Research Topics
Genomes and GenesSpecies | Pierre Marie LledoSummaryAffiliation: Institut Pasteur Country: France Publications
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Publications
Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memoryChristelle Rochefort
Perception and Memory Laboratory, , Institut Pasteur, 75 724 Paris Cedex 15, France
J Neurosci 22:2679-89. 2002..By maintaining a constitutive turnover of granule cells subjected to modulation by environmental cues, ongoing bulbar neurogenesis could be associated with improved olfactory memory...- Adult neurogenesis and functional plasticity in neuronal circuitsPierre Marie Lledo
Laboratory of Perception and Memory, Institut Pasteur, Centre National de la Recherche Scientifique Unit de Recherche Associée 2182, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
Nat Rev Neurosci 7:179-93. 2006..The functional benefits of this whole-cell plasticity, however, remain a matter for debate... 
The impact of adult neurogenesis on olfactory bulb circuits and computationsGabriel Lepousez
Laboratory of Perception and Memory, Institut Pasteur, F 75015 Paris, France email
Annu Rev Physiol 75:339-63. 2013..This review extracts clues regarding the contribution of adult-born neurons to the different circuits of the olfactory bulb and specifically how new neurons participate in existing computations and enable new computational functions...
Dynamic development of the first synapse impinging on adult-born neurons in the olfactory bulb circuitHiroyuki Katagiri
Laboratory for Perception and Memory, Institut Pasteur, Paris, France
Neural Syst Circuits 1:6. 2011..Together, these findings show that the first glutamatergic inputs to adult-generated OB interneurons undergo a unique sequence of maturation stages...- Integrating new neurons into the adult olfactory bulb: joining the network, life-death decisions, and the effects of sensory experiencePierre Marie Lledo
Laboratory of Perception and Memory, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Pasteur Institute, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
Trends Neurosci 28:248-54. 2005.... - Information processing in the mammalian olfactory systemPierre Marie Lledo
Laboratory of Perception and Memory, Pasteur Institute, Paris, France
Physiol Rev 85:281-317. 2005..Recent observations supporting the necessity of such plasticity for adult brain functions are also discussed. Due to space constraints, this review focuses mainly on the olfactory systems of vertebrates, and primarily those of mammals... - Adjusting neurophysiological computations in the adult olfactory bulbPierre Marie Lledo
Laboratory of Perception and Memory, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Pasteur Institute, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Semin Cell Dev Biol 17:443-53. 2006..We discuss how local inhibitory interneurons transpose the spatial dimension into temporal patterning. Remarkably, this transposition is not fixed but highly flexible to continuously optimize olfactory information processing... - Inhibitory interneurons in the olfactory bulb: from development to functionPierre Marie Lledo
Laboratory of Perception and Memory, Centre National de la Recherche Scientifique, Pasteur Institute, Paris, France
Neuroscientist 10:292-303. 2004..This review brings together recently described properties and emerging principles of interneuron functions that may convey, into bulbar neuronal networks, a degree of circuit adaptation unmatched by synaptic plasticity alone... - Origin and function of olfactory bulb interneuron diversityPierre Marie Lledo
Laboratory of Perception and Memory, Pasteur Institute, CNRS URA 2182, Paris Cedex, France
Trends Neurosci 31:392-400. 2008..The mosaic organization of the SVZ offers a unique opportunity to understand the origin of interneuron diversity and how this assortment of neurons contributes to plasticity of postnatal olfactory circuits... - Neuronal replacement in microcircuits of the adult olfactory systemPierre Marie Lledo
Laboratoire de perception et mémoire, CNRS URA 2182, départment de neuroscience, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
C R Biol 330:510-20. 2007.... - Dissecting the pathophysiology of depression with a Swiss army knifePierre Marie Lledo
