Hervé Lecoeur

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Reprogramming neutral lipid metabolism in mouse dendritic leucocytes hosting live Leishmania amazonensis amastigotes
    Hervé Lecoeur
    Institut Pasteur, Département de Parasitologie et Mycologie, Laboratoire Immunophysiologie et Parasitisme, Paris, France
    PLoS Negl Trop Dis 7:e2276. 2013
  2. doi request reprint Sorting of Leishmania-bearing dendritic cells reveals subtle parasite-induced modulation of host-cell gene expression
    Hervé Lecoeur
    Institut Pasteur, Unité d Immunophysiologie et Parasitisme Intracellulaire, Département de Parasitologie et Mycologie, Paris Cedex 15, France
    Microbes Infect 12:46-54. 2010
  3. pmc Early curative applications of the aminoglycoside WR279396 on an experimental Leishmania major-loaded cutaneous site do not impair the acquisition of immunity
    Hervé Lecoeur
    Institut Pasteur, Département de Parasitologie et Mycologie, Unité d Immunophysiologie et Parasitisme Intracellulaire, 25 rue du Dr Roux, Paris 75724 Cedex 15, France
    Antimicrob Agents Chemother 54:984-90. 2010
  4. doi request reprint A combined luciferase imaging and reverse transcription polymerase chain reaction assay for the study of Leishmania amastigote burden and correlated mouse tissue transcript fluctuations
    Emilie de La Llave
    Institut Pasteur, Département de Parasitologie et Mycologie, Immunophysiologie et Parasitisme Intracellulaire, 25 rue du Dr Roux, 75724 Paris Cedex15, France
    Cell Microbiol 13:81-91. 2011
  5. pmc Distinct transcriptional signatures of bone marrow-derived C57BL/6 and DBA/2 dendritic leucocytes hosting live Leishmania amazonensis amastigotes
    Emilie Giraud
    Département de Parasitologie et Mycologie, Laboratoire Immunophysiologie et Parasitisme, Institut Pasteur, Paris, France
    PLoS Negl Trop Dis 6:e1980. 2012
  6. doi request reprint Imaging Leishmania development in their host cells
    Thierry Lang
    Institut Pasteur, Département de Parasitologie et Mycologie, Unité d Immunophysiologie et Parasitisme Intracellulaire, 75724 Paris Cedex 15, France
    Trends Parasitol 25:464-73. 2009
  7. ncbi request reprint The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver
    Olivier Terradillos
    Unite de Recombinaison et Expression Genetique, INSERM U163, Institut Pasteur, Paris, France
    Oncogene 21:377-86. 2002
  8. ncbi request reprint Real-time flow cytometry analysis of permeability transition in isolated mitochondria
    Hervé Lecoeur
    Theraptosis Research Laboratory, Theraptosis S A, Institut Pasteur, 75015 Paris, France
    Exp Cell Res 294:106-17. 2004
  9. ncbi request reprint Unveiling pathways used by Leishmania amazonensis amastigotes to subvert macrophage function
    José Osorio y Fortéa
    Département de Parasitologie et Mycologie, Unité d Immunophysiologie et Parasitisme Intracellulaire, Institut Pasteur, Paris, France
    Immunol Rev 219:66-74. 2007
  10. ncbi request reprint Multiparametric flow cytometric analysis of biochemical and functional events associated with apoptosis and oncosis using the 7-aminoactinomycin D assay
    Hervé Lecoeur
    Département de Médecine Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Immunol Methods 265:81-96. 2002

