Research Topics
Genomes and Genes | Marc LecuitSummaryAffiliation: Institut Pasteur Country: France Publications
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Publications
Understanding how Listeria monocytogenes targets and crosses host barriersM Lecuit
INSERM U 604, Département de Biologie Cellulaire et Infection, Institut Pasteur and Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Universite Rene Descartes Paris 5, Paris, France
Clin Microbiol Infect 11:430-6. 2005..monocytogenes to target and cross the placental barrier. Further investigations are currently focusing on the molecular mechanisms by which L. monocytogenes targets and crosses the blood-brain barrier...- Human listeriosis and animal modelsMarc Lecuit
Avenir Group INSERM U604 Microbial Interactions with Host Barriers, Bacteria Cell Interactions Unit, Department of Cell Biology and Infection, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
Microbes Infect 9:1216-25. 2007..Finally, we present some of the critical determinants for the choice of an appropriate animal model to study human listeriosis... 
Targeting and crossing of the human maternofetal barrier by Listeria monocytogenes: role of internalin interaction with trophoblast E-cadherinMarc Lecuit
Unité des Interactions Bactéries Cellules and Unité d Histotechnologie et Pathologie, Institut Pasteur, Paris 75015, France
Proc Natl Acad Sci U S A 101:6152-7. 2004..monocytogenes to target and cross the placental barrier. Such a ligand-receptor interaction allowing a pathogen to specifically cross the placental villous trophoblast barrier has not been reported previously...- Immunoproliferative small intestinal disease associated with Campylobacter jejuniMarc Lecuit
Hopital Avicenne, Paris, France
N Engl J Med 350:239-48. 2004..Early-stage disease responds to antibiotics, suggesting a bacterial origin. We attempted to identify a causative agent... 
Conjugated action of two species-specific invasion proteins for fetoplacental listeriosisOlivier Disson
Institut Pasteur, Groupe Microorganismes et Barrières de l Hôte, Unité des Interactions Bactéries Cellules, F 75015 Paris, France
Nature 455:1114-8. 2008....- The stress-induced virulence protein InlH controls interleukin-6 production during murine listeriosisNicolas Personnic
Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris F 75015, France
Infect Immun 78:1979-89. 2010..These results strongly suggest that InlH is a stress-induced surface protein that facilitates pathogen survival in tissues by tempering the inflammatory response... - Modeling human listeriosis in natural and genetically engineered animalsOlivier Disson
Institut Pasteur, Microbes and Host Barriers, Paris, France
Nat Protoc 4:799-810. 2009..monocytogenes crossing of human host barriers. The whole procedure (inoculation, in vivo imaging, bacterial enumeration, histopathology) takes one full week to complete, including 3 d of actual experiments... - Adherence to preventive measures after splenectomy in the hospital setting and in the communityHélène Coignard-Biehler
Paris Descartes University, Paris, France
J Infect Public Health 4:187-94. 2011..Overwhelming post-splenectomy infection (OPSI) remains a long-term risk in asplenic patients, which may be reduced by appropriate preventive measures. Specific guidelines have been developed to lower its incidence... - Human polyomavirus related to African green monkey lymphotropic polyomavirusVirginie Sauvage
Institut Pasteur, Paris, France
Emerg Infect Dis 17:1364-70. 2011..These results provide information on the viral ecology of human skin and raise new questions regarding the pathology of virus-associated skin disorders... - Species specificity of the Listeria monocytogenes InlB proteinNadia Khelef
Institut Pasteur, Unité des Interactions Bactéries Cellules, 25 28 Rue du Docteur Roux, Paris, F 75015 France
Cell Microbiol 8:457-70. 2006..These results unravel a second L. monocytogenes species specificity critical for understanding human listeriosis and emphasize the need for developing new animal models for studying InlA and InlB functions in the same animal model... - LPXTG protein InlJ, a newly identified internalin involved in Listeria monocytogenes virulenceChristophe Sabet
Unité des Interactions Bactéries Cellules, Institut Pasteur, INSERM U604, INRA USC2020, Paris, France