Institut Pasteur, Centre National de la Recherche Scientifique CNRS, URA 2182, Paris, France
Neuron 62:453-5. 2009..This report prompts us to revisit our understanding of the neural circuitry mediating mood disorders and also provides a framework for developing new antidepressant treatments... - Olfactory processing in a changing brainPierre Marie Lledo
Laboratory of Perception and Memory, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
Neuroreport 14:1655-63. 2003..These recent findings not only provide new fuel for the molecular and cellular bases of sensory perception but should also shed light onto cellular bases of learning and memory... - [Odors and olfaction]Pierre Marie Lledo
Institut Pasteur, Unité Postulante Perception et Mémoire olfactive, 25, rue du Docteur Roux, 75724 Paris, France
J Soc Biol 196:59-65. 2002..Due to space constraints, this review focuses exclusively on the olfactory systems of vertebrates and primarily those of mammals... - Cellular and behavioral effects of cranial irradiation of the subventricular zone in adult miceFrancoise Lazarini
Institut Pasteur, Laboratory for Perception and Memory, Paris, France
PLoS ONE 4:e7017. 2009..Thousands of new neurons appear each day, but the function of this ongoing neurogenesis remains unclear... - Tenascin-R mediates activity-dependent recruitment of neuroblasts in the adult mouse forebrainArmen Saghatelyan
Laboratory of Perception and Memory, CNRS URA 2182, Pasteur Institute, 25 rue du Dr Roux, 75015 Paris Cedex, France
Nat Neurosci 7:347-56. 2004.... - Delayed onset of odor detection in neonatal mice lacking tenascin-CAntoine de Chevigny
Laboratory of Perception and Memory, CNRS URA 2182, Pasteur Institute, 25 rue du Dr Roux, 75015 Paris Cedex, France
Mol Cell Neurosci 32:174-86. 2006..Thus, we conclude that a constitutive lack of TNC does not affect bulbar neurogenesis, but instead leads to ontogenetically early impairments in olfactory detection... - Functional maturation of the first synapse in olfaction: development and adult neurogenesisMatthew S Grubb
Perception and Memory Laboratory, Unité de Recherche Associée 2182, Centre National de la Recherche Scientifique, Institut Pasteur, F 75724 Paris Cedex 15, France
J Neurosci 28:2919-32. 2008.... - Nicotinic receptors regulate the survival of newborn neurons in the adult olfactory bulbNaguib Mechawar
Receptors and Cognition Unit, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Pasteur Institute, 75724 Paris Cedex 15, France
Proc Natl Acad Sci U S A 101:9822-6. 2004..They also indicate that an increase in the number of granule cells does not necessarily correlate with better olfactory performance and further highlight the importance of cholinergic afferents for olfactory processing... - Activation of adult-born neurons facilitates learning and memoryMariana Alonso
Institut Pasteur, Laboratory for Perception and Memory, Paris, France
Nat Neurosci 15:897-904. 2012..Taken together, our results demonstrate an immediate causal relationship between the activity of adult-born neurons and the function of the olfactory bulb circuit... - Short-term survival of newborn neurons in the adult olfactory bulb after exposure to a complex odor environmentChristelle Rochefort
Pasteur Institute, Laboratory of Perception and Memory, CNRS UMR 2182, 25 rue du Dr Roux, 75015 Paris, France
Eur J Neurosci 22:2863-70. 2005.... - Turning astrocytes from the rostral migratory stream into neurons: a role for the olfactory sensory organMariana Alonso
Laboratory for Perception and Memory, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Institut Pasteur, 75724 Paris Cedex 15, France
J Neurosci 28:11089-102. 2008..New neurons in the adult OB can therefore arise from different neurogenic areas that can be separately regulated... - Learning and survival of newly generated neurons: when time mattersAurélie Mouret
Perception and Memory Laboratory, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Institut Pasteur, 75015 Paris, France
J Neurosci 28:11511-6. 2008..This study provides new insight into the contribution of the newly generated interneurons to OB function. It demonstrates that neuronal elimination is an active process, rather than a simple consequence of nonuse... - GABAergic inhibition at dendrodendritic synapses tunes gamma oscillations in the olfactory bulbSamuel Lagier
