Lionel Larue

Summary

Affiliation: Institut Curie
Country: France

Publications

  1. ncbi request reprint The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
    Sylvia Julien Grille
    Developmental Genetics of Melanocytes, UMR 146 CNRS Institut Curie, 91405 Orsay Cedex, France
    Cancer Res 63:2172-8. 2003
  2. ncbi request reprint Cutaneous melanoma in genetically modified animals
    Lionel Larue
    Developmental Genetics of Melanocytes, UMR146 CNRS, Institut Curie, Orsay, France
    Pigment Cell Res 20:485-97. 2007
  3. pmc Automated cell tracking and analysis in phase-contrast videos (iTrack4U): development of Java software based on combined mean-shift processes
    Fabrice P Cordelières
    Institut Curie, CNRS UMR3348, plate forme IBISA d imagerie cellulaire et tissulaire, Orsay, France
    PLoS ONE 8:e81266. 2013
  4. pmc A subpopulation of smooth muscle cells, derived from melanocyte-competent precursors, prevents patent ductus arteriosus
    Ichiro Yajima
    Developmental Genetics of Melanocytes, Institut Curie, Orsay, France
    PLoS ONE 8:e53183. 2013
  5. doi request reprint Modeling melanoblast development
    Lionel Larue
    Institut Curie, Centre de Recherche, Developmental Genetics of Melanocytes, 91405, Orsay, France
    Cell Mol Life Sci 70:1067-79. 2013
  6. doi request reprint Origin of mouse melanomas
    Lionel Larue
    Centre de Recherche, Developmental Genetics of Melanocytes, Institut Curie, Orsay, France
    J Invest Dermatol 132:2135-6. 2012
  7. ncbi request reprint Beta-catenin in the melanocyte lineage
    Lionel Larue
    Developmental Genetics of Melanocytes, CNRS Institut Curie, Orsay Cedex, France
    Pigment Cell Res 16:312-7. 2003
  8. doi request reprint Bypassing melanocyte senescence by beta-catenin: a novel way to promote melanoma
    L Larue
    Institut Curie, Developmental Genetics of Melanocytes, Batiment 110, 91405 Orsay Cedex, France
    Pathol Biol (Paris) 57:543-7. 2009
  9. ncbi request reprint Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways
    Lionel Larue
    Developmental Genetics of Melanocytes, UMR 146, CNRS, Institut Curie, Centre Universitaire, Orsay, France
    Oncogene 24:7443-54. 2005
  10. doi request reprint Biological and mathematical modeling of melanocyte development
    Flavie Luciani
    Institut Curie, Centre de Recherche, Developmental Genetics of Melanocytes, 91405 Orsay, France
    Development 138:3943-54. 2011

Collaborators

Detail Information

Publications51

  1. ncbi request reprint The protein kinase Akt induces epithelial mesenchymal transition and promotes enhanced motility and invasiveness of squamous cell carcinoma lines
    Sylvia Julien Grille
    Developmental Genetics of Melanocytes, UMR 146 CNRS Institut Curie, 91405 Orsay Cedex, France
    Cancer Res 63:2172-8. 2003
    ..These findings suggest that future therapies based on AKT inhibition may complement conventional treatments by controlling tumor cell invasion and metastasis...
  2. ncbi request reprint Cutaneous melanoma in genetically modified animals
    Lionel Larue
    Developmental Genetics of Melanocytes, UMR146 CNRS, Institut Curie, Orsay, France
    Pigment Cell Res 20:485-97. 2007
    ..In this review, we summarize the work of currently available transgenic melanoma models and discuss the most recent progress in creating improved and/or inducible models reflecting the human disease...
  3. pmc Automated cell tracking and analysis in phase-contrast videos (iTrack4U): development of Java software based on combined mean-shift processes
    Fabrice P Cordelières
    Institut Curie, CNRS UMR3348, plate forme IBISA d imagerie cellulaire et tissulaire, Orsay, France
    PLoS ONE 8:e81266. 2013
    ..Another major interest of iTrack4U is the standardization and the lack of inter-experimenter differences. Finally, iTrack4U is adapted for phase contrast and fluorescent cells. ..
