P Mehlen

Summary

Affiliation: Institut Paoli-Calmettes
Country: France

Publications

  1. ncbi Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation
    Christelle Forcet
    Apoptosis Differentiation Laboratory label La Ligue Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
    Nature 417:443-7. 2002
  2. ncbi [Netrin-1 and axonal guidance: signaling and asymmetrical translation]
    Patrick Mehlen
    Laboratoire Apoptose, Cancer et Développement, Equipe Labellisée La Ligue, CNRS UMR 5238, Universite de Lyon, Centre Leon Berard, 28, rue Laennec, 69008 Lyon, France
    Med Sci (Paris) 23:311-5. 2007
  3. doi Dependence receptors: the trophic theory revisited
    Patrick Mehlen
    Apoptose, Cancer et Développement, CNRS UMR5538, Centre Leon Berard, University of Lyon, Lyon, France
    Sci Signal 3:pe47. 2010
  4. pmc Netrin-1 acts as a survival factor for aggressive neuroblastoma
    Céline Delloye-Bourgeois
    Centre National de la Recherche Scientifique UMR, Universite de Lyon, France
    J Exp Med 206:833-47. 2009
  5. ncbi Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis
    P Mehlen
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS FRE2870, Lyon, France
    Cell Mol Life Sci 62:2599-616. 2005
  6. ncbi [Dependence receptors DCC and UNC5H: the role of apoptosis in the control of tumorigenesis]
    Patrick Mehlen
    Centre Leon Berard, Apoptose, Cancer et Développement, Laboratoire labellisé, La Ligue, CNRS FRE2870, 69008 Lyon
    J Soc Biol 199:211-8. 2005
  7. doi Novel roles for Slits and netrins: axon guidance cues as anticancer targets?
    Patrick Mehlen
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CRCL UMR INSERM U1052 CNRS 5286, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Nat Rev Cancer 11:188-97. 2011
  8. ncbi Metastasis: a question of life or death
    Patrick Mehlen
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS FRE2870, Centre Leon Berard, Universite Claude Bernard Lyon 1, 69008 Lyon, France
    Nat Rev Cancer 6:449-58. 2006
  9. ncbi Morphogens and cell survival during development
    Patrick Mehlen
    Laboratoire Apoptose, Cancer et Développement, Equipe labelisée La Ligue, CNRS FRE2870, Centre Leon Berard, 69008 Lyon, France
    J Neurobiol 64:357-66. 2005
  10. pmc Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers
    P Mehlen
    1Apoptosis, Cancer and Development Laboratory, Laboratoire labellisé La Ligue, CNRS FRE2870, Centre Leon Berard, 28 rue Laennec, 69008 Lyon, France
    Br J Cancer 93:1-6. 2005

Collaborators

Detail Information

Publications57

  1. ncbi Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation
    Christelle Forcet
    Apoptosis Differentiation Laboratory label La Ligue Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
    Nature 417:443-7. 2002
    ..Inhibition of ERK-1/2 antagonizes netrin-dependent axon outgrowth and orientation. Thus, activation of MAPK signalling through Dcc contributes to netrin signalling in axon growth and guidance...
  2. ncbi [Netrin-1 and axonal guidance: signaling and asymmetrical translation]
    Patrick Mehlen
    Laboratoire Apoptose, Cancer et Développement, Equipe Labellisée La Ligue, CNRS UMR 5238, Universite de Lyon, Centre Leon Berard, 28, rue Laennec, 69008 Lyon, France
    Med Sci (Paris) 23:311-5. 2007
    ..Thus, this asymetrically synthesized beta-actin may direct actin polymerization and consequently the migration of the growth cone toward the cue...
  3. doi Dependence receptors: the trophic theory revisited
    Patrick Mehlen
    Apoptose, Cancer et Développement, CNRS UMR5538, Centre Leon Berard, University of Lyon, Lyon, France
    Sci Signal 3:pe47. 2010
    ..The dependence receptor theory postulates key roles for these receptors during embryonic development, neurodegenerative diseases, or cancer progression and metastasis and is bolstered by new evidence...