Laboratory of Perception and Memory, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Institut Pasteur, 25 rue du Dr Roux, F 75724 Paris Cedex 15, France
Proc Natl Acad Sci U S A 104:7259-64. 2007..We conclude, therefore, that fast oscillations in the OB circuit are strongly constrained by the precise location, subunit composition and kinetics of GABA(A) receptors expressed in mitral cells... - MARK2/Par-1 guides the directionality of neuroblasts migrating to the olfactory bulbSheyla Mejia-Gervacio
Institut Pasteur, Laboratory for Perception and Memory, Department of Neurosciences F 75015 Paris, France
Mol Cell Neurosci 49:97-103. 2012.... - NKCC1 controls GABAergic signaling and neuroblast migration in the postnatal forebrainSheyla Mejia-Gervacio
Institut Pasteur, Laboratory for Perception and Memory, Paris, France
Neural Dev 6:4. 2011..All in all, our findings show that early stages of the postnatal recruitment of OB interneurons rely on precise, orchestrated mechanisms that depend on multiple actions of NKCC1... - Adult neurogenesis promotes synaptic plasticity in the olfactory bulbAntoine Nissant
Laboratory for Perception and Memory, Institut Pasteur, CNRS URA 2182, Paris, France
Nat Neurosci 12:728-30. 2009.... - The how and why of adult neurogenesisInmaculada Ortega-Perez
Laboratory for Perception and Memory, Pasteur Institute, CNRS URA 2182, Paris Cedex 15, 75724, France
J Mol Histol 38:555-62. 2007..To ensure this function, the production, migration, and survival of newborn neurons must be tightly controlled. We attempt to address some of these questions here, using the olfactory bulb as a model system... - How, when, and where new inhibitory neurons release neurotransmitters in the adult olfactory bulbCedric Bardy
Laboratory for Perception and Memory, Institut Pasteur, Paris Cedex 15, France
J Neurosci 30:17023-34. 2010..Thus, this study provides new insights into how new neurons integrate into the adult neural network and may influence the sense of smell... - Circuit properties generating gamma oscillations in a network model of the olfactory bulbBrice Bathellier
Laboratory of Perception and Memory, , Paris, France
J Neurophysiol 95:2678-91. 2006..Thus we have shown that lateral inhibition provides a mechanism by which the dynamic processing of odor information might be finely tuned within the OB circuit... - Turnover of newborn olfactory bulb neurons optimizes olfactionAurélie Mouret
Institut Pasteur, Perception and Memory Unit, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, F 75724 Paris, France
J Neurosci 29:12302-14. 2009.... - Fragile X mental retardation protein regulates new neuron differentiation in the adult olfactory bulbSophie Scotto-Lomassese
Avenir INSERM and Fondation pour la Recherche Médicale Team Development and Plasticity of Neural Networks, Université Pierre et Marie Curie UPMC Paris 06, Unité Mixte de Recherche UMR 7102, Paris, France
J Neurosci 31:2205-15. 2011.... - Is adult neurogenesis essential for olfaction?Francoise Lazarini
Institut Pasteur, Laboratory for Perception and Memory, 75015 Paris, France
Trends Neurosci 34:20-30. 2011..In this review we highlight the role of network activity in shaping ongoing neurogenesis and, in turn, how the integration of adult-born neurons refines pre-existing network function, and consequently olfactory behavior... - Inflammation-induced subventricular zone dysfunction leads to olfactory deficits in a targeted mouse model of multiple sclerosisVanja Tepavcevic
UPMC, CRicm, UMR S 975, Paris, France
J Clin Invest 121:4722-34. 2011..Thus, our findings suggest that neuroinflammation induces functional alteration of adult NSCs that may contribute to olfactory dysfunction in MS patients... - Disruption of Adult Neurogenesis in the Olfactory Bulb Affects Social Interaction but not Maternal BehaviorClaudia E Feierstein
Laboratory for Perception and Memory, Institut Pasteur Paris, France
Front Behav Neurosci 4:176. 2010..Disruption of OB neurogenesis, however, neither impaired maternal-related behaviors, nor did it affect the ability of mothers to discriminate their own progeny from others... - Abnormal neuronal migration changes the fate of developing neurons in the postnatal olfactory bulbRichard Belvindrah
Institut Pasteur, Laboratory for Perception and Memory, F 75015 Paris, France
