Research Topics
Genomes and Genes | P MehlenSummaryAffiliation: Institut Paoli-Calmettes Country: France Publications
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Publications
Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activationChristelle Forcet
Apoptosis Differentiation Laboratory label La Ligue Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
Nature 417:443-7. 2002..Inhibition of ERK-1/2 antagonizes netrin-dependent axon outgrowth and orientation. Thus, activation of MAPK signalling through Dcc contributes to netrin signalling in axon growth and guidance...- [Netrin-1 and axonal guidance: signaling and asymmetrical translation]Patrick Mehlen
Laboratoire Apoptose, Cancer et Développement, Equipe Labellisée La Ligue, CNRS UMR 5238, Universite de Lyon, Centre Leon Berard, 28, rue Laennec, 69008 Lyon, France
Med Sci (Paris) 23:311-5. 2007..Thus, this asymetrically synthesized beta-actin may direct actin polymerization and consequently the migration of the growth cone toward the cue... 
Dependence receptors: the trophic theory revisitedPatrick Mehlen
Apoptose, Cancer et Développement, CNRS UMR5538, Centre Leon Berard, University of Lyon, Lyon, France
Sci Signal 3:pe47. 2010..The dependence receptor theory postulates key roles for these receptors during embryonic development, neurodegenerative diseases, or cancer progression and metastasis and is bolstered by new evidence...
Role of netrin-1 and netrin-1 dependence receptors in colorectal cancersP Mehlen
1Apoptosis, Cancer and Development Laboratory, Laboratoire labellisé La Ligue, CNRS FRE2870, Centre Leon Berard, 28 rue Laennec, 69008 Lyon, France
Br J Cancer 93:1-6. 2005....- Morphogens and cell survival during developmentPatrick Mehlen
Laboratoire Apoptose, Cancer et Développement, Equipe labelisée La Ligue, CNRS FRE2870, Centre Leon Berard, 69008 Lyon, France
J Neurobiol 64:357-66. 2005..In this review, we will present morphogens, with a specific emphasis on Sonic Hedgehog, a mammalian member of the Hh family, not as a positive regulators of cell differentiation but as key regulators of cell survival... - Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesisP Mehlen
Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS FRE2870, Lyon, France
Cell Mol Life Sci 62:2599-616. 2005..We will suggest some possible roles of netrin-1 in nervous system development, neovascularisation, adhesion and tumorigenesis... - Netrin-1 and its dependence receptors as original targets for cancer therapyPatrick Mehlen
Apoptosis, Cancer and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon, France
Curr Opin Oncol 22:46-54. 2010..The purpose of this review is to show, with the example of netrin-1 dependence receptors, the path from cell biology to promising anticancer-targeted therapy... - [Dependence receptors DCC and UNC5H: the role of apoptosis in the control of tumorigenesis]Patrick Mehlen
Centre Leon Berard, Apoptose, Cancer et Développement, Laboratoire labellisé, La Ligue, CNRS FRE2870, 69008 Lyon
J Soc Biol 199:211-8. 2005..In this review, we will describe the implication of the netrin-1/receptor pairs as novel negative regulators of tumor development... - Novel roles for Slits and netrins: axon guidance cues as anticancer targets?Patrick Mehlen
Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CRCL UMR INSERM U1052 CNRS 5286, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
Nat Rev Cancer 11:188-97. 2011..Moreover, recent data suggest that these ligand-receptor pairs could be promising targets for personalized anticancer therapies... - Metastasis: a question of life or deathPatrick Mehlen
Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS FRE2870, Centre Leon Berard, Universite Claude Bernard Lyon 1, 69008 Lyon, France
Nat Rev Cancer 6:449-58. 2006..Here we stress that the inhibition of cell death, apart from its extensively described function in primary tumour development, is a crucial characteristic of metastatic cancer cells... - The dependence receptor hypothesisP Mehlen
Apoptosis Differentiation Laboratory, Equipe labelisée La Ligue, Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
