S Negrier

Summary

Affiliation: Institut Paoli-Calmettes
Country: France

Publications

  1. ncbi request reprint Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    Robert J Motzer
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    N Engl J Med 356:115-24. 2007
  2. doi request reprint Antiangiogenic treatments and mechanisms of action in renal cell carcinoma
    Sylvie Negrier
    Université de Lyon Centre Léon Bérard, 28 rue Laennec, 69373 Lyon Cedex 08, France
    Invest New Drugs 30:1791-801. 2012
  3. doi request reprint Duration of targeted therapy for metastatic renal cell carcinoma: a review of current practices
    Sylvie Negrier
    Centre Leon Berard, Lyon, France
    Oncology 82:189-96. 2012
  4. ncbi request reprint [Treatment planning visit in oncology: factors predictive of satisfaction with the meeting with the physician and benefits of a second interview with a nurse]
    Sylvie Negrier
    Departement d Oncologie Medicale, Centre Leon Berard, Lyon Cedex
    Presse Med 36:779-85. 2007
  5. ncbi request reprint Medroxyprogesterone, interferon alfa-2a, interleukin 2, or combination of both cytokines in patients with metastatic renal carcinoma of intermediate prognosis: results of a randomized controlled trial
    Sylvie Negrier
    Universite de Lyon, Department of Medical Oncology and Cytokines and Cancer Research Unit, Leon Berard Center, INSERM U590, Lyon, France
    Cancer 110:2468-77. 2007
  6. ncbi request reprint Prognostic factors of response or failure of treatment in patients with metastatic renal carcinomas treated by cytokines: a report from the Groupe Français d'Immunothérapie
    Sylvie Negrier
    Department of Biostatistics, Centre Leon Berard, 28 rue Laennec, 69373 Lyon Cedex 08 France
    World J Urol 23:161-5. 2005
  7. doi request reprint Efficacy and safety of sorafenib in patients with advanced renal cell carcinoma with and without prior cytokine therapy, a subanalysis of TARGET
    S Negrier
    Centre Leon Berard and Claude Bernard University, 28 rue Laennec, Lyon, 69008, France
    Med Oncol 27:899-906. 2010
  8. ncbi request reprint Interleukin-6, interleukin-10, and vascular endothelial growth factor in metastatic renal cell carcinoma: prognostic value of interleukin-6--from the Groupe Francais d'Immunotherapie
    Sylvie Negrier
    Cytokines and Cancer Research Unit, INSERM U 590 and Medical Oncology Department, Cedex 08, France
    J Clin Oncol 22:2371-8. 2004
  9. ncbi request reprint [Metastatic kidney cancer: new therapeutic approaches]
    Sylvie Negrier
    Departement d Oncologie Medicale, Centre Leon Berard, 28, rue Laennec, 69373 Lyon, France
    Prog Urol 12:703-8. 2002
  10. ncbi request reprint Prognostic factors of survival and rapid progression in 782 patients with metastatic renal carcinomas treated by cytokines: a report from the Groupe Français d'Immunothérapie
    S Negrier
    Departments of Biostatistics and Medicine, Centre Leon Berard, Lyon, France
    Ann Oncol 13:1460-8. 2002

Detail Information

Publications39

  1. ncbi request reprint Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
    Robert J Motzer
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    N Engl J Med 356:115-24. 2007
    ..Since sunitinib malate has shown activity in two uncontrolled studies in patients with metastatic renal-cell carcinoma, a comparison of the drug with interferon alfa in a phase 3 trial is warranted...
  2. doi request reprint Antiangiogenic treatments and mechanisms of action in renal cell carcinoma
    Sylvie Negrier
    Université de Lyon Centre Léon Bérard, 28 rue Laennec, 69373 Lyon Cedex 08, France
    Invest New Drugs 30:1791-801. 2012
    ..In this article, we consider the modes of action of these targeted agents and their differing target receptor profiles and we also evaluate how these correlate with their clinical efficacy and tolerability profiles...