J Neurosci 31:7551-62. 2011.... - Postnatal neurogenesis: from neuroblast migration to neuronal integrationRichard Belvindrah
Perception and Memory Unit, 2CNRS, URA 2182, Institut Pasteur, Paris, France
Rev Neurosci 20:331-46. 2009..The elucidation of these mechanisms may be crucial to understand the functional role of adult neurogenesis and eventually develop therapeutic strategies aimed at re-routing neuroblasts to altered circuits... - Interplay between local GABAergic interneurons and relay neurons generates gamma oscillations in the rat olfactory bulbSamuel Lagier
Laboratory of Perception and Memory, Centre National de la Recherche Scientifique, , Pasteur Institute, 75724 Paris, France
J Neurosci 24:4382-92. 2004..We concluded that interneurons located in the granule cell layer generate synaptic activity capable of synchronizing activity of output neurons by interacting with both their subthreshold and spiking activity... - [Adult neurogenesis: from basic research to clinical applications]Pierre Marie Lledo
Laboratoire Perception et Mémoire, Institut Pasteur, CNRS URA 2182, Paris
Bull Acad Natl Med 190:385-400; discussion 400-2. 2006.... - Early activation of microglia triggers long-lasting impairment of adult neurogenesis in the olfactory bulbFrancoise Lazarini
Institut Pasteur, Laboratory for Perception and Memory, F 75015 Paris, France
J Neurosci 32:3652-64. 2012..We conclude that the status of the resident microglia in the olfactory bulb is an important factor directly regulating the survival of immature adult-born neurons... - Centrifugal drive onto local inhibitory interneurons of the olfactory bulbAurélie Mouret
Laboratory for Perception and Memory, Institut Pasteur, CNRS, Paris, France
Ann N Y Acad Sci 1170:239-54. 2009..This review deals with the neuromodulation of granule cell activity and of the continuous recruitment of these cells throughout life... - Becoming a new neuron in the adult olfactory bulbAlan Carleton
Pasteur Institute, Laboratory of Perception and Memory, CNRS UMR 2182, 25 rue du Dr Roux, 75015 Paris, France
Nat Neurosci 6:507-18. 2003..Our results show that newly born cells recruited into the olfactory bulb become neurons, and a unique sequence of events leads to their functional integration... - Olfactory discrimination learning increases the survival of adult-born neurons in the olfactory bulbMariana Alonso
Perception and Memory Laboratory, Centre National de la Recherche Scientifique, , Pasteur Institute, 75724 Paris Cedex 15, France
J Neurosci 26:10508-13. 2006..Shaping the distribution of newborn neurons by influencing their survival could optimize the olfactory information processing required for odor discrimination... - Neonatal and adult neurogenesis provide two distinct populations of newborn neurons to the mouse olfactory bulbMorgane Lemasson
Laboratory of Perception and Memory, Centre National de la Recherche Scientifique, , Pasteur Institute, 75724 Paris Cedex 15, France
J Neurosci 25:6816-25. 2005..Together, these results demonstrate that early postnatal neurogenesis endows the neonate bulbar circuit with newborn GCs that differ morphologically and functionally from those produced in the adult... - [Heterogeneous neuronal fate of subventricular zone neural stem cells in adults: a predestined mosaic of cell types]Aurélie Mouret
Laboratoire de perception et mémoire, CNRS URA 2182, Département de Neuroscience, Institut Pasteur, 25 rue du Docteur Roux, Paris, France
Med Sci (Paris) 24:9-11. 2008 - Control of early events in olfactory processing by adult neurogenesisGilles Gheusi
Laboratory of Perception and Memory, Pasteur Institute, CNRS URA 2182, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
Chem Senses 32:397-409. 2007..Nevertheless, there is already considerable correlative evidence to indicate that adult neurogenesis is a plastic mechanism by which the performance of the brain can be optimized in a given environment... - Synapse-specific localization of vesicular glutamate transporters in the rat olfactory bulbMarie Madeleine Gabellec
Laboratory of Perception and Memory, CNRS URA 2182, Pasteur Institute, 25 rue du Dr Roux, 75015 Paris Cedex, France
Eur J Neurosci 25:1373-83. 2007.... - [The odor of the other]Gilles Gheusi
, CNRS URA 2182, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