Apoptosis 9:37-49. 2004..Here, we review the current knowledge concerning dependence receptors, including the shared mechanisms for cell death induction and their potential relevance in nervous system development and regulation of tumorigenesis... - Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta productionF C Lourenço
Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Centre Leon Berard, University of Lyon, Lyon, France
Cell Death Differ 16:655-63. 2009..Finally, we show that netrin-1 brain administration in Alzheimer model transgenic mice may be associated with an amelioration of the Alzheimer's phenotype... - Netrin-1 acts as a survival factor via its receptors UNC5H and DCCF Llambi
Apoptosis Differentiation Laboratory label La Ligue, Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
EMBO J 20:2715-22. 2001..Altogether, these results argue for a role of netrin-1 during the development of the nervous system, not only as a guidance cue but as a survival factor via its receptors DCC and UNC5H... - Dependence receptors: a new paradigm in cell signaling and cancer therapyD Goldschneider
Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Centre Leon Berard, Universite de Lyon, Lyon, France
Oncogene 29:1865-82. 2010.... - Interfering with multimerization of netrin-1 receptors triggers tumor cell deathF Mille
Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon 69008, France
Cell Death Differ 16:1344-51. 2009..Taking advantage of this property, we utilized a recombinant specific domain of DCC that (i) interacts with netrin-1 and (ii) inhibits netrin-1-induced multimerization, to trigger apoptosis in netrin-dependent tumor cells... - [Netrin-1 and its dependence receptors: role in colorectal cancers]A Bernet
Apoptose, Cancer et Développement, Laboratoire labellisé La Ligue, FRE CNRS, Centre Leon Berard, 28, rue Laennec, 69008 Lyon, France
Pathol Biol (Paris) 53:328-33. 2005.... - Dependence receptors: between life and deathP Mehlen
Apoptosis Differentiation Laboratory, Equipe labelisée La Ligue, Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622, Villeurbanne, France
Cell Mol Life Sci 61:1854-66. 2004..In this review we will present the proposed mechanisms for cell death induction by these receptors and their potential function in nervous system development and regulation of tumorigenesis... - Targeting heat shock protein 27 (HspB1) interferes with bone metastasis and tumour formation in vivoB Gibert
Centre de Genetique Moleculaire et Cellulaire, CNRS UMR5534, Universite Lyon 1, Universite de Lyon, 43 Bd 11 Novembre 1918, 69622 Villeurbanne Cedex, France
Br J Cancer 107:63-70. 2012..However, its role in the later stage of tumour progression and, more specifically, in the later and most deadly stage of tumour metastasis is still unclear... - Dependence receptors: when apoptosis controls tumor progressionAgnès Bernet
Apoptosis, Cancer and Development Laboratory, Laboratoire labellisé La Ligue, CNRS FRE2870, Centre Leon Berard, 69008 Lyon, France
Bull Cancer 94:E12-7. 2007..In this review, we will describe the implication of the netrin-1/receptor pairs as novel negative regulators of tumor development... - Netrin-1 is a survival factor during commissural neuron navigationCéline Furne
Apoptosis, Cancer, and Development Laboratory, Equipe Labellisée La Ligue, Centre Léon Berard and Unité Mixte de Recherche 5238, Centre National de la Recherche Scientifique, Universite de Lyon, 69008 Lyon, France
Proc Natl Acad Sci U S A 105:14465-70. 2008..Thus, adequate commissural neurons navigation requires both the attractive activity of netrin-1 and the anti-apoptotic function of this cue... - Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancerJulien Fitamant
Apoptosis, Cancer, and Development Laboratory Equipe Labellisée La Ligue, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5238, Centre Leon Berard, Université de Lyon 69008 Lyon, France
Proc Natl Acad Sci U S A 105:4850-5. 2008.... - The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitmentKarine Thiebault
