Marc Lecuit

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint Human listeriosis and animal models
    Marc Lecuit
    Avenir Group INSERM U604 Microbial Interactions with Host Barriers, Bacteria Cell Interactions Unit, Department of Cell Biology and Infection, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Microbes Infect 9:1216-25. 2007
  2. pmc Splenic rupture and malignant Mediterranean spotted fever
    Laura Schmulewitz
    Emerg Infect Dis 14:995-7. 2008
  3. pmc Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin
    Marc Lecuit
    Unité des Interactions Bactéries Cellules and Unité d Histotechnologie et Pathologie, Institut Pasteur, Paris 75015, France
    Proc Natl Acad Sci U S A 101:6152-7. 2004
  4. ncbi request reprint Understanding how Listeria monocytogenes targets and crosses host barriers
    M Lecuit
    INSERM U 604, Département de Biologie Cellulaire et Infection, Institut Pasteur and Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Universite Rene Descartes Paris 5, Paris, France
    Clin Microbiol Infect 11:430-6. 2005
  5. ncbi request reprint Immunoproliferative small intestinal disease associated with Campylobacter jejuni
    Marc Lecuit
    Hopital Avicenne, Paris, France
    N Engl J Med 350:239-48. 2004
  6. doi request reprint Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis
    Olivier Disson
    Institut Pasteur, Groupe Microorganismes et Barrières de l Hôte, Unité des Interactions Bactéries Cellules, F 75015 Paris, France
    Nature 455:1114-8. 2008
  7. doi request reprint Modeling human listeriosis in natural and genetically engineered animals
    Olivier Disson
    Institut Pasteur, Microbes and Host Barriers, Paris, France
    Nat Protoc 4:799-810. 2009
  8. pmc The stress-induced virulence protein InlH controls interleukin-6 production during murine listeriosis
    Nicolas Personnic
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Infect Immun 78:1979-89. 2010
  9. pmc Species-specific impact of the autophagy machinery on Chikungunya virus infection
    Delphine Judith
    Institut Pasteur, Biology of Infection Unit, Paris, France
    EMBO Rep 14:534-44. 2013
  10. pmc ActA promotes Listeria monocytogenes aggregation, intestinal colonization and carriage
    Laetitia Travier
    Biology of Infection Unit, Institut Pasteur, Paris, France
    PLoS Pathog 9:e1003131. 2013

Detail Information

Publications87

  1. ncbi request reprint Human listeriosis and animal models
    Marc Lecuit
    Avenir Group INSERM U604 Microbial Interactions with Host Barriers, Bacteria Cell Interactions Unit, Department of Cell Biology and Infection, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Microbes Infect 9:1216-25. 2007
    ..Finally, we present some of the critical determinants for the choice of an appropriate animal model to study human listeriosis...
  2. pmc Splenic rupture and malignant Mediterranean spotted fever
    Laura Schmulewitz
    Emerg Infect Dis 14:995-7. 2008
  3. pmc Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherin
    Marc Lecuit
    Unité des Interactions Bactéries Cellules and Unité d Histotechnologie et Pathologie, Institut Pasteur, Paris 75015, France
    Proc Natl Acad Sci U S A 101:6152-7. 2004
    ..monocytogenes to target and cross the placental barrier. Such a ligand-receptor interaction allowing a pathogen to specifically cross the placental villous trophoblast barrier has not been reported previously...
  4. ncbi request reprint Understanding how Listeria monocytogenes targets and crosses host barriers
    M Lecuit
    INSERM U 604, Département de Biologie Cellulaire et Infection, Institut Pasteur and Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Universite Rene Descartes Paris 5, Paris, France
    Clin Microbiol Infect 11:430-6. 2005
    ..monocytogenes to target and cross the placental barrier. Further investigations are currently focusing on the molecular mechanisms by which L. monocytogenes targets and crosses the blood-brain barrier...
  5. ncbi request reprint Immunoproliferative small intestinal disease associated with Campylobacter jejuni
    Marc Lecuit
    Hopital Avicenne, Paris, France
    N Engl J Med 350:239-48. 2004
    ..Early-stage disease responds to antibiotics, suggesting a bacterial origin. We attempted to identify a causative agent...