Infect Immun 73:6912-22. 2005..In conclusion, this postgenomic approach identified InlJ as a new virulence factor among the proteins belonging to the internalin family in L. monocytogenes... - Gp96 is a receptor for a novel Listeria monocytogenes virulence factor, Vip, a surface proteinDidier Cabanes
Unité des Interactions Bactéries Cellules Institut Pasteur, INSERM U604, INRA USC 2020, Paris, France
EMBO J 24:2827-38. 2005..Vip thus appears as a new virulence factor exploiting Gp96 as a receptor for cell invasion and/or signalling events that may interfere with the host immune response in the course of the infection... - Listeria monocytogenes internalin and E-cadherin: from structure to pathogenesisMatteo Bonazzi
Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris, France
Cell Microbiol 11:693-702. 2009.... - Listeria monocytogenes internalin and E-cadherin: from bench to bedsideMatteo Bonazzi
Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, F 75015, France
Cold Spring Harb Perspect Biol 1:a003087. 2009.... - The Listeria transcriptional landscape from saprophytism to virulenceAlejandro Toledo-Arana
Institut Pasteur, Unité des Interactions Bactéries Cellules, F 75015 Paris, France
Nature 459:950-6. 2009..Together, our data unravel successive and coordinated global transcriptional changes during infection and point to previously unknown regulatory mechanisms in bacteria... - The Listeria monocytogenes virulence factor InlJ is specifically expressed in vivo and behaves as an adhesinChristophe Sabet
UIBC, Institut Pasteur, INSERM, U604, INRA, USC2020, 25 rue du Dr Roux, Paris F 75015, France
Infect Immun 76:1368-78. 2008..innocua promotes bacterial adherence to human cells in vitro. Taken together, these results strongly suggest that InlJ acts as a novel L. monocytogenes sortase-anchored adhesin specifically expressed during infection in vivo... - Recurrent Mycobacterium avium infection after seven years of latency in a HIV-infected patient receiving efficient antiretroviral therapyGuillaume Bussone
Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
J Infect 64:613-7. 2012..avium bacteriaemia. Articular puncture grew M. avium. The isolates of the first and second infection were identical using repetitive-sequence-based Polymerase Chain Reaction analyses... - Human listeriosis caused by Listeria ivanoviiChristelle Guillet
Universite Paris Descartes, Paris, France
Emerg Infect Dis 16:136-8. 2010..We report L. ivanovii-associated gastroenteritis and bacteremia in a man. This isolate was indistinguishable from prototypic ruminant strains. L. ivanovii is thus an enteric opportunistic human pathogen... - Real-time observation of listeria monocytogenes-phagocyte interactions in living zebrafish larvaeJean Pierre Levraud
Macrophages et Développement de l Immunité, Institut Pasteur, Paris, France
Infect Immun 77:3651-60. 2009..monocytogenes pathogenesis and particularly for the dissection of its interactions with phagocytes in vivo, a key factor of L. monocytogenes virulence... - Unconventional myosin VIIa and vezatin, two proteins crucial for Listeria entry into epithelial cellsSandra Sousa
, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris Cedex 15, France
J Cell Sci 117:2121-30. 2004..These results provide the first evidence for the role of an unconventional myosin in bacterial internalization and a novel example of the exploitation of mammalian proteins, by a pathogen, to establish a successful infection... - Therapeutic drug monitoring of posaconazole: a monocentric study with 54 adultsDavid Lebeaux
Universite Paris Descartes, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, Paris, France
Antimicrob Agents Chemother 53:5224-9. 2009..Therapeutic drug monitoring of posaconazole is therefore mandatory for immunosuppressed adults, at least for those with gastrointestinal disorders... - Impact of lactobacilli on orally acquired listeriosisCristel Archambaud
Unité des Interactions Bactéries Cellules, Institut Pasteur, 75015 Paris, France
Proc Natl Acad Sci U S A 109:16684-9. 2012..monocytogenes infection by treatment with lactobacilli correlates with a decrease in host gene expression, in particular ISGs, miR regulation, and a dramatic reshaping of L. monocytogenes transcriptome... - Serum Aspergillus galactomannan for the management of disseminated histoplasmosis in AIDSSébastien Rivière
Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Paris, France