  4. pmc Netrin-1 acts as a survival factor for aggressive neuroblastoma
    Céline Delloye-Bourgeois
    Centre National de la Recherche Scientifique UMR, Universite de Lyon, France
    J Exp Med 206:833-47. 2009
    ....
  5. ncbi Netrin-1: when a neuronal guidance cue turns out to be a regulator of tumorigenesis
    P Mehlen
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS FRE2870, Lyon, France
    Cell Mol Life Sci 62:2599-616. 2005
    ..We will suggest some possible roles of netrin-1 in nervous system development, neovascularisation, adhesion and tumorigenesis...
  6. ncbi [Dependence receptors DCC and UNC5H: the role of apoptosis in the control of tumorigenesis]
    Patrick Mehlen
    Centre Leon Berard, Apoptose, Cancer et Développement, Laboratoire labellisé, La Ligue, CNRS FRE2870, 69008 Lyon
    J Soc Biol 199:211-8. 2005
    ..In this review, we will describe the implication of the netrin-1/receptor pairs as novel negative regulators of tumor development...
  7. doi Novel roles for Slits and netrins: axon guidance cues as anticancer targets?
    Patrick Mehlen
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CRCL UMR INSERM U1052 CNRS 5286, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Nat Rev Cancer 11:188-97. 2011
    ..Moreover, recent data suggest that these ligand-receptor pairs could be promising targets for personalized anticancer therapies...
  8. ncbi Metastasis: a question of life or death
    Patrick Mehlen
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS FRE2870, Centre Leon Berard, Universite Claude Bernard Lyon 1, 69008 Lyon, France
    Nat Rev Cancer 6:449-58. 2006
    ..Here we stress that the inhibition of cell death, apart from its extensively described function in primary tumour development, is a crucial characteristic of metastatic cancer cells...
  9. ncbi Morphogens and cell survival during development
    Patrick Mehlen
    Laboratoire Apoptose, Cancer et Développement, Equipe labelisée La Ligue, CNRS FRE2870, Centre Leon Berard, 69008 Lyon, France
    J Neurobiol 64:357-66. 2005
    ..In this review, we will present morphogens, with a specific emphasis on Sonic Hedgehog, a mammalian member of the Hh family, not as a positive regulators of cell differentiation but as key regulators of cell survival...
  10. pmc Role of netrin-1 and netrin-1 dependence receptors in colorectal cancers
    P Mehlen
    1Apoptosis, Cancer and Development Laboratory, Laboratoire labellisé La Ligue, CNRS FRE2870, Centre Leon Berard, 28 rue Laennec, 69008 Lyon, France
    Br J Cancer 93:1-6. 2005
    ....
  11. doi Netrin-1 and its dependence receptors as original targets for cancer therapy
    Patrick Mehlen
    Apoptosis, Cancer and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon, France
    Curr Opin Oncol 22:46-54. 2010
    ..The purpose of this review is to show, with the example of netrin-1 dependence receptors, the path from cell biology to promising anticancer-targeted therapy...
  12. ncbi The dependence receptor hypothesis
    P Mehlen
    Apoptosis Differentiation Laboratory, Equipe labelisée La Ligue, Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
    Apoptosis 9:37-49. 2004
    ..Here, we review the current knowledge concerning dependence receptors, including the shared mechanisms for cell death induction and their potential relevance in nervous system development and regulation of tumorigenesis...
  13. pmc Netrin-1 acts as a survival factor via its receptors UNC5H and DCC
    F Llambi
    Apoptosis Differentiation Laboratory label La Ligue, Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
    EMBO J 20:2715-22. 2001
    ..Altogether, these results argue for a role of netrin-1 during the development of the nervous system, not only as a guidance cue but as a survival factor via its receptors DCC and UNC5H...
  14. pmc Netrin-1 interacts with amyloid precursor protein and regulates amyloid-beta production
    F C Lourenço
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Centre Leon Berard, University of Lyon, Lyon, France
    Cell Death Differ 16:655-63. 2009
    ..Finally, we show that netrin-1 brain administration in Alzheimer model transgenic mice may be associated with an amelioration of the Alzheimer's phenotype...
  15. doi Dependence receptors: a new paradigm in cell signaling and cancer therapy
    D Goldschneider
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Centre Leon Berard, Universite de Lyon, Lyon, France
    Oncogene 29:1865-82. 2010
    ....
