Research Topics
| S LapercheSummaryAffiliation: Institut National de la Transfusion Sanguine Country: France Publications
| Collaborators
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Detail Information
Publications
Simultaneous detection of hepatitis C virus (HCV) core antigen and anti-HCV antibodies improves the early detection of HCV infectionSyria Laperche
National Reference Center for Hepatitis B and C in Transfusion, Institut National de la Transfusion Sanguine, 6 rue Alexandre Cabanel, 75015 Paris, France
J Clin Microbiol 43:3877-83. 2005....
Is an assay for simultaneous detection of hepatitis C virus core antigen and antibody a valuable alternative to nucleic acid testing?Syria Laperche
National Reference Center for Hepatitis B and C in Transfusion, National Institute of Blood Transfusion, Paris, France
Transfusion 45:1965-72. 2005....- A new HCV core antigen assay based on disassociation of immune complexes: an alternative to molecular biology in the diagnosis of early HCV infectionSyria Laperche
Department of Blood Transmissible Agents, National Institute of Blood Transfusion, Paris, France
Transfusion 43:958-62. 2003..An EIA based on immune complex disassociation of nucleocapsid proteins of HCV has been developed to detect and quantify HCV core antigen... 
A revised method for estimating hepatitis B virus transfusion residual risk based on antibody to hepatitis B core antigen incident casesSyria Laperche
Centre National de Référence pour les Hépatites B et C en Transfusion, Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, Paris, France
Transfusion 48:2308-14. 2008....- Blood safety strategies for human T-cell lymphotropic virus in EuropeS Laperche
Reference National Centre for hepatitis B et C and HIV in transfusion, Institut National de la Transfusion Sanguine, Paris, France
Vox Sang 96:104-10. 2009..Furthermore, leucoreduction of blood components has been implemented to preclude the transmission of infectious agents present in white blood cells... - Interpretation of real-time PCR results for hepatitis C virus RNA when viral load is below quantification limitsSyria Laperche
Centre National de Référence pour les Hépatites B et C en Transfusion, Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, Paris, France
J Clin Microbiol 49:1113-5. 2011..5 to 500 IU/ml) showed a score of correct results of up to 93.5%. However, 55.6% of the laboratories did not follow the recommendations for the interpretation of their results, leading to ambiguous conclusions... - Expertise of laboratories in viral load quantification, genotyping, and precore mutant determination for hepatitis B virus in a multicenter studySyria Laperche
Centre National de Référence pour les Hépatites B et C en Transfusion, Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, Paris, France
J Clin Microbiol 44:3600-7. 2006..Furthermore, the clinical implications of HBV genotyping and the determination of precore/core mutants need to be clearly stated to justify the standardization of these methods... - Transfusion safety on the African continent: an international quality control of virus testing in blood banksSyria Laperche
National Reference Center for Hepatitis B and C and HIV in Transfusion, National Blood Transfusion Institute, 6 rue Alexandre Cabanel, F 75015 Paris, France
Transfusion 49:1600-8. 2009.... - [Recent HCV infections in blood donors (1994-2001)]S Laperche
, , Institut National de la Transfusion Sanguine, 6, rue Alexandre-Cabanel, 75015, Paris, France
Transfus Clin Biol 10:78-80. 2003 - [Genetic diversity of human erythroviruses. Consequences on infectious safety of plasma derivatives]A Servant-Delmas
Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, 6, rue Alexandre Cabanel, 75015 Paris, France
Transfus Clin Biol 16:482-8. 2009..Recently, a new human parvovirus (PARV4) has been discovered. The consequences on blood transfusion of this blood-borne agent and its pathogenicity are still unknown... - Determination of hepatitis B virus subtypes by an enzyme immunoassay method using monoclonal antibodies to type-specific epitopes of HBsAgS Laperche
Unité de Virologie Transfusionnelle, Institut National de la Transfusion Sanguine, Paris, France
J Viral Hepat 8:447-53. 2001.... - Efficacy of HCV core antigen detection during the preseroconversion periodA M Courouce
Department of Virology, National Institute of Blood Transfusion, Lille, France
Transfusion 40:1198-202. 2000..The purpose of this study was to compare the performances of HCV core antigen (HCV Ag) testing with HCV RNA detection during the preseroconversion period... - High levels of serum hepatitis B virus DNA in patients with 'anti-HBc alone': role of HBsAg mutantsO Launay
Universite Paris Descartes, Faculte de Medecine, Paris, France
J Viral Hepat 18:721-9. 2011.... - [Genetic diversity of human Erythroviruses]A Servant-Delmas
Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, 6, rue Alexandre Cabanel, 75739 Paris cedex 15, France
Pathol Biol (Paris) 57:167-74. 2009..A prospective French study performed between 1999 and 2001 indicated that genotypes 2 and 3 viruses circulated with a significant frequency (10%). Pathogenic properties might not differ according to the genotype... - Lessons from a multicentre study of the detectability of viral genomes based on a two-round quality control of GB virus C (GBV-C)/hepatitis G virus (HGV) polymerase chain reaction assayJ J Lefrere