  6. doi request reprint Conjugated action of two species-specific invasion proteins for fetoplacental listeriosis
    Olivier Disson
    Institut Pasteur, Groupe Microorganismes et Barrières de l Hôte, Unité des Interactions Bactéries Cellules, F 75015 Paris, France
    Nature 455:1114-8. 2008
    ....
  7. doi request reprint Modeling human listeriosis in natural and genetically engineered animals
    Olivier Disson
    Institut Pasteur, Microbes and Host Barriers, Paris, France
    Nat Protoc 4:799-810. 2009
    ..monocytogenes crossing of human host barriers. The whole procedure (inoculation, in vivo imaging, bacterial enumeration, histopathology) takes one full week to complete, including 3 d of actual experiments...
  8. pmc The stress-induced virulence protein InlH controls interleukin-6 production during murine listeriosis
    Nicolas Personnic
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
    Infect Immun 78:1979-89. 2010
    ..These results strongly suggest that InlH is a stress-induced surface protein that facilitates pathogen survival in tissues by tempering the inflammatory response...
  9. pmc Species-specific impact of the autophagy machinery on Chikungunya virus infection
    Delphine Judith
    Institut Pasteur, Biology of Infection Unit, Paris, France
    EMBO Rep 14:534-44. 2013
    ..These results highlight the distinct roles of p62 and NDP52 in viral infection, and identify NDP52 as a cellular factor that accounts for CHIKV species specificity...
  10. pmc ActA promotes Listeria monocytogenes aggregation, intestinal colonization and carriage
    Laetitia Travier
    Biology of Infection Unit, Institut Pasteur, Paris, France
    PLoS Pathog 9:e1003131. 2013
    ....
  11. pmc Human polyomavirus related to African green monkey lymphotropic polyomavirus
    Virginie Sauvage
    Institut Pasteur, Paris, France
    Emerg Infect Dis 17:1364-70. 2011
    ..These results provide information on the viral ecology of human skin and raise new questions regarding the pathology of virus-associated skin disorders...
  12. pmc The Listeria monocytogenes virulence factor InlJ is specifically expressed in vivo and behaves as an adhesin
    Christophe Sabet
    UIBC, Institut Pasteur, INSERM, U604, INRA, USC2020, 25 rue du Dr Roux, Paris F 75015, France
    Infect Immun 76:1368-78. 2008
    ..innocua promotes bacterial adherence to human cells in vitro. Taken together, these results strongly suggest that InlJ acts as a novel L. monocytogenes sortase-anchored adhesin specifically expressed during infection in vivo...
  13. pmc Human listeriosis caused by Listeria ivanovii
    Christelle Guillet
    Universite Paris Descartes, Paris, France
    Emerg Infect Dis 16:136-8. 2010
    ..We report L. ivanovii-associated gastroenteritis and bacteremia in a man. This isolate was indistinguishable from prototypic ruminant strains. L. ivanovii is thus an enteric opportunistic human pathogen...
  14. pmc Therapeutic drug monitoring of posaconazole: a monocentric study with 54 adults
    David Lebeaux
    Universite Paris Descartes, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, Paris, France
    Antimicrob Agents Chemother 53:5224-9. 2009
    ..Therapeutic drug monitoring of posaconazole is therefore mandatory for immunosuppressed adults, at least for those with gastrointestinal disorders...
  15. doi request reprint Adherence to preventive measures after splenectomy in the hospital setting and in the community
    Hélène Coignard-Biehler
    Paris Descartes University, Paris, France
    J Infect Public Health 4:187-94. 2011
    ..Overwhelming post-splenectomy infection (OPSI) remains a long-term risk in asplenic patients, which may be reduced by appropriate preventive measures. Specific guidelines have been developed to lower its incidence...
  16. doi request reprint Listeria monocytogenes internalin and E-cadherin: from structure to pathogenesis
    Matteo Bonazzi
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Cell Microbiol 11:693-702. 2009
    ....
  17. ncbi request reprint Species specificity of the Listeria monocytogenes InlB protein
    Nadia Khelef
    Institut Pasteur, Unité des Interactions Bactéries Cellules, 25 28 Rue du Docteur Roux, Paris, F 75015 France
    Cell Microbiol 8:457-70. 2006
    ..These results unravel a second L. monocytogenes species specificity critical for understanding human listeriosis and emphasize the need for developing new animal models for studying InlA and InlB functions in the same animal model...