  16. pmc Interfering with multimerization of netrin-1 receptors triggers tumor cell death
    F Mille
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon 69008, France
    Cell Death Differ 16:1344-51. 2009
    ..Taking advantage of this property, we utilized a recombinant specific domain of DCC that (i) interacts with netrin-1 and (ii) inhibits netrin-1-induced multimerization, to trigger apoptosis in netrin-dependent tumor cells...
  17. ncbi [Netrin-1 and its dependence receptors: role in colorectal cancers]
    A Bernet
    Apoptose, Cancer et Développement, Laboratoire labellisé La Ligue, FRE CNRS, Centre Leon Berard, 28, rue Laennec, 69008 Lyon, France
    Pathol Biol (Paris) 53:328-33. 2005
    ....
  18. ncbi Dependence receptors: between life and death
    P Mehlen
    Apoptosis Differentiation Laboratory, Equipe labelisée La Ligue, Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622, Villeurbanne, France
    Cell Mol Life Sci 61:1854-66. 2004
    ..In this review we will present the proposed mechanisms for cell death induction by these receptors and their potential function in nervous system development and regulation of tumorigenesis...
  19. pmc Targeting heat shock protein 27 (HspB1) interferes with bone metastasis and tumour formation in vivo
    B Gibert
    Centre de Genetique Moleculaire et Cellulaire, CNRS UMR5534, Universite Lyon 1, Universite de Lyon, 43 Bd 11 Novembre 1918, 69622 Villeurbanne Cedex, France
    Br J Cancer 107:63-70. 2012
    ..However, its role in the later stage of tumour progression and, more specifically, in the later and most deadly stage of tumour metastasis is still unclear...
  20. pmc Netrin-1 is a survival factor during commissural neuron navigation
    Céline Furne
    Apoptosis, Cancer, and Development Laboratory, Equipe Labellisée La Ligue, Centre Léon Berard and Unité Mixte de Recherche 5238, Centre National de la Recherche Scientifique, Universite de Lyon, 69008 Lyon, France
    Proc Natl Acad Sci U S A 105:14465-70. 2008
    ..Thus, adequate commissural neurons navigation requires both the attractive activity of netrin-1 and the anti-apoptotic function of this cue...
  21. ncbi Dependence receptors: when apoptosis controls tumor progression
    Agnès Bernet
    Apoptosis, Cancer and Development Laboratory, Laboratoire labellisé La Ligue, CNRS FRE2870, Centre Leon Berard, 69008 Lyon, France
    Bull Cancer 94:E12-7. 2007
    ..In this review, we will describe the implication of the netrin-1/receptor pairs as novel negative regulators of tumor development...
  22. ncbi Netrin-1 controls colorectal tumorigenesis by regulating apoptosis
    Laetitia Mazelin
    Apoptosis Differentiation Laboratory Equipe labellisée La Ligue Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
    Nature 431:80-4. 2004
    ..These data demonstrate that netrin-1 can promote intestinal tumour development, probably by regulating cell survival. Thus, a netrin-1 receptor or receptors function as conditional tumour suppressors...
  23. pmc The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment
    Karine Thiebault
    ApoptosisDifferentiation Laboratory, Equipe Labellisée La Ligue, Molecular and Cellular Genetic Center, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5534, University of Lyon, 69622 Villeurbanne, France
    Proc Natl Acad Sci U S A 100:4173-8. 2003
    ..Hence, UNC5H1, UNC5H2, and UNC5H3 receptors may represent tumor suppressors that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis...
  24. pmc Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer
    Julien Fitamant
    Apoptosis, Cancer, and Development Laboratory Equipe Labellisée La Ligue, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5238, Centre Leon Berard, Université de Lyon 69008 Lyon, France
    Proc Natl Acad Sci U S A 105:4850-5. 2008
    ....
  25. pmc The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation
    C Forcet
    Apoptosis Differentiation Laboratory, Molecular and Cellular Genetic Center, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5534, University of Lyon, 69622 Villeurbanne, France
    Proc Natl Acad Sci U S A 98:3416-21. 2001
    ..Hence, DCC defines an additional pathway for the apoptosome-independent caspase activation...