Unité de recherches biocliniques, Institut National de la Transfusion Sanguine, Paris, France
J Virol Methods 85:117-24. 2000.... - Sensitivity of hepatitis B virus DNA transcription-mediated amplification testing in hepatitis B surface antigen-positive blood donationsFrançoise Bouchardeau
Expertise unit of Virology, National Reference Center for Hepatitis B and C Viruses in Transfusion, National Institute of Blood Transfusion, Paris, France
Transfusion 46:2047-52. 2006..The objective was to evaluate the performance of nucleic acid testing (NAT) in the detection of hepatitis B virus (HBV) infection in hepatitis B surface antigen (HBsAg)-positive blood donations... - Hepatitis G virus: a suitable marker of in vivo efficacy for pathogen inactivationJ J Lefrere
Department of Blood Transmissible Agents, National Institute of Blood Transfusion, Paris, France
Vox Sang 95:76-8. 2008..The in vivo efficacy of pathogen inactivation methods could be assessed by the absence of hepatitis G virus markers after transfusion of pathogen-inactivated blood products, in recipients susceptible to infection before the transfusion... - Blood donors infected with the hepatitis B virus but persistently lacking antibodies to the hepatitis B core antigenS Laperche
Unité de Virologie Transfusionnelle, Institut National de la Transfusion Sanguine, 6 rue Alexandre Cabanel, 75739 Paris, France
Vox Sang 80:90-4. 2001..Through a national epidemiological survey, two young and first-time blood donors, originating from HBV-endemic areas, were identified as HBV carriers with an absence of anti-HBc reactivity... - [Safety of blood products and B19 parvovirus]J J Lefrere
Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, 6, rue Alexandre Cabanel, 75709 Paris cedex 15, France
Transfus Clin Biol 13:235-41. 2006..If not, a screening of blood donors positive for B19 IgG would be a sufficient preventive measure... - Impact of hepatitis B virus genotypes and surface antigen variants on the performance of HBV real time PCR quantificationVincent Thibault
Laboratoire de Virologie, AP HP Hôpital de la Pitié Salpêtrière, Paris, France
J Virol Methods 159:265-70. 2009..In conclusion, the Abbott RT assay can detect and quantify DNA from different HBV variants with equivalent performance and is thus suitable for routine monitoring of patients with chronic HBV infections... - Improvement of hepatitis C virus (HCV) genotype determination with the new version of the INNO-LiPA HCV assayFrançoise Bouchardeau
Institut National de la Transfusion Sanguine, 6 rue Alexandre Cabanel, 75015 Paris, France
J Clin Microbiol 45:1140-5. 2007..Thus, the Versant HCV Genotype 2.0 assay remains a useful tool for clinical practice when only the discrimination between major HCV genotypes is necessary... - Comparison of hepatitis C virus NS5b and 5' noncoding gene sequencing methods in a multicenter studySyria Laperche
, , Institut National de la Transfusion Sanguine, 6 rue Alexandre-Cabanel, 75015 Paris, France
J Clin Microbiol 43:733-9. 2005.... - Unique NS5b hepatitis C virus gene sequence consensus database is essential for standardization of genotype determinations in multicenter epidemiological studiesSyria Laperche
Institut National de la Transfusion Sanguine, 6 rue Alexandre-Cabanel, 75015 Paris, France
J Clin Microbiol 44:614-6. 2006.... - Outbreak of hepatitis C virus infection in a hemodialysis unit: potential transmission by the hemodialysis machine?Elisabeth Delarocque-Astagneau
Institut de Veille Sanitaire, Paris, France
Infect Control Hosp Epidemiol 23:328-34. 2002..To identify the routes of transmission during an outbreak of infection with hepatitis C virus (HCV) genotype 2a/2c in a hemodialysis unit... - Complete or partial seroreversion in immunocompetent individuals after self-limited HCV infection: consequences for transfusionJean Jacques Lefrere
Laboratory of Hematology, Hospital of Amiens, Paris, France
Transfusion 44:343-8. 2004..However, it has important implications in the context of transfusion inquiries, in particular in case of a blood donor suspected to have transmitted HCV through a past blood donation... - Genetic diversity within human erythroviruses: identification of three genotypesAnnabelle Servant
Laboratoire de Virologie, Hopital Armand Trousseau, EA2391, UFR Saint Antoine, Paris, France
J Virol 76:9124-34. 2002.... - Multicenter trials need to use the same assay for hepatitis C virus viral load determinationSyria Laperche
Centre National de Référence pour les Hépatites B et C en Transfusion, Département des Agents Transmissibles par le Sang, Institut National de la Transfusion Sanguine, 6 rue Alexandre Cabanel, 75015, Paris, France
J Clin Microbiol 45:3788-90. 2007..This underlines the importance of using the same assay in multicenter studies or when monitoring antiviral therapy... - Persistent B19 infection in immunocompetent individuals: implications for transfusion safetyJean Jacques Lefrere
Institut National de la Transfusion Sanguine, 6 rue Alexandre Cabanel, 75015 Paris, France
