Olivier Lortholary

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients
    Pierre Loulergue
    University Paris V, Paris, France
    Emerg Infect Dis 13:1647-52. 2007
  2. pmc Cryptococcal neuroradiological lesions correlate with severity during cryptococcal meningoencephalitis in HIV-positive patients in the HAART era
    Caroline Charlier
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA 3012, Institut Pasteur, Paris, France
    PLoS ONE 3:e1950. 2008
  3. ncbi request reprint Evidence for human immunodeficiency virus and Cryptococcus neoformans interactions in the pro-inflammatory and anti-inflammatory responses in blood during AIDS-associated cryptococcosis
    O Lortholary
    Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, Institut Pasteur, Paris, France
    Clin Microbiol Infect 11:296-300. 2005
  4. ncbi request reprint Endemic mycoses: a treatment update
    O Lortholary
    Service de Medecine Interne, Centre de Recherche en Pathologie Infectieuse et Tropicale, Hopital Avicenne, Universite Paris Nord, Bobigny, France
    J Antimicrob Chemother 43:321-31. 1999
  5. ncbi request reprint Long-term outcome of AIDS-associated cryptococcosis in the era of combination antiretroviral therapy
    Olivier Lortholary
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, Institut Pasteur, Paris, France
    AIDS 20:2183-91. 2006
  6. pmc In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing
    Olivier Lortholary
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA3012, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 51:3378-80. 2007
  7. ncbi request reprint Incidence and risk factors of immune reconstitution inflammatory syndrome complicating HIV-associated cryptococcosis in France
    Olivier Lortholary
    National Reference Centre for Mycoses and Antifungals, Molecular Mycology Unit bEmerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France
    AIDS 19:1043-9. 2005
  8. doi request reprint [Chronic granulomatous disease: pathogenesis and therapy of associated fungal infections]
    ANNE DESJARDINS
    Service de Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Paris, France
    Med Sci (Paris) 28:963-9. 2012
  9. doi request reprint Recurrent Mycobacterium avium infection after seven years of latency in a HIV-infected patient receiving efficient antiretroviral therapy
    Guillaume Bussone
    Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    J Infect 64:613-7. 2012
  10. doi request reprint Invasive mold infections in chronic granulomatous disease: a 25-year retrospective survey
    Sophie Blumental
    Immunology and Haematology Unit, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 53:e159-69. 2011

Detail Information

Publications152 found, 100 shown here

  1. pmc Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients
    Pierre Loulergue
    University Paris V, Paris, France
    Emerg Infect Dis 13:1647-52. 2007
    ..We report 3 cases of imported African histoplasmosis diagnosed in France in HIV-infected patients and a literature review on similar cases...
  2. pmc Cryptococcal neuroradiological lesions correlate with severity during cryptococcal meningoencephalitis in HIV-positive patients in the HAART era
    Caroline Charlier
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA 3012, Institut Pasteur, Paris, France
    PLoS ONE 3:e1950. 2008
    ..Given this, we suggest that investigation for cryptococcosis-related lesions is merited, even in the absence of neurological abnormality, if a high fungal burden is suspected on the basis of high serum and/or CSF antigen titers...
  3. ncbi request reprint Evidence for human immunodeficiency virus and Cryptococcus neoformans interactions in the pro-inflammatory and anti-inflammatory responses in blood during AIDS-associated cryptococcosis
    O Lortholary
    Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, Institut Pasteur, Paris, France
    Clin Microbiol Infect 11:296-300. 2005
    ..01). During antifungal therapy, sTNFR II levels decreased (p 0.003) in parallel with the virus load and with an increase in CD4 T-cell numbers...
  4. ncbi request reprint Endemic mycoses: a treatment update
    O Lortholary
    Service de Medecine Interne, Centre de Recherche en Pathologie Infectieuse et Tropicale, Hopital Avicenne, Universite Paris Nord, Bobigny, France
    J Antimicrob Chemother 43:321-31. 1999
    ..Fluconazole has relatively poor efficacy against histoplasmosis, blastomycosis and sporotrichosis. New antifungal agents have been tested in vitro or in animal models and may soon be evaluated in clinical trials...
  5. ncbi request reprint Long-term outcome of AIDS-associated cryptococcosis in the era of combination antiretroviral therapy
    Olivier Lortholary
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, Institut Pasteur, Paris, France
    AIDS 20:2183-91. 2006
    ..Immune restoration following combination antiretroviral therapy (cART) questions the maintenance of prophylaxis among HIV-infected patients with cryptococcosis...
  6. pmc In vitro susceptibility to posaconazole of 1,903 yeast isolates recovered in France from 2003 to 2006 and tested by the method of the European committee on antimicrobial susceptibility testing
    Olivier Lortholary
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA3012, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 51:3378-80. 2007
    ..Ninety percent of isolates with fluconazole MICs of > or =8 microg/ml (n = 509) and 90% of those with voriconazole MICs of > or =2 microg/ml (n = 80) were inhibited by 2 and 8 microg/ml of posaconazole, respectively...
  7. ncbi request reprint Incidence and risk factors of immune reconstitution inflammatory syndrome complicating HIV-associated cryptococcosis in France
    Olivier Lortholary
    National Reference Centre for Mycoses and Antifungals, Molecular Mycology Unit bEmerging Diseases Epidemiology Unit, Institut Pasteur, Paris, France
    AIDS 19:1043-9. 2005
    ..Immune reconstitution inflammatory syndrome (IRIS) in association with cryptococcosis has been anecdotically reported following administration of highly active antiretroviral therapy (HAART)...