Collaborators

Detail Information

Publications14

  1. pmc Reprogramming neutral lipid metabolism in mouse dendritic leucocytes hosting live Leishmania amazonensis amastigotes
    Hervé Lecoeur
    Institut Pasteur, Département de Parasitologie et Mycologie, Laboratoire Immunophysiologie et Parasitisme, Paris, France
    PLoS Negl Trop Dis 7:e2276. 2013
    ..In the study reported here, we investigated whether the presence of live L. amazonensis amastigotes in mouse bone marrow-derived DLs is able to trigger re-programming of DL lipid, and particularly neutral lipid metabolism...
  2. doi request reprint Sorting of Leishmania-bearing dendritic cells reveals subtle parasite-induced modulation of host-cell gene expression
    Hervé Lecoeur
    Institut Pasteur, Unité d Immunophysiologie et Parasitisme Intracellulaire, Département de Parasitologie et Mycologie, Paris Cedex 15, France
    Microbes Infect 12:46-54. 2010
    ..In conclusion, this approach provides a powerful method for further characterisation, of amastigote-hosting DCs in the skin and the skin-draining lymph nodes...
  3. pmc Early curative applications of the aminoglycoside WR279396 on an experimental Leishmania major-loaded cutaneous site do not impair the acquisition of immunity
    Hervé Lecoeur
    Institut Pasteur, Département de Parasitologie et Mycologie, Unité d Immunophysiologie et Parasitisme Intracellulaire, 25 rue du Dr Roux, Paris 75724 Cedex 15, France
    Antimicrob Agents Chemother 54:984-90. 2010
    ..major multiplication phase, did not impair the acquisition of immunity to a second L. major challenge. This is reassuring from the perspective of the wide deployment of WR279396-based therapy in foci where L. major is endemic...
  4. doi request reprint A combined luciferase imaging and reverse transcription polymerase chain reaction assay for the study of Leishmania amastigote burden and correlated mouse tissue transcript fluctuations
    Emilie de La Llave
    Institut Pasteur, Département de Parasitologie et Mycologie, Immunophysiologie et Parasitisme Intracellulaire, 25 rue du Dr Roux, 75724 Paris Cedex15, France
    Cell Microbiol 13:81-91. 2011
    ..We argue that these two combined technologies will have the potential to provide further insights on complex phenotypes driven by Leishmania developmental programs in the tissues of the mammal hosts...
  5. pmc Distinct transcriptional signatures of bone marrow-derived C57BL/6 and DBA/2 dendritic leucocytes hosting live Leishmania amazonensis amastigotes
    Emilie Giraud
    Département de Parasitologie et Mycologie, Laboratoire Immunophysiologie et Parasitisme, Institut Pasteur, Paris, France
    PLoS Negl Trop Dis 6:e1980. 2012
    ....
  6. doi request reprint Imaging Leishmania development in their host cells
    Thierry Lang
    Institut Pasteur, Département de Parasitologie et Mycologie, Unité d Immunophysiologie et Parasitisme Intracellulaire, 75724 Paris Cedex 15, France
    Trends Parasitol 25:464-73. 2009
    ..Finally, we discuss how innovative imaging technologies will allow further refinement of our understanding of the interplay between Leishmania and its hosts...
  7. ncbi request reprint The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver
    Olivier Terradillos
    Unite de Recombinaison et Expression Genetique, INSERM U163, Institut Pasteur, Paris, France
    Oncogene 21:377-86. 2002
    ..Our data indicate that the dominant function of HBx upon Bcl-2-regulated control of apoptosis might play an important role in the pathogenesis of chronic hepatitis B...
  8. ncbi request reprint Real-time flow cytometry analysis of permeability transition in isolated mitochondria
    Hervé Lecoeur
    Theraptosis Research Laboratory, Theraptosis S A, Institut Pasteur, 75015 Paris, France
    Exp Cell Res 294:106-17. 2004
    ..These simple, highly sensitive and quantitative FC-based methods will be pertinent to evaluate compounds for their ability to control MMP...
  9. ncbi request reprint Unveiling pathways used by Leishmania amazonensis amastigotes to subvert macrophage function
    José Osorio y Fortéa
    Département de Parasitologie et Mycologie, Unité d Immunophysiologie et Parasitisme Intracellulaire, Institut Pasteur, Paris, France
    Immunol Rev 219:66-74. 2007
    ..that persist within the mammalian dermis reach a non-replicating developmental stage? If so, is this developmental stage the only one displaying the features required for further development as promastigotes within the sand fly gut lumen?..
  10. ncbi request reprint Multiparametric flow cytometric analysis of biochemical and functional events associated with apoptosis and oncosis using the 7-aminoactinomycin D assay
    Hervé Lecoeur
    Département de Médecine Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Immunol Methods 265:81-96. 2002
    ..Finally, we show that this assay is not specific for apoptosis since it detects oncosis, the early stage of primary necrosis...
  11. pmc Optimization of topical therapy for Leishmania major localized cutaneous leishmaniasis using a reliable C57BL/6 Model
    Hervé Lecoeur
    Unité d Immunophysiologie et Parasitisme Intracellulaire, Institut Pasteur, Paris, France
    PLoS Negl Trop Dis 1:e34. 2007
    ..One main objective was to help optimize the treatment modalities of human LCL with WR279396, a topical formulation of aminoglycosides that was recently proven to be efficient and safe for use in humans...
  12. ncbi request reprint Nuclear apoptosis detection by flow cytometry: influence of endogenous endonucleases
    Hervé Lecoeur
    Theraptosis Research Laboratory, Theraptosis S A Pasteur Biotop, Institut Pasteur, Paris, France
    Exp Cell Res 277:1-14. 2002
    ..This review underlines the need for strategies to accurately detect and quantify nuclear apoptosis by flow cytometry when new cell systems and apoptotic conditions are considered...
  13. doi request reprint Analysis of apoptotic pathways by multiparametric flow cytometry: application to HIV infection
    Hervé Lecoeur
    Unité d Immunophysiologie et Parasitisme Intracellulaire, Paris, France
    Methods Enzymol 442:51-82. 2008
    ..Several examples of combined staining of apoptotic cells are shown on peripheral blood lymphocytes from chronically HIV-infected patients, prone to undergo premature apoptosis...
  14. doi request reprint A flavivirus protein M-derived peptide directly permeabilizes mitochondrial membranes, triggers cell death and reduces human tumor growth in nude mice
    Magali Brabant
    Theraptosis Research Laboratory, Pasteur Biotop, 75015, Paris, France
    Apoptosis 14:1190-203. 2009
    ..Together, these findings support the notion of using viral genomes as valuable sources to discover mitochondria-targeted sequences that may lead to the development of new anticancer compounds...