapping of cell displacements...
  5. pmc RalB mobilizes the exocyst to drive cell migration
    Carine Rosse
    Institut Curie, Inserm U528, Transduction Networks Analysis Group, 26 Rue d Ulm, 75248 Paris Cedex 05, France
    Mol Cell Biol 26:727-34. 2006
    ..We propose that RalB regulation of exocyst function is required for the coordinated delivery of secretory vesicles to the sites of dynamic plasma membrane expansion that specify directional movement...
  6. pmc Cell motility: The necessity of Rac1 GDP/GTP flux
    Maria Carla Parrini
    Institut Curie, Centre de Recherche, Inserm U830 Paris, France
    Commun Integr Biol 4:772-4. 2011
    ..The future challenge is to understand why the GTPase flux is so important for the biological actions of Rho GTPases...
  7. ncbi request reprint Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
    M Lei
    Laboratory of Molecular Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Cell 102:387-97. 2000
    ..GTPase binding will refold part of the IS domain and unfold the rest. A related switch has been seen in the Wiskott-Aldrich syndrome protein (WASP)...