Christian Muchardt

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi Regulation of an inducible promoter by an HP1beta-HP1gamma switch
    Bogdan Mateescu
    Institut Pasteur, Departement de Biologie du Developpement, URA2578 du CNRS, Cedex 15, France
    EMBO Rep 9:267-72. 2008
  2. ncbi Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression
    Marc Lavigne
    Institut Pasteur, Departement de Biologie du Developpement, Unité de Recherche Associée URA2578 du Centre National de la Recherche Scientifique CNRS, Unité de Régulation Epigénétique, équipe AVENIR de l Institut National de la Santé Et de la Recherche Médicale INSERM, Paris, France
    PLoS Genet 5:e1000769. 2009
  3. ncbi Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha
    Christian Muchardt
    Expression Génétique et Maladies, URA 1644 du CNRS, Institut Pasteur, Paris, France
    EMBO Rep 3:975-81. 2002
  4. ncbi Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation
    Brigitte Bourachot
    Expression Génétique et Maladies, URA1644 du CNRS, Departement de Biologie du Developpement, Institut Pasteur, Paris, France
    EMBO J 22:6505-15. 2003
  5. ncbi Human BAHD1 promotes heterochromatic gene silencing
    Helene Bierne
    Institut Pasteur, Unité des Interactions Bactéries Cellules, INSERM U604, INRA USC2020, Paris, F 75015, France
    Proc Natl Acad Sci U S A 106:13826-31. 2009
  6. ncbi Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons
    Violaine Saint-André
    Institut Pasteur, Departement de Biologie du Developpement, Unité de Régulation Epigénétique, Paris, France
    Nat Struct Mol Biol 18:337-44. 2011
  7. ncbi The human SWI/SNF subunit Brm is a regulator of alternative splicing
    Eric Batsche
    Expression Génétique et Maladies, FRE 2850 du CNRS, Departement de Biologie du Developpement, Institut Pasteur, Paris, France
    Nat Struct Mol Biol 13:22-9. 2006
  8. ncbi Histone modifications induced by a family of bacterial toxins
    Mélanie Anne Hamon
    Unité des Interactions Bactéries Cellules, Unité de Régulation pigénétique, and Génopole, Plate forme 2, Institut Pasteur, F 75015 Paris, France
    Proc Natl Acad Sci U S A 104:13467-72. 2007
  9. ncbi Citrullination of histone H3 interferes with HP1-mediated transcriptional repression
    Priyanka Sharma
    Departement de Biologie du Developpement, Institut Pasteur, CNRS URA2578, Unité de Régulation Epigénétique, Paris, France
    PLoS Genet 8:e1002934. 2012
  10. ncbi Anthrax lethal toxin impairs IL-8 expression in epithelial cells through inhibition of histone H3 modification
    Benoit Raymond
    Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
    PLoS Pathog 5:e1000359. 2009