ApoptosisDifferentiation Laboratory, Equipe Labellisée La Ligue, Molecular and Cellular Genetic Center, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5534, University of Lyon, 69622 Villeurbanne, France
Proc Natl Acad Sci U S A 100:4173-8. 2003..Hence, UNC5H1, UNC5H2, and UNC5H3 receptors may represent tumor suppressors that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis... - Netrin-1 controls colorectal tumorigenesis by regulating apoptosisLaetitia Mazelin
Apoptosis Differentiation Laboratory Equipe labellisée La Ligue Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
Nature 431:80-4. 2004..These data demonstrate that netrin-1 can promote intestinal tumour development, probably by regulating cell survival. Thus, a netrin-1 receptor or receptors function as conditional tumour suppressors... - The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activationC Forcet
Apoptosis Differentiation Laboratory, Molecular and Cellular Genetic Center, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5534, University of Lyon, 69622 Villeurbanne, France
Proc Natl Acad Sci U S A 98:3416-21. 2001..Hence, DCC defines an additional pathway for the apoptosome-independent caspase activation... - Netrin-1 acts as a survival factor for aggressive neuroblastomaCéline Delloye-Bourgeois
Centre National de la Recherche Scientifique UMR, Universite de Lyon, France
J Exp Med 206:833-47. 2009.... - The dependence receptors DCC and UNC5H as a link between neuronal guidance and survivalPatrick Mehlen
Apoptosis Differentiation Laboratory, Equipe labellisée, Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
Biol Cell 95:425-36. 2003..We then conclude to the possible roles of DCC and UNC5H pro-apoptotic activities in both nervous system development and tumorigenesis... - NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptorsAndrea Paradisi
Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR 5238, Universite de Lyon, Centre Leon Berard, Lyon, France
Gastroenterology 135:1248-57. 2008..We have investigated whether netrin-1 is up-regulated in colorectal cancer and have searched for a link between NF-kappaB activation and netrin-1 up-regulation... - The dependence receptor UNC5H2 mediates apoptosis through DAP-kinaseFabien Llambi
Apoptosis, Cancer and Development Laboratory, Equipe Labellisée La Ligue, CNRS FRE2870, Centre Leon Berard, Lyon, France
EMBO J 24:1192-201. 2005..Thus, the pair netrin-1/UNC5H2 may regulate cell fate by controlling the proapoptotic kinase activity of DAP-kinase... - Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesisMarie Castets
Apoptosis, Cancer, and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon, France
Dev Cell 16:614-20. 2009..Thus, the proapoptotic effect of unbound UNC5B and the survival effect of netrin-1 on endothelial cells finely tune the angiogenic process... - Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progressionAndrea Paradisi
Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
Proc Natl Acad Sci U S A 106:17146-51. 2009.... - Interference with netrin-1 and tumor cell death in non-small cell lung cancerCéline Delloye-Bourgeois
Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon, France
J Natl Cancer Inst 101:237-47. 2009..The status of netrin-1 and its receptors in non-small cell lung cancer (NSCLC) was unknown... - Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5HCarine Maisse
Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
Exp Cell Res 314:2544-52. 2008..Thus, we propose that the UNC5H dependence receptors require lipid raft localization and palmitoylation to trigger apoptosis... - [The deadly rafts: when lipid rafts regulate dependence receptors]Céline Furne
Apoptose, Cancer et Dévelopement, Equipe Labellisée La Ligue, CNRS FRE2870, Centre Leon Berard, 69008 Lyon, France
Med Sci (Paris) 22:909-10. 2006 - Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehogChantal Thibert
Apoptosis Differentiation Laboratory, La Ligue, Molecular and Cellular Genetic Center, CNRS Unite Mixte Recherche UMR 5534, University of Lyon, 69622 Villeurbanne, France