  18. pmc LPXTG protein InlJ, a newly identified internalin involved in Listeria monocytogenes virulence
    Christophe Sabet
    Unité des Interactions Bactéries Cellules, Institut Pasteur, INSERM U604, INRA USC2020, Paris, France
    Infect Immun 73:6912-22. 2005
    ..In conclusion, this postgenomic approach identified InlJ as a new virulence factor among the proteins belonging to the internalin family in L. monocytogenes...
  19. pmc Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface protein
    Didier Cabanes
    Unité des Interactions Bactéries Cellules Institut Pasteur, INSERM U604, INRA USC 2020, Paris, France
    EMBO J 24:2827-38. 2005
    ..Vip thus appears as a new virulence factor exploiting Gp96 as a receptor for cell invasion and/or signalling events that may interfere with the host immune response in the course of the infection...
  20. pmc Listeria monocytogenes internalin and E-cadherin: from bench to bedside
    Matteo Bonazzi
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, F 75015, France
    Cold Spring Harb Perspect Biol 1:a003087. 2009
    ....
  21. doi request reprint The Listeria transcriptional landscape from saprophytism to virulence
    Alejandro Toledo-Arana
    Institut Pasteur, Unité des Interactions Bactéries Cellules, F 75015 Paris, France
    Nature 459:950-6. 2009
    ..Together, our data unravel successive and coordinated global transcriptional changes during infection and point to previously unknown regulatory mechanisms in bacteria...
  22. pmc "Epidemic clones" of Listeria monocytogenes are widespread and ancient clonal groups
    Thomas Cantinelli
    Institut Pasteur, French National Reference Center for Listeria and WHO Collaborating Center for Listeria, Biology of Infection Unit, Paris, France
    J Clin Microbiol 51:3770-9. 2013
    ....
  23. doi request reprint Fungal infections in immunocompromised travelers
    Olivier Lortholary
    Universite Paris Descartes, Sorbonne Paris Cité, Hopital Necker Enfants Malades, Centre d lnfectiologie Necker Pasteur, and Institut Imagine, Paris, France
    Clin Infect Dis 56:861-9. 2013
    ..Finally, infectious diseases physicians should be aware of major clinical patterns of travel-acquired fungal infection, as well as the fungi involved, and risk factors according to the geographical area visited...
  24. doi request reprint Recurrent Mycobacterium avium infection after seven years of latency in a HIV-infected patient receiving efficient antiretroviral therapy
    Guillaume Bussone
    Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    J Infect 64:613-7. 2012
    ..avium bacteriaemia. Articular puncture grew M. avium. The isolates of the first and second infection were identical using repetitive-sequence-based Polymerase Chain Reaction analyses...
  25. pmc Real-time observation of listeria monocytogenes-phagocyte interactions in living zebrafish larvae
    Jean Pierre Levraud
    Macrophages et Développement de l Immunité, Institut Pasteur, Paris, France
    Infect Immun 77:3651-60. 2009
    ..monocytogenes pathogenesis and particularly for the dissection of its interactions with phagocytes in vivo, a key factor of L. monocytogenes virulence...
  26. ncbi request reprint Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cells
    Sandra Sousa
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    J Cell Sci 117:2121-30. 2004
    ..These results provide the first evidence for the role of an unconventional myosin in bacterial internalization and a novel example of the exploitation of mammalian proteins, by a pathogen, to establish a successful infection...
  27. pmc Iatrogenic Cushing's syndrome induced by posaconazole
    Benoit Pilmis
    Service de Maladies Infectieuses et Tropicales, Groupe Hospitalier Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, Paris, France
    Antimicrob Agents Chemother 57:5727-8. 2013
    ..After a switch to posaconazole, the patient developed Cushingoid symptoms. ..
  28. pmc Impact of lactobacilli on orally acquired listeriosis
    Cristel Archambaud
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 109:16684-9. 2012
    ..monocytogenes infection by treatment with lactobacilli correlates with a decrease in host gene expression, in particular ISGs, miR regulation, and a dramatic reshaping of L. monocytogenes transcriptome...
  29. pmc Serum Aspergillus galactomannan for the management of disseminated histoplasmosis in AIDS
    Sébastien Rivière
    Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Paris, France
    Am J Trop Med Hyg 87:303-5. 2012
    ..Here, we report the contribution of galactomannan serum detection for the management of an HIV-infected patient with disseminated histoplasmosis...
