Affiliation: Institut Curie
Manfrini N, Trovesi C, Wery M, Martina M, Cesena D, Descrimes M, et al
. RNA-processing proteins regulate Mec1/ATR activation by promoting generation of RPA-coated ssDNA. EMBO Rep. 2015;16:221-31 pubmed publisher
..Noteworthy, deep transcriptome analyses do not identify common misregulated gene expression that could explain the observed phenotypes. Our results provide a novel link between RNA processing and genome stability. ..
Kwapisz M, Ruault M, van Dijk E, Gourvennec S, Descrimes M, Taddei A, et al
. Expression of Subtelomeric lncRNAs Links Telomeres Dynamics to RNA Decay in S. cerevisiae. Noncoding RNA. 2015;1:94-126 pubmed publisher
..Our data suggest that subtelomeric RNAs expression links telomere maintenance to RNA degradation pathways. ..
Wery M, Descrimes M, Vogt N, Dallongeville A, Gautheret D, Morillon A. Nonsense-Mediated Decay Restricts LncRNA Levels in Yeast Unless Blocked by Double-Stranded RNA Structure. Mol Cell. 2016;61:379-392 pubmed publisher
..Our results indicate that aslncRNAs form dsRNA that are only translatedÂ and targeted to NMD if dissociated by Mtr4 and Dbp2. We propose that NMD buffers genome expression by discarding pervasive regulatory transcripts. ..
de Andrés Pablo A, Morillon A, Wery M. LncRNAs, lost in translation or licence to regulate?. Curr Genet. 2017;63:29-33 pubmed publisher
..In this perspective, we have explored the idea that translation can be part of the fate of cytoplasmic lncRNAs, raising the possibility for them to work as bifunctional RNAs, endowed with dual coding and regulatory functions. ..
Sinturel F, Navickas A, Wery M, Descrimes M, Morillon A, Torchet C, et al
. Cytoplasmic Control of Sense-Antisense mRNA Pairs. Cell Rep. 2015;12:1853-64 pubmed publisher
Jarroux J, Morillon A, Pinskaya M. History, Discovery, and Classification of lncRNAs. Adv Exp Med Biol. 2017;1008:1-46 pubmed publisher
..Finally, we will present a non-exhaustive catalogue of lncRNA classes, thus illustrating the vast complexity of eukaryotic transcriptomes. ..
Wery M, Gautier C, Descrimes M, Yoda M, Vennin Rendos H, Migeot V, et al
. Native elongating transcript sequencing reveals global anti-correlation between sense and antisense nascent transcription in fission yeast. RNA. 2018;24:196-208 pubmed publisher
..Our work highlights that antisense transcription is much more extended than anticipated and might constitute an additional nonpromoter determinant of gene regulation complexity. ..
Descrimes M, Ben Zouari Y, Wery M, Legendre R, Gautheret D, Morillon A. VING: a software for visualization of deep sequencing signals. BMC Res Notes. 2015;8:419 pubmed publisher
..It is available at http://vm-gb.curie.fr/ving/. We also developed a Galaxy wrapper, available in the Galaxy tool shed with installation and usage instructions. ..