  4. pmc A subpopulation of smooth muscle cells, derived from melanocyte-competent precursors, prevents patent ductus arteriosus
    Ichiro Yajima
    Developmental Genetics of Melanocytes, Institut Curie, Orsay, France
    PLoS ONE 8:e53183. 2013
    ....
  5. doi request reprint Modeling melanoblast development
    Lionel Larue
    Institut Curie, Centre de Recherche, Developmental Genetics of Melanocytes, 91405, Orsay, France
    Cell Mol Life Sci 70:1067-79. 2013
    ..We also present a robust mathematical model for estimating the doubling-time of dermal and epidermal melanoblasts for all coat color phenotypes from black to white...
  6. doi request reprint Origin of mouse melanomas
    Lionel Larue
    Centre de Recherche, Developmental Genetics of Melanocytes, Institut Curie, Orsay, France
    J Invest Dermatol 132:2135-6. 2012
    ..The histological location of a melanoma when discovered, whether in the epidermis or dermis, does not necessarily reflect the location of the original cell...
  7. ncbi request reprint Beta-catenin in the melanocyte lineage
    Lionel Larue
    Developmental Genetics of Melanocytes, CNRS Institut Curie, Orsay Cedex, France
    Pigment Cell Res 16:312-7. 2003
    ..Here, we review the known beta-catenin interacting factors and targets involved in the development and transformation of melanocytes and in particular its role in the expression of the crucial gene of melanocyte development, Mitf...
  8. doi request reprint Bypassing melanocyte senescence by beta-catenin: a novel way to promote melanoma
    L Larue
    Institut Curie, Developmental Genetics of Melanocytes, Batiment 110, 91405 Orsay Cedex, France
    Pathol Biol (Paris) 57:543-7. 2009
    ..Finally, we discuss how beta-catenin-induced immortalization can cooperate with MAPKinase pathways to produce melanoma...
  9. ncbi request reprint Epithelial-mesenchymal transition in development and cancer: role of phosphatidylinositol 3' kinase/AKT pathways
    Lionel Larue
    Developmental Genetics of Melanocytes, UMR 146, CNRS, Institut Curie, Centre Universitaire, Orsay, France
    Oncogene 24:7443-54. 2005
    ..Interactions between PI3K/AKT and other EMT-inducing pathways are presented, along with a discussion of the therapeutic implications of modulating EMT in order to achieve cancer control...
  10. doi request reprint Biological and mathematical modeling of melanocyte development
    Flavie Luciani
    Institut Curie, Centre de Recherche, Developmental Genetics of Melanocytes, 91405 Orsay, France
    Development 138:3943-54. 2011
    ..Modeling melanoblast expansion revealed novel links between cell division, cell localization within the embryo and appropriate feedback control through β-catenin...
  11. pmc Phosphorylation of BRN2 modulates its interaction with the Pax3 promoter to control melanocyte migration and proliferation
    Irina Berlin
    Institut Curie, Developmental Genetics of Melanocytes, Orsay, France
    Mol Cell Biol 32:1237-47. 2012
    ..Our findings show that melanocyte migration and proliferation are controlled both through the regulation of PAX3 by nonphosphorylated BRN2 and through the regulation of MITF-M by the overall BRN2 level...
  12. pmc Beta-catenin induces immortalization of melanocytes by suppressing p16INK4a expression and cooperates with N-Ras in melanoma development
    Veronique Delmas
    Developmental Genetics of Melanocytes, UMR 146, Centre National de Recherche Scientifique Institut Curie, 91405 Orsay Cedex, France
    Genes Dev 21:2923-35. 2007
    ..The results reveal that synergy between the Wnt and mitogen-activated protein (MAP) kinase pathways may represent an important mechanism underpinning the genesis of melanoma, a highly aggressive and increasingly common disease...