  3. doi request reprint Duration of targeted therapy for metastatic renal cell carcinoma: a review of current practices
    Sylvie Negrier
    Centre Leon Berard, Lyon, France
    Oncology 82:189-96. 2012
    ..In addition, practical strategies for achieving optimal treatment duration, through adverse event management, are discussed...
  4. ncbi request reprint [Treatment planning visit in oncology: factors predictive of satisfaction with the meeting with the physician and benefits of a second interview with a nurse]
    Sylvie Negrier
    Departement d Oncologie Medicale, Centre Leon Berard, Lyon Cedex
    Presse Med 36:779-85. 2007
    ..This is why a specific process, the so-called "diagnosis disclosure visit", is included in the management protocol for cancer patients. The distress engendered by the news may, however, hinder the information process...
  5. ncbi request reprint Medroxyprogesterone, interferon alfa-2a, interleukin 2, or combination of both cytokines in patients with metastatic renal carcinoma of intermediate prognosis: results of a randomized controlled trial
    Sylvie Negrier
    Universite de Lyon, Department of Medical Oncology and Cytokines and Cancer Research Unit, Leon Berard Center, INSERM U590, Lyon, France
    Cancer 110:2468-77. 2007
    ..The Programme Etude Rein Cytokines (PERCY) Quattro trial was designed to evaluate both cytokines for their survival benefit to intermediate prognosis patients, who represent the majority of candidates for these treatments...
  6. ncbi request reprint Prognostic factors of response or failure of treatment in patients with metastatic renal carcinomas treated by cytokines: a report from the Groupe Français d'Immunothérapie
    Sylvie Negrier
    Department of Biostatistics, Centre Leon Berard, 28 rue Laennec, 69373 Lyon Cedex 08 France
    World J Urol 23:161-5. 2005
    ..Patients who combine at least three of these factors have over 80% probability of rapid progression despite treatment. We think that these results must be taken into account for cytokine treatment decision...
  7. doi request reprint Efficacy and safety of sorafenib in patients with advanced renal cell carcinoma with and without prior cytokine therapy, a subanalysis of TARGET
    S Negrier
    Centre Leon Berard and Claude Bernard University, 28 rue Laennec, Lyon, 69008, France
    Med Oncol 27:899-906. 2010
    ....
  8. ncbi request reprint Interleukin-6, interleukin-10, and vascular endothelial growth factor in metastatic renal cell carcinoma: prognostic value of interleukin-6--from the Groupe Francais d'Immunotherapie
    Sylvie Negrier
    Cytokines and Cancer Research Unit, INSERM U 590 and Medical Oncology Department, Cedex 08, France
    J Clin Oncol 22:2371-8. 2004
    ..Our objective was to analyze the prognostic value of circulating vascular endothelial growth factor (VEGF), interleukin-10 (IL-10), and interleukin-6 (IL-6)...
  9. ncbi request reprint [Metastatic kidney cancer: new therapeutic approaches]
    Sylvie Negrier
    Departement d Oncologie Medicale, Centre Leon Berard, 28, rue Laennec, 69373 Lyon, France
    Prog Urol 12:703-8. 2002
    ..Finally, various molecules with promising antiangiogenic properties are currently under development in renal cancer...
  10. ncbi request reprint Prognostic factors of survival and rapid progression in 782 patients with metastatic renal carcinomas treated by cytokines: a report from the Groupe Français d'Immunothérapie
    S Negrier
    Departments of Biostatistics and Medicine, Centre Leon Berard, Lyon, France
    Ann Oncol 13:1460-8. 2002
    ..Patients who combined at least three of these factors have >80% probability of rapid progression despite treatment. We think that these results must be taken into account when making the decision to treat with cytokine...
  11. ncbi request reprint [Interleukin-2 and interferon in metastatic kidney cancer. Experience of the French Immunotherapy Group]
    Sylvie Negrier
    Departement d Oncologie Medicale, Centre Leon Berard, 28, rue Laennec, 69373 Lyon
    Prog Urol 12:213-8. 2002
    ..c. cytokine regimens are therefore fairly disappointing. These results were taken into account in the ongoing evaluation programme (Percy programme) based on patient selection as a function of prognostic factors...