  8. doi request reprint [Chronic granulomatous disease: pathogenesis and therapy of associated fungal infections]
    ANNE DESJARDINS
    Service de Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Paris, France
    Med Sci (Paris) 28:963-9. 2012
    ..Here we review the genetic basis, pathogenesis and clinical presentation associated with fungal infections in chronic granulomatous disease as well as the current prophylaxis and newly available therapies...
  9. doi request reprint Recurrent Mycobacterium avium infection after seven years of latency in a HIV-infected patient receiving efficient antiretroviral therapy
    Guillaume Bussone
    Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    J Infect 64:613-7. 2012
    ..avium bacteriaemia. Articular puncture grew M. avium. The isolates of the first and second infection were identical using repetitive-sequence-based Polymerase Chain Reaction analyses...
  10. doi request reprint Invasive mold infections in chronic granulomatous disease: a 25-year retrospective survey
    Sophie Blumental
    Immunology and Haematology Unit, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 53:e159-69. 2011
    ..This study offers a descriptive review of invasive mold infection (mIFI) in children with CGD over an extended period of time...
  11. doi request reprint Adherence to preventive measures after splenectomy in the hospital setting and in the community
    Hélène Coignard-Biehler
    Paris Descartes University, Paris, France
    J Infect Public Health 4:187-94. 2011
    ..Overwhelming post-splenectomy infection (OPSI) remains a long-term risk in asplenic patients, which may be reduced by appropriate preventive measures. Specific guidelines have been developed to lower its incidence...
  12. pmc Therapeutic drug monitoring of posaconazole: a monocentric study with 54 adults
    David Lebeaux
    Universite Paris Descartes, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, Paris, France
    Antimicrob Agents Chemother 53:5224-9. 2009
    ..Therapeutic drug monitoring of posaconazole is therefore mandatory for immunosuppressed adults, at least for those with gastrointestinal disorders...
  13. pmc Efficacy of amphotericin B in combination with flucytosine against flucytosine-susceptible or flucytosine-resistant isolates of Cryptococcus neoformans during disseminated murine cryptococcosis
    Patrick Schwarz
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, Institut Pasteur, CNRS FRE2849, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 50:113-20. 2006
    ..This study demonstrates the beneficial effect of the addition of flucytosine to amphotericin B against experimental disseminated cryptococcal infection even when the C. neoformans isolate is resistant to flucytosine...
  14. pmc Determinants of disease presentation and outcome during cryptococcosis: the CryptoA/D study
    Francoise Dromer
    Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, CNRS URA3042, Institut Pasteur, Paris, France
    PLoS Med 4:e21. 2007
    ....
  15. pmc Combination of amphotericin B with flucytosine is active in vitro against flucytosine-resistant isolates of Cryptococcus neoformans
    Patrick Schwarz
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS FRE2849, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 51:383-5. 2007
    ..Although differences were observed depending on the technique used, antagonism was never observed. The synergistic interaction was related to the mechanism of flucytosine resistance of the isolates...
  16. pmc Recent exposure to caspofungin or fluconazole influences the epidemiology of candidemia: a prospective multicenter study involving 2,441 patients
    Olivier Lortholary
    Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, Paris, France
    Antimicrob Agents Chemother 55:532-8. 2011
    ..53; 95% CI = 1.43 to 4.48; P = 0.001) and with recent exposure to caspofungin (OR = 4.79; 95% CI = 2.47 to 9.28; P < 0.001). These findings could influence future recommendations for the management of candidemia...
  17. doi request reprint Pediatric mastocytosis is a clonal disease associated with D816V and other activating c-KIT mutations
    Christine Bodemer
    Service de Dermatologie, Hopital Necker, CEREMAST, centre de référence des mastocytoses, Faculte Necker, Universite Rene Descartes Paris V, Paris, France
    J Invest Dermatol 130:804-15. 2010
    ..These findings strongly support the idea that, although pediatric mastocytosis can spontaneously regress, it is a clonal disease most commonly associated with activating mutations in c-KIT...
  18. doi request reprint Renal mucormycosis complicating extracorporeal membrane oxygenation
    Pierre Charles
    Hopital Foch, Service de Medecine Interne, Suresnes, France
    Med Mycol 51:193-5. 2013
    ..The outcome of such complication can be favorable with the utilization of new antifungal therapies...
  19. doi request reprint Gastrointestinal manifestations in mastocytosis: a study of 83 patients
    Harry Sokol
    Service de Gastroenterologie et Nutrition, Hopital Saint Antoine, AP HP, Universite Pierre et Marie Curie Paris 6, Paris, France Equipe AVENIR, Laboratoire INSERM U1057 UMR CNRS 7203, Universite Pierre et Marie Curie 6, Paris, France Equipe Interactions des bactéries commensales et probiotiques avec l hôte, Micalis, INRA, Jouy en Josas, France Centre de Référence des Mastocytoses, Faculté de Médecine et AP HP Necker Enfants Malades, Paris, France
    J Allergy Clin Immunol 132:866-73.e1-3. 2013
    ..Gastrointestinal manifestations of systemic mastocytosis have been previously studied in small cohorts of patients, and no specific histologic description is available...
  20. pmc Prior caspofungin exposure in patients with hematological malignancies is a risk factor for subsequent fungemia due to decreased susceptibility in Candida spp.: a case-control study in Paris, France
    Elodie Blanchard
    INSERM U 657, Paris, France
    Antimicrob Agents Chemother 55:5358-61. 2011
    ..25; 95% confidence interval [95% CI], 1.68-16.35) and with an age of ≤ 65 years (OR = 3.27; 95% CI, 1.26-8.50)...
  21. pmc Cost-effectiveness of primary prophylaxis of AIDS associated cryptococcosis in Cambodia
    Romain Micol
    Unité d Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France
    PLoS ONE 5:e13856. 2010
    ..This study assessed the cost-effectiveness of three strategies for cryptococcosis prevention in HIV-infected patients...
