Eric Pailhoux

Summary

Affiliation: Institut National de la Recherche Agronomique
Country: France

Publications

  1. ncbi request reprint Time course of female-to-male sex reversal in 38,XX fetal and postnatal pigs
    E Pailhoux
    Unité de Biologie du Développement et Biotechnologies, INRA, Jouy en Josas, France
    Dev Dyn 222:328-40. 2001
  2. ncbi request reprint Mammalian gonadal differentiation: the pig model
    E Pailhoux
    Unité de Biologie du Développement et Biotechnologies, Bâtiment J Poly INRA, 78350 Jouy en Josas, France
    Reprod Suppl 58:65-80. 2001
  3. ncbi request reprint Ontogenesis of female-to-male sex-reversal in XX polled goats
    Eric Pailhoux
    laboratoire de biologie du développement et biotechnologies, INRA Bâtiment J Poly, 78350 Jouy en Josas, France
    Dev Dyn 224:39-50. 2002
  4. pmc TOPAZ1, a novel germ cell-specific expressed gene conserved during evolution across vertebrates
    Adrienne Baillet
    INRA, UMR 1198 Biologie du Developpement et Reproduction, Jouy en Josas, France
    PLoS ONE 6:e26950. 2011
  5. pmc Gonad differentiation in the rabbit: evidence of species-specific features
    Nathalie Daniel-Carlier
    UMR 1198, Biologie du Developpement et Reproduction, Institut National de la Recherche Agronomique, Jouy en Josas, France
    PLoS ONE 8:e60451. 2013
  6. doi request reprint R-spondin1 is required for normal epithelial morphogenesis during mammary gland development
    Sead Chadi
    INRA, UMR1313 Genetique Animale et Biologie Integrative, F 78350 Jouy en Josas, France
    Biochem Biophys Res Commun 390:1040-3. 2009
  7. doi request reprint A study of goat SRY protein expression suggests putative new roles for this gene in the developing testis of a species with long-lasting SRY expression
    Fatemeh Montazer-Torbati
    INRA, Biologie du Développement et Reproduction Bât J Poly, Jouy en Josas, France
    Dev Dyn 239:3324-35. 2010
  8. pmc Novel insights into the bovine polled phenotype and horn ontogenesis in Bovidae
    Aurélie Allais-Bonnet
    Institut National de la Recherche Agronomique, UMR 1198 Biologie du Developpement et Reproduction, Jouy en Josas, France
    PLoS ONE 8:e63512. 2013
  9. ncbi request reprint Goat RSPO1 over-expression rescues sex-reversal in Rspo1-knockout XX mice but does not perturb testis differentiation in XY or sex-reversed XX mice
    Laurine Buscara
    UR339, Laboratoire de Génétique Biochimique et de Cytogénétique, Institut National de la Recherche Agronomique, 78350, Jouy en Josas, France
    Transgenic Res 18:649-54. 2009
  10. ncbi request reprint FOXL2 activates P450 aromatase gene transcription: towards a better characterization of the early steps of mammalian ovarian development
    Maelle Pannetier
    Biologie du Développement et de la Reproduction UMR 1198 INRA ENVA, Bât J Poly, 78350 Jouy en Josas, France
    J Mol Endocrinol 36:399-413. 2006