  30. pmc Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherin
    Georgios Nikitas
    Microbes and Host Barriers Group, French National Reference Center and World Health Organization Collaborating Center on Listeria, Institut Pasteur, Paris, France
    J Exp Med 208:2263-77. 2011
    ....
  31. pmc Nocardia pseudobrasiliensis as an emerging cause of opportunistic infection after allogeneic hematopoietic stem cell transplantation
    David Lebeaux
    Université Paris Descartes Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, AP HP, Centre d Infectiologie Necker Pasteur, 149 rue de Sevres, 75743 Paris Cedex 15, France
    J Clin Microbiol 48:656-9. 2010
    ..Culture of the bronchoalveolar lavage fluid revealed Nocardia pseudobrasiliensis. This recently described carbapenem-resistant species should be included in the differential diagnosis of fungal infection in this setting...
  32. pmc Worldwide distribution of major clones of Listeria monocytogenes
    Viviane Chenal-Francisque
    Institut Pasteur, Paris, France
    Emerg Infect Dis 17:1110-2. 2011
    ..Cosmopolitan distribution indicates the need for genotyping standardization...
  33. ncbi request reprint Src, cortactin and Arp2/3 complex are required for E-cadherin-mediated internalization of Listeria into cells
    Sandra Sousa
    Institut Pasteur, Unité des Interactions Bactéries Cellules Inserm, U604 and INRA, USC2020, Paris F 75015, France
    Cell Microbiol 9:2629-43. 2007
    ..Together, these data suggest a model in which Src tyrosine kinase and Rac1 promote recruitment of cortactin and activation of Arp2/3 at Listeria entry site, mimicking events that occur during adherens junction formation...
  34. ncbi request reprint A molecular marker for evaluating the pathogenic potential of foodborne Listeria monocytogenes
    Christine Jacquet
    Laboratoire des Listeria, Centre National de Référence des Listeria, World Health Organization Collaborating Center for Foodborne Listeriosis, Institut Pasteur, Paris, France
    J Infect Dis 189:2094-100. 2004
    ..The relevance of these findings for humans is challenged by the observation that some L. monocytogenes isolates express a truncated nonfunctional form of internalin...
  35. doi request reprint Listeria monocytogenes-associated joint and bone infections: a study of 43 consecutive cases
    Caroline Charlier
    Institut Pasteur, French National Reference Center and WHO Collaborating Center for Listeria, Microbes and Host Barriers Group, Universite Paris Descartes, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Paris, France
    Clin Infect Dis 54:240-8. 2012
    ..Little is known about Listeria monocytogenes-associated bone and joint infections. Only case reports of this infection have been published...
  36. pmc Murinization of internalin extends its receptor repertoire, altering Listeria monocytogenes cell tropism and host responses
    Yu Huan Tsai
    Institut Pasteur, Biology of Infection Unit, Paris, France
    PLoS Pathog 9:e1003381. 2013
    ..These results challenge the relevance of using InlA(m)-expressing Lm to study human listeriosis and in vivo host responses to this human pathogen...
  37. pmc Mycobacterium genavense as a cause of subacute pneumonia in patients with severe cellular immunodeficiency
    Blandine Rammaert
    Universite Paris Descartes, Hopital Necker Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Paris, France
    BMC Infect Dis 11:311. 2011
    ..M. genavense culture is fastidious, requiring supplemented media. Pulmonary involvement rarely occurs as a primary localization...
  38. doi request reprint Success of posaconazole therapy in a heart transplanted patient with Alternaria infectoria cutaneous infection
    Blandine Rammaert
    Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Universite Paris Descartes, 149, rue de Sevres, 75743 Paris Cedex 15, France
    Med Mycol 50:518-21. 2012
    ..in solid organ transplant recipients...
  39. doi request reprint Healthcare-associated mucormycosis
    Blandine Rammaert
    Sorbonne Paris Cité, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, APHP, Universite Paris Descartes, Centre d Infectiologie Necker Pasteur, 149 rue de Sevres, Paris Cedex 15, France
    Clin Infect Dis 54:S44-54. 2012
    ..Thorough investigations are mandatory to identify healthcare-associated mucormycosis, notably in neonatology, hematological, and transplantation units...
