Michel Leibovici

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint Initial characterization of kinocilin, a protein of the hair cell kinocilium
    Michel Leibovici
    Unité de Génétique des Déficits Sensoriels, INSERM U587, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Hear Res 203:144-53. 2005
  2. pmc Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane
    Elisabeth Verpy
    Unite de Genetique et Physiologie de l Audition, Institut Pasteur, Paris, France
    J Comp Neurol 519:194-210. 2011
  3. doi request reprint Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape
    Raphaël Etournay
    Unite de Genetique et Physiologie de l Audition, INSERM UMRS587 Université Paris VI, Institut Pasteur, 25 rue du Dr Roux, Paris Cedex 15, France
    Development 137:1373-83. 2010
  4. pmc Stereocilin-deficient mice reveal the origin of cochlear waveform distortions
    Elisabeth Verpy
    Institut Pasteur, Unite de Genetique et Physiologie de l Audition, F75015 Paris, France
    Nature 456:255-8. 2008
  5. pmc Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells
    Amel Bahloul
    Institut Pasteur, Unite de Genetique et Physiologie de l Audition, Paris, France
    EMBO Mol Med 1:125-38. 2009
  6. pmc Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22
    Ingrid Zwaenepoel
    Unité de Génétique des Déficits Sensoriels, Centre National de la Recherche Scientifique, Paris Cedex 15, France
    Proc Natl Acad Sci U S A 99:6240-5. 2002
  7. doi request reprint Mouse models for human hereditary deafness
    Michel Leibovici
    Institut Pasteur, Unite de Genetique et Physiologie de l Audition, Paris, France
    Curr Top Dev Biol 84:385-429. 2008
  8. ncbi request reprint Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy
    Sedigheh Delmaghani
    Unité de Génétique des Déficits Sensoriels INSERM U587, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Nat Genet 38:770-8. 2006

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Initial characterization of kinocilin, a protein of the hair cell kinocilium
    Michel Leibovici
    Unité de Génétique des Déficits Sensoriels, INSERM U587, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Hear Res 203:144-53. 2005
    ..The protein is also present in the manchette of the spermatids, a transient structure enriched in interconnected microtubules. We propose that kinocilin has a role in stabilizing dense microtubular networks or in vesicular trafficking...
  2. pmc Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane
    Elisabeth Verpy
    Unite de Genetique et Physiologie de l Audition, Institut Pasteur, Paris, France
    J Comp Neurol 519:194-210. 2011
    ..We conclude that stereocilin is essential to the formation of horizontal top connectors. We propose that these links, which maintain the cohesiveness of the mature OHC hair bundle, are required for tip-link turnover...
  3. doi request reprint Cochlear outer hair cells undergo an apical circumference remodeling constrained by the hair bundle shape
    Raphaël Etournay
    Unite de Genetique et Physiologie de l Audition, INSERM UMRS587 Université Paris VI, Institut Pasteur, 25 rue du Dr Roux, Paris Cedex 15, France
    Development 137:1373-83. 2010
    ..We propose that this remodeling contributes to optimize the mechanical coupling between the basal and apical poles of mature OHCs...
  4. pmc Stereocilin-deficient mice reveal the origin of cochlear waveform distortions
    Elisabeth Verpy
    Institut Pasteur, Unite de Genetique et Physiologie de l Audition, F75015 Paris, France
    Nature 456:255-8. 2008
    ....
  5. pmc Vezatin, an integral membrane protein of adherens junctions, is required for the sound resilience of cochlear hair cells
    Amel Bahloul
    Institut Pasteur, Unite de Genetique et Physiologie de l Audition, Paris, France
    EMBO Mol Med 1:125-38. 2009
    ..Our results emphasize the overlooked role of the junctions between hair cells and their supporting cells in the auditory epithelium resilience to sound trauma...
  6. pmc Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22
    Ingrid Zwaenepoel
    Unité de Génétique des Déficits Sensoriels, Centre National de la Recherche Scientifique, Paris Cedex 15, France
    Proc Natl Acad Sci U S A 99:6240-5. 2002
    ..We propose that otoancorin ensures the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells...
  7. doi request reprint Mouse models for human hereditary deafness
    Michel Leibovici
    Institut Pasteur, Unite de Genetique et Physiologie de l Audition, Paris, France
    Curr Top Dev Biol 84:385-429. 2008
    ....
  8. ncbi request reprint Mutations in the gene encoding pejvakin, a newly identified protein of the afferent auditory pathway, cause DFNB59 auditory neuropathy
    Sedigheh Delmaghani
    Unité de Génétique des Déficits Sensoriels INSERM U587, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Nat Genet 38:770-8. 2006
    ..Unlike previously described sensorineural deafness genes, all of which underlie cochlear cell pathologies, DFNB59 is the first human gene implicated in nonsyndromic deafness due to a neuronal defect...