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Time course of female-to-male sex reversal in 38,XX fetal and postnatal pigs
    E Pailhoux
    Unité de Biologie du Développement et Biotechnologies, INRA, Jouy en Josas, France
    Dev Dyn 222:328-40. 2001
    ....
  2. ncbi request reprint Mammalian gonadal differentiation: the pig model
    E Pailhoux
    Unité de Biologie du Développement et Biotechnologies, Bâtiment J Poly INRA, 78350 Jouy en Josas, France
    Reprod Suppl 58:65-80. 2001
    ..Identification of the genes involved in this pathology will improve our knowledge of mammalian gonadal differentiation and may allow the eradication of this genetic disease in pigs...
  3. ncbi request reprint Ontogenesis of female-to-male sex-reversal in XX polled goats
    Eric Pailhoux
    laboratoire de biologie du développement et biotechnologies, INRA Bâtiment J Poly, 78350 Jouy en Josas, France
    Dev Dyn 224:39-50. 2002
    ..These observations indicated that the causal mutation of PIS acts very early in the sex-determining cascade and affects primarily the supporting cells of the gonad...
  4. pmc TOPAZ1, a novel germ cell-specific expressed gene conserved during evolution across vertebrates
    Adrienne Baillet
    INRA, UMR 1198 Biologie du Developpement et Reproduction, Jouy en Josas, France
    PLoS ONE 6:e26950. 2011
    ..Some of these transcripts might be potential new oocyte and granulosa cell markers. We have now characterized one of them, named TOPAZ1 for the Testis and Ovary-specific PAZ domain gene...
  5. pmc Gonad differentiation in the rabbit: evidence of species-specific features
    Nathalie Daniel-Carlier
    UMR 1198, Biologie du Developpement et Reproduction, Institut National de la Recherche Agronomique, Jouy en Josas, France
    PLoS ONE 8:e60451. 2013
    ..This was probably a consequence of the synchronous strong NANOS2 gene expression in XY gonad. In conclusion, our data highlighted some rabbit-specific findings with respect to the gonad differentiation process...
  6. doi request reprint R-spondin1 is required for normal epithelial morphogenesis during mammary gland development
    Sead Chadi
    INRA, UMR1313 Genetique Animale et Biologie Integrative, F 78350 Jouy en Josas, France
    Biochem Biophys Res Commun 390:1040-3. 2009
    ..Our data demonstrate that local epithelial Rspo1 signalling is required for normal development of the mammary gland...
  7. doi request reprint A study of goat SRY protein expression suggests putative new roles for this gene in the developing testis of a species with long-lasting SRY expression
    Fatemeh Montazer-Torbati
    INRA, Biologie du Développement et Reproduction Bât J Poly, Jouy en Josas, France
    Dev Dyn 239:3324-35. 2010
    ..Our data indicate that in goat, the role of SRY may not be limited to testis determination and could have other functions in testicular maintenance and hence male fertility...
  8. pmc Novel insights into the bovine polled phenotype and horn ontogenesis in Bovidae
    Aurélie Allais-Bonnet
    Institut National de la Recherche Agronomique, UMR 1198 Biologie du Developpement et Reproduction, Jouy en Josas, France
    PLoS ONE 8:e63512. 2013
    ..Our results represent a first and important step in understanding the genetic pathways and key process involved in horn bud differentiation in Bovidae...
  9. ncbi request reprint Goat RSPO1 over-expression rescues sex-reversal in Rspo1-knockout XX mice but does not perturb testis differentiation in XY or sex-reversed XX mice
    Laurine Buscara
    UR339, Laboratoire de Génétique Biochimique et de Cytogénétique, Institut National de la Recherche Agronomique, 78350, Jouy en Josas, France
    Transgenic Res 18:649-54. 2009
    ..On the contrary, over-expression of gRSPO1 within a mSRY or a gSRY-XX genotypes did not interfere with the SRY-induced male phenotype...
  10. ncbi request reprint FOXL2 activates P450 aromatase gene transcription: towards a better characterization of the early steps of mammalian ovarian development
    Maelle Pannetier
    Biologie du Développement et de la Reproduction UMR 1198 INRA ENVA, Bât J Poly, 78350 Jouy en Josas, France
    J Mol Endocrinol 36:399-413. 2006
    ..This period, of 20 days in goat, seems to have no equivalent in mouse. This species-specific difference could explain the phenotype discrepancy observed between XX goat PIS(-/-) and XX mouse Foxl2(-/-)...
  11. ncbi request reprint Goat SRY induces testis development in XX transgenic mice
    Maelle Pannetier
    INRA, Biologie du Developpement et Reproduction, Bât J Poly, 78350 Jouy en Josas, France
    FEBS Lett 580:3715-20. 2006
    ..Our results demonstrate that sex-reversal can be induced in XX-mice by a non-mouse SRY thus suggesting a conserved molecular mechanism of action of this testis-determining gene across mammalian species...
  12. pmc R-spondin1 and FOXL2 act into two distinct cellular types during goat ovarian differentiation
    Ayhan Kocer
    INRA, UMR 1198, ENVA, CNRS, FRE 2857, Biologie du Développement et de la Reproduction, Jouy en Josas, F 78350, France
    BMC Dev Biol 8:36. 2008
    ..Furthermore, since functional redundancy between different R-spondins may influence gonad development, we also studied the expression patterns of RSPO2, 3 and 4...
  13. ncbi request reprint Ovarian-specific expression of a new gene regulated by the goat PIS region and transcribed by a FOXL2 bidirectional promoter
    Maelle Pannetier
    Biologie du Développement et de la Reproduction, Institut National de la Recherche Agronomique, Bât J Poly, 78350 Jouy en Josas, France