  12. ncbi request reprint Treatment of patients with metastatic renal carcinoma with a combination of subcutaneous interleukin-2 and interferon alfa with or without fluorouracil. Groupe Français d'Immunothérapie, Fédération Nationale des Centres de Lutte Contre le Cancer
    S Negrier
    Centre L BERARD, Lyon, France
    J Clin Oncol 18:4009-15. 2000
    ..Most results, coming from noncontrolled phase II trials, showed inconsistent rates of response. More recently, the addition of fluorouracil (FU) was proposed to improve the efficacy of these regimens...
  13. doi request reprint Temsirolimus and bevacizumab, or sunitinib, or interferon alfa and bevacizumab for patients with advanced renal cell carcinoma (TORAVA): a randomised phase 2 trial
    Sylvie Negrier
    Medical Oncology Department, University of Lyon, Centre Leon Berard, Lyon, France
    Lancet Oncol 12:673-80. 2011
    ..We aimed to assess the potential synergistic or additive effect of the combination of bevacizumab, directed against the VEGF receptor, and temsirolimus, an mTOR inhibitor, in metastatic renal cell carcinoma...
  14. doi request reprint [Management of side effects associated with antiangiogenic treatment in renal cell carcinoma]
    A Flechon
    Centre Leon Berard, Universite de Lyon, Departement d Oncologie Medicale, 28, rue Laennec, 69008 Lyon, France
    Bull Cancer 97:73-82. 2010
    ..The management of toxic effects is essential to ensure treatment compliance and patient quality of life. The present report describes in detail the adverse events associated with each therapeutic class and the management of side effects...
  15. pmc Patients with metastatic renal carcinoma candidate for immunotherapy with cytokines. Analysis of a single institution study on 181 patients
    T Philip
    Medical Oncology Department, , Lyon, France
    Br J Cancer 68:1036-42. 1993
    ..This study clearly evidences the selection of the patients receiving immunotherapy and the modification in referrals of a disease induced by a new available therapy. This emphasises the need for prospective studies in this setting...
  16. pmc Correlation between clinical response to interleukin 2 and HLA phenotypes in patients with metastatic renal cell carcinoma
    C Bain
    Department of Tumor Biology, , Lyon, France
    Br J Cancer 75:283-6. 1997
    ..008). Thus, these results suggest that, in vivo, IL-2 may enhance cellular-mediated immunity against a tumour antigen and that some MHC molecules are more efficient than others for endogenous tumour antigen presentation...
  17. ncbi request reprint Role of interleukin-6 in the paraneoplastic inflammatory syndrome associated with renal-cell carcinoma
    J Y Blay
    Unite Cytokine et Cancer et Département de Médecine, Centre Leon Berard, Lyon, France
    Int J Cancer 72:424-30. 1997
    ....
  18. ncbi request reprint Breast cancer predictions by neural networks analysis: a comparison with logistic regression
    V S Bourdès
    Themis ICTA Group, Lyon, France
    Conf Proc IEEE Eng Med Biol Soc 2007:5424-7. 2007
    ....
  19. pmc Intravenous interleukin-2 in patients over 65 with metastatic renal carcinoma
    S Negrier
    Department of Medical Oncology, Centre L BERARD, Lyon, France
    Br J Cancer 65:723-6. 1992
    ..Thus, if age does not seem to modify the potential for response to IL2 therapy, cardiac toxicity appears as a limiting factor for intravenous schedules of IL2...
  20. ncbi request reprint Response rate accuracy in oncology trials: reasons for interobserver variability. Groupe Français d'Immunothérapie of the Fédération Nationale des Centres de Lutte Contre le Cancer
    P Thiesse
    Department of Radiology, Centre régional Léon Bérard, Lyon, France
    J Clin Oncol 15:3507-14. 1997
    ..We evaluated the impact of an evaluation committee (EC) on patients' overall response status in a large multicenter trial in oncology. We identified reasons for disagreements between investigators and the EC...