  26. doi NF-kappaB regulates netrin-1 expression and affects the conditional tumor suppressive activity of the netrin-1 receptors
    Andrea Paradisi
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR 5238, Universite de Lyon, Centre Leon Berard, Lyon, France
    Gastroenterology 135:1248-57. 2008
    ..We have investigated whether netrin-1 is up-regulated in colorectal cancer and have searched for a link between NF-kappaB activation and netrin-1 up-regulation...
  27. ncbi The dependence receptors DCC and UNC5H as a link between neuronal guidance and survival
    Patrick Mehlen
    Apoptosis Differentiation Laboratory, Equipe labellisée, Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
    Biol Cell 95:425-36. 2003
    ..We then conclude to the possible roles of DCC and UNC5H pro-apoptotic activities in both nervous system development and tumorigenesis...
  28. pmc The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase
    Fabien Llambi
    Apoptosis, Cancer and Development Laboratory, Equipe Labellisée La Ligue, CNRS FRE2870, Centre Leon Berard, Lyon, France
    EMBO J 24:1192-201. 2005
    ..Thus, the pair netrin-1/UNC5H2 may regulate cell fate by controlling the proapoptotic kinase activity of DAP-kinase...
  29. pmc Netrin-1 up-regulation in inflammatory bowel diseases is required for colorectal cancer progression
    Andrea Paradisi
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Proc Natl Acad Sci U S A 106:17146-51. 2009
    ....
  30. doi Inhibition of endothelial cell apoptosis by netrin-1 during angiogenesis
    Marie Castets
    Apoptosis, Cancer, and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon, France
    Dev Cell 16:614-20. 2009
    ..Thus, the proapoptotic effect of unbound UNC5B and the survival effect of netrin-1 on endothelial cells finely tune the angiogenic process...
  31. doi Lipid raft localization and palmitoylation: identification of two requirements for cell death induction by the tumor suppressors UNC5H
    Carine Maisse
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Exp Cell Res 314:2544-52. 2008
    ..Thus, we propose that the UNC5H dependence receptors require lipid raft localization and palmitoylation to trigger apoptosis...
  32. doi Interference with netrin-1 and tumor cell death in non-small cell lung cancer
    Céline Delloye-Bourgeois
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, Lyon, France
    J Natl Cancer Inst 101:237-47. 2009
    ..The status of netrin-1 and its receptors in non-small cell lung cancer (NSCLC) was unknown...
  33. ncbi [The deadly rafts: when lipid rafts regulate dependence receptors]
    Céline Furne
    Apoptose, Cancer et Dévelopement, Equipe Labellisée La Ligue, CNRS FRE2870, Centre Leon Berard, 69008 Lyon, France
    Med Sci (Paris) 22:909-10. 2006
  34. ncbi Inhibition of neuroepithelial patched-induced apoptosis by sonic hedgehog
    Chantal Thibert
    Apoptosis Differentiation Laboratory, La Ligue, Molecular and Cellular Genetic Center, CNRS Unite Mixte Recherche UMR 5534, University of Lyon, 69622 Villeurbanne, France
    Science 301:843-6. 2003
    ..Thus, the proapoptotic activity of unbound Ptc and the positive effect of Shh-bound Ptc on cell differentiation probably cooperate to achieve the appropriate spinal cord development...
  35. pmc The dependence receptor DCC requires lipid raft localization for cell death signaling
    Céline Furne
    Apoptosis, Cancer, and Development Laboratory, Equipe la Ligue, Centre National de la Recherche Scientifique Formation de Recherche en Evolution 2870 CNRS FRE 2870, Centre Leon Berard, 69008 Lyon, France
    Proc Natl Acad Sci U S A 103:4128-33. 2006
    ..Thus, dependence receptors may require lipid raft localization for cell death signaling...
  36. ncbi Role of the dependence receptor DCC in colorectal cancer pathogenesis
    Patrick Mehlen
    Apoptosis Differentiation Laboratory Equipe labelisée La Ligue Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France
    J Clin Oncol 22:3420-8. 2004
    ..Here, we review DCC's candidacy as a tumor suppressor gene, with an emphasis on how recent molecular analyses of DCC have offered support for the notion that DCC may function as a tumor suppressor gene...