  22. doi request reprint Therapeutic drug monitoring of voriconazole after intravenous administration in infants and children with primary immunodeficiency
    Magdalena Gerin
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Paris, France
    Ther Drug Monit 33:464-6. 2011
    ..The aim of this work was to describe the probability of not achieving this target concentration in infants and children receiving intravenous voriconazole...
  23. pmc Iatrogenic Cushing's syndrome induced by posaconazole
    Benoit Pilmis
    Service de Maladies Infectieuses et Tropicales, Groupe Hospitalier Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, Paris, France
    Antimicrob Agents Chemother 57:5727-8. 2013
    ..After a switch to posaconazole, the patient developed Cushingoid symptoms. ..
  24. ncbi request reprint [Physiopathology of meningoencephalitis caused by Cryptococcus neoformans]
    Ségolène Neuville
    Service de Maladies Infectieuses et Tropicales, Hopital Saint Louis, Paris, France
    Ann Med Interne (Paris) 153:323-8. 2002
    ..In other immunodepressed hosts, a granulomatous inflammation containing few yeasts is usually seen. This may reflect an altered local immunological defect against C. neoformans in AIDS patients with cryptococcosis...
  25. ncbi request reprint A multicentre pharmacoepidemiological study of therapeutic practices in invasive fungal infections in France during 1998-1999
    Olivier Lortholary
    Centre National de Référence Mycologie et Antifongiques, Institut Pasteur, Paris and Hôpital Necker, Paris, France
    J Antimicrob Chemother 54:456-64. 2004
    ..To study the pharmacoepidemiology of the prescription of systemic antifungal agents in 48 French haematology, intensive care and infectious diseases units...
  26. doi request reprint Severe cutaneous bacillus Calmette-Guérin infection in immunocompromised children: the relevance of skin biopsy
    Amélie Gantzer
    Department of Dermatology, Hopital Necker Enfants Malades, Universite Rene Descartes, APHP, Paris, France
    J Cutan Pathol 40:30-7. 2013
    ..Skin biopsy is a useful part of the diagnostic workup for disseminated BCGitis, directing the clinician toward severe immunodeficiency. Moreover, skin biopsy may be a useful means of monitoring immune restoration for prognostic purposes...
  27. ncbi request reprint Fungal infections in immunocompromised travelers
    Olivier Lortholary
    Universite Paris Descartes, Sorbonne Paris Cité, Hopital Necker Enfants Malades, Centre d lnfectiologie Necker Pasteur, and Institut Imagine, Paris, France
    Clin Infect Dis 56:861-9. 2013
    ..Finally, infectious diseases physicians should be aware of major clinical patterns of travel-acquired fungal infection, as well as the fungi involved, and risk factors according to the geographical area visited...
  28. pmc In vitro combination of anidulafungin and voriconazole against intrinsically azole-susceptible and -resistant Aspergillus spp
    Virginie Planche
    Universite Paris Descartes, Faculte de Medecine, APHP, Hopital Europeen Georges Pompidou, Unité de Parasitologie Mycologie, Service de Microbiologie, Paris, France
    Antimicrob Agents Chemother 56:4500-3. 2012
    ..5 to 2) and for 100% of the isolates by the agar diffusion method (variation of -2 to +1 log(2) dilutions)...
  29. pmc Serum Aspergillus galactomannan for the management of disseminated histoplasmosis in AIDS
    Sébastien Rivière
    Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Paris, France
    Am J Trop Med Hyg 87:303-5. 2012
    ..Here, we report the contribution of galactomannan serum detection for the management of an HIV-infected patient with disseminated histoplasmosis...
  30. pmc Candida spp. with acquired echinocandin resistance, France, 2004-2010
    Eric Dannaoui
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA3012, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    Emerg Infect Dis 18:86-90. 2012
    ..harboring diverse and new Fksp mutations. For 12 patients, initial isolates (low MIC, wild-type Fksp sequence) and subsequent isolates (after caspofungin treatment, high MIC, mutated Fksp) were genetically related...
  31. pmc In vitro interactions between antifungals and immunosuppressive drugs against zygomycetes
    Eric Dannaoui
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA3012, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, Cedex 15, France
    Antimicrob Agents Chemother 53:3549-51. 2009
    ..In summary, calcineurin inhibitors and rapamycin can be synergistic in vitro with amphotericin B and azoles against zygomycetes...
  32. ncbi request reprint Prevalence, determinants of positivity, and clinical utility of cryptococcal antigenemia in Cambodian HIV-infected patients
    Romain Micol
    Unité d Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France
    J Acquir Immune Defic Syndr 45:555-9. 2007
    ..To determine the prevalence, determinants ofpositivity, and clinical utility of serum cryptococcal polysaccharide (CPS) antigen testing among HIV-infected patients in 2004 in Cambodia, an area highly endemic for cryptococcosis...
  33. pmc Carbon assimilation profiles as a tool for identification of zygomycetes
    Patrick Schwarz
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA3012, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    J Clin Microbiol 45:1433-9. 2007
    ..In conclusion, carbon assimilation profiles allowed precise and accurate identification of most Zygomycetes to the species level...
  34. pmc Host factors and portal of entry outweigh bacterial determinants to predict the severity of Escherichia coli bacteremia
    Agnes Lefort
    AP HP, Hopital Beaujon, Service de Medecine Interne, 92110 Clichy Cedex, France
    J Clin Microbiol 49:777-83. 2011
    ..46 [95% CI, 0.30 to 0.70] and OR = 0.53 [95% CI, 0.30 to 0.91], respectively). In summary, host factors and the portal of entry outweigh bacterial determinants for predicting E. coli bacteremia severity...