  21. ncbi request reprint [Guidelines for clinical practice: Standards, Options and Recommendations 2005 for the management of adult patients exhibiting an M0 cutaneous melanoma, full report. National Federation of Cancer Campaign Centers. French Dermatology Society. Update of the
    S Negrier
    Centre Leon Berard, Lyon
    Ann Dermatol Venereol 132:10S3-10S85. 2005
  22. ncbi request reprint A phase II study with 5-fluorouracil, folinic acid and oxaliplatin (FOLFOX-4 regimen) in patients with metastatic renal cell carcinoma
    J Bennouna
    Centre Rene Gauducheau, Nantes, France
    Oncology 64:25-7. 2003
    ..To investigate the efficacy and safety of the FOLFOX-4 regimen for patients with metastatic renal cell carcinoma (MRCC)...
  23. ncbi request reprint Why don't cancer patients enter clinical trials? A review
    Patrick Castel
    ONCORA, Centre Leon Berard, 28 rue Laennec, 69008 Lyon, France
    Eur J Cancer 42:1744-8. 2006
    ....
  24. doi request reprint Phase I study of daily irinotecan as a radiation sensitizer for locally advanced pancreatic cancer
    Christelle De la Fouchardiere
    Department of Medical Oncology, University of Lyon Centre Léon Bérard, Lyon, France
    Int J Radiat Oncol Biol Phys 77:409-13. 2010
    ..The study aimed to determine the maximum tolerated dose of daily irinotecan given with concomitant radiotherapy in patients with locally advanced adenocarcinoma of the pancreas...
  25. ncbi request reprint Prognostic factors in patients with advanced renal cell carcinoma: development of an international kidney cancer working group
    Ronald M Bukowski
    Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, Ohio and Centre Leon Berard, Lyon, France
    Clin Cancer Res 10:6310S-4S. 2004
    ..This project is now under way...
  26. doi request reprint Randomized study of intravenous versus subcutaneous interleukin-2, and IFNalpha in patients with good prognosis metastatic renal cancer
    Sylvie Negrier
    Universite de Lyon, Centre Leon Berard, Medical Oncology Department, Institut National de la Sante et de la Recherche Medicale U 590 and Biostatistics Unit, Centre Leon Berard, Lyon Cedex 08, France
    Clin Cancer Res 14:5907-12. 2008
    ..A French immunotherapy intergroup multicenter trial assessed the potential benefit of i.v. over s.c. administration of IL-2 in this combination...
  27. ncbi request reprint Phase-I study of Innacell gammadelta, an autologous cell-therapy product highly enriched in gamma9delta2 T lymphocytes, in combination with IL-2, in patients with metastatic renal cell carcinoma
    Jaafar Bennouna
    Department of Medical Oncology, Centre Rene Gauducheau, Nantes Saint Herblain, France
    Cancer Immunol Immunother 57:1599-609. 2008
    ....
  28. ncbi request reprint Diffuse medulla oblongata and pontine gliomas in childhood. A review of 37 cases
    Christian Carrie
    Radiation Oncology Department, Centre Leon Berard, 69373 Lyon Cedex 08, France
    Bull Cancer 91:E167-83. 2004
    ..Relapses always occurred in the radiotherapy field. Medulla oblongata and pontine tumours would appear to have the worst outcome of all brain stem gliomas and should be separately analysed...
  29. ncbi request reprint [Cardiac metastases and colorectal cancer: a case study]
    Christelle De la Fouchardiere
    Departement de cancerologie medicale, Centre Leon Berard, 28 rue Laennec, 69008 Lyon
    Gastroenterol Clin Biol 31:621-3. 2007
    ..These metastatic lesions are uncommon and after a description of the index case we provide a review of the most recently published cases...