Am J Trop Med Hyg 87:303-5. 2012..Here, we report the contribution of galactomannan serum detection for the management of an HIV-infected patient with disseminated histoplasmosis... - Worldwide distribution of major clones of Listeria monocytogenesViviane Chenal-Francisque
Institut Pasteur, Paris, France
Emerg Infect Dis 17:1110-2. 2011..Cosmopolitan distribution indicates the need for genotyping standardization... - Src, cortactin and Arp2/3 complex are required for E-cadherin-mediated internalization of Listeria into cellsSandra Sousa
Institut Pasteur, Unité des Interactions Bactéries Cellules Inserm, U604 and INRA, USC2020, Paris F 75015, France
Cell Microbiol 9:2629-43. 2007..Together, these data suggest a model in which Src tyrosine kinase and Rac1 promote recruitment of cortactin and activation of Arp2/3 at Listeria entry site, mimicking events that occur during adherens junction formation... - Transcytosis of Listeria monocytogenes across the intestinal barrier upon specific targeting of goblet cell accessible E-cadherinGeorgios Nikitas
Microbes and Host Barriers Group, French National Reference Center and World Health Organization Collaborating Center on Listeria, Institut Pasteur, Paris, France
J Exp Med 208:2263-77. 2011.... - A molecular marker for evaluating the pathogenic potential of foodborne Listeria monocytogenesChristine Jacquet
Laboratoire des Listeria, , World Health Organization Collaborating Center for Foodborne Listeriosis, Institut Pasteur, Paris, France
J Infect Dis 189:2094-100. 2004..It provides a molecular explanation for the predominance of serovar 4b among clinical strains and supports the usefulness of studying the expression of internalin as a marker of virulence in humans... - Nocardia pseudobrasiliensis as an emerging cause of opportunistic infection after allogeneic hematopoietic stem cell transplantationDavid Lebeaux
Université Paris Descartes Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, AP HP, Centre d Infectiologie Necker Pasteur, 149 rue de Sevres, 75743 Paris Cedex 15, France
J Clin Microbiol 48:656-9. 2010..Culture of the bronchoalveolar lavage fluid revealed Nocardia pseudobrasiliensis. This recently described carbapenem-resistant species should be included in the differential diagnosis of fungal infection in this setting... - Success of posaconazole therapy in a heart transplanted patient with Alternaria infectoria cutaneous infectionBlandine Rammaert
Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, Universite Paris Descartes, 149, rue de Sevres, 75743 Paris Cedex 15, France
Med Mycol 50:518-21. 2012..in solid organ transplant recipients... - Healthcare-associated mucormycosisBlandine Rammaert
Sorbonne Paris Cité, Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, APHP, Universite Paris Descartes, Centre d Infectiologie Necker Pasteur, 149 rue de Sevres, Paris Cedex 15, France
Clin Infect Dis 54:S44-54. 2012..Thorough investigations are mandatory to identify healthcare-associated mucormycosis, notably in neonatology, hematological, and transplantation units... - Epidemiology and outcome of invasive fungal diseases in patients with chronic granulomatous disease: a multicenter study in FranceJulien Beauté
Centre de Référence Déficits Immunitaires Héréditaires, Hopital Necker Enfants Malades, AP HP, Paris, France
Pediatr Infect Dis J 30:57-62. 2011..This study is aimed at assessing the incidence, prevalence, and outcome of IFDs among CGD patients followed in France... - Listeria rocourtiae sp. novAlexandre Leclercq
Groupe Microorganismes et Barrières de l Hôte, French National Reference Center for Listeria, Paris, France
Int J Syst Evol Microbiol 60:2210-4. 2010..nov. is proposed for the novel species. The type strain is CIP 109804(T) (=DSM 22097(T) =Allerberger 700284/02(T)). The type strain is avirulent as assessed by cell culture assays and inoculation of mice... - ActA promotes Listeria monocytogenes aggregation, intestinal colonization and carriageLaetitia Travier
Biology of Infection Unit, Institut Pasteur, Paris, France
PLoS Pathog 9:e1003131. 2013.... - Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placentaHelene Bierne
Institut Pasteur, Unité des Interactions Bactéries Cellules, Paris, France
PLoS ONE 7:e39080. 2012..In addition, the feto-placental tissue was responsive to IFN-λ2. Together, these results suggest that IFN-λ may be an important modulator of the immune response to Gram-positive intracellular bacteria in epithelial tissues... - Chikungunya virus infection of corneal graftsThérèse Couderc
