Serge Mostowy

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. doi Entrapment of intracytosolic bacteria by septin cage-like structures
    Serge Mostowy
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris F 75015, France
    Cell Host Microbe 8:433-44. 2010
  2. pmc Autophagy and the cytoskeleton: new links revealed by intracellular pathogens
    Serge Mostowy
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    Autophagy 7:780-2. 2011
  3. pmc p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways
    Serge Mostowy
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    J Biol Chem 286:26987-95. 2011
  4. pmc Septin 11 restricts InlB-mediated invasion by Listeria
    Serge Mostowy
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris F 75015, France
    J Biol Chem 284:11613-21. 2009
  5. pmc A role for septins in the interaction between the Listeria monocytogenes INVASION PROTEIN InlB and the Met receptor
    Serge Mostowy
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Biophys J 100:1949-59. 2011
  6. doi Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game
    Serge Mostowy
    Institut Pasteur, Département de Biologie Cellulaire et Infection, Unité des Interactions Bactéries Cellules, Paris, F 75015 France
    Cell Motil Cytoskeleton 66:816-23. 2009
  7. pmc Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy
    Laurent Dortet
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    PLoS Pathog 7:e1002168. 2011
  8. pmc Species-specific impact of the autophagy machinery on Chikungunya virus infection
    Delphine Judith
    Institut Pasteur, Biology of Infection Unit, Paris, France
    EMBO Rep 14:534-44. 2013
  9. pmc Listeria and autophagy escape: involvement of InlK, an internalin-like protein
    Laurent Dortet
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    Autophagy 8:132-4. 2012
  10. pmc Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length
    Rania Ghossoub
    Inserm U1016, Insitut Cochin, Paris, France
    J Cell Sci 126:2583-94. 2013

Collaborators

Detail Information

Publications17

  1. doi Entrapment of intracytosolic bacteria by septin cage-like structures
    Serge Mostowy
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris F 75015, France
    Cell Host Microbe 8:433-44. 2010
    ..Finally, we show that septin cages entrap bacteria targeted to autophagy. Together, these results reveal an unsuspected mechanism of host defense that restricts dissemination of invasive pathogens...
  2. pmc Autophagy and the cytoskeleton: new links revealed by intracellular pathogens
    Serge Mostowy
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    Autophagy 7:780-2. 2011
    ..Understanding the role of septins, a so far poorly characterized component of the cytoskeleton, will thus provide new insights into bacterial infection and autophagy...
  3. pmc p62 and NDP52 proteins target intracytosolic Shigella and Listeria to different autophagy pathways
    Serge Mostowy
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    J Biol Chem 286:26987-95. 2011
    ..These data provide a new molecular framework to understand the emerging complexity of autophagy and its ability to achieve specific clearance of intracytosolic bacteria...
  4. pmc Septin 11 restricts InlB-mediated invasion by Listeria
    Serge Mostowy
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris F 75015, France
    J Biol Chem 284:11613-21. 2009
    ..Because SEPT2 is essential for the InlB-mediated entry of Listeria, but SEPT11 is not, our findings distinguish the roles of different mammalian septins...
  5. pmc A role for septins in the interaction between the Listeria monocytogenes INVASION PROTEIN InlB and the Met receptor
    Serge Mostowy
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Biophys J 100:1949-59. 2011
    ..Septins are therefore likely to participate in anchorage of the Met receptor to the actin cytoskeleton, and represent a critical determinant in surface receptor function...
  6. doi Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game
    Serge Mostowy
    Institut Pasteur, Département de Biologie Cellulaire et Infection, Unité des Interactions Bactéries Cellules, Paris, F 75015 France
    Cell Motil Cytoskeleton 66:816-23. 2009
    ..The challenge is now to decipher how all of these components orchestrate themselves to permit entry into normally non-phagocytic cells...
  7. pmc Recruitment of the major vault protein by InlK: a Listeria monocytogenes strategy to avoid autophagy
    Laurent Dortet
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    PLoS Pathog 7:e1002168. 2011
    ..Together these results reveal that MVP is hijacked by L. monocytogenes in order to counteract the autophagy process, a finding that could have major implications in deciphering the cellular role of vault particles...
  8. pmc Species-specific impact of the autophagy machinery on Chikungunya virus infection
    Delphine Judith
    Institut Pasteur, Biology of Infection Unit, Paris, France
    EMBO Rep 14:534-44. 2013
    ..These results highlight the distinct roles of p62 and NDP52 in viral infection, and identify NDP52 as a cellular factor that accounts for CHIKV species specificity...
  9. pmc Listeria and autophagy escape: involvement of InlK, an internalin-like protein
    Laurent Dortet
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    Autophagy 8:132-4. 2012
    ..Understanding the role of MVP may provide new insights into bacterial infection and autophagy...
  10. pmc Septins 2, 7 and 9 and MAP4 colocalize along the axoneme in the primary cilium and control ciliary length
    Rania Ghossoub
    Inserm U1016, Insitut Cochin, Paris, France
    J Cell Sci 126:2583-94. 2013
    ..Taken together, our data provide new insights into the functions and regulation of septins and MAP4 in the organization of the primary cilium and microtubule-based activities in cells. ..
  11. doi Virulence factors that modulate the cell biology of Listeria infection and the host response
    Serge Mostowy
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    Adv Immunol 113:19-32. 2012
    ..This review will update our knowledge of Listeria virulence factors and highlight their role during the Listeria infection process...
  12. ncbi Septins as key regulators of actin based processes in bacterial infection
    Serge Mostowy
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    Biol Chem 392:831-5. 2011
    ..The challenge now is to decipher the precise role of septins during actin rearrangements and how these different cytoskeleton components orchestrate infection processes...
  13. pmc Mycolactone activation of Wiskott-Aldrich syndrome proteins underpins Buruli ulcer formation
    Laure Guenin-Macé
    Institut Pasteur, Unité d Immunobiologie de l Infection, Paris, France
    J Clin Invest 123:1501-12. 2013
    ..Our findings should allow for the rationale design of competitive inhibitors of mycolactone binding to N-WASP, with anti-Buruli ulcer therapeutic potential...
  14. doi Septins: the fourth component of the cytoskeleton
    Serge Mostowy
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Département de Biologie Cellulaire et Infection, F 75015 Paris, France
    Nat Rev Mol Cell Biol 13:183-94. 2012
    ....
  15. doi Bacterial autophagy: restriction or promotion of bacterial replication?
    Serge Mostowy
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Département de Biologie Cellulaire et Infection, F 75015 Paris, France
    Trends Cell Biol 22:283-91. 2012
    ..A complete understanding of bacterial autophagy in vivo shall be critical to exploit autophagy and its therapeutic potential...
  16. pmc Septins regulate bacterial entry into host cells
    Serge Mostowy
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    PLoS ONE 4:e4196. 2009
    ..We previously identified SEPT9 associated with phagosomes containing latex beads coated with the Listeria surface protein InlB...
  17. pmc The zebrafish as a new model for the in vivo study of Shigella flexneri interaction with phagocytes and bacterial autophagy
    Serge Mostowy
    Section of Microbiology, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, London, United Kingdom Institut Pasteur, Unité des Interactions Bactéries Cellules, Département de Biologie Cellulaire et Infection, Paris, France INSERM, U604, Paris, France INRA, USC2020, Paris, France
    PLoS Pathog 9:e1003588. 2013
    ..These results show the zebrafish larva as a new model for the study of S. flexneri interaction with phagocytes, and the manipulation of autophagy for anti-bacterial therapy in vivo. ..