  13. ncbi request reprint The WNT/Beta-catenin pathway in melanoma
    Lionel Larue
    Developmental Genetics of Melanocytes, UMR 146 CNRS Institut Curie, Bat 110, 91405, Orsay Cedex, France
    Front Biosci 11:733-42. 2006
    ....
  14. ncbi request reprint Ednrb2 orients cell migration towards the dorsolateral neural crest pathway and promotes melanocyte differentiation
    Patrick Pla
    Developmental Genetics of Melanocytes, UMR 146 CNRS Institut Curie, Orsay, France
    Pigment Cell Res 18:181-7. 2005
    ..The in ovo migration of Ednrb2-expressing ES cells was massively oriented towards the dorsolateral pathway, unlike that of WT or Ednrb-expressing ES cells. Thus, Ednrb2 is involved in melanoblast differentiation and migration...
  15. pmc GLI2-mediated melanoma invasion and metastasis
    Vasileia Ismini Alexaki
    Curie Institute, INSERM U1021 CNRS UMR3347, University Center, Orsay Cedex, France
    J Natl Cancer Inst 102:1148-59. 2010
    ..Recently, we identified GLI2, a mediator of the hedgehog pathway, as a transcriptional target of TGF-beta signaling...
  16. ncbi request reprint Involvement of cadherins 7 and 20 in mouse embryogenesis and melanocyte transformation
    Robert Moore
    Developmental Genetics of Melanocytes, UMR146 CNRS, Institut Curie, Bat 110, 91405 Orsay Cedex, France
    Oncogene 23:6726-35. 2004
    ..Finally, during oncogenesis, cadherin-7, N-cad and E-cad could be used as an efficient marker set for melanoma...
  17. ncbi request reprint Spatiotemporal gene control by the Cre-ERT2 system in melanocytes
    Ichiro Yajima
    Developmental Genetics of Melanocytes, UMR 146 CNRS Institut Curie, Centre Universitaire, Orsay, France
    Genesis 44:34-43. 2006
    ..Thus, the Tyr::Cre-ERT2 transgenic mice provides a valuable tool for following this cell lineage and for investigating gene function in melanocyte development and transformation...
  18. ncbi request reprint [Malignant melanoma and the role of the paradoxal protein Microphthalmia transcription factor]
    Laurence Denat
    Developmental Genetics of Melanocytes, UMR146 CNRS, Institut Curie, Bat 110, 91405, Orsay Cedex
    Bull Cancer 94:81-92. 2007
    ..Essential protein of the melanocyte lineage, Mitf was proposed as diagnostic/pronostic marker for cutaneous melanoma. However, could we then consider MITF as the unique marker of such a cancer?..
  19. pmc Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction
    Isabel Puig
    Institut Curie, Centre de Recherche, Developmental Genetics of Melanocytes, Orsay, France
    J Clin Invest 119:3586-96. 2009
    ..Our study thus reveals that loss of PTEN disrupts development of the ENS and identifies the PI3K/PTEN-AKT-S6K signaling pathway as a potential therapeutic target for ganglioneuromatosis forms of CIPO...
  20. doi request reprint Cellular and molecular mechanisms controlling the migration of melanocytes and melanoma cells
    Jacky Bonaventure
    Developmental Genetics of Melanocytes, Institut Curie, Centre de Recherche, Orsay, France
    Pigment Cell Melanoma Res 26:316-25. 2013
    ....
  21. doi request reprint Genomic localization of the Z/EG transgene in the mouse genome
    Sophie Colombo
    Institut Curie, Centre de Recherche, Developmental Genetics of Melanocytes, 91405, Orsay, France
    Genesis 48:96-100. 2010
    ..The insertion of the Z/EG transgene in the C57BL/6 genetic background had no effect on Rasa4 expression. Homozygous Z/EG mice therefore had no obvious phenotype...
  22. ncbi request reprint [Regulation of E-cadherin by the Akt protein kinase B]
    Sylvia Grille
    Developmental Genetics of Melanocytes, UMR 146 CNRS Institut Curie, Bat 110, 91405 Orsay Cedex, France
    J Soc Biol 198:375-8. 2004
    ..At the molecular level, cells expressing a constitutive active form of Akt express also a transcription factor, Snail, known to repress the expression of E-cadherin...