  35. pmc Evidence for cognitive impairment in mastocytosis: prevalence, features and correlations to depression
    Daniela Silva Moura
    centre de référence des mastocytoses, Hopital Necker Enfants Malades, Fondation Imagine Paris, Universite Paris Descartes, Sorbonne, Paris Cité, Paris, France
    PLoS ONE 7:e39468. 2012
    ..These results suggest differential effects of mast-cell activity in the brain, on systems involved in emotionality and in cognition...
  36. doi request reprint Mucormycosis in organ and stem cell transplant recipients
    Fanny Lanternier
    Centre d lnfectiologie Necker Pasteur, Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 54:1629-36. 2012
    ....
  37. pmc Autosomal dominant STAT3 deficiency and hyper-IgE syndrome: molecular, cellular, and clinical features from a French national survey
    Marie Olivia Chandesris
    Hematology Department, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris, Paris, France
    Medicine (Baltimore) 91:e1-19. 2012
    ..Overall, the prognosis of STAT3 deficiency may be considered good, provided that multiple prophylactic measures, including IgG infusions, are implemented...
  38. doi request reprint Epidemiology and outcome of invasive fungal diseases in patients with chronic granulomatous disease: a multicenter study in France
    Julien Beauté
    Centre de Référence Déficits Immunitaires Héréditaires, Hopital Necker Enfants Malades, AP HP, Paris, France
    Pediatr Infect Dis J 30:57-62. 2011
    ..This study is aimed at assessing the incidence, prevalence, and outcome of IFDs among CGD patients followed in France...
  39. doi request reprint Mycobacterium genavense infections: a retrospective multicenter study in France, 1996-2007
    Pierre Charles
    Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    Medicine (Baltimore) 90:223-30. 2011
    ..The 1-year survival rate was 72%.The prognosis of M. genavense infection in HIV-infected patients has dramatically improved with HAART. Clinical presentations in HIV and non-HIV immunocompromised patients were similar...
  40. pmc Major role for amphotericin B-flucytosine combination in severe cryptococcosis
    Francoise Dromer
    Institut Pasteur, Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, CNRS URA3012, Paris, France
    PLoS ONE 3:e2870. 2008
    ..We assessed here the optimal therapeutic strategies for severe cryptococcosis using the observational prospective CryptoA/D study after analyzing routine clinical care of cryptococcosis in university or tertiary care hospitals...
  41. pmc Antifungal therapy of Aspergillus invasive otitis externa: efficacy of voriconazole and review
    Perrine Parize
    Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    Antimicrob Agents Chemother 53:1048-53. 2009
    ..These observations demonstrate that voriconazole could be an effective and well-tolerated therapeutic option for the management of Aspergillus IOE...
  42. ncbi request reprint Immune reconstitution inflammatory syndrome in HIV-infected patients with disseminated histoplasmosis
    Guillaume Breton
    Department of Infectious and Tropical Diseases, Hopital Bichat Claude Bernard, Paris, France
    AIDS 20:119-21. 2006
    ..Partial immune reconstitution induced by HAART during disseminated histoplasmosis either related to the variety capsulatum or duboisii may be associated with immune reconstitution inflammatory syndrome...
  43. doi request reprint Prevalence, risk factors, and impact on outcome of cytomegalovirus replication in serum of Cambodian HIV-infected patients (2004-2007)
    Romain Micol
    Unité d Epidémiologie des Maladies Emergentes, Institut Pasteur, Paris, France
    J Acquir Immune Defic Syndr 51:486-91. 2009
    ..We estimated the prevalence of replicating CMV in sera of newly diagnosed HIV-infected Cambodian patients and examined its impact on mortality...
  44. ncbi request reprint Successful treatment of black-grain mycetoma with voriconazole
    Pierre Loulergue
    Centre d Infectiologie Necker Pasteur, et Service de Radiologie, Hopital Necker Enfants Malades, Universite Paris V, Paris, France
    Am J Trop Med Hyg 75:1106-7. 2006
    ..We report a case of black-grain fungal mycetoma successfully treated with voriconazole without side effects. The duration of the treatment remains unclear, but must be prolonged because of the frequency of relapses...
  45. pmc Capsule structure changes associated with Cryptococcus neoformans crossing of the blood-brain barrier
    Caroline Charlier
    Unité de Mycologie Moléculaire, CNRS FRE2948, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Am J Pathol 166:421-32. 2005
    ..The rapid changes in capsule structure could contribute to inability of the host immune response to control cryptococcal infection in extrapulmonary spaces...
  46. doi request reprint Leukocyte telomere length in mastocytosis: correlations with depression and perceived stress
    Sophie Georgin-Lavialle
    centre de référence des mastocytoses, Universite Paris Descartes, Sorbonne, Paris Cité, Hopital Necker Enfants Malades, Paris, France Institut Imagine Université Paris Descartes, Sorbonne, Paris Cité, Hopital Necker Enfants Malades, Paris, France CNRS UMR 8147, Hopital Necker Enfants Malades, 149 rue des Sèvres, 75743 Paris Cedex 15, France Electronic address
    Brain Behav Immun 35:51-7. 2014
    ..Taken together these observations led us to hypothesize that mast cells activity could be involved in both negative emotionality and telomere shortening in mastocytosis...
  47. pmc Case-control cohort study of patients' perceptions of disability in mastocytosis
    Olivier Hermine
    Service de Dermatologie, Centre de référence sur la mastocytose, Hopital Necker, Paris, France
    PLoS ONE 3:e2266. 2008
    ..We therefore performed a case-control cohort study to examine self-reported disability and impact of symptoms on the quality of life in patients with mastocytosis...