  30. doi request reprint Endobronchial metastases from colorectal adenocarcinomas: clinical and endoscopic characteristics and patient prognosis
    Romain Coriat
    Oncology Department, Centre Leon Berard, Lyon, France
    Oncology 73:395-400. 2007
    ..This study aimed to evaluate the clinical and bronchoscopic aspects of EBM from colorectal carcinomas and the prognosis of the patients...
  31. ncbi request reprint [Combination of neoadjuvant chemotherapy, cryotherapy and surgery in the treatment of unresectable colorectal liver metastases. Long-term results]
    F Mariani
    Centre Leon Berard, Lyon, France
    Tumori 89:107-8. 2003
  32. doi request reprint Irinotecan associated with cetuximab given every 2 weeks versus cetuximab weekly in metastatic colorectal cancer
    Hind Mrabti
    Department of Medical Oncology, Centre Leon Berard, Lyon, France
    J Cancer Res Ther 5:272-6. 2009
    ..The aim of the present study was to compare the efficacy and safety of weekly versus an every 2-week administration of cetuximab in association with irinotecan in patients with metastatic colorectal cancer (MCRC)...
  33. ncbi request reprint Nonmetastatic renal-cell carcinoma: is it really possible to define rational guidelines for post-treatment follow-up?
    Olivier Rouviere
    Department of Urinary, Vascular and Interventional Radiology, Edouard Herriot Hospital, Lyon, France
    Nat Clin Pract Oncol 3:200-13. 2006
    ..Recent advances in tumor biology have contributed to a better understanding of this cancer and have indicated that personalized follow-up regimens, based on tumor and host molecular characteristics, might be possible in the near future...
  34. pmc Addition of bevacizumab to temsirolimus in kidney cancer patients
    H Boyle
    Centre Leon Berard, Department of Medical Oncology, Lyon, France
    Case Rep Oncol 4:531-3. 2011
    ..However, resistance occurs. We report here two cases of patients who benefited, both on disease control and side effects, from the addition of bevacizumab to temsirolimus, after progression on the mTOR inhibitor alone...
  35. ncbi request reprint Low serum albumin levels and liver metastasis are powerful prognostic markers for survival in patients with carcinomas of unknown primary site
    Pascal Seve
    Department of Internal Medicine, Hotel Dieu, Hospices Civils de Lyon, Lyon, France
    Cancer 107:2698-705. 2006
    ..The authors investigated how lymphopenia and low serum albumin levels correlate with the prognosis of patients with carcinoma of unknown primary (CUP)...
  36. ncbi request reprint Sorafenib in advanced clear-cell renal-cell carcinoma
    Bernard Escudier
    Department of Medicine, Institut Gustave Roussy, Villejuif, France
    N Engl J Med 356:125-34. 2007
    ..We conducted a phase 3, randomized, double-blind, placebo-controlled trial of sorafenib, a multikinase inhibitor of tumor-cell proliferation and angiogenesis, in patients with advanced clear-cell renal-cell carcinoma...
  37. ncbi request reprint Phase I/II trial of temsirolimus combined with interferon alfa for advanced renal cell carcinoma
    Robert J Motzer
    Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    J Clin Oncol 25:3958-64. 2007
    ..A recommended dose and safety profile for the combination of temsirolimus and interferon alfa (IFN) were determined in patients with advanced RCC...
  38. ncbi request reprint Dacarbazine, cisplatin, and interferon-alfa-2b with or without interleukin-2 in metastatic melanoma: a randomized phase III trial (18951) of the European Organisation for Research and Treatment of Cancer Melanoma Group
    Ulrich Keilholz
    Department of Medicine III, Charite, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Clin Oncol 23:6747-55. 2005
    ..This study was performed to determine whether interleukin-2 (IL-2) as a component of chemoimmunotherapy influences survival of patients with metastatic melanoma...
  39. doi request reprint Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma
    Toni K Choueiri
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Clin Oncol 26:127-31. 2008
    ..The activity of sunitinib and sorafenib in non-clear cell histologies has not been evaluated...