  23. doi request reprint [Migration of melanocytic lineage-derived cells]
    Mélanie J Domingues
    Institut Curie, CNRS UMR3347, INSERM U1021, Génétique du développement des mélanocytes, Centre de Recherche, Batiment 110, 91405 Orsay, France
    Med Sci (Paris) 29:287-92. 2013
    ..Here, we summarize how these data allow a better understanding of the complex mechanisms controlling migration of normal and pathological cells of the melanocytic lineage...
  24. doi request reprint Efficient gene expression profiling of laser-microdissected melanoma metastases
    Samira Makhzami
    Developmental Genetics of Melanocytes, Institut Curie, Centre de Recherche, Orsay, France
    Pigment Cell Melanoma Res 25:783-91. 2012
    ..We detected only minor transcriptomic differences between primary and metastatic melanoma tissue. This optimized workflow could be very valuable for various studies requiring cell type-specific transcriptomic analysis...
  25. doi request reprint Transcriptomic analysis of mouse embryonic skin cells reveals previously unreported genes expressed in melanoblasts
    Sophie Colombo
    Institut Curie, Centre de Recherche, Developmental Genetics of Melanocytes, Orsay, France
    J Invest Dermatol 132:170-8. 2012
    ..This study demonstrates the feasibility of the transcriptomic analysis of purified melanoblasts at different embryonic stages and reveals the involvement of previously unreported genes in melanoblast development...
  26. ncbi request reprint Dct::lacZ ES cells: a novel cellular model to study melanocyte determination and differentiation
    Patrick Pla
    Developmental Genetics of Melanocytes, UMR 146 CNRS Institut Curie, Bat 110, 91405, Orsay Cedex, France
    Pigment Cell Res 17:142-9. 2004
    ..Thus, Dct::lacZ ES cells can be used as a model to study determination, proliferation and differentiation in the melanocyte lineage in vitro...
  27. ncbi request reprint [Cadherins in the mammary gland and the melanocyte lineage]
    Veronique Delmas
    Developmental Genetics of Melanocytes, UMR146 CNRS Institut Curie, Bat 110, 91405, Orsay Cedex, France
    J Soc Biol 198:385-9. 2004
    ..The specific functions mediated by this very dynamic cadherin expression are not yet known and their characterisation represents a challenge for the future...
  28. ncbi request reprint Involvement of endothelin receptors in normal and pathological development of neural crest cells
    Patrick Pla
    Developmental Genetics of Melanocytes, UMR 146 CNRS Institut Curie, Orsay, France
    Int J Dev Biol 47:315-25. 2003
    ..Data obtained in vitro and in vivo have provided insight into the roles of these proteins in cell proliferation, migration, differentiation and transformation...
  29. doi request reprint B-Raf and C-Raf are required for melanocyte stem cell self-maintenance
    Agathe Valluet
    Institut Curie, Centre Universitaire, Orsay F 91405, France
    Cell Rep 2:774-80. 2012
    ..Therefore, Raf signaling is dispensable for early melanocyte lineage development, but necessary for MSC maintenance...
  30. doi request reprint Small-molecule drugs mimicking DNA damage: a new strategy for sensitizing tumors to radiotherapy
    Maria Quanz
    Institut Curie, Centre de Recherche, Orsay, France
    Clin Cancer Res 15:1308-16. 2009
    ..Enhanced DNA repair activity is often associated with tumor resistance to radiotherapy. We hypothesized that inhibiting DNA damage repair would sensitize tumors to radiation-induced DNA damage...
  31. doi request reprint PTEN and melanomagenesis
    Alejandro Conde-Perez
    Institut Curie, Developmental Genetics of Melanocytes, Bat 110, 91405, Orsay, France
    Future Oncol 8:1109-20. 2012
    ..Moreover, the acquisition of basic knowledge will help patient management with appropriate therapies that are already, or will shortly be, on the market...
