Alain Mauviel

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. pmc Pro-invasive activity of the Hippo pathway effectors YAP and TAZ in cutaneous melanoma
    Flore Nallet-Staub
    1 Team TGF β and Oncogenesis, Centre de Recherche, Institut Curie, Orsay, France 2 INSERM U1021, Orsay, France 3 CNRS UMR 3347, Orsay, France
    J Invest Dermatol 134:123-32. 2014
  2. pmc Insights into the Transforming Growth Factor-β Signaling Pathway in Cutaneous Melanoma
    Carole Yolande Perrot
    Institut Curie, Team TGF β and Oncogenesis, Equipe Labellisée Ligue contre le Cancer, Orsay, France INSERM U1021 Orsay, France CNRS UMR 3347, Orsay, France
    Ann Dermatol 25:135-44. 2013
  3. doi Integrating developmental signals: a Hippo in the (path)way
    A Mauviel
    Institut Curie, Centre de Recherche, Orsay, France
    Oncogene 31:1743-56. 2012
  4. pmc Expression of microphthalmia-associated transcription factor (MITF), which is critical for melanoma progression, is inhibited by both transcription factor GLI2 and transforming growth factor-β
    Marie Jeanne Pierrat
    Institut Curie, Centre de Recherche, INSERM U1021, CNRS UMR3347, and Université Paris XI, 91400 Orsay, France
    J Biol Chem 287:17996-8004. 2012
  5. ncbi GLI2 cooperates with ZEB1 for transcriptional repression of CDH1 expression in human melanoma cells
    Carole Y Perrot
    Institut Curie, Team TGF β and Oncogenesis, Orsay, France INSERM U1021, Orsay, France CNRS UMR 3347, Orsay, France
    Pigment Cell Melanoma Res 26:861-73. 2013
  6. doi GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells
    Delphine Javelaud
    Institut Curie, Centre de Recherche, Orsay, France
    Pigment Cell Melanoma Res 24:932-43. 2011
  7. pmc TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis
    Delphine Javelaud
    Institut Curie, Centre de Recherche, France
    Cancer Res 71:5606-10. 2011
  8. pmc Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression
    Delphine Javelaud
    Institut Curie, University Center, Building 110, Orsay, France
    Mol Cancer 10:2. 2011
  9. doi Crosstalk between TGF-β and hedgehog signaling in cancer
    Delphine Javelaud
    Institut Curie, Centre de Recherche, 91400 Orsay, France
    FEBS Lett 586:2016-25. 2012
  10. pmc GLI2-mediated melanoma invasion and metastasis
    Vasileia Ismini Alexaki
    Curie Institute, INSERM U1021 CNRS UMR3347, University Center, Orsay Cedex, France
    J Natl Cancer Inst 102:1148-59. 2010

Collaborators

  • Delphine Javelaud
  • Marius Sudol
  • Veronique Bataille
  • Ling Li
  • Kunxin Luo
  • Theresa A Guise
  • Leon van Kempen
  • Reinhard Dummer
  • Lionel Larue
  • Carole Y Perrot
  • Veronique Marsaud
  • Patricia Juarez
  • Flore Nallet-Staub
  • Cristele Gilbert
  • Carole Yolande Perrot
  • Marie Jeanne Pierrat
  • Daniel S Widmer
  • Khalid S Mohammad
  • Keith S Hoek
  • Vasileia Ismini Alexaki
  • Meenhard Herlyn
  • Sophie Dodier
  • Antonio Postigo
  • Juan Juan Yin
  • Marie C Zipser
  • Ossia M Eichhoff
  • Benedetta C Belloni
  • Pierrick G J Fournier
  • Ryan C McKenna
  • Holly W Davis
  • Xiang H Peng
  • Phil F Cheng
  • Maria Niewolna
  • John M Chirgwin
  • Natalie C Schlegel
  • Veronique Delmas
  • Philippe Saiag
  • Simon Saule
  • Corine Bertolotto
  • Sylviane Dennler
  • Franck Verrecchia
  • James S Goydos
  • Flavie Luciani
  • Robert Ballotti
  • Claire Sibon
  • Pierrick J Fournier