Blood 106:2890-5. 2005.... - HIV antibody screening remains indispensable for ensuring viral safety of blood components despite NAT implementationSyria Laperche
Study Unit of Blood-Borne Agents and National Reference Center on Post-transfusion Hepatitis, National Institute of Blood Transfusion, Paris, France
Transfusion 43:1428-32. 2003..02). CONCLUSION: The results clearly demonstrate that anti-HIV screening should not be withdrawn from biologic qualification procedures of blood donations, even when single NAT is performed... - Overestimation of incidence of hepatitis B virus mixed-genotype infections by use of the new line probe INNO-LiPA genotyping assayMélanie Mercier
National Reference Center for Hepatitis B and C in Blood Transfusion, Institut National de la Transfusion Sanguine, 6 rue Alexandre Cabanel, 75015 Paris, France
J Clin Microbiol 49:1154-6. 2011..Our study demonstrates that INNO-LiPA overestimates mixed infections as a result of erroneous genotype H detection... - Alternatives to nucleic acid testing in the blood transfusion serviceSyria Laperche
Lancet 360:1519. 2002 - Molecular characterization of genotype 2 and 4 hepatitis C virus isolates in French blood donorsJean Francois Cantaloube
Unité Emergence et coévolution virale, UMR 6578, CNRS Etablissement Français du Sang Alpes Méditerranée, Marseille, France
J Med Virol 80:1732-9. 2008..The inferred histories of population growth indicated that transmission rates differed according to HCV subtype. These results may help to predict the future burden of HCV in France... - Analysis of the 5' noncoding region versus the NS5b region in genotyping hepatitis C virus isolates from blood donors in FranceJean Francois Cantaloube
Unité des Virus Emergents EA3292, Etablissement Francais du Sang Alpes Mediterranee, 149 bd Baille, 13005 Marseille, France
J Clin Microbiol 44:2051-6. 2006..Sequence analysis of the NS5b region is mandatory for epidemiologic studies... - HIV-1 and HCV infections among antibody-negative blood donorsSyria Laperche
N Engl J Med 351:2232-5; author reply 2232-5. 2004 - An incident case-control study of modes of hepatitis C virus transmission in FranceElisabeth Delarocque-Astagneau
From the Institut de Veille Sanitaire, Saint Maurice cedex, France
Ann Epidemiol 17:755-62. 2007..We undertook a case-control study of incident HCV infection to identify persistent modes of transmission in France... - Prevalence of Borna disease virus RNA in populations at high or low risk for blood-borne infectionsJean Jacques Lefrere
Transfusion 44:1396. 2004 - Sensitivities of four new commercial hepatitis B virus surface antigen (HBsAg) assays in detection of HBsAg mutant formsThoai Duong Ly
Laboratoire Claude Levy, 78 av de Verdun, 94200 Ivry sur Seine, France
J Clin Microbiol 44:2321-6. 2006..The prevalence and clinical impact of HBsAg mutants are under investigation. However, the manufacturers must be vigilant in the design of the assays in order to reduce the risk of missing a broad range of described S gene mutants... - Trends in residual risk of transfusion-transmitted viral infections in France between 1992 and 2000Josiane Pillonel
National Institute for Public Health Surveillance, Saint Maurice, France
Transfusion 42:980-8. 2002..Monitoring trends in residual risks of transfusion-transmitted viral infections (HIV, HTLV, HBV, and HCV) is important to assess improvements in blood safety. In France, theses trends were analyzed between 1992 and 2000... - Repository of blood samples from recipients of red blood cell transfusions in FranceJean Jacques Lefrere
Transfusion 48:195; author reply 195-6. 2008 - Performance of the Cobas AmpliPrep/Cobas TaqMan real-time PCR assay for hepatitis B virus DNA quantificationStephane Chevaliez
French National Reference Center for Viral Hepatitis B, C and delta, Department of Virology, Hopital Henri Mondor, Universite Paris 12
J Clin Microbiol 46:1716-23. 2008..Samples with HBV DNA concentrations above the upper limit of quantification need to be diluted and then retested. Broad use of fully automated real-time PCR assays should improve the management of patients with chronic HBV infection... - Antigen-antibody combination assays for blood donor screening: weighing the advantages and costsSyria Laperche
Transfusion 48:576-9. 2008 - Human immunodeficiency virus type 1 incidence among blood donors in France, 1992 through 2006: use of an immunoassay to identify recent infectionsJosiane Pillonel
Institut de Veille Sanitaire, Departement des Maladies Infectieuses, Saint Maurice, France
Transfusion 48:1567-75. 2008..The characteristics of recently infected donors, estimates of HIV-1 incidence, and the residual risk of transfusion-transmitted HIV-1 are presented, in both first-time and repeat donors... - Group o human immunodeficiency virus type 1 infection that escaped detection in two immmunoassaysSaid Zouhair
Department of Biology, Hopital de Versailles, 177 rue de Versailles, Le Chesnay 78150, France
J Clin Microbiol 44:662-5. 2006..The sera were strongly reactive to the V3 peptide of group O but not to the gp41 immunodominant epitope. Gp41 was sequenced, confirming that this virus belonged to group O...