  40. doi request reprint Epidemiology and outcome of invasive fungal diseases in patients with chronic granulomatous disease: a multicenter study in France
    Julien Beauté
    Centre de Référence Déficits Immunitaires Héréditaires, Hopital Necker Enfants Malades, AP HP, Paris, France
    Pediatr Infect Dis J 30:57-62. 2011
    ..This study is aimed at assessing the incidence, prevalence, and outcome of IFDs among CGD patients followed in France...
  41. doi request reprint Listeria rocourtiae sp. nov
    Alexandre Leclercq
    Groupe Microorganismes et Barrières de l Hôte, French National Reference Center for Listeria, Paris, France
    Int J Syst Evol Microbiol 60:2210-4. 2010
    ..nov. is proposed for the novel species. The type strain is CIP 109804(T) (=DSM 22097(T) =Allerberger 700284/02(T)). The type strain is avirulent as assessed by cell culture assays and inoculation of mice...
  42. doi request reprint Pristinamycin for Rickettsia africae infection
    Frédéric Méchaï
    Centre d Infectiologie Necker Pasteur, Paris, France
    J Travel Med 16:136-7. 2009
    ..The gold standard treatment is doxycycline. Here, we present a case of R africae infection associated with quick complete resolution following the initiation of pristinamycin therapy...
  43. pmc Chikungunya virus-associated long-term arthralgia: a 36-month prospective longitudinal study
    Clementine Schilte
    Unité Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, Paris, France
    PLoS Negl Trop Dis 7:e2137. 2013
    ..Individuals were followed as part of a longitudinal study to investigate in details the long-term outcome of Chikungunya...
  44. pmc Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta
    Helene Bierne
    Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
    PLoS ONE 7:e39080. 2012
    ..In addition, the feto-placental tissue was responsive to IFN-λ2. Together, these results suggest that IFN-λ may be an important modulator of the immune response to Gram-positive intracellular bacteria in epithelial tissues...
  45. ncbi request reprint Chikungunya virus infection of corneal grafts
    Thérèse Couderc
    Microbes and Host Barriers Group, Paris, France
    J Infect Dis 206:851-9. 2012
    ..Chikungunya virus (CHIKV) is an arbovirus with a high potential to spread globally. We investigated whether CHIKV is transmittable via corneal grafts...
  46. doi request reprint Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia
    Romain Micol
    CEREDIH network French National Reference Center for Primary Immunodeficiencies, Hopital Necker Enfants Malades, AP HP, Paris, France
    J Allergy Clin Immunol 129:770-7. 2012
    ..It is not known whether patients able to secrete IgM (eg, those with hyper-IgM [HIgM] syndrome) are as susceptible to these infections as patients who lack IgM production (eg, those with panhypogammaglobulinemia [PHG])...
  47. doi request reprint Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotype
    Romain Micol
    CEREDIH, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 75743 Paris Cedex 15, France
    J Allergy Clin Immunol 128:382-9.e1. 2011
    ..The course of the disease is characterized by neurologic manifestations, infections, and cancers...
  48. doi request reprint [Pregnancy: a high risk factor in influenza infection]
    Caroline Charlier
    Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Groupe infections de la mère et de l enfant, Assistance Publique Hopitaux de Paris, 149, rue de Sevres, 75015 Paris, France
    Med Sci (Paris) 26:100-4. 2010
    ..We also provide an update on the epidemiological data available for the A/H1N1v infection in this population, and discuss the benefit/risk ratio of treatment with the antiviral medications...
  49. ncbi request reprint [Infections in splenectomized patient]
    Hélène Coignard-Biehler
    Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Paris, France
    Rev Prat 58:2209-14. 2008
    ..Furthermore, long-term education is mandatory. Application of preventing measures is effective and patient's education remains the cornerstone of prevention...
  50. doi request reprint Impact of norovirus/sapovirus-related diarrhea in renal transplant recipients hospitalized for diarrhea
    Damien Roos-Weil
    Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, AP HP, Centre d Infectiologie Necker Pasteur, Paris, France
    Transplantation 92:61-9. 2011
    ..Norovirus (NoV) and sapovirus (SaV) have been sporadically reported to cause chronic diarrhea in immunocompromised patients...
  51. doi request reprint Adjuvant corticosteroid therapy for chronic disseminated candidiasis
    Faezeh Legrand
    Universite Paris 7, Service d Hématologie Pédiatrique, Hopital Robert Debre, Paris, France
    Clin Infect Dis 46:696-702. 2008
    ..Chronic disseminated candidiasis (CDC) is typically observed during neutrophil recovery in patients with acute leukemia and requires protracted antifungal therapy...