Collaborators

Detail Information

Publications22

  1. ncbi Regulation of an inducible promoter by an HP1beta-HP1gamma switch
    Bogdan Mateescu
    Institut Pasteur, Departement de Biologie du Developpement, URA2578 du CNRS, Cedex 15, France
    EMBO Rep 9:267-72. 2008
    ..Our data show that HP1 recruitment-release is a sequential mechanism that is precisely regulated and highly dependent on transcription...
  2. ncbi Interaction of HP1 and Brg1/Brm with the globular domain of histone H3 is required for HP1-mediated repression
    Marc Lavigne
    Institut Pasteur, Departement de Biologie du Developpement, Unité de Recherche Associée URA2578 du Centre National de la Recherche Scientifique CNRS, Unité de Régulation Epigénétique, équipe AVENIR de l Institut National de la Santé Et de la Recherche Médicale INSERM, Paris, France
    PLoS Genet 5:e1000769. 2009
    ..Altogether, our data suggest that HP1 chromoshadow-domains can benefit from the opening of nucleosomal structures to bind chromatin and that HP1 proteins use this property to detect and arrest unwanted chromatin remodeling...
  3. ncbi Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha
    Christian Muchardt
    Expression Génétique et Maladies, URA 1644 du CNRS, Institut Pasteur, Paris, France
    EMBO Rep 3:975-81. 2002
    ..Our data suggest the existence of complex heterochromatin binding sites composed of methylated histone H3 tails and RNA, with each being recognized by a separate domain of HP1alpha...
  4. ncbi Growth inhibition by the mammalian SWI-SNF subunit Brm is regulated by acetylation
    Brigitte Bourachot
    Expression Génétique et Maladies, URA1644 du CNRS, Departement de Biologie du Developpement, Institut Pasteur, Paris, France
    EMBO J 22:6505-15. 2003
    ..Removal of the HDAC inhibitors from the growth medium of these clones leads to downregulation of cyclin D1. This downregulation is absent in cell transformed by oncogenic ras...
  5. ncbi Human BAHD1 promotes heterochromatic gene silencing
    Helene Bierne
    Institut Pasteur, Unité des Interactions Bactéries Cellules, INSERM U604, INRA USC2020, Paris, F 75015, France
    Proc Natl Acad Sci U S A 106:13826-31. 2009
    ..Collectively, these findings provide evidence that BAHD1 acts as a silencer by recruiting at specific promoters a set of proteins that coordinate heterochromatin assembly...
  6. ncbi Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons
    Violaine Saint-André
    Institut Pasteur, Departement de Biologie du Developpement, Unité de Régulation Epigénétique, Paris, France
    Nat Struct Mol Biol 18:337-44. 2011
    ..They further implicate HP1γ as a possible bridging molecule between the chromatin and the maturating mRNA, with a general impact on splicing decisions...
  7. ncbi The human SWI/SNF subunit Brm is a regulator of alternative splicing
    Eric Batsche
    Expression Génétique et Maladies, FRE 2850 du CNRS, Departement de Biologie du Developpement, Institut Pasteur, Paris, France
    Nat Struct Mol Biol 13:22-9. 2006
    ....
  8. ncbi Histone modifications induced by a family of bacterial toxins
    Mélanie Anne Hamon
    Unité des Interactions Bactéries Cellules, Unité de Régulation pigénétique, and Génopole, Plate forme 2, Institut Pasteur, F 75015 Paris, France
    Proc Natl Acad Sci U S A 104:13467-72. 2007
    ....
  9. ncbi Citrullination of histone H3 interferes with HP1-mediated transcriptional repression
    Priyanka Sharma
    Departement de Biologie du Developpement, Institut Pasteur, CNRS URA2578, Unité de Régulation Epigénétique, Paris, France
    PLoS Genet 8:e1002934. 2012
    ....
  10. ncbi Anthrax lethal toxin impairs IL-8 expression in epithelial cells through inhibition of histone H3 modification
    Benoit Raymond
    Institut Pasteur, Unité de Défense Innée et Inflammation, Paris, France
    PLoS Pathog 5:e1000359. 2009
    ..This epigenetic reprogramming, in addition to previously reported effects of LT, may represent an efficient strategy used by B. anthracis for invading the host...
  11. ncbi Role for Brm in cell growth control
    Marjorie Coisy-Quivy
    Institut de Genetique Moleculaire, Centre National de la Recherche Scientifique, Montpellier, France and Institut Pasteur, Paris, France
    Cancer Res 66:5069-76. 2006
    ..However, they remain profoundly affected, unable to enter a canonical quiescent state, presenting a shorter S phase, and finally unable to perform correct chromosome segregation...