  37. ncbi Meeting report: cellular dependence--old concept, new mechanisms
    Patrick Mehlen
    Centre Genetique Moleculaire et Cellulaire, Equipe Labellisée La Ligue, CNRS UMR5534, University of Lyon, Lyon, France
    Sci STKE 2003:pe55. 2003
    ..With several of the receptors implicated in various human developmental disorders or disease states, gaining an understanding of the molecular mechanisms controlling dependence receptor-mediated cell death has clear clinical relevance...
  38. pmc Inactivation of the UNC5C Netrin-1 receptor is associated with tumor progression in colorectal malignancies
    Agnès Bernet
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, Centre National de la Recherche Scientifique, CNRS UMR5238, University of Lyon, Centre Leon Berard, Lyon, France
    Gastroenterology 133:1840-8. 2007
    ..We investigate here whether UNC5C acts as a tumor suppressor in colorectal malignancies...
  39. pmc Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis
    Jimena Bouzas-Rodriguez
    Apoptosis, Cancer and Development Laboratory Equipe labellisée La Ligue, CNRS UMR, Universite de Lyon, France
    J Clin Invest 120:850-8. 2010
    ..Thus, we believe that our data suggest that NT-3/TrkC disruption is a putative alternative targeted therapeutic strategy for the treatment of NB...
  40. pmc The Patched dependence receptor triggers apoptosis through a DRAL-caspase-9 complex
    Frédéric Mille
    Apoptosis, Cancer and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Nat Cell Biol 11:739-46. 2009
    ..Thus, we propose that in the absence of its ligand Shh the dependence receptor Ptc serves as the anchor for a caspase-activating complex that includes DRAL, and caspase-9...
  41. doi Clonal expansion of HTLV-1 positive CD8+ cells relies on cIAP-2 but not on c-FLIP expression
    Linda Zane
    CNRS UMR5239, Universite de Lyon, Oncovirologie et Biothérapies, Centre Leon Berard, 69008 Lyon, France
    Virology 407:341-51. 2010
    ..These results support a role for Tax-dependent cIAP-2 expression in preventing the death of naturally infected CD8(+) cells and thereby in their clonal expansion in vivo...
  42. doi Small ruminant lentivirus Tat protein induces apoptosis in caprine cells in vitro by the intrinsic pathway
    Angela Rea-Boutrois
    Universite de Lyon, INRA, UMR754, Universite Lyon 1, Ecole Nationale Veterinaire de Lyon, Ecole Pratique des Hautes Etudes, IFR 128, 50 avenue Tony Garnier, 69 366 Lyon Cedex 07, France
    Virology 383:93-102. 2009
    ..A simultaneous disruption of mitochondrial membrane potential indicates an involvement of the mitochondrial pathway...
  43. pmc EphrinB3 is an anti-apoptotic ligand that inhibits the dependence receptor functions of EphA4 receptors during adult neurogenesis
    Céline Furne
    Laboratory Apoptosis Cancer and Development, CNRS UMR 5238, Center Léon Bérard, University of Lyon, Lyon, France
    Biochim Biophys Acta 1793:231-8. 2009
    ..Furthermore, infusion of soluble ephrinB3 into the lateral ventricle reduced cell death, and together these results support a dependence role for EphA4 in adult neurogenesis...
  44. pmc The neogenin intracellular domain regulates gene transcription via nuclear translocation
    David Goldschneider
    Apoptosis, Cancer, and Development Laboratory, Equipe Labellisée La Ligue, CNRS UMR5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Mol Cell Biol 28:4068-79. 2008
    ..Together, we reveal here a novel aspect of neogenin signaling that relies on the direct implication of its intracellular domain in transcriptional regulation...
  45. ncbi Netrin PIPes up
    Patrick Mehlen
    Nat Cell Biol 7:1052-3. 2005
  46. pmc GDNF-deprived sympathetic neurons die via a novel nonmitochondrial pathway
    Li Ying Yu
    Research Program in Molecular Neurobiology, Institute of Biotechnology, University of Helsinki, FIN 00014 Helsinki, Finland
    J Cell Biol 163:987-97. 2003
    ..In many NGF-deprived neurons, the ultrastructure of the mitochondria was changed. Thus, a novel nonmitochondrial caspase-dependent death pathway is activated in GDNF-deprived sympathetic neurons...