Microbes and Host Barriers Group, Paris, France
J Infect Dis 206:851-9. 2012..Chikungunya virus (CHIKV) is an arbovirus with a high potential to spread globally. We investigated whether CHIKV is transmittable via corneal grafts... - Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemiaRomain Micol
CEREDIH network French National Reference Center for Primary Immunodeficiencies, Hopital Necker Enfants Malades, AP HP, Paris, France
J Allergy Clin Immunol 129:770-7. 2012..It is not known whether patients able to secrete IgM (eg, those with hyper-IgM [HIgM] syndrome) are as susceptible to these infections as patients who lack IgM production (eg, those with panhypogammaglobulinemia [PHG])... - Mycobacterium genavense as a cause of subacute pneumonia in patients with severe cellular immunodeficiencyBlandine Rammaert
Universite Paris Descartes, Hopital Necker Enfants Malades, Service des Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Paris, France
BMC Infect Dis 11:311. 2011..M. genavense culture is fastidious, requiring supplemented media. Pulmonary involvement rarely occurs as a primary localization... - Listeria monocytogenes-associated joint and bone infections: a study of 43 consecutive casesCaroline Charlier
Institut Pasteur, French National Reference Center and WHO Collaborating Center for Listeria, Microbes and Host Barriers Group, Universite Paris Descartes, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Paris, France
Clin Infect Dis 54:240-8. 2012..Little is known about Listeria monocytogenes-associated bone and joint infections. Only case reports of this infection have been published... - [Infections in splenectomized patient]Hélène Coignard-Biehler
Universite Paris Descartes, Assistance Publique Hopitaux de Paris, Hopital Necker Enfants Malades, Paris, France
Rev Prat 58:2209-14. 2008..Furthermore, long-term education is mandatory. Application of preventing measures is effective and patient's education remains the cornerstone of prevention... - [Pregnancy: a high risk factor in influenza infection]Caroline Charlier
Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Groupe infections de la mère et de l enfant, Assistance Publique Hopitaux de Paris, 149, rue de Sevres, 75015 Paris, France
Med Sci (Paris) 26:100-4. 2010..We also provide an update on the epidemiological data available for the A/H1N1v infection in this population, and discuss the benefit/risk ratio of treatment with the antiviral medications... - Morbidity and mortality from ataxia-telangiectasia are associated with ATM genotypeRomain Micol
CEREDIH, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 75743 Paris Cedex 15, France
J Allergy Clin Immunol 128:382-9.e1. 2011..The course of the disease is characterized by neurologic manifestations, infections, and cancers... - Fungal infections in immunocompromised travelersOlivier Lortholary
Universite Paris Descartes, Sorbonne Paris Cité, Hopital Necker Enfants Malades, Centre d lnfectiologie Necker Pasteur, and Institut Imagine
Clin Infect Dis 56:861-9. 2013..Finally, infectious diseases physicians should be aware of major clinical patterns of travel-acquired fungal infection, as well as the fungi involved, and risk factors according to the geographical area visited... - Characterization of the novel Listeria monocytogenes PCR serogrouping profile IVb-v1Alexandre Leclercq
Institut Pasteur, WHO Collaborating Centre and French National Reference Centre for Listeria, Microbes and Host Barriers Group, Paris, France
Int J Food Microbiol 147:74-7. 2011..We have updated the WHOCCL serogroup-related PCR typing scheme to include this new profile... - Cervical schistosomiasis as a risk factor of cervical uterine dysplasia in a travelerArnaud Dzeing-Ella
Faculte de Medecine, Paris Descartes, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Service des Maladies Infectieuses et Tropicales, Paris Cedex, France
Am J Trop Med Hyg 81:549-50. 2009..FGS should be kept in mind as a possible cause of cervical dysplasia in endemic areas. Medical treatment with praziquantel improves this condition... - Mycobacterium genavense infections: a retrospective multicenter study in France, 1996-2007Pierre Charles
Universite Paris Descartes, Hopital Necker Enfants Malades, Paris, France