  52. doi request reprint Characterization of the novel Listeria monocytogenes PCR serogrouping profile IVb-v1
    Alexandre Leclercq
    Institut Pasteur, WHO Collaborating Centre and French National Reference Centre for Listeria, Microbes and Host Barriers Group, Paris, France
    Int J Food Microbiol 147:74-7. 2011
    ..We have updated the WHOCCL serogroup-related PCR typing scheme to include this new profile...
  53. doi request reprint Mycobacterium genavense infections: a retrospective multicenter study in France, 1996-2007
    Pierre Charles
    Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    Medicine (Baltimore) 90:223-30. 2011
    ..The 1-year survival rate was 72%.The prognosis of M. genavense infection in HIV-infected patients has dramatically improved with HAART. Clinical presentations in HIV and non-HIV immunocompromised patients were similar...
  54. doi request reprint Cervical schistosomiasis as a risk factor of cervical uterine dysplasia in a traveler
    Arnaud Dzeing-Ella
    Faculte de Medecine, Paris Descartes, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Service des Maladies Infectieuses et Tropicales, Paris Cedex, France
    Am J Trop Med Hyg 81:549-50. 2009
    ..FGS should be kept in mind as a possible cause of cervical dysplasia in endemic areas. Medical treatment with praziquantel improves this condition...
  55. pmc A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system
    Ivo G Boneca
    Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 75724 Paris, France
    Proc Natl Acad Sci U S A 104:997-1002. 2007
    ..The presence of deacetylase genes in other pathogenic bacteria indicates that PG N-deacetylation could be a general mechanism used by bacteria to evade the host innate immune system...
  56. ncbi request reprint Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosis
    Olivier Dussurget
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
    Mol Microbiol 45:1095-106. 2002
    ..Taken together, these results demonstrate that BSH is a novel PrfA-regulated L. monocytogenes virulence factor involved in the intestinal and hepatic phases of listeriosis...
  57. pmc Emergence of disseminated infections due to Geosmithia argillacea in patients with chronic granulomatous disease receiving long-term azole antifungal prophylaxis
    Marie Machouart
    Service de Parasitologie Mycologie, CHU de Nancy, Hopital Brabois, 11 allee du morvan, 54511 Vandoeuvre les Nancy, France
    J Clin Microbiol 49:1681-3. 2011
    ..One patient died despite receiving a combination of four antifungals, and the other developed cerebral and medullary lesions under a combination of caspofungin, posaconazole, terbinafine, and gamma interferon...
  58. ncbi request reprint FbpA, a novel multifunctional Listeria monocytogenes virulence factor
    S Dramsi
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, France
    Mol Microbiol 53:639-49. 2004
    ..Thus, FbpA, in addition to being a fibronectin-binding protein, behaves as a chaperone or an escort protein for two important virulence factors and appears as a novel multifunctional virulence factor of L. monocytogenes...
  59. pmc Interactions of Listeria monocytogenes with mammalian cells during entry and actin-based movement: bacterial factors, cellular ligands and signaling
    P Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    EMBO J 17:3797-806. 1998
    ..Their study may lead to a better understanding of important questions in cell biology such as ligand receptor signalling and dynamics of actin polymerization in mammalian cells...
  60. pmc Antifungal therapy of Aspergillus invasive otitis externa: efficacy of voriconazole and review
    Perrine Parize
    Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
    Antimicrob Agents Chemother 53:1048-53. 2009
    ..These observations demonstrate that voriconazole could be an effective and well-tolerated therapeutic option for the management of Aspergillus IOE...
  61. doi request reprint [Risk of fungal disease during systemic diseases]
    David Lebeaux
    Service des Maladies Infectieuses et Tropicales, Universite Paris Descartes, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, F 75743 Paris Cedex 15, France
    Presse Med 38:260-73. 2009
    ..Guidelines for invasive fungal disease curative treatment are available but preventive strategies need to be evaluated in the population of patients with systemic diseases...
  62. pmc Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral component
    Mehdi Bouraï
    Unité de Génomique Virale et Vaccination, Institut Pasteur, CNRS URA 3015, Paris, France
    J Virol 86:3121-34. 2012
    ..Altogether, this report provides the first interaction map between CHIKV and human proteins and describes new host cell proteins involved in the replication cycle of this virus...
