I Landrieu

Summary

Affiliation: Institut Pasteur de Lille
Country: France

Publications

  1. ncbi p13(SUC1) and the WW domain of PIN1 bind to the same phosphothreonine-proline epitope
    I Landrieu
    CNRS UMR 8525, Institut de Biologie de Lille Pasteur Institute of Lille, 59019 Lille Cedex, France
    J Biol Chem 276:1434-8. 2001
  2. ncbi Solution structure of the single-domain prolyl cis/trans isomerase PIN1At from Arabidopsis thaliana
    Isabelle Landrieu
    UMR 8525 CNRS Lille2, Institut de Biologie de Lille Pasteur Institute of Lille, 59019 Lille Cedex, France
    J Mol Biol 320:321-32. 2002
  3. ncbi 1H NMR study on the binding of Pin1 Trp-Trp domain with phosphothreonine peptides
    R Wintjens
    Institut de Biologie de Lille, Institut Pasteur de Lille, CNRS UMR 8525, 1 rue du Professeur Calmette, BP 447, Lille 59021, France
    J Biol Chem 276:25150-6. 2001
  4. ncbi High-resolution magic angle spinning NMR of the neuronal tau protein integrated in Alzheimer's-like paired helical fragments
    Alain Sillen
    CNRS Université de Lille 2 UMR 8525 and Inserm IFR17, Institut Pasteur de Lille, BP 245 F 59019 Lille Cedex, France
    J Am Chem Soc 127:10138-9. 2005
  5. ncbi Control of protein-protein interactions: structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 WW domain and phosphopeptides
    Caroline Smet
    CNRS University of Lille 2 UMR 8525, Institut Pasteur de Lille, Molecular Drug Discovery, 3 rue du Professeur Laguesse, 59000 Lille, France
    J Med Chem 48:4815-23. 2005
  6. ncbi Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy
    Guy Lippens
    CNRS Université de Lille2 UMR 8525, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex France
    Protein Pept Lett 13:235-46. 2006
  7. ncbi NMR analysis of a Tau phosphorylation pattern
    Isabelle Landrieu
    CNRS UMR 8525, Institut Pasteur de Lille, 59019 Lille Cedex, France
    J Am Chem Soc 128:3575-83. 2006
  8. pmc Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A
    Marco da Costa
    Laboratoire de Biologie Cellulaire, Institut National de la Recherche Agronomique, F 78026 Versailles Cedex, France
    Plant Cell 18:1426-37. 2006
  9. ncbi Exploring the molecular function of PIN1 by nuclear magnetic resonance
    Isabelle Landrieu
    CNRS UMR 8576, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq, France
    Curr Protein Pept Sci 7:179-94. 2006
  10. ncbi Structural impact of heparin binding to full-length Tau as studied by NMR spectroscopy
    Nathalie Sibille
    CNRS UMR 8576, Unite de Glycobiologie Structurale et Fonctionnelle, Université des Sciences et Technologies de Lille 1, 59655, Villeneuve d Ascq Cedex, France
    Biochemistry 45:12560-72. 2006

Collaborators

  • G Lippens
  • Tony Lefebvre
  • L Buee
  • Alain R Baulard
  • Harald Schwalbe
  • Claude Alain Maurage
  • Francoise Jacob-Dubuisson
  • Andre Delacourte
  • Thomas Langer
  • Jean Michel Wieruszeski
  • Xavier Hanoulle
  • Caroline Smet
  • Alain Sillen
  • Arnaud Leroy
  • Jean Francois Bodart
  • Malika Hamdane
  • Nathalie Sibille
  • Benoit Odaert
  • Anne Véronique Sambo
  • Vanessa Dehennaut
  • Jean Pierre Vilain
  • Hélène Hodak
  • Sophie Rodius
  • Camille Locht
  • Marco da Costa
  • Pierre Rousselot-Pailley
  • Dragos Horvath
  • Dirk Inze
  • Patrice Delobel
  • Séverine Bégard
  • Peter Casteels
  • Ruud Scheek
  • Klaas Dijkstra
  • Gea Schuurman-Wolters
  • R Wintjens
  • Laziza Amniai
  • Caroline Smet-Nocca
  • Jean Claude Michalski
  • Alexandre Wohlkonig
  • Hervé Drobecq
  • Marc Jamin
  • Minghui Lin
  • Michèle Moes
  • Arlette Rousseau-Lescuyer
  • Olivier Chaloin
  • Ji Zhang
  • Magalie Senechal
  • Elisabeth Schaffner-Reckinger
  • Nelly Kieffer
  • Benjamin Parent
  • Sylvie Lefebvre
  • Vincent Peyrot
  • Fabrice Allain
  • Agnes Denys
  • Pascale Barbier
  • Aurélie Melchior
  • Lien Bach
  • Jean Denis Faure
  • Lieven De Veylder
  • Yannick Bellec
  • Spencer Brown
  • Olivier Catrice
  • Barbara Mulloy
  • Anne Loyens
  • Amena Ben Younes
  • Benoit Deprez
  • Jean Frederic Duckert
  • Jean Claude Beauvillain
  • Carmen Odberg-Ferragut
  • Bernard Clantin
  • Eglantine Rollet
  • Jean Pierre Bohin
  • Vincent Villeret
  • Stephane Flament
  • Anne Violleau
  • Nicolas Sergeant
  • René Wintjens
  • Antoine Ghestem
  • P Rousselot-Pailley
  • J M Wieruszeski
  • H Drobecq