  32. doi request reprint The location of heart melanocytes is specified and the level of pigmentation in the heart may correlate with coat color
    Ichiro Yajima
    Developmental Genetics of Melanocytes, UMR 146 CNRS, Institut Curie, Orsay Cedex, France
    Pigment Cell Melanoma Res 21:471-6. 2008
    ..In this respect, melanocytes found in the valves and septa of the heart are probably not essential in a healthy and non-stressful environment...
  33. doi request reprint Human relevance of NRAS/BRAF mouse melanoma models
    Alejandro Conde-Perez
    Institut Curie, Normal and Pathological Development of Melanocytes, 91405 Orsay, France CNRS UMR3347, France INSERM U1021, France
    Eur J Cell Biol 93:82-6. 2014
    ..Here, we summarize and evaluate the human relevance of various RAF and RAS mouse melanoma models and their contribution to our understanding of melanoma. ..
  34. ncbi request reprint [Homologous recombination and gene targeting]
    Elodie Biet
    UMR 2027 CNRS Institut Curie, Batiment 110, 15, rue Georges Clemenceau, 91405 Orsay, France
    C R Biol 326:51-64. 2003
    ..Here, we review the limiting steps of classical approaches and the new strategies developed to improve the efficiency of homologous recombination in gene-targeting experiments...
  35. ncbi request reprint Stable overexpression of Smad7 in human melanoma cells inhibits their tumorigenicity in vitro and in vivo
    Delphine Javelaud
    INSERM U697, Pavillon Bazin, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    Oncogene 24:7624-9. 2005
    ..These results suggest that TGF-beta production by melanoma cells not only affects the tumor environment but also directly contributes to tumor cell aggressiveness through autocrine activation of Smad signaling...
  36. ncbi request reprint Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 OTL, UK
    Nature 433:764-9. 2005
    ..The mutation of genes associated with melanoma, such as INK4a or BRAF that would affect either Mitf cooperation with Rb1 or Mitf stability respectively, would impair Mitf-mediated cell cycle control...
  37. ncbi request reprint Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells
    Maria José Barberà
    Unitat de Biologia Cel lular i Molecular, Institut Municipal d Investigacio Medica, Universitat Pompeu Fabra, Barcelona, Spain
    Oncogene 23:7345-54. 2004
    ..These results indicate that Snail transcription is driven by signaling pathways known to induce epithelial to mesenchymal transition, reinforcing the role of Snail in this process...
  38. ncbi request reprint Cell surface molecules and truncal neural crest ontogeny: a perspective
    Robert Moore
    Human Genetics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA
    Birth Defects Res C Embryo Today 72:140-50. 2004
    ..Here, we review some of the molecules present in this location and how they influence the fate of the neural crest and generate disease...
  39. pmc Brn-2 expression controls melanoma proliferation and is directly regulated by beta-catenin
    Jane Goodall
    Signaling and Development Laboratory, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, United Kingdom
    Mol Cell Biol 24:2915-22. 2004
    ..These results, together with the observation that BRAF signaling also induces Brn-2 expression, reveal that Brn-2 is a focus for the convergence of two key melanoma-associated signaling pathways that are linked to cell proliferation...
  40. pmc Genetic dissection of cadherin function during nephrogenesis
    Ulf Dahl
    Department of Medical Biochemistry, Goteborg University, S 405 30 Goteborg, Sweden
    Mol Cell Biol 22:1474-87. 2002
    ..Surprisingly, however, in none of the compound knockout strains was kidney development affected to a greater extent than within the individual cadherin knockout strains...
  41. ncbi request reprint A French academic network for sharing transgenic materials and knowledge
    Martin Holzenberger
    Transgenic Res 14:801-2. 2005
  42. ncbi request reprint Cre-mediated recombination in the skin melanocyte lineage
    Veronique Delmas
    Genesis 36:73-80. 2003
    ..In conclusion, Tyr::Cre transgenic mice provide a valuable tool to follow the cell lineage and to examine gene function in melanocyte development and transformation...