Detail Information

Publications13

  1. pmc Pro-invasive activity of the Hippo pathway effectors YAP and TAZ in cutaneous melanoma
    Flore Nallet-Staub
    1 Team TGF β and Oncogenesis, Centre de Recherche, Institut Curie, Orsay, France 2 INSERM U1021, Orsay, France 3 CNRS UMR 3347, Orsay, France
    J Invest Dermatol 134:123-32. 2014
    ..Together, these results demonstrate that both YAP and TAZ contribute to the invasive and metastatic capacity of melanoma cells and may represent worthy targets for therapeutic intervention. ..
  2. pmc Insights into the Transforming Growth Factor-β Signaling Pathway in Cutaneous Melanoma
    Carole Yolande Perrot
    Institut Curie, Team TGF β and Oncogenesis, Equipe Labellisée Ligue contre le Cancer, Orsay, France INSERM U1021 Orsay, France CNRS UMR 3347, Orsay, France
    Ann Dermatol 25:135-44. 2013
    ..This review summarizes the current knowledge on the implication of TGF-β signaling in melanoma...
  3. doi Integrating developmental signals: a Hippo in the (path)way
    A Mauviel
    Institut Curie, Centre de Recherche, Orsay, France
    Oncogene 31:1743-56. 2012
    ..This review highlights some of the recent findings in the Hippo field with an emphasis on how the Hippo pathway is integrated with other pathways to mediate diverse processes...
  4. pmc Expression of microphthalmia-associated transcription factor (MITF), which is critical for melanoma progression, is inhibited by both transcription factor GLI2 and transforming growth factor-β
    Marie Jeanne Pierrat
    Institut Curie, Centre de Recherche, INSERM U1021, CNRS UMR3347, and Université Paris XI, 91400 Orsay, France
    J Biol Chem 287:17996-8004. 2012
    ..Increased GLI2 binding to its cognate cis-element, associated with reduced CREB-dependent transcription, allowed maximal inhibition of the M-MITF promoter via two distinct mechanisms...
  5. ncbi GLI2 cooperates with ZEB1 for transcriptional repression of CDH1 expression in human melanoma cells
    Carole Y Perrot
    Institut Curie, Team TGF β and Oncogenesis, Orsay, France INSERM U1021, Orsay, France CNRS UMR 3347, Orsay, France
    Pigment Cell Melanoma Res 26:861-73. 2013
    ..These data identify GLI2 as a critical modulator of the cadherin switch in melanoma, a molecular process that is critical for metastatic spread of the disease. ..
  6. doi GLI2 and M-MITF transcription factors control exclusive gene expression programs and inversely regulate invasion in human melanoma cells
    Delphine Javelaud
    Institut Curie, Centre de Recherche, Orsay, France
    Pigment Cell Melanoma Res 24:932-43. 2011
    ..These findings thus identify GLI2 as a critical transcription factor antagonizing M-MITF function to promote melanoma cell phenotypic plasticity and invasive behavior...
  7. pmc TGF-β/SMAD/GLI2 signaling axis in cancer progression and metastasis
    Delphine Javelaud
    Institut Curie, Centre de Recherche, France
    Cancer Res 71:5606-10. 2011
    ..This short review summarizes recent knowledge about GLI2 function and mechanisms of action downstream of TGF-β in cancer...
  8. pmc Efficient TGF-β/SMAD signaling in human melanoma cells associated with high c-SKI/SnoN expression
    Delphine Javelaud
    Institut Curie, University Center, Building 110, Orsay, France
    Mol Cancer 10:2. 2011
    ..TGF-β, on the other hand, induces rapid, proteasome-mediated, degradation of both proteins. How elevated SKI and SnoN protein levels co-exist with active autocrine TGF-β signaling in cancer cells is yet to be understood...
  9. doi Crosstalk between TGF-β and hedgehog signaling in cancer
    Delphine Javelaud
    Institut Curie, Centre de Recherche, 91400 Orsay, France
    FEBS Lett 586:2016-25. 2012
    ..We herein review the current knowledge on HH signaling and summarize the recent findings on the crosstalks between the HH and TGF-β pathways in cancer...
  10. pmc GLI2-mediated melanoma invasion and metastasis
    Vasileia Ismini Alexaki
    Curie Institute, INSERM U1021 CNRS UMR3347, University Center, Orsay Cedex, France
    J Natl Cancer Inst 102:1148-59. 2010
    ..Recently, we identified GLI2, a mediator of the hedgehog pathway, as a transcriptional target of TGF-beta signaling...
  11. doi Overlapping activities of TGF-β and Hedgehog signaling in cancer: therapeutic targets for cancer treatment
    Carole Y Perrot
    Institut Curie, Team TGF β and Oncogenesis, 91400, Orsay, France INSERM U1021, 91400, Orsay, France
    Pharmacol Ther 137:183-99. 2013
    ....
  12. doi Systematic classification of melanoma cells by phenotype-specific gene expression mapping
    Daniel S Widmer
    Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland
    Pigment Cell Melanoma Res 25:343-53. 2012
    ..These findings reinforce the concept that a two-state system, as described by the phenotype switching model, underlies melanoma progression...
  13. doi Halofuginone inhibits the establishment and progression of melanoma bone metastases
    Patricia Juarez
    Division of Endocrinology and Metabolism, Department of Medicine, Indiana University Purdue University Indianapolis, Walther Hall, C132 980 W Walnut Street, Indianapolis, IN 46202, USA
    Cancer Res 72:6247-56. 2012
    ..Moreover, halofuginone treatment reduced melanoma metastasis to the brain, showing the potential of this novel treatment against cancer metastasis...