Science 301:843-6. 2003..Thus, the proapoptotic activity of unbound Ptc and the positive effect of Shh-bound Ptc on cell differentiation probably cooperate to achieve the appropriate spinal cord development... - The dependence receptor DCC requires lipid raft localization for cell death signalingCéline Furne
Apoptosis, Cancer, and Development Laboratory, Equipe la Ligue, Centre National de la Recherche Scientifique Formation de Recherche en Evolution 2870 CNRS FRE 2870, Centre Leon Berard, 69008 Lyon, France
Proc Natl Acad Sci U S A 103:4128-33. 2006..Thus, dependence receptors may require lipid raft localization for cell death signaling... - Role of the dependence receptor DCC in colorectal cancer pathogenesisPatrick Mehlen
Apoptosis Differentiation Laboratory Equipe labelisée La Ligue Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
J Clin Oncol 22:3420-8. 2004..Here, we review DCC's candidacy as a tumor suppressor gene, with an emphasis on how recent molecular analyses of DCC have offered support for the notion that DCC may function as a tumor suppressor gene... - Meeting report: cellular dependence--old concept, new mechanismsPatrick Mehlen
Centre Genetique Moleculaire et Cellulaire, , CNRS UMR5534, University of Lyon, Lyon, France
Sci STKE 2003:pe55. 2003..With several of the receptors implicated in various human developmental disorders or disease states, gaining an understanding of the molecular mechanisms controlling dependence receptor-mediated cell death has clear clinical relevance... - Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignanciesAgnès Bernet
Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, Centre National de la Recherche Scientifique, CNRS UMR5238, University of Lyon, Centre Leon Berard, Lyon, France
Gastroenterology 133:1840-8. 2007..We investigate here whether UNC5C acts as a tumor suppressor in colorectal malignancies... - Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosisJimena Bouzas-Rodriguez
Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR, Universite de Lyon, France
J Clin Invest 120:850-8. 2010..Thus, we believe that our data suggest that NT-3/TrkC disruption is a putative alternative targeted therapeutic strategy for the treatment of NB... - The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complexFrédéric Mille
Apoptosis, Cancer and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
Nat Cell Biol 11:739-46. 2009..Thus, we propose that in the absence of its ligand Shh the dependence receptor Ptc serves as the anchor for a caspase-activating complex that includes DRAL, and caspase-9... - Clonal expansion of HTLV-1 positive CD8+ cells relies on cIAP-2 but not on c-FLIP expressionLinda Zane
CNRS UMR5239, Universite de Lyon, Oncovirologie et Biothérapies, Centre Leon Berard, 69008 Lyon, France
Virology 407:341-51. 2010..These results support a role for Tax-dependent cIAP-2 expression in preventing the death of naturally infected CD8(+) cells and thereby in their clonal expansion in vivo... - Small ruminant lentivirus Tat protein induces apoptosis in caprine cells in vitro by the intrinsic pathwayAngela Rea-Boutrois
Universite de Lyon, INRA, UMR754, Universite Lyon 1, Ecole Nationale Veterinaire de Lyon, Ecole Pratique des Hautes Etudes, IFR 128, 50 avenue Tony Garnier, 69 366 Lyon Cedex 07, France
Virology 383:93-102. 2009..A simultaneous disruption of mitochondrial membrane potential indicates an involvement of the mitochondrial pathway... - EphrinB3 is an anti-apoptotic ligand that inhibits the dependence receptor functions of EphA4 receptors during adult neurogenesisCéline Furne
Laboratory Apoptosis Cancer and Development, CNRS UMR 5238, Center Léon Bérard, University of Lyon, Lyon, France
Biochim Biophys Acta 1793:231-8. 2009..Furthermore, infusion of soluble ephrinB3 into the lateral ventricle reduced cell death, and together these results support a dependence role for EphA4 in adult neurogenesis... - The neogenin intracellular domain regulates gene transcription via nuclear translocationDavid Goldschneider