    Genomics 85:715-26. 2005
    ..Finally, we discuss evidence arguing for regulation of the level of FOXL2 transcription via the bidirectional promoter and the level of transcription of PFOXic...
  14. doi request reprint Loss of R-spondin1 and Foxl2 amplifies female-to-male sex reversal in XX mice
    A Auguste
    INRA, UMR 1198, Biologie du Développement et de la Reproduction, Jouy en Josas, France
    Sex Dev 5:304-17. 2011
    ..Ectopic development of the steroidogenic lineage is more pronounced in XX Foxl2(-/-)/Rspo1(-/-) gonads than in XX Rspo1(-/-) embryos, suggesting that Foxl2 is involved in preventing ectopic steroidogenesis in foetal ovaries...
  15. doi request reprint [Sex differentiation: state of the art and future prospects]
    Maelle Pannetier
    INRA, UMR1198 Biologie du développement et de la reproduction, Bâtiment J Poly, Jouy en Josas, France
    Med Sci (Paris) 27:859-65. 2011
    ..Existing differences between the widely used mouse model and other mammals, such as human and goat, will be highlighted...
  16. doi request reprint FOXL2 is a female sex-determining gene in the goat
    Laurent Boulanger
    INRA, UMR 1198 Biologie du Developpement et Reproduction, 78350 Jouy en Josas, France
    Curr Biol 24:404-8. 2014
    ..They also highlight a stage-dependent role of FOXL2 in the ovary, different between goats and mice, being important for fetal development in the former but for postnatal maintenance in the latter...
  17. pmc Identification of transcripts involved in meiosis and follicle formation during ovine ovary development
    Adrienne Baillet
    INRA, ENVA, UMR 1198 Biologie du Developpement et Reproduction, F 78350 Jouy en Josas, France
    BMC Genomics 9:436. 2008
    ..In sheep, these steps occur during fetal life, between 55 and 80 days of gestation, respectively. The aim of this study was to identify differentially expressed ovarian genes during prophase I meiosis and early folliculogenesis in sheep...
  18. ncbi request reprint Isolation of chicken homolog of the FOXL2 gene and comparison of its expression patterns with those of aromatase during ovarian development
    Marina S Govoroun
    Station de Recherches Avicoles, INRA, Nouzilly, France
    Dev Dyn 231:859-70. 2004
    ..A high level of cFoxL2 transcription was also observed in maturing and ovulated oocytes. Our results confirm that FoxL2 is an early regulator of ovarian development in birds and may be involved in aromatase transcription regulation...
  19. pmc Positional cloning of the PIS mutation in goats and its impact on understanding mammalian sex-differentiation
    Eric Pailhoux
    Laboratoire de Biologie du Développement et Reproduction, Institut National de la Recherche Agronomique, 78352 Jouy en Josas Cedex, France
    Genet Sel Evol 37:S55-64. 2005
    ..Under this hypothesis, SRY, the testis-determining factor would inhibit these two genes in the gonads of XY males, to ensure testis differentiation...
  20. doi request reprint Transgenesis applied to goat: current applications and ongoing research
    Laurent Boulanger
    Biologie du Développement et de la Reproduction, Institut National de la Recherche Agronomique, INRA UMR1198, Jouy en Josas, France
    Transgenic Res 21:1183-90. 2012
    ..This short review aims at highlighting the current applications and limitations of the goat genome manipulation...
  21. ncbi request reprint Prnp knockdown in transgenic mice using RNA interference
    Micaela Gallozzi
    UR 339, Laboratoire de Génétique Biochimique et de Cytogénétique, Institut National de la Recherche Agronomique, 78350, Jouy en Josas, France
    Transgenic Res 17:783-91. 2008
    ..This result highlights the potential and limitations of the RNA interference approach when applied to disease resistance...
  22. pmc A 3.7 Mb deletion encompassing ZEB2 causes a novel polled and multisystemic syndrome in the progeny of a somatic mosaic bull
    Aurélien Capitan
    INRA, UMR1313 Genetique Animale et Biologie Integrative, Jouy en Josas, France
    PLoS ONE 7:e49084. 2012
    ..This result sets PMS as a unique model to study sex-specific gene expression/regulation...
  23. ncbi request reprint Molecular genetics of sex determination
    Corinne Cotinot
    Unité de Biologie du Développement et Biotechnologies, INRA, Jouy en Josas, France
    Semin Reprod Med 20:157-68. 2002
    ..In both sexes, genetic analysis of sex-reversed individuals (XX males, XX and XY hermaphrodites, and XY with complete or partial dysgenesis) remains an approach of choice to isolate new genes involved in sex determination...
  24. ncbi request reprint Foxl2 gene and the development of the ovary: a story about goat, mouse, fish and woman
    Daniel Baron
    Equipe Sexualite et Reproduction, INRA SCRIBE, Département PHASE, Campus de Beaulieu, 35042 Rennes Cedex, France
    Reprod Nutr Dev 45:377-82. 2005
    ..Particularly, we developed the study of the FOXL2 gene and its implication in genetic anomalies in goats (PIS mutation) and humans (BPES). We present the expression of FOXL2 in the ovaries of different species...
  25. ncbi request reprint Differential aggregation and functional impairment induced by polyalanine expansions in FOXL2, a transcription factor involved in cranio-facial and ovarian development
    Lara Moumné
    Department of Genetics and Development, INSERM U567, Team21 Genomics and Epigenetics of Placental Diseases, Paris, France
    Hum Mol Genet 17:1010-9. 2008
    ....