  63. pmc Identification of the first human gyrovirus, a virus related to chicken anemia virus
    Virginie Sauvage
    Institut Pasteur, Laboratory for Urgent Responses to Biological Threats, 25 rue du Docteur Roux, F 75015 Paris, France
    J Virol 85:7948-50. 2011
    ..By PCR screening, HGyV was found in 5 of 115 other nonlesional skin specimens but in 0 of 92 bronchoalveolar lavages or nasopharyngeal aspirates and in 0 of 92 fecal samples...
  64. pmc A new perspective on Listeria monocytogenes evolution
    Marie Ragon
    Institut Pasteur, Laboratoire des Listeria, Paris, France
    PLoS Pathog 4:e1000146. 2008
    ..This work provides a reference evolutionary framework for future studies on L. monocytogenes epidemiology, ecology, and virulence...
  65. ncbi request reprint [Listeriosis, a rare but severe foodborne infection]
    Caroline Charlier-Woerther
    Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 75015 Paris, France
    Rev Prat 59:905-11. 2009
    ..Diagnosis is based on the isolation of L. monocytogenes from blood and cerebrospinal fluid cultures. Treatment relies on the synergic combination amoxicillin and gentamicin, with a mortality rate up to 30% despite adequate therapy...
  66. doi request reprint Pneumocystis jirovecii Pneumonia
    Emilie Catherinot
    Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, 149 rue de Sevres, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Paris 75015, France
    Infect Dis Clin North Am 24:107-38. 2010
    ..Pneumocystis pneumonia still remains a severe opportunistic infection, associated with a high mortality rate...
  67. pmc Unmasking leprosy: an unusual immune reconstitution inflammatory syndrome in a patient infected with human immunodeficiency virus
    Guillaume Bussone
    Service de Maladies Infectieuses et Tropicales, et Service de Microbiologie, Centre d Infectiologie Necker Pasteur, Universite Paris Descartes, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
    Am J Trop Med Hyg 83:13-4. 2010
    ..These lesions were associated with microbiologically proven leprosy. Thus, latent leprosy can appear as IRIS, and leprosy-associated IRIS should be considered in HIV-infected patients from areas endemic for leprosy...
  68. ncbi request reprint A transgenic model for listeriosis: role of internalin in crossing the intestinal barrier
    M Lecuit
    , Station Centrale de Microscopie Electronique, Institut Pasteur, 75724 Paris Cedex 15, France
    Science 292:1722-5. 2001
    ..These results illustrate how relevant animal models for human infections can be generated...
  69. pmc Targeting of the central nervous system by Listeria monocytogenes
    Olivier Disson
    Microbes and Host Barriers Group, French National Reference Center and WHO Collaborating Center for Listeria, Institut Pasteur, Paris, France
    Virulence 3:213-21. 2012
    ....
  70. doi request reprint Focus on Chikungunya pathophysiology in human and animal models
    Thérèse Couderc
    Groupe Microorganismes et Barrières de l Hôte, Institut Pasteur, Paris, France
    Microbes Infect 11:1197-205. 2009
    ..Our results are discussed in the light of the current knowledge regarding other arthritogenic Alphaviruses...
  71. doi request reprint Entrapment of intracytosolic bacteria by septin cage-like structures
    Serge Mostowy
    Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris F 75015, France
    Cell Host Microbe 8:433-44. 2010
    ..Finally, we show that septin cages entrap bacteria targeted to autophagy. Together, these results reveal an unsuspected mechanism of host defense that restricts dissemination of invasive pathogens...
  72. pmc Evaluation of high-throughput sequencing for identifying known and unknown viruses in biological samples
    Justine Cheval
    Institut Pasteur, Genotyping of Pathogens and Public Health Platform, 28 rue du Docteur Roux, F 75015 Paris, France
    J Clin Microbiol 49:3268-75. 2011
    ..When the virus load was sufficiently high, de novo assembly permitted the generation of long contigs corresponding to nearly full-length genomes and thus should facilitate the identification of novel viruses...
  73. ncbi request reprint Invasion of mammalian cells by Listeria monocytogenes: functional mimicry to subvert cellular functions
    Pascale Cossart
    Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
    Trends Cell Biol 13:23-31. 2003
    ..Manipulating the bacterial invasion proteins offers us an unprecedented tool with which to understand the complex phenomenon of phagocytosis...