  48. pmc Altered responses to homeostatic cytokines in patients with idiopathic CD4 lymphocytopenia
    Florence Bugault
    Unité d Immunogénétique Cellulaire, Institut Pasteur, Paris, France
    PLoS ONE 8:e55570. 2013
    ..Increased TSLP responses point to a compensatory homeostatic mechanism that may mitigate defects in γc cytokine responses...
  49. pmc Mycobacterium genavense as a cause of subacute pneumonia in patients with severe cellular immunodeficiency
    Blandine Rammaert
    Universite Paris Descartes, Hopital Necker Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Paris, France
    BMC Infect Dis 11:311. 2011
    ..M. genavense culture is fastidious, requiring supplemented media. Pulmonary involvement rarely occurs as a primary localization...
  50. doi request reprint Blood CD34-c-Kit+ cell rate correlates with aggressive forms of systemic mastocytosis and behaves like a mast cell precursor
    Sophie Georgin-Lavialle
    Service d Hématologie Adultes et Centre de Référence sur les Mastocytoses, Hopital Necker Enfants Malades, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, France
    Blood 118:5246-9. 2011
    ..Monitoring peripheral CD34(-)c-Kit(+) cells by flow cytometry could be a useful and low-invasive tool to determine the disease severity and the relapses and to assess treatment efficiency...
  51. doi request reprint Plasma exchange for disseminated cryptococcosis
    Guillaume Bollée
    Department of Nephrology, AP HP, Hopital Necker, Universite Paris V, Paris, France
    Am J Kidney Dis 53:673-6. 2009
    ..We report a peculiar case of disseminated cryptococcosis complicated by acute renal failure associated with obstruction of intrarenal capillaries by Cryptococus neoformans dead bodies and successfully treated with plasma exchanges...
  52. ncbi request reprint [Infections in splenectomized patient]
    Hélène Coignard-Biehler
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Paris, France
    Rev Prat 58:2209-14. 2008
    ..Furthermore, long-term education is mandatory. Application of preventing measures is effective and patient's education remains the cornerstone of prevention...
  53. pmc Molecular detection and identification of zygomycetes species from paraffin-embedded tissues in a murine model of disseminated zygomycosis: a collaborative European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Fungal Infection Study G
    Eric Dannaoui
    Institut Pasteur, Unité de Mycologie Moléculaire, 25, rue du Dr Roux, Paris 75724 Cedex 15, France
    J Clin Microbiol 48:2043-6. 2010
    ....
  54. doi request reprint [Mucormycosis: therapeutic news]
    Benoit Pilmis
    Universite Paris Descartes, Hopital Necker Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Paris, France
    Med Sci (Paris) 29:25-30. 2013
    ..Maintenance therapy/secondary prophylaxis by posaconazole has to be considered in persistently immuno compromised patients...
  55. doi request reprint Adjuvant corticosteroid therapy for chronic disseminated candidiasis
    Faezeh Legrand
    Universite Paris 7, Service d Hématologie Pédiatrique, Hopital Robert Debre, Paris, France
    Clin Infect Dis 46:696-702. 2008
    ..Chronic disseminated candidiasis (CDC) is typically observed during neutrophil recovery in patients with acute leukemia and requires protracted antifungal therapy...
  56. pmc In vitro evaluation of double and triple combinations of antifungal drugs against Aspergillus fumigatus and Aspergillus terreus
    Eric Dannaoui
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, Institut Pasteur, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 48:970-8. 2004
    ..warrants further investigations. Animal studies are needed to evaluate the in vivo efficacies of these combinations...
  57. ncbi request reprint Primary cutaneous cryptococcosis: a distinct clinical entity
    Ségolène Neuville
    Centre National de Référence des Mycoses et des Antifongiques, Unité de Mycologie Moléculaire, Institut Pasteur, 75724 Paris Cedex 15, France
    Clin Infect Dis 36:337-47. 2003
    ..neoformans serotype D. Therefore, PCC is a distinct epidemiological and clinical entity with a favorable prognosis even for immunocompromised hosts...
  58. ncbi request reprint Voriconazole for invasive bone aspergillosis: a worldwide experience of 20 cases
    Houria Mouas
    Service des Maladies Infectieuses et Tropicales, Hopital Necker, Paris, France
    Clin Infect Dis 40:1141-7. 2005
    ..BACKGROUND; Bone aspergillosis remains a rare but potentially devastating fungal disease. Although voriconazole is effective for invasive pulmonary aspergillosis, evidence of its efficacy for aspergillosis located in bone is limited...
  59. doi request reprint Immunological efficacy of a three-dose schedule of hepatitis A vaccine in HIV-infected adults: HEPAVAC study
    Odile Launay
    Universite Paris Descartes, Faculte de Medecine, Paris, France
    J Acquir Immune Defic Syndr 49:272-5. 2008
    ..The immunogenicity of vaccines, including vaccine against hepatitis A virus (HAV), is impaired in patients with HIV infection, requiring revised immunization regimens...
  60. pmc Molecular identification of black-grain mycetoma agents
    Marie Desnos-Ollivier
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS FRE2849, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Clin Microbiol 44:3517-23. 2006
    ..Epidemiological and therapeutic studies could benefit from a precise identification of the fungi responsible for black-grain mycetoma based not only on phenotypical characteristics but also on ITS sequencing...
  61. pmc International retrospective analysis of 73 cases of invasive fusariosis treated with voriconazole
    Olivier Lortholary
    Institut Pasteur, National Reference Center for Mycoses and Antifungals, Molecular Mycology Unit, CNRS URA3012, Paris, France
    Antimicrob Agents Chemother 54:4446-50. 2010
    ..02). Median survival (in days) by species was as follows: F. solani, 213; F. oxysporum, 112; Fusarium spp., 101; F. proliferatum, 84; F. moniliforme, 76. We conclude that voriconazole is a therapeutic option for invasive fusariosis...