  47. pmc Netrin-1 mediates neuronal survival through PIKE-L interaction with the dependence receptor UNC5B
    Xiaoling Tang
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Nat Cell Biol 10:698-706. 2008
    ..Thus, PIKE-L acts as a downstream survival effector for netrin-1 through UNC5B in the nervous system...
  48. pmc Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage
    David Tulasne
    CNRS UMR 8117, Institut de Biologie de Lille, Institut Pasteur de Lille, B P 447, 59021 Lille, France
    Mol Cell Biol 24:10328-39. 2004
    ..Finally, HGF/SF treatment does not favor MET cleavage and apoptosis, confirming the known survival role of ligand-activated MET. Our results show that stress stimuli convert the MET survival receptor into a proapoptotic factor...
  49. ncbi DCC association with lipid rafts is required for netrin-1-mediated axon guidance
    Zoltan Herincs
    Death Receptor Signalling Laboratory Equipe ATIP CNRS, Institute of Signalling, Developmental Biology and Cancer Research, CNRS UMR 6543 Centre A Lacassagne 33 Avenue Valombrose 06189 Nice, France
    J Cell Sci 118:1687-92. 2005
    ..Thus, the presence of axon guidance-related receptors in lipid rafts appears to be a crucial pre-requisite for growth cone response to chemo-attractive or repulsive cues...
  50. ncbi RGM and its receptor neogenin regulate neuronal survival
    Eiji Matsunaga
    UMR CNRS 7102, Universite Paris 6, 9 quai Saint Bernard, 75005 Paris, France
    Nat Cell Biol 6:749-55. 2004
    ..Thus neogenin is a dependence receptor inducing cell death in the absence of RGM, whereas the presence of RGM inhibits this effect...
  51. ncbi Cell death in the nervous system
    Dale E Bredesen
    Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, California 94945, USA
    Nature 443:796-802. 2006
    ..Surprisingly, although the cell death itself may occur relatively late in the course of the degenerative process, the mediators of the underlying cell-death pathways have shown promise as potential therapeutic targets...
  52. ncbi [Patched is a dependence receptor]
    Patrick Mehlen
    Med Sci (Paris) 19:1062. 2003
  53. pmc Epidermal growth factor triggers an original, caspase-independent pituitary cell death with heterogeneous phenotype
    Joanna Fombonne
    Interactions Cellulaires Neuroendocriniennes, Unite Mixte de Recherche 6544, Centre National de Recherche Scientifique Université de la Méditerranée, Institut Jean Roche, Faculte de Medecine Nord, 13916 Marseille, France
    Mol Biol Cell 15:4938-48. 2004
    ....
  54. pmc Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage
    Jaouhar Mourali
    INSERM U563, CPTP, CHU Purpan, BP3028, 31024 Toulouse Cedex 3, France
    Mol Cell Biol 26:6209-22. 2006
    ..These properties place ALK in the growing family of dependence receptors...
  55. pmc The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm
    Servane Tauszig-Delamasure
    Apoptosis, Cancer and Development Laboratory, Equipe Labellisée La Ligue, Centre National de la Recherche Scientifique, Unite Mixte de Recherche 5238, Universite de Lyon, Centre Leon Berard, 69008 Lyon, France
    Proc Natl Acad Sci U S A 104:13361-6. 2007
    ..Thus, the death of neurons upon disappearance of NT-3 is not only due to a loss of survival signals but also to the active proapoptotic activity of the unbound TrkC dependence receptor...
  56. ncbi Neurobiology: a new way to network
    Patrick Mehlen
    Nature 424:381-2. 2003
  57. ncbi Inhibitory role of endophilin 3 in receptor-mediated endocytosis
    Hiroko Sugiura
    Department of Neuropharmacology, Tokyo Metropolitan Institute for Neuroscience, Fuchu, Tokyo 183 8526, Japan
    J Biol Chem 279:23343-8. 2004
    ..These results indicate that Endo3 may act as a negative regulator of clathrin-mediated endocytosis in brain neurons...