Detail Information

Publications31

  1. ncbi p13(SUC1) and the WW domain of PIN1 bind to the same phosphothreonine-proline epitope
    I Landrieu
    CNRS UMR 8525, Institut de Biologie de Lille Pasteur Institute of Lille, 59019 Lille Cedex, France
    J Biol Chem 276:1434-8. 2001
    ....
  2. ncbi Solution structure of the single-domain prolyl cis/trans isomerase PIN1At from Arabidopsis thaliana
    Isabelle Landrieu
    UMR 8525 CNRS Lille2, Institut de Biologie de Lille Pasteur Institute of Lille, 59019 Lille Cedex, France
    J Mol Biol 320:321-32. 2002
    ..Based on our experimental results and the molecular specificities of the PIN1At enzyme, functional implications of the lack of WW domains in this plant PIN-type PPIase will be discussed...
  3. ncbi 1H NMR study on the binding of Pin1 Trp-Trp domain with phosphothreonine peptides
    R Wintjens
    Institut de Biologie de Lille, Institut Pasteur de Lille, CNRS UMR 8525, 1 rue du Professeur Calmette, BP 447, Lille 59021, France
    J Biol Chem 276:25150-6. 2001
    ....
  4. ncbi High-resolution magic angle spinning NMR of the neuronal tau protein integrated in Alzheimer's-like paired helical fragments
    Alain Sillen
    CNRS Université de Lille 2 UMR 8525 and Inserm IFR17, Institut Pasteur de Lille, BP 245 F 59019 Lille Cedex, France
    J Am Chem Soc 127:10138-9. 2005
    ..HRMAS NMR of tau paired helical fragments assembled with heparin show an intensity decrease for those amino acids that are incorporated into the rigid core region, whereas the N-terminal amino acids maintain their full mobility...
  5. ncbi Control of protein-protein interactions: structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 WW domain and phosphopeptides
    Caroline Smet
    CNRS University of Lille 2 UMR 8525, Institut Pasteur de Lille, Molecular Drug Discovery, 3 rue du Professeur Laguesse, 59000 Lille, France
    J Med Chem 48:4815-23. 2005
    ..Our structure-based strategy implies the synthesis of analogues of the Ac-Thr(PO(3)H(2))-Pro-NH(2) dipeptide and relies on high resolution NMR spectroscopy to accurately measure the affinity constants even in the high micromolar range...
  6. ncbi Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopy
    Guy Lippens
    CNRS Université de Lille2 UMR 8525, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex France
    Protein Pept Lett 13:235-46. 2006
    ..Preliminary NMR data on the fibers show that the assignment enables a precise mapping of the rigid core. Future NMR experiments should allow one to gain more insight into the conformational aspects of this intriguing protein...
  7. ncbi NMR analysis of a Tau phosphorylation pattern
    Isabelle Landrieu
    CNRS UMR 8525, Institut Pasteur de Lille, 59019 Lille Cedex, France
    J Am Chem Soc 128:3575-83. 2006
    ..We finally demonstrate that the NMR approach can equally be used to evaluate potential kinase inhibitors in a straightforward manner...
  8. pmc Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase A
    Marco da Costa
    Laboratoire de Biologie Cellulaire, Institut National de la Recherche Agronomique, F 78026 Versailles Cedex, France
    Plant Cell 18:1426-37. 2006
    ....
  9. ncbi Exploring the molecular function of PIN1 by nuclear magnetic resonance
    Isabelle Landrieu
    CNRS UMR 8576, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq, France
    Curr Protein Pept Sci 7:179-94. 2006
    ..Finally, isomerization catalysis is thought to regulate the (de)phosphorylation of specific pThr/pSer-Pro motifs, exemplified by the stimulation of the dephosphorylation of pThr231 of Tau by the PP2A phosphatase...
  10. ncbi Structural impact of heparin binding to full-length Tau as studied by NMR spectroscopy
    Nathalie Sibille
    CNRS UMR 8576, Unite de Glycobiologie Structurale et Fonctionnelle, Université des Sciences et Technologies de Lille 1, 59655, Villeneuve d Ascq Cedex, France