  62. doi request reprint Residual HIV-1 RNA and HIV-1 DNA production in the genital tract reservoir of women treated with HAART: the prospective ANRS EP24 GYNODYN study
    Odile Launay
    Faculté de Médecine Paris Descartes, Universite Paris Descartes, Paris, France
    Antivir Ther 16:843-52. 2011
    ..The objective of this study was to prospectively assess residual HIV-1 RNA and HIV-1 DNA production in the genital tract reservoir of women initiating HAART over an 18-month period...
  63. ncbi request reprint Pathogenesis of cerebral Cryptococcus neoformans infection after fungemia
    Fabrice Chretien
    Laboratoire de Neuropathologie, Faculté de médecine Paris Ouest, Hopital Raymond Poincare, Garches, Paris, France
    J Infect Dis 186:522-30. 2002
    ..Thus, our data established the relevance and interest that this experimental model has for investigation of the pathogenesis of human cryptococcal meningitis...
  64. doi request reprint Listeria monocytogenes-associated joint and bone infections: a study of 43 consecutive cases
    Caroline Charlier
    Institut Pasteur, French National Reference Center and WHO Collaborating Center for Listeria, Microbes and Host Barriers Group, Universite Paris Descartes, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 54:240-8. 2012
    ..Little is known about Listeria monocytogenes-associated bone and joint infections. Only case reports of this infection have been published...
  65. ncbi request reprint Gastrointestinal involvement and manifestations in systemic mastocytosis
    Harry Sokol
    Department of Gastroenterology and Nutrition, Saint Antoine Hospital, Universite Paris VI, Faculte de Medecine, Assistance Publique Hopitaux de Paris, Paris, France
    Inflamm Bowel Dis 16:1247-53. 2010
    ..Diagnosis of mastocytosis GI manifestations should be evoked in the case of unexplained severe GI disorders...
  66. doi request reprint Pharmacodynamics and pharmacokinetics of antibacterial drugs in the management of febrile neutropenia
    Olivier Lortholary
    Universite Paris Descartes, Department of Infectious and Tropical Diseases, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Paris, France
    Lancet Infect Dis 8:612-20. 2008
    ....
  67. doi request reprint Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia
    Romain Micol
    CEREDIH network French National Reference Center for Primary Immunodeficiencies, Hopital Necker Enfants Malades, AP HP, Paris, France
    J Allergy Clin Immunol 129:770-7. 2012
    ..It is not known whether patients able to secrete IgM (eg, those with hyper-IgM [HIgM] syndrome) are as susceptible to these infections as patients who lack IgM production (eg, those with panhypogammaglobulinemia [PHG])...
  68. pmc Depression in patients with mastocytosis: prevalence, features and effects of masitinib therapy
    Daniela Silva Moura
    Universite Paris Descartes, Sorbonne, Paris Cité, Service d Hematologie, centre de référence des mastocytoses, Hopital Necker Enfants Malades, Paris, France
    PLoS ONE 6:e26375. 2011
    ..We conclude that depression in mastocytosis may originate from processes related to mast cells activation. Masitinib could therefore be a useful treatment for mastocytosis patients with depression and anxiety symptoms...
  69. doi request reprint Systemic antifungal therapy in critically ill patients without invasive fungal infection*
    Elie Azoulay
    Paris 7 University, EA, Saint Louis Hospital, Paris, France
    Crit Care Med 40:813-22. 2012
    ..To determine the number of adult or pediatric intensive care unit patients without documented invasive fungal infection who receive systemic antifungal therapy...
  70. pmc In vitro interaction of flucytosine with conventional and new antifungals against Cryptococcus neoformans clinical isolates
    Patrick Schwarz
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, Institut Pasteur, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 47:3361-4. 2003
    ..Antagonism was never observed. Killing curves showed indifferent interactions between triazoles and flucytosine and synergy between amphotericin B and flucytosine...
  71. pmc Molecular diagnosis of Saksenaea vasiformis cutaneous infection after scorpion sting in an immunocompetent adolescent
    Pauline Lechevalier
    AP HP, Hopital Robert Debre, Service de Pediatrie Generale, Université Paris Diderot Paris VII, Paris, France
    J Clin Microbiol 46:3169-72. 2008
    ..Saksenaea vasiformis was identified by PCR amplification and sequencing of the fungal DNA on a cutaneous biopsy. Successful treatment was obtained by surgery and liposomal amphotericin B...
  72. pmc Phylogenetic and genomic diversity of human bacteremic Escherichia coli strains
    Françoise Jaureguy
    INSERM UMR570, Faculte de Medecine, Universite Paris Descartes, Paris, France
    BMC Genomics 9:560. 2008
    ..A subset representative of the clonal diversity was subjected to comparative genomic hybridization (CGH) using 2,324 amplicons from the flexible gene pool of E. coli...
  73. doi request reprint Pristinamycin for Rickettsia africae infection
    Frédéric Méchaï
    Centre d Infectiologie Necker Pasteur, Paris, France
    J Travel Med 16:136-7. 2009
    ..The gold standard treatment is doxycycline. Here, we present a case of R africae infection associated with quick complete resolution following the initiation of pristinamycin therapy...