Apoptosis, Cancer, and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
Mol Cell Biol 28:4068-79. 2008..Together, we reveal here a novel aspect of neogenin signaling that relies on the direct implication of its intracellular domain in transcriptional regulation... - Netrin PIPes upPatrick Mehlen
Nat Cell Biol 7:1052-3. 2005 - GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathwayLi-Ying Yu
Research Program in Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, FIN-00014 Helsinki, Finland
J Cell Biol 163:987-97. 2003..In many NGF-deprived neurons, the ultrastructure of the mitochondria was changed. Thus, a novel nonmitochondrial caspase-dependent death pathway is activated in GDNF-deprived sympathetic neurons... - Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5BXiaoling Tang
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
Nat Cell Biol 10:698-706. 2008..Thus, PIKE-L acts as a downstream survival effector for netrin-1 through UNC5B in the nervous system... - Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavageDavid Tulasne
CNRS UMR 8117, Institut de Biologie de Lille, Institut Pasteur de Lille, B P 447, 59021 Lille, France
Mol Cell Biol 24:10328-39. 2004..Finally, HGF/SF treatment does not favor MET cleavage and apoptosis, confirming the known survival role of ligand-activated MET. Our results show that stress stimuli convert the MET survival receptor into a proapoptotic factor... - DCC association with lipid rafts is required for netrin-1-mediated axon guidanceZoltan Herincs
Death Receptor Signalling Laboratory Equipe ATIP CNRS, Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR 6543 Centre A Lacassagne 33 Avenue Valombrose 06189 Nice, France
J Cell Sci 118:1687-92. 2005..Thus, the presence of axon guidance-related receptors in lipid rafts appears to be a crucial pre-requisite for growth cone response to chemo-attractive or repulsive cues... - RGM and its receptor neogenin regulate neuronal survivalEiji Matsunaga
UMR CNRS 7102, Universite Paris 6, 9 quai Saint Bernard, 75005 Paris, France
Nat Cell Biol 6:749-55. 2004..Thus neogenin is a dependence receptor inducing cell death in the absence of RGM, whereas the presence of RGM inhibits this effect... - Cell death in the nervous systemDale E Bredesen
Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA
Nature 443:796-802. 2006..Surprisingly, although the cell death itself may occur relatively late in the course of the degenerative process, the mediators of the underlying cell-death pathways have shown promise as potential therapeutic targets... - [Patched is a dependence receptor]Patrick Mehlen
Med Sci (Paris) 19:1062. 2003 - Epidermal growth factor triggers an original, caspase-independent pituitary cell death with heterogeneous phenotypeJoanna Fombonne
Interactions Cellulaires Neuroendocriniennes, Unite Mixte de Recherche 6544, Centre National de Recherche Scientifique Université de la Méditerranée, Institut Jean Roche, Faculte de Medecine Nord, 13916 Marseille, France
Mol Biol Cell 15:4938-48. 2004.... - Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavageJaouhar Mourali
INSERM U563, CPTP, CHU Purpan, BP3028, 31024 Toulouse Cedex 3, France
Mol Cell Biol 26:6209-22. 2006..These properties place ALK in the growing family of dependence receptors... - The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigmServane Tauszig-Delamasure
Apoptosis, Cancer and Development Laboratory, Equipe Labellisée La Ligue, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
Proc Natl Acad Sci U S A 104:13361-6. 2007..Thus, the death of neurons upon disappearance of NT-3 is not only due to a loss of survival signals but also to the active proapoptotic activity of the unbound TrkC dependence receptor... - Neurobiology: a new way to networkPatrick Mehlen
Nature 424:381-2. 2003 - Inhibitory role of endophilin 3 in receptor-mediated endocytosisHiroko Sugiura
Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183-8526, Japan
J Biol Chem 279:23343-8. 2004..These results indicate that Endo3 may act as a negative regulator of clathrin-mediated endocytosis in brain neurons...