Medicine (Baltimore) 90:223-30. 2011..The 1-year survival rate was 72%.The prognosis of M. genavense infection in HIV-infected patients has dramatically improved with HAART. Clinical presentations in HIV and non-HIV immunocompromised patients were similar... - A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune systemIvo G Boneca
Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, 75724 Paris, France
Proc Natl Acad Sci U S A 104:997-1002. 2007..The presence of deacetylase genes in other pathogenic bacteria indicates that PG N-deacetylation could be a general mechanism used by bacteria to evade the host innate immune system... - Listeria monocytogenes bile salt hydrolase is a PrfA-regulated virulence factor involved in the intestinal and hepatic phases of listeriosisOlivier Dussurget
, Institut Pasteur, Paris, France
Mol Microbiol 45:1095-106. 2002..Taken together, these results demonstrate that BSH is a novel PrfA-regulated L. monocytogenes virulence factor involved in the intestinal and hepatic phases of listeriosis... - Emergence of disseminated infections due to Geosmithia argillacea in patients with chronic granulomatous disease receiving long-term azole antifungal prophylaxisMarie Machouart
Service de Parasitologie Mycologie, CHU de Nancy, Hopital Brabois, 11 allee du morvan, 54511 Vandoeuvre les Nancy, France
J Clin Microbiol 49:1681-3. 2011..One patient died despite receiving a combination of four antifungals, and the other developed cerebral and medullary lesions under a combination of caspofungin, posaconazole, terbinafine, and gamma interferon... - Interactions of Listeria monocytogenes with mammalian cells during entry and actin-based movement: bacterial factors, cellular ligands and signalingP Cossart
Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
EMBO J 17:3797-806. 1998..Their study may lead to a better understanding of important questions in cell biology such as ligand receptor signalling and dynamics of actin polymerization in mammalian cells... - FbpA, a novel multifunctional Listeria monocytogenes virulence factorS Dramsi
, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, France
Mol Microbiol 53:639-49. 2004..Thus, FbpA, in addition to being a fibronectin-binding protein, behaves as a chaperone or an escort protein for two important virulence factors and appears as a novel multifunctional virulence factor of L. monocytogenes... - Mapping of Chikungunya virus interactions with host proteins identified nsP2 as a highly connected viral componentMehdi Bouraï
Unité de Génomique Virale et Vaccination, Institut Pasteur, CNRS URA 3015, Paris, France
J Virol 86:3121-34. 2012..Altogether, this report provides the first interaction map between CHIKV and human proteins and describes new host cell proteins involved in the replication cycle of this virus... - [Listeriosis, a rare but severe foodborne infection]Caroline Charlier-Woerther
Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, 75015 Paris, France
Rev Prat 59:905-11. 2009..Diagnosis is based on the isolation of L. monocytogenes from blood and cerebrospinal fluid cultures. Treatment relies on the synergic combination amoxicillin and gentamicin, with a mortality rate up to 30% despite adequate therapy... - Pristinamycin for Rickettsia africae infectionFrédéric Méchaï
Centre d Infectiologie Necker Pasteur, Paris, France
J Travel Med 16:136-7. 2009..The gold standard treatment is doxycycline. Here, we present a case of R africae infection associated with quick complete resolution following the initiation of pristinamycin therapy... - Identification of the first human gyrovirus, a virus related to chicken anemia virusVirginie Sauvage
Institut Pasteur, Laboratory for Urgent Responses to Biological Threats, 25 rue du Docteur Roux, F 75015 Paris, France
J Virol 85:7948-50. 2011..By PCR screening, HGyV was found in 5 of 115 other nonlesional skin specimens but in 0 of 92 bronchoalveolar lavages or nasopharyngeal aspirates and in 0 of 92 fecal samples... - Impact of norovirus/sapovirus-related diarrhea in renal transplant recipients hospitalized for diarrheaDamien Roos-Weil
Service des Maladies Infectieuses et Tropicales, Hopital Necker Enfants Malades, AP HP, Centre d Infectiologie Necker Pasteur, Paris, France
Transplantation 92:61-9. 2011..Norovirus (NoV) and sapovirus (SaV) have been sporadically reported to cause chronic diarrhea in immunocompromised patients... - Adjuvant corticosteroid therapy for chronic disseminated candidiasisFaezeh Legrand