  74. ncbi request reprint [Early capsule structure changes associated with Cryptococcus neoformans crossing of the blood-brain barrier]
    Caroline Charlier
    Unité de Mycologie Moléculaire, CNRS FRE 2849, Institut Pasteur, 28 rue du Docteur Roux, 75015 Paris, France
    Med Sci (Paris) 21:685-7. 2005
  75. doi request reprint Cutaneous findings in sporadic and familial autosomal dominant hyper-IgE syndrome: a retrospective, single-center study of 21 patients diagnosed using molecular analysis
    Amani Olaiwan
    Department of Dermatology, Necker Enfants Malades Hospital, Assistance Publique Hopitaux de Paris AP HP, Paris, France
    J Am Acad Dermatol 65:1167-72. 2011
    ..Recent identification of STAT3 mutations in autosomal dominant (AD) hyper-IgE syndrome (HIES) has improved the clinical, genetic, and molecular classification of the HIES...
  76. pmc Imported acquired immunodeficiency syndrome-related histoplasmosis in metropolitan France: a comparison of pre-highly active anti-retroviral therapy and highly active anti-retroviral therapy eras
    Vincent Peigne
    Institut Pasteur, Unité de Mycologie Moléculaire, Centre National de Référence Mycologie et Antifongiques, Paris, France
    Am J Trop Med Hyg 85:934-41. 2011
    ..Histoplasmosis is a rare invasive fungal infection outside disease-endemic areas. Its prognosis improved significantly during the HAART era...
  77. doi request reprint [Positive interaction between immunosuppressive and antifungal drugs]
    Blandine Rammaert
    Institut Pasteur du Cambodge, unité d épidémiologie et de santé publique, BP 983, Phnom Penh, Royaume du Cambodge, Paris, France
    Med Sci (Paris) 26:747-52. 2010
    ..These results are confirmed by clinical findings and thus offer further therapeutic possibilities in the context of solid organ transplantation. double dagger...
  78. doi request reprint Impact of norovirus/sapovirus-related diarrhea in renal transplant recipients hospitalized for diarrhea
    Damien Roos-Weil
    Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, AP HP, Centre d Infectiologie Necker Pasteur, Paris, France
    Transplantation 92:61-9. 2011
    ..Norovirus (NoV) and sapovirus (SaV) have been sporadically reported to cause chronic diarrhea in immunocompromised patients...
  79. ncbi request reprint Isolated Mycobacterium simiae pancreatic abscess in a patient receiving antiretroviral therapy
    Frederic Marrache
    Service des Maladies Infectieuses et Tropicales, Hopital Avicenne, Bobigny, France
    Clin Gastroenterol Hepatol 2:xviii. 2004
  80. doi request reprint Fournier's gangrene due to Candida glabrata
    Pierre Loulergue
    Service des Maladies Infectieuses et Tropicales, Faculte de Medecine, Hopital Necker Enfants Malades, Universite Paris Descartes, Paris, France
    Med Mycol 46:171-3. 2008
    ..albicans Candida sp. Fournier's gangrene who survived with an appropriate antifungal therapy. Yeasts should be considered as emerging pathogens in pelvic infections due to the increase in long-term immunocompromised patients...
  81. ncbi request reprint Contribution of molecular tools for the diagnosis of endogenous pneumococcal endophthalmitis in a patient with the acquired immunodeficiency syndrome
    Marie Olivia Chandesris
    Departments of Infectious Diseases and Tropical Medicine, Necker Enfants Malades Hospital, Paris, France
    Scand J Infect Dis 39:1080-1. 2007
    ..Here we report the first case of Streptococcus pneumoniae endophthalmitis diagnosed by polymerase chain reaction. Molecular biology should be considered as a new tool for the diagnosis of such sequestered sites as the eye...
  82. pmc Unmasking leprosy: an unusual immune reconstitution inflammatory syndrome in a patient infected with human immunodeficiency virus
    Guillaume Bussone
    Service de Maladies Infectieuses et Tropicales, et Service de Microbiologie, Centre d Infectiologie Necker Pasteur, Universite Paris Descartes, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Am J Trop Med Hyg 83:13-4. 2010
    ..These lesions were associated with microbiologically proven leprosy. Thus, latent leprosy can appear as IRIS, and leprosy-associated IRIS should be considered in HIV-infected patients from areas endemic for leprosy...
  83. doi request reprint [Lymph nodes: first barrier against Plasmodium]
    Caroline Charlier-Woerther
    Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Universite Paris V, Centre d Infectiologie Necker Pasteur, 149 rue de Sevres, Paris Cedex 15, France
    Med Sci (Paris) 24:18-9. 2008
  84. ncbi request reprint Immunoproliferative small intestinal disease associated with Campylobacter jejuni
    Marc Lecuit
    Hopital Avicenne, Paris, France
    N Engl J Med 350:239-48. 2004
    ..Early-stage disease responds to antibiotics, suggesting a bacterial origin. We attempted to identify a causative agent...
  85. pmc Emergence of disseminated infections due to Geosmithia argillacea in patients with chronic granulomatous disease receiving long-term azole antifungal prophylaxis
    Marie Machouart
    Service de Parasitologie Mycologie, CHU de Nancy, Hopital Brabois, 11 allee du morvan, 54511 Vandoeuvre les Nancy, France
    J Clin Microbiol 49:1681-3. 2011
    ..One patient died despite receiving a combination of four antifungals, and the other developed cerebral and medullary lesions under a combination of caspofungin, posaconazole, terbinafine, and gamma interferon...
  86. ncbi request reprint Mycoses in AIDS
    B Dupont
    Unite de Mycologie, Institut Pasteur, H pital Necker, Paris, France
    Med Mycol 38:259-67. 2000
    ..The epidemiology is dramatically different in the countries which cannot afford the cost of HAART for the majority of patients, such as South Africa. These topics will be discussed in this paper...