    Biochemistry 45:12560-72. 2006
    ..Heparin thus becomes integrated into the rigid core region of the PHF, probably providing the charge compensation for the lysine-rich stretches that form upon the in-register, parallel stacking of the repeat regions...
  11. ncbi NMR investigation of the interaction between the neuronal protein tau and the microtubules
    Alain Sillen
    CNRS UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle, Université des Sciences et Technologies de Lille 1, 59655, Villeneuve d Ascq Cedex, France
    Biochemistry 46:3055-64. 2007
    ..The presence of an intramolecular disulfide bridge, on the contrary, does lead to a partial detachment of the C-terminus of Tau, and decreases significantly the overloading of Tau on the MT surface...
  12. ncbi Structural and functional characterization of the interaction between cyclophilin B and a heparin-derived oligosaccharide
    Xavier Hanoulle
    Structural and Functional Glycobiology Unit, UMR 8576 CNRS, University of Sciences and Technologies of Lille, 59655 Villeneuve d Ascq, France
    J Biol Chem 282:34148-58. 2007
    ..We thus conclude that the glycanic moiety of HSPG serves as anchor for CypB at the cell surface, and that the signal could be transduced by CypB via its PPIase activity toward CD147...
  13. doi The peptidyl-prolyl isomerase and chaperone Par27 of Bordetella pertussis as the prototype for a new group of parvulins
    Hélène Hodak
    INSERM U629, Lille, France
    J Mol Biol 376:414-26. 2008
    ..Par27 displays both PPIase and chaperone activities in vitro. In vivo, Par27 might function as a general periplasmic chaperone in B. pertussis...
  14. ncbi Regulation of Pin1 peptidyl-prolyl cis/trans isomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau protein
    Caroline Smet
    UMR CNRS 8525 Structure et fonction des Biomolecules, Institut de Biologie de Lille, Institut Pasteur de Lille, BP 245 F 59019 Lille Cedex, France
    FEBS Lett 579:4159-64. 2005
    ..We therefore conclude that the WW domain can act as a negative regulator of enzymatic activity when multiple phosphorylation is present, thereby suggesting a subtle mechanism of its functional regulation...
  15. pmc The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridges
    Sophie Rodius
    Laboratoire de Biologie et Physiologie Intégrée CNRS GDRE ITI, Université du Luxembourg, L 1511 Luxembourg, Grand Duchy of Luxembourg
    J Biol Chem 283:24212-23. 2008
    ....
  16. ncbi Solution NMR study of the monomeric form of p13suc1 protein sheds light on the hinge region determining the affinity for a phosphorylated substrate
    Benoit Odaert
    CNRS Université de Lille 2 UMR 8525, Institut Pasteur de Lille Institut de Biologie de Lille, 59019 Lille Cedex, France
    J Biol Chem 277:12375-81. 2002
    ....
  17. ncbi Pin1: a therapeutic target in Alzheimer neurodegeneration
    Malika Hamdane
    INSERM U422, IMPRT, Place de Verdun, Lille, France
    J Mol Neurosci 19:275-87. 2002
    ..The involvement of Pin1 in the G0/G1 transition in neurons points to its function as a good target for the development of new therapeutic strategies in neurodegenerative disorders...
  18. ncbi Neurofibrillary degeneration of the Alzheimer-type: an alternate pathway to neuronal apoptosis?
    Malika Hamdane
    INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Place de Verdun, F 59045 Lille Cedex, France
    Biochem Pharmacol 66:1619-25. 2003
    ....
  19. ncbi Proline-directed random-coil chemical shift values as a tool for the NMR assignment of the tau phosphorylation sites
    Guy Lippens
    CNRS Université de Lille 2 UMR 8525, Institut Pasteur de Lille, BP 245 59019 Lille Cedex, France
    Chembiochem 5:73-8. 2004
    ..This is a first step toward the study