Universite Paris 7, Service d Hématologie Pédiatrique, Hopital Robert Debre, Paris, France
Clin Infect Dis 46:696-702. 2008..Chronic disseminated candidiasis (CDC) is typically observed during neutrophil recovery in patients with acute leukemia and requires protracted antifungal therapy... - A new perspective on Listeria monocytogenes evolutionMarie Ragon
Institut Pasteur, Laboratoire des Listeria, Paris, France
PLoS Pathog 4:e1000146. 2008..This work provides a reference evolutionary framework for future studies on L. monocytogenes epidemiology, ecology, and virulence... - Pneumocystis jirovecii PneumoniaEmilie Catherinot
Universite Paris Descartes, Service de Maladies Infectieuses et Tropicales, 149 rue de Sevres, Centre d Infectiologie Necker Pasteur, Hopital Necker Enfants Malades, Paris 75015, France
Infect Dis Clin North Am 24:107-38. 2010..Pneumocystis pneumonia still remains a severe opportunistic infection, associated with a high mortality rate... - Unmasking leprosy: an unusual immune reconstitution inflammatory syndrome in a patient infected with human immunodeficiency virusGuillaume Bussone
Service de Maladies Infectieuses et Tropicales, et Service de Microbiologie, Centre d Infectiologie Necker Pasteur, Universite Paris Descartes, Hopital Necker Enfants Malades, Assistance Publique Hopitaux de Paris, Paris, France
Am J Trop Med Hyg 83:13-4. 2010..These lesions were associated with microbiologically proven leprosy. Thus, latent leprosy can appear as IRIS, and leprosy-associated IRIS should be considered in HIV-infected patients from areas endemic for leprosy... - A transgenic model for listeriosis: role of internalin in crossing the intestinal barrierM Lecuit
, Station Centrale de Microscopie Electronique, Institut Pasteur, 75724 Paris Cedex 15, France
Science 292:1722-5. 2001..These results illustrate how relevant animal models for human infections can be generated... - Targeting of the central nervous system by Listeria monocytogenesOlivier Disson
Microbes and Host Barriers Group, French National Reference Center and WHO Collaborating Center for Listeria, Institut Pasteur, Paris, France
Virulence 3:213-21. 2012.... - Focus on Chikungunya pathophysiology in human and animal modelsThérèse Couderc
Groupe Microorganismes et Barrières de l Hôte, Institut Pasteur, Paris, France
Microbes Infect 11:1197-205. 2009..Our results are discussed in the light of the current knowledge regarding other arthritogenic Alphaviruses... - Evaluation of high-throughput sequencing for identifying known and unknown viruses in biological samplesJustine Cheval
Institut Pasteur, Genotyping of Pathogens and Public Health Platform, 28 rue du Docteur Roux, F 75015 Paris, France
J Clin Microbiol 49:3268-75. 2011..When the virus load was sufficiently high, de novo assembly permitted the generation of long contigs corresponding to nearly full-length genomes and thus should facilitate the identification of novel viruses... - Invasion of mammalian cells by Listeria monocytogenes: functional mimicry to subvert cellular functionsPascale Cossart
Unité des Interactions Bactéries Cellules, Institut Pasteur, 28 rue du Docteur Roux, Paris 75015, France
Trends Cell Biol 13:23-31. 2003..Manipulating the bacterial invasion proteins offers us an unprecedented tool with which to understand the complex phenomenon of phagocytosis... - Entrapment of intracytosolic bacteria by septin cage-like structuresSerge Mostowy
Unité des Interactions Bactéries Cellules, Institut Pasteur, Paris F 75015, France
Cell Host Microbe 8:433-44. 2010..Finally, we show that septin cages entrap bacteria targeted to autophagy. Together, these results reveal an unsuspected mechanism of host defense that restricts dissemination of invasive pathogens... - A role for alpha-and beta-catenins in bacterial uptakeM Lecuit
Unité des Interactions Bactéries Cellules, Station Centrale de Microscopie Electronique, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
Proc Natl Acad Sci U S A 97:10008-13. 2000..Taken together, these results reveal that E-cadherin, via beta- and alpha-catenins, can trigger dynamic events of actin polymerization and membrane extensions culminating in bacterial uptake... - Vezatin, a novel transmembrane protein, bridges myosin VIIA to the cadherin-catenins complexP Kussel-Andermann