  87. pmc Comparative in vitro activities of caspofungin and micafungin, determined using the method of the European Committee on Antimicrobial Susceptibility Testing, against yeast isolates obtained in France in 2005-2006
    E Dannaoui
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS URA3012, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 52:778-81. 2008
    ..A clear correlation was seen between the MICs for the two drugs...
  88. pmc Results obtained with various antifungal susceptibility testing methods do not predict early clinical outcome in patients with cryptococcosis
    E Dannaoui
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS FRE2849, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    Antimicrob Agents Chemother 50:2464-70. 2006
    ..These findings suggest that the in vitro antifungal susceptibility of C. neoformans, as determined with the techniques used, is not able to predict the early clinical outcome in patients with cryptococcosis...
  89. ncbi request reprint Use of voriconazole in a patient with aspergilloma caused by an itraconazole-resistant strain of Aspergillus fumigatus
    E Dannaoui
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS FRE2849, Institut Pasteur, 75724 Paris Cedex 15, France
    J Med Microbiol 55:1457-9. 2006
    ..fumigatus strains is of value during long-term therapy with itraconazole, and that voriconazole may be a good option for treatment of patients infected with itraconazole-resistant strains of A. fumigatus...
  90. doi request reprint A population analysis of weight-related differences in lopinavir pharmacokinetics and possible consequences for protease inhibitor-naive and -experienced patients
    Marion Bouillon-Pichault
    Universite Paris Descartes, Paris, France
    Antivir Ther 14:923-9. 2009
    ..However, the probability to achieve these target C(troughs) with the current 400 mg twice-daily or 800 mg once-daily doses of the new tablet form, and the influence of body weight on this probability are unknown...
  91. ncbi request reprint [Pharmacokinetics-pharmacodynamics of antifungal drugs. Consequences for therapeutic drug monitoring]
    Vincent Jullien
    Universite Paris Descartes, Faculte de Medecine, Paris, France
    Therapie 61:209-17. 2006
    ..The main causes explaining this lack of data are reviewed and the possible use in humans of the parameters obtained from animal models is discussed...
  92. ncbi request reprint Addressing the challenge of extended-spectrum beta-lactamases
    Jean Ralph Zahar
    Universite Rene Descartes, Hygiene Hospitaliere, Centre d Infectiologie Necker Pasteur, CHU Necker Enfants Malades, Paris, France
    Curr Opin Investig Drugs 10:172-80. 2009
    ..Carbapenems should be considered as the drug of choice for treating serious systemic infections caused by ESBL-producing bacteria, but preventing the spread of and appropriately managing these infections remains difficult...
  93. pmc Human listeriosis caused by Listeria ivanovii
    Christelle Guillet
    Universite Paris Descartes, Paris, France
    Emerg Infect Dis 16:136-8. 2010
    ..We report L. ivanovii-associated gastroenteritis and bacteremia in a man. This isolate was indistinguishable from prototypic ruminant strains. L. ivanovii is thus an enteric opportunistic human pathogen...
  94. pmc Molecular identification of zygomycetes from culture and experimentally infected tissues
    Patrick Schwarz
    Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, CNRS FRE2849, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Clin Microbiol 44:340-9. 2006
    ....
  95. doi request reprint [Antifungal combination therapy in invasive fungal infections]
    J Gellen-Dautremer
    Service de Medecine Interne, Hopital Beaujon, Clichy, France
    Rev Med Interne 31:72-81. 2010
    ..Randomised studies are necessary to confirm these data. A study assessing anidulafungin plus voriconazole association in aspergillosis is oncoming...
  96. ncbi request reprint Immune mediators in cerebrospinal fluid during cryptococcosis are influenced by meningeal involvement and human immunodeficiency virus serostatus
    O Lortholary
    , , Paris, France
    J Infect Dis 183:294-302. 2001
    ..Overall, these data support the idea that inflammatory responses are crucial to the eradication of cryptococcal infections in the central nervous system...
  97. ncbi request reprint Influence of gender and age on course of infection and cytokine responses in mice with disseminated Cryptococcus neoformans infection
    O Lortholary
    Unité de Mycologie Moléculaire, Institut Pasteur, Paris, France
    Clin Microbiol Infect 8:31-7. 2002
    ..To study the influence of gender and age on the course of infection and the cytokine response in a murine model of disseminated cryptococcosis...
  98. ncbi request reprint Enhanced sensitivity of tumor necrosis factor/lymphotoxin-alpha-deficient mice to Cryptococcus neoformans infection despite increased levels of nitrite/nitrate, interferon-gamma, and interleukin-12
    N Rayhane
    Unite d Immuno Allergie, Institut Pasteur, Paris, France
    J Infect Dis 180:1637-47. 1999
    ....
  99. doi request reprint Liposomal amphotericin B: what is its role in 2008?
    F Lanternier
    Faculté de Médecine Paris Descartes, Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Paris, France
    Clin Microbiol Infect 14:71-83. 2008
    ..Finally, LAmB may also be considered as a therapeutic option for the management of candidaemia and remains a cornerstone for the treatment of some visceral localisations during systemic candidosis...
  100. doi request reprint Stable frequency of HIV-1 transmitted drug resistance in patients at the time of primary infection over 1996-2006 in France
    Marie Laure Chaix
    Université Paris Descartes EA 3620, AP HP, Laboratoire de Virologie, CHU Necker Enfants Malades, Paris, France
    AIDS 23:717-24. 2009
    ....
  101. ncbi request reprint Tuberculosis in HIV-infected patients: a comprehensive review
    L Aaron
    Service de Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Paris, France
    Clin Microbiol Infect 10:388-98. 2004
    ..Finally, immune restoration induced by highly active anti-retroviral therapy (HAART) in developed countries may be responsible for a paradoxical worsening of TB manifestations...