  12. ncbi Inhibition of PP1 phosphatase activity by HBx: a mechanism for the activation of hepatitis B virus transcription
    Delphine Cougot
    Oncogenèse et Virologie Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Sci Signal 5:ra1. 2012
    ..Our results illustrate a previously unknown mechanism of HBV transcriptional activation by HBx in which HBx interferes with the inactivation of CREB by the PP1 and HDAC1 complex...
  13. ncbi Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3
    Bogdan Mateescu
    , URA1644 du CNRS, , Institut Pasteur, , 25, rue du Docteur Roux, 7S724, Paris Cedex 15, France
    EMBO Rep 5:490-6. 2004
    ..We propose that phosphoacetylation of histone H3 could be a general mechanism allowing the cell to overcome HP1-mediated transcriptional repression...
  14. ncbi An injected bacterial effector targets chromatin access for transcription factor NF-kappaB to alter transcription of host genes involved in immune responses
    Laurence Arbibe
    Unite de Pathogenie Microbienne Moleculaire, Institut Pasteur, F75724 Paris Cedex 15, France
    Nat Immunol 8:47-56. 2007
    ..S. flexneri has thus evolved the capacity to precisely modulate host cell epigenetic 'information' as a strategy for repressing innate immunity...
  15. ncbi The SWI/SNF chromatin-remodeling complex subunit SNF5 is essential for hepatocyte differentiation
    Lionel Gresh
    Unité Expression Génétique et Maladies CNRS FRE 2850, Departement de Biologie du Developpement, Institut Pasteur, Paris, France
    EMBO J 24:3313-24. 2005
    ..Our results emphasize the role of chromatin remodeling in the activation of cell-type-specific genetic programs and driving cell differentiation...
  16. ncbi Splicing, transcription, and chromatin: a ménage à trois
    Eric Allemand
    Institut Pasteur, CNRS URA2578, Unité de Régulation Epigénétique, Avenir INSERM, Departement de Biologie du Developpement, Paris, France
    Curr Opin Genet Dev 18:145-51. 2008
    ..We also suggest that chromatin could function as an RNA-binding matrix displaying the immature transcripts to the spliceosomes...
  17. ncbi SWI/SNF chromatin-remodeling factors induce changes in DNA methylation to promote transcriptional activation
    Fatima Banine
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    Cancer Res 65:3542-7. 2005
    ....
  18. ncbi Roles of Brahma and Brahma/SWI2-related gene 1 in hypoxic induction of the erythropoietin gene
    Feng Wang
    Department of Pathology and Laboratory Medicine, Jonsson Comprehensive Cancer Center, Molecular Biology Institute, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 279:46733-41. 2004
    ....
  19. ncbi SWI/SNF chromatin remodeling and cancer
    Agnes Klochendler-Yeivin
    Department of Cellular Biochemistry and Human Genetics, The Hebrew University Hadassah Medical School, Ein Kerem, Jerusalem 91120, Israel
    Curr Opin Genet Dev 12:73-9. 2002
    ..These activities provide molecular insight into the mechanism underlying SWI/SNF function in tumor suppression...
  20. ncbi Coregulators: transducing signal from transcription to alternative splicing
    Didier Auboeuf
    INSERM, U685 AVENIR, Centre G Hayem, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    Trends Endocrinol Metab 18:122-9. 2007
    ..Recent technical advances that help to elucidate the impact of stimuli on the exon content of regulated gene transcripts are also discussed...
  21. ncbi Cyclin A repression in quiescent cells is associated with chromatin remodeling of its promoter and requires Brahma/SNF2alpha
    Marjorie Coisy
    , CNRS, UMR 5535, 1919 Route de Mende, 34293 Montpellier Cedex 5, France
    Mol Cell 15:43-56. 2004
    ..These results provide molecular explanations for the transcriptional repression state of cyclin A, as well as insights into the action of Brm chromatin remodeling factor as cell cycle regulator...
  22. ncbi SNR1 is an essential subunit in a subset of Drosophila brm complexes, targeting specific functions during development
    Claudia B Zraly
    Department of Biology, Syracuse University, Syracuse, NY 13244 1270, USA
    Dev Biol 253:291-308. 2003
    ..Thus, SNR1 is essential for some, but not all Brm functions, and it likely serves as an optional subunit, directing Brm complex activity to specific gene loci or cellular processes...