Unité de Génétique des Déficits Sensoriels, CNRS URA 1968 and Unité des Interactions Bactéries Cellules, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
EMBO J 19:6020-9. 2000..In myosin VIIA-defective mutants, inactivity of the vezatin-myosin VIIA complex at both sites could account for splaying out of the hair cell stereocilia... - Chikungunya Virus-associated Long-term Arthralgia: A 36-month Prospective Longitudinal StudyClementine Schilte
Unité Immunobiologie des Cellules Dendritiques, Department of Immunology, Institut Pasteur, Paris, France Institut National de la Santé et de la Recherche Médicale INSERM U818, Paris, France
PLoS Negl Trop Dis 7:e2137. 2013..CONCLUSIONSSIGNIFICANCE: This study demonstrates that chronic arthralgia is a frequent complication of acute Chikungunya disease and suggests that it results from a local rather than systemic inflammation... - [Risk of fungal disease during systemic diseases]David Lebeaux
Service des Maladies Infectieuses et Tropicales, Universite Paris Descartes, Hopital Necker Enfants Malades, Centre d Infectiologie Necker Pasteur, F 75743 Paris Cedex 15, France
Presse Med 38:260-73. 2009..Guidelines for invasive fungal disease curative treatment are available but preventive strategies need to be evaluated in the population of patients with systemic diseases... - Morganella morganii pericarditis 3 years after allogenic bone marrow transplantation for mantle cell lymphomaZhi-Tao Yang
Department of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades Hospital, , Paris, France
J Infect 53:e223-5. 2006..M. morganii should be added to the list of bacteria causing purulent pericarditis, especially in immunocompromised hosts... - Two unusual glandular presentations of tick-borne tularemiaP Charles
Centre d'Infectiologie Necker-Pasteur, Paris, France
Med Mal Infect 38:159-61. 2008 - Antimicrobial resistance of Listeria monocytogenes strains isolated from humans in FranceA Morvan
Institut Pasteur, Centre National de Référence de la Résistance aux Antibiotiques, Paris, France
Antimicrob Agents Chemother 54:2728-31. 2010.... - Animal models of Listeria infectionDidier Cabanes
Group of Molecular Microbiology, Instituto de Biologia Molecular e Celular IBMC, Universidade do Porto, Portugal
Curr Protoc Microbiol . 2008..Although mice and guinea pigs can be infected with Listeria by a variety of routes, the intragastric route is the most relevant to the human foodborne listeriosis... - [Molecular basis of Listeria monocytogenes fetoplacental tropism]Marc Lecuit
Med Sci (Paris) 21:17-9. 2005 - ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasionSandra Sousa
, INSERM U604, INRA USC2020, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
Nat Cell Biol 7:954-60. 2005..monocytogenes entry. Altogether, our results show that ARHGAP10 is a new component of cell-cell junctions that controls alpha-catenin recruitment and has a key role during L. monocytogenes uptake... - Functional genomic studies of the intestinal response to a foodborne enteropathogen in a humanized gnotobiotic mouse modelMarc Lecuit
Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri 63108, USA
J Biol Chem 282:15065-72. 2007..Together, these studies establish that hly, rather than bacterial invasion of the lamina propria mediated by InlA, is a dominant determinant of the intensity of the host response to L. monocytogenes infection via the oral route... - Novel extended-spectrum beta-lactamase in Shigella sonneiAgnes Lefort
Emerg Infect Dis 13:653-4. 2007 - Genetically-modified-animal models for human infections: the Listeria paradigmMarc Lecuit
Dept of Molecular Biology and Pharmacology, Washington University School of Medicine Campus Box 8103, 660 So Euclid Ave, St Louis, MO 63110, USA
Trends Mol Med 8:537-42. 2002..This model is presented here as a paradigm of a genetically-modified-animal model for studying a human infectious disease... - Multidisciplinary prospective study of mother-to-child chikungunya virus infections on the island of La RéunionPatrick Gerardin
Neonatal and Pediatric Intensive Care Unit, pôle Mère Enfant, Groupe Hospitalier Sud Reunion, Saint Pierre, La Reunion, France
PLoS Med 5:e60. 2008.... - Hafnia alvei endocarditis following pyelonephritis in a permanent pacemaker carrierPierre Loulergue
Clin Infect Dis 44:621. 2007 - [Immunoproliferative small intestinal disease associated with Campylobacter jejuni]Marc Lecuit
Med Sci (Paris) 20:638-40. 2004