Med Sci (Paris) 21:698-700. 2005 - A niche for adult neurogenesis in social behaviorGilles Gheusi
Laboratory for Perception and Memory, Pasteur Institut, Unite de Recherche Associee, CNRS 2182, Paris, France
Behav Brain Res 200:315-22. 2009.... - In vivo imaging of migrating neurons in the mammalian forebrainMarc Davenne
Laboratory of Perception and Memory, Pasteur Institute, 25 rue du Dr Roux, 75724 Paris, France
Chem Senses 30:i115-6. 2005 - Activity-dependent adjustments of the inhibitory network in the olfactory bulb following early postnatal deprivationArmen Saghatelyan
Laboratory of Perception and Memory, Pasteur Institute, Centre National de la Recherche, Scientifique (URA 2182, 75015 Paris Cedex, France
Neuron 46:103-16. 2005..Together, this study reveals a unique form of adaptive response brought about exclusively by the cohort of newborn cells and used to maintain normal functioning of the MOB... - Local neurons play key roles in the mammalian olfactory bulbArmen Saghatelyan
Laboratory of Perception and Memory, Centre National de la Recherche Scientifique, , Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, France
J Physiol Paris 97:517-28. 2003..Due to space constraints, this review focuses exclusively on the olfactory systems of vertebrates and primarily those of mammals... - Bone marrow cell transplantation restores olfaction in the degenerated olfactory bulbDavid Diaz
Laboratory of Neuronal Plasticity and Neurorepair, Institute for Neuroscience of Castilla y León INCyL and Universidad de Salamanca, E 37007 Salamanca, Spain
J Neurosci 32:9053-8. 2012.... - [Olfactory bulb neurogenesis and its neurological impact]Antoine de Chevigny
Institut Pasteur, , CNRS URA 2182, 25, rue du Docteur-Roux, 75724 Paris Cedex 15, France
Med Sci (Paris) 22:607-13. 2006..Finally, we review some of the advantages and limits of strategies aimed at using endogenous progenitors and their relevance to human clinics... - [On the convergence between humankind and Nature to create tools]Fernand Gaillot
Laboratoire Perception et Mémoire, Institut Pasteur et CNRS, Paris, France
C R Biol 330:711-21. 2007..The authors' purpose will be here to underline the continuity of the adaptative processes that make Homo sapiens, sometimes a brilliant inventor, sometimes a mere imitator, forging tools already conceived by Nature itself... - Life and death decision in adult neurogenesis: in praise of nappingGabriel Lepousez
Laboratory for Perception and Memory Unit, Institut Pasteur, F 75724 Paris, France
Neuron 71:768-71. 2011..In this issue of Neuron, Yokoyama et al. take steps toward deciphering the behavioral contexts that regulate newborn cell elimination... - Subpallial origin of a population of projecting pioneer neurons during corticogenesisJavier Morante-Oria
Laboratory of Perception and Memory, Centre National de la Recherche Scientifique, , Pasteur Institute, 25 rue du Docteur Roux, 75724 Paris, France
Proc Natl Acad Sci U S A 100:12468-73. 2003..Finally, we show that, in early corticogenesis, reelin controls both the tangential migration of cortical interneurons toward the cortical plate and the tangential migration of pioneer neurons toward the marginal zone... - Neuronal fate determinants of adult olfactory bulb neurogenesisMichael A Hack
GSF-National Research Center for Environment and Health, Institute for Stem Cell Research, , D-85764 Neuherberg, Germany
Nat Neurosci 8:865-72. 2005..Together, these data explain both extrinsic and intrinsic mechanisms controlling neuronal identity in adult neurogenesis... - [The adult brain: always under construction]Morgane Lemasson
Med Sci (Paris) 19:664-6. 2003 - Chronic inhibition of nitric oxide synthesis enhances both subventricular zone neurogenesis and olfactory learning in adult miceCarmen Romero-Grimaldi
, Facultad de Medicina, , , Spain
Eur J Neurosci 24:2461-70. 2006.... - [From nose to brain : a subtle connection]Aurélie Mouret
Med Sci (Paris) 23:252-5. 2007 - BM88/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cellsLida Katsimpardi
Laboratory of Cellular and Molecular Neurobiology, Hellenic Pasteur Institute, 127 Vassilissis Sofias Avenue, Athens 115 21, Greece
Stem Cells 26:1796-807. 2008.... - [Tenascin: key molecule in recruiting neo-neurons in adults]Antoine de Chevigny
Med Sci (Paris) 20:620-2. 2004