C Manach

Summary

Affiliation: Institut National de la Recherche Agronomique
Country: France

Publications

  1. ncbi request reprint Pharmacokinetics and metabolism of dietary flavonoids in humans
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    Free Radic Res 38:771-85. 2004
  2. ncbi request reprint Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties
    C Manach
    Unité des Maladies Métaboliques et Micronutriments, I N R A de Clermont Ferrand Theix, St Genes Champanelle, France
    FEBS Lett 426:331-6. 1998
  3. ncbi request reprint Polyphenols: food sources and bioavailability
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    Am J Clin Nutr 79:727-47. 2004
  4. ncbi request reprint Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Am J Clin Nutr 81:230S-242S. 2005
  5. ncbi request reprint Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    Gary Williamson
    Nutrient Bioavailability Group, Nestle Research Center, Lausanne, Switzerland
    Am J Clin Nutr 81:243S-255S. 2005
  6. ncbi request reprint Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice
    C Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA Clermont Theix, St Genes Champanelle, France
    Eur J Clin Nutr 57:235-42. 2003
  7. ncbi request reprint Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract or the procyanidin dimer B3
    Jennifer L Donovan
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Br J Nutr 87:299-306. 2002
  8. ncbi request reprint Comparison of the bioavailability of quercetin and catechin in rats
    C Manach
    Unité des Maladies Métaboliques et Micronutriments, I N R A de Clermont Ferrand Theix, St Genes Champanelle, France
    Free Radic Biol Med 27:1259-66. 1999
  9. ncbi request reprint Comparison of the intestinal absorption of quercetin, phloretin and their glucosides in rats
    V Crespy
    Laboratoire des Maladies Métaboliques et des Micronutriments, Institut National de la Recherche Agronomique, de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    J Nutr 131:2109-14. 2001
  10. ncbi request reprint Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen
    V Crespy
    Laboratoire des Maladies Métaboliques et des Micronutriments, Institut National de la Recherche Agronomique de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    Am J Physiol 277:G120-6. 1999