  74. pmc A role for alpha-and beta-catenins in bacterial uptake
    M Lecuit
    Unité des Interactions Bactéries Cellules, Station Centrale de Microscopie Electronique, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 97:10008-13. 2000
    ..Taken together, these results reveal that E-cadherin, via beta- and alpha-catenins, can trigger dynamic events of actin polymerization and membrane extensions culminating in bacterial uptake...
  75. pmc Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complex
    P Kussel-Andermann
    Unité de Génétique des Déficits Sensoriels, CNRS URA 1968 and Unité des Interactions Bactéries Cellules, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO J 19:6020-9. 2000
    ..In myosin VIIA-defective mutants, inactivity of the vezatin-myosin VIIA complex at both sites could account for splaying out of the hair cell stereocilia...
  76. ncbi request reprint Morganella morganii pericarditis 3 years after allogenic bone marrow transplantation for mantle cell lymphoma
    Zhi Tao Yang
    Department of Infectious Diseases and Tropical Medicine, Necker Enfants Malades Hospital, René Descartes Paris 5 University Medical School, Paris, France
    J Infect 53:e223-5. 2006
    ..M. morganii should be added to the list of bacteria causing purulent pericarditis, especially in immunocompromised hosts...
  77. pmc Antimicrobial resistance of Listeria monocytogenes strains isolated from humans in France
    A Morvan
    Institut Pasteur, Centre National de Référence de la Résistance aux Antibiotiques, Paris, France
    Antimicrob Agents Chemother 54:2728-31. 2010
    ....
  78. doi request reprint Two unusual glandular presentations of tick-borne tularemia
    P Charles
    Centre d Infectiologie Necker Pasteur, Paris, France
    Med Mal Infect 38:159-61. 2008
  79. doi request reprint Animal models of Listeria infection
    Didier Cabanes
    Group of Molecular Microbiology, Instituto de Biologia Molecular e Celular IBMC, Universidade do Porto, Portugal
    Curr Protoc Microbiol . 2008
    ..Although mice and guinea pigs can be infected with Listeria by a variety of routes, the intragastric route is the most relevant to the human foodborne listeriosis...
  80. ncbi request reprint Functional genomic studies of the intestinal response to a foodborne enteropathogen in a humanized gnotobiotic mouse model
    Marc Lecuit
    Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Biol Chem 282:15065-72. 2007
    ..Together, these studies establish that hly, rather than bacterial invasion of the lamina propria mediated by InlA, is a dominant determinant of the intensity of the host response to L. monocytogenes infection via the oral route...
  81. ncbi request reprint [Molecular basis of Listeria monocytogenes fetoplacental tropism]
    Marc Lecuit
    Med Sci (Paris) 21:17-9. 2005
  82. ncbi request reprint ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion
    Sandra Sousa
    Unité des Interactions Bactéries Cellules Institut Pasteur, INSERM U604, INRA USC2020, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nat Cell Biol 7:954-60. 2005
    ..monocytogenes entry. Altogether, our results show that ARHGAP10 is a new component of cell-cell junctions that controls alpha-catenin recruitment and has a key role during L. monocytogenes uptake...
  83. ncbi request reprint [Immunoproliferative small intestinal disease associated with Campylobacter jejuni]
    Marc Lecuit
    Med Sci (Paris) 20:638-40. 2004
  84. ncbi request reprint Genetically-modified-animal models for human infections: the Listeria paradigm
    Marc Lecuit
    Dept of Molecular Biology and Pharmacology, Washington University School of Medicine Campus Box 8103, 660 So Euclid Ave, St Louis, MO 63110, USA
    Trends Mol Med 8:537-42. 2002
    ..This model is presented here as a paradigm of a genetically-modified-animal model for studying a human infectious disease...
  85. ncbi request reprint Hafnia alvei endocarditis following pyelonephritis in a permanent pacemaker carrier
    Pierre Loulergue
    Clin Infect Dis 44:621. 2007
  86. pmc Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La Réunion
    Patrick Gerardin
    Neonatal and Pediatric Intensive Care Unit, pôle Mère Enfant, Groupe Hospitalier Sud Reunion, Saint Pierre, La Reunion, France
    PLoS Med 5:e60. 2008
    ....
  87. pmc Novel extended-spectrum beta-lactamase in Shigella sonnei
    Agnes Lefort
    Emerg Infect Dis 13:653-4. 2007