  43. ncbi request reprint E-cadherin synergistically induces hepatospecific phenotype and maturation of embryonic stem cells in conjunction with hepatotrophic factors
    Anouska Dasgupta
    Department of Chemical and Biochemical Engineering, Rutgers University, 98 Brett Road, Piscataway, New Jersey 08873, USA
    Biotechnol Bioeng 92:257-66. 2005
    ..Thus, cadherin-engineered ES cells could be used to harness the cross-talk between the hepatotrophic and cadherin-based signaling pathways for controlled acceleration of ES hepatodifferentiation...
  44. pmc Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells
    Mariko Moriyama
    Laboratory for Stem Cell Biology, RIKEN Center for Developmental Biology, Hyogo 650 0047, Japan
    J Cell Biol 173:333-9. 2006
    ..Thus, these data provide evidence that Notch signaling, acting through Hes1, plays a crucial role in the survival of immature Mbs by preventing initiation of apoptosis...
  45. ncbi request reprint [Hereditary diffuse gastric cancer]
    Alain Sezeur
    Service de Chirurgie Digestive, Groupe Hospitalier Diaconesses Croix Saint Simon, Paris
    Gastroenterol Clin Biol 30:1205-13. 2006
    ..The search for the genetic mutation should be recommended to families corresponding to clinical criteria such as the number of affected family members, degree of relationship and age of onset of these tumors...
  46. ncbi request reprint Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner
    Karine Schouwey
    ISREC Swiss Institute for Experimental Cancer Research, National Center of Competence in Research Molecular Oncology, Epalinges, Switzerland
    Dev Dyn 236:282-9. 2007
    ..We suggest that both Notch1 and Notch2 receptors contribute to the maintenance of melanoblasts and melanocyte stem cells, and are essential for proper hair pigmentation...
  47. pmc Mitf regulation of Dia1 controls melanoma proliferation and invasiveness
    Suzanne Carreira
    Signalling and Development Laboratory, Marie Curie Research Institute, Oxted, Surrey, RH8 0TL, United Kingdom
    Genes Dev 20:3426-39. 2006
    ..The results imply variations in the repertoire of environmental cues that determine Mitf activity will dictate the differentiation, proliferative, and invasive/migratory potential of melanoma cells through a dynamic epigenetic mechanism...
  48. doi request reprint Melanoblasts' proper location and timed differentiation depend on Notch/RBP-J signaling in postnatal hair follicles
    Geneviève Aubin-Houzelstein
    INRA, UMR955 Génétique Moléculaire et Cellulaire Ecole Nationale Vétérinaire d Alfort, Maisons Alfort, France
    J Invest Dermatol 128:2686-95. 2008
    ..These findings reveal previously unrecognized roles for Notch signaling in the melanocyte lineage...
  49. doi request reprint [How keratinocytes instruct melanocytes to deliver the pigment]
    Veronique Delmas
    Med Sci (Paris) 24:147-8. 2008
  50. ncbi request reprint Stable overexpression of Smad7 in human melanoma cells impairs bone metastasis
    Delphine Javelaud
    INSERM U697, Hopital Saint Louis, 1 avenue Claude Vellefaux, 75010 Paris, France
    Cancer Res 67:2317-24. 2007
    ..Blockade of TGF-beta signaling may be an effective treatment for melanoma metastasis to bone...
  51. ncbi request reprint Le(x) glycan mediates homotypic adhesion of embryonal cells independently from E-cadherin: a preliminary note
    Kazuko Handa
    Division of Biomembrane Research, Pacific Northwest Research Institute, Department of Pathobiology, University of Washington, Seattle, WA 98122, USA
    Biochem Biophys Res Commun 358:247-52. 2007
    ..Thus, ES or EC cells display autoaggregation and strong adhesion to Le(x)-coated plates in the absence of Ecad, further supporting the notion of Le(x) self-recognition (i.e., Le(x)-to-Le(x) interaction) in cell adhesion...