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Pharmacokinetics and metabolism of dietary flavonoids in humans
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    Free Radic Res 38:771-85. 2004
    ..These data should be considered in the design and interpretation of studies investigating the mechanisms and potential health effects of flavonoids...
  2. ncbi request reprint Quercetin is recovered in human plasma as conjugated derivatives which retain antioxidant properties
    C Manach
    Unité des Maladies Métaboliques et Micronutriments, I N R A de Clermont Ferrand Theix, St Genes Champanelle, France
    FEBS Lett 426:331-6. 1998
    ..3'-O-Methylquercetin and conjugated derivatives of quercetin significantly prolonged the lag phase, but the magnitude of their effect was about half that of the aglycone...
  3. ncbi request reprint Polyphenols: food sources and bioavailability
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    Am J Clin Nutr 79:727-47. 2004
    ..A thorough knowledge of the bioavailability of the hundreds of dietary polyphenols will help us to identify those that are most likely to exert protective health effects...
  4. ncbi request reprint Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Am J Clin Nutr 81:230S-242S. 2005
    ..Data are still too limited for assessment of hydroxycinnamic acids and other polyphenols. These data may be useful for the design and interpretation of intervention studies investigating the health effects of polyphenols...
  5. ncbi request reprint Bioavailability and bioefficacy of polyphenols in humans. II. Review of 93 intervention studies
    Gary Williamson
    Nutrient Bioavailability Group, Nestle Research Center, Lausanne, Switzerland
    Am J Clin Nutr 81:243S-255S. 2005
    ..The length of human intervention studies should be increased, to more closely reflect the long-term dietary consumption of polyphenols...
  6. ncbi request reprint Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice
    C Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA Clermont Theix, St Genes Champanelle, France
    Eur J Clin Nutr 57:235-42. 2003
    ..The aim of the present study was to determine the nature of the circulating metabolites, the plasma kinetics and the urinary excretion patterns of the flavanones, hesperidin and narirutin...
  7. ncbi request reprint Procyanidins are not bioavailable in rats fed a single meal containing a grapeseed extract or the procyanidin dimer B3
    Jennifer L Donovan
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Br J Nutr 87:299-306. 2002
    ..Future research should focus on other procyanidin metabolites such as phenolic acids and on the effects of the unabsorbed oligomers and polymers on the human gastrointestinal tract...
  8. ncbi request reprint Comparison of the bioavailability of quercetin and catechin in rats
    C Manach
    Unité des Maladies Métaboliques et Micronutriments, I N R A de Clermont Ferrand Theix, St Genes Champanelle, France
    Free Radic Biol Med 27:1259-66. 1999
    ....
  9. ncbi request reprint Comparison of the intestinal absorption of quercetin, phloretin and their glucosides in rats
    V Crespy
    Laboratoire des Maladies Métaboliques et des Micronutriments, Institut National de la Recherche Agronomique, de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    J Nutr 131:2109-14. 2001
    ..05). Whatever the perfused compound, the efficiency of the absorption seemed to be linked to the intestinal conjugation process and to the luminal secretion of metabolites...
  10. ncbi request reprint Part of quercetin absorbed in the small intestine is conjugated and further secreted in the intestinal lumen
    V Crespy
    Laboratoire des Maladies Métaboliques et des Micronutriments, Institut National de la Recherche Agronomique de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    Am J Physiol 277:G120-6. 1999
    ..The present work shows that a rapid quercetin absorption in the small intestine is very effective together with its active conjugation in intestinal cells...
  11. ncbi request reprint Bioavailability of phloretin and phloridzin in rats
    V Crespy
    Laboratoire des Maladies Métaboliques et des Micronutriments, I N R A de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    J Nutr 131:3227-30. 2001
    ..The total urinary excretion rate of phloretin was not affected by the forms administered, and was estimated to be 8.5 micromol/24 h in rats fed phloretin or phloridzin. Thus, 10.4% of the ingested dose was recovered in urine after 24 h...
  12. ncbi request reprint Quercetin 3-O-beta-glucoside is better absorbed than other quercetin forms and is not present in rat plasma
    C Morand
    Unité des Maladies Métaboliques et des Micronutriments, INRA de Clermont Ferrand Theix, St Genes Champanelle, France
    Free Radic Res 33:667-76. 2000
    ..This result suggests that quercetin 3-O-beta-glucoside is hydrolysed before or during its intestinal absorption...
  13. ncbi request reprint Catechin is metabolized by both the small intestine and liver of rats
    J L Donovan
    , INRA, , France
    J Nutr 131:1753-7. 2001
    ..The data further demonstrate the role of the rat small intestine in the glucuronidation and methylation of flavonoids as well as the role of the liver in sulfation, methylation and biliary excretion...
  14. ncbi request reprint Respective bioavailability of quercetin aglycone and its glycosides in a rat model
    C Morand
    Unité des Maladies Métaboliques et des Micronutriments, INRA Theix, Ceyrat, France
    Biofactors 12:169-74. 2000
    ..Quercetin 3-glucose can be absorbed in the small intestine and is better absorbed than quercetin itself. By contrast, glycosides containing a rhamnose moiety could not be absorbed in the small intestine...
  15. ncbi request reprint Polyphenols and prevention of cardiovascular diseases
    Claudine Manach
    Unité des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    Curr Opin Lipidol 16:77-84. 2005
    ..This paper reviews the recent studies on the prevention of cardiovascular diseases by polyphenols, focusing on human studies...
  16. ncbi request reprint Co-administration of quercetin and catechin in rats alters their absorption but not their metabolism
    Mathieu Silberberg
    Laboratoire des Maladies Métaboliques et des Micronutriments, I N R A, Centre de Recherche de Clermont Ferrant Theix, 63122 Saint Genes Champanelle, France
    Life Sci 77:3156-67. 2005
    ....
  17. ncbi request reprint Dietary polyphenols and the prevention of diseases
