Philippe Langella


Affiliation: Institut National de la Recherche Agronomique
Country: France


  1. Martín R, Miquel S, Chain F, Natividad J, Jury J, Lu J, et al. Faecalibacterium prausnitzii prevents physiological damages in a chronic low-grade inflammation murine model. BMC Microbiol. 2015;15:67 pubmed publisher
    ..These observations confirm the potential of this bacterium as a novel probiotic treatment in the management of gut dysfunction and low-grade inflammation. ..
  2. Miquel S, Beaumont M, Martín R, Langella P, Braesco V, Thomas M. A proposed framework for an appropriate evaluation scheme for microorganisms as novel foods with a health claim in Europe. Microb Cell Fact. 2015;14:48 pubmed publisher
    ..We propose a framework and suggest a list of criteria that should be assessed to obtain marketing authorization and health claim for a bacterium in accordance with European health policy. ..
  3. Bermúdez Humarán L, Motta J, Aubry C, Kharrat P, Rous Martin L, Sallenave J, et al. Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci. Microb Cell Fact. 2015;14:26 pubmed publisher
    ..Altogether, these results strongly suggest that serine protease inhibitors are the most efficient anti-inflammatory molecules to be delivered by recLAB at the mucosal level for IBD treatment. ..
  4. Miquel S, Leclerc M, Martín R, Chain F, Lenoir M, Raguideau S, et al. Identification of metabolic signatures linked to anti-inflammatory effects of Faecalibacterium prausnitzii. MBio. 2015;6: pubmed publisher
    ..We identified a molecule, salicylic acid, directly involved in the protective effect of F. prausnitzii. Targeting its metabolic pathways could be an attractive therapeutic strategy in IBD. ..
  5. Cortes Perez N, Dumoulin R, Gaubert S, Lacoux C, Bugli F, Martín R, et al. Overexpression of Enterococcus faecalis elr operon protects from phagocytosis. BMC Microbiol. 2015;15:112 pubmed publisher
    ..Altogether, our results indicate that overexpression of the elr operon facilitates the E. faecalis escape from host immune defenses. ..
  6. Michon C, Christophe M, Kuczkowska K, Langella P, Eijsink V, Mathiesen G, et al. Surface display of an anti-DEC-205 single chain Fv fragment in Lactobacillus plantarum increases internalization and plasmid transfer to dendritic cells in vitro and in vivo. Microb Cell Fact. 2015;14:95 pubmed publisher
    ..It is likely that the more embedded localization of aDec in the latter case is favorable when cells are exposed to the harsh conditions of the gastro-intestinal tract. ..
  7. Aubry C, Michon C, Chain F, Chvatchenko Y, Goffin L, Zimmerli S, et al. Protective effect of TSLP delivered at the gut mucosa level by recombinant lactic acid bacteria in DSS-induced colitis mouse model. Microb Cell Fact. 2015;14:176 pubmed publisher
    ..TSLP showed an anti-inflammatory protective role in DSS-induced colitis. We have demonstrated that a short and early administration of LL-TSLP is more efficient than a long lasting treatment. ..
  8. Rhimi M, Bermúdez Humarán L, Huang Y, Boudebbouze S, Gaci N, Garnier A, et al. The secreted L-arabinose isomerase displays anti-hyperglycemic effects in mice. Microb Cell Fact. 2015;14:204 pubmed publisher
    ..The L. lactis strains secreting the L-arabinose isomerase has the ability to produce D-tagatose in vivo and conferred an anti-hyperglycemic effect to mice. ..
  9. Wrzosek L, Miquel S, Noordine M, Bouet S, Joncquel Chevalier Curt M, Robert V, et al. Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent. BMC Biol. 2013;11:61 pubmed publisher
    ..thetaiotaomicron affected goblet cell differentiation, mucin synthesis and glycosylation in the colonic epithelium. We then investigated how F. prausnitzii influenced the colonic epithelial responses to B. thetaiotaomicron...