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Centre de Recherche de Clermont Ferrand Theix, St Genes Champanelle, France
    Crit Rev Food Sci Nutr 45:287-306. 2005
    ..More human studies are needed to provide clear evidence of their health protective effects and to better evaluate the risks possibly resulting from too high a polyphenol consumption...
  18. ncbi request reprint Polyphenol levels in human urine after intake of six different polyphenol-rich beverages
    Hideyuki Ito
    Unite des Maladies Metaboliques et Micronutrients, INRA, 63122 Saint Genes Champanelle, France
    Br J Nutr 94:500-9. 2005
    ..Levels of urinary excretion suggest that chlorogenic acid, gallic acid, epicatechin, naringenin or hesperetin could be used as specific biomarkers to evaluate the consumption of coffee, wine, tea or cocoa, and citrus juices respectively...
  19. ncbi request reprint Absorption and metabolism of caffeic acid and chlorogenic acid in the small intestine of rats
    Sophie Lafay
    Unite de Nutrition Humaine, Institut National de la Recherche Agronomique, Centre de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    Br J Nutr 96:39-46. 2006
    ..In contrast to numerous flavonoids, absorbed phenolic acids are poorly excreted in the bile or gut lumen. Their bioavailability therefore appears to be governed largely by their uptake into the gut mucosa...
  20. ncbi request reprint Chlorogenic acid is absorbed in its intact form in the stomach of rats
    Sophie Lafay
    Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    J Nutr 136:1192-7. 2006
    ..No other metabolites could be detected by HPLC-electrospray ionization-MS-MS. These results show for the first time that chlorogenic acid is quickly absorbed in the rat stomach in its intact form...
  21. ncbi request reprint High-throughput profiling of dietary polyphenols and their metabolites by HPLC-ESI-MS-MS in human urine
    Hideyuki Ito
    Unite des Maladies Metaboliques et Micronutrients, INRA, 63122 Saint Genes Champanelle, France
    Biofactors 22:241-3. 2004
    ..It has been applied to human urine samples collected from volunteers after consumption of different polyphenol-rich beverages in controlled conditions...
  22. ncbi request reprint Anthocyanins are efficiently absorbed from the small intestine in rats
    Severine Talavera
    Laboratoire de Pharmacognosie, Faculte de Pharmacie, 63001 Clermont Ferrand, France
    J Nutr 134:2275-9. 2004
    ..Furthermore, anthocyanins are quickly metabolized and excreted into bile and urine as intact glycosides as well as methylated forms and glucuronidated derivatives...
  23. ncbi request reprint Quercetin, but not its glycosides, is absorbed from the rat stomach
    Vanessa Crespy
    Laboratoire des Maladies Métaboliques et des Micronutriments, INRA de Clermont Ferrand Theix, 63122 Saint Genes Champanelle, France
    J Agric Food Chem 50:618-21. 2002
    ..In conclusion, when flavonols are present in the diet as aglycons, they could be partly absorbed in the stomach, in contrast to their glycosidic forms which are not absorbed...
  24. ncbi request reprint Absorption and metabolism of polyphenols in the gut and impact on health
    Augustin Scalbert
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, Saint Genes Champanelle, France
    Biomed Pharmacother 56:276-82. 2002
    ..Alternatively, some health effects of polyphenols may not require their absorption through the gut barrier. Their role as iron chelators in the gut lumen is briefly discussed...
  25. ncbi request reprint Mammalian lignan formation in rats fed a wheat bran diet
    Catherine Nicolle
    Laboratoire des Maladies Métaboliques et Micronutriments, INRA, 63122 Saint Genes Champanelle, France
    J Agric Food Chem 50:6222-6. 2002
    ..These results show that the formation of lignans from wheat bran is influenced by the diet, possibly because of an adaptation of the colonic microflora...
  26. ncbi request reprint Microbial aromatic acid metabolites formed in the gut account for a major fraction of the polyphenols excreted in urine of rats fed red wine polyphenols
    Marie Paule Gonthier
    Unité des Maladies Métaboliques et Micronutriments, INRA Theix, 63122 Saint Genes Champanelle, France
    J Nutr 133:461-7. 2003
    ..More attention should be given in the future to these microbial metabolites and their biological properties to help explain the health effects of polyphenols that are not easily absorbed through the gut barrier...
  27. ncbi request reprint Apple pectin and a polyphenol-rich apple concentrate are more effective together than separately on cecal fermentations and plasma lipids in rats
    Olivier Aprikian
    Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont Ferrand Theix, 63122 St Genes Champanelle, France
    J Nutr 133:1860-5. 2003
    ....
  28. ncbi request reprint How should we assess the effects of exposure to dietary polyphenols in vitro?
    Paul A Kroon
    Nutrition Division, Institute of Food Research, Norwich, United Kingdom
    Am J Clin Nutr 80:15-21. 2004
    ..1-10 micromol/L. For correct interpretation of results, future efforts to define biological activities of polyphenols must make use of the available data concerning bioavailability and metabolism in humans...
  29. doi request reprint Orally administered isoflavones are present as glucuronides in the human prostate
    Laurent Guy
    CHU Clermont Ferrand, Service Urologie, Clermont Ferrand, France
    Nutr Cancer 60:461-8. 2008
    ..Isoflavone mechanisms of action should thus be investigated in in vitro cell studies using physiological conditions, intracellular concentrations below 5 nmol/g and no intracellular deconjugation of the monoglucuronide metabolites...
  30. ncbi request reprint Lyophilized apple counteracts the development of hypercholesterolemia, oxidative stress, and renal dysfunction in obese Zucker rats
    Olivier Aprikian
    Unité des Maladies Métaboliques et Micronutriments, INRA de Clermont Ferrand Theix and CRNH d Auvergne, 63122 St Genes Champanelle, France
    J Nutr 132:1969-76. 2002
    ....
  31. doi request reprint Tissue distribution of isoflavones in ewes after consumption of red clover silage
    Mireia Urpi-Sarda
    Nutrition and Food Science Department, XaRTA, Pharmacy Faculty, University of Barcelona, 08028 Barcelona, Spain
    Arch Biochem Biophys 476:205-10. 2008
    ..Reproductive organs contained higher concentrations of isoflavones than heart, muscle, or thymus. Distribution of isoflavones in ewe tissues is unequal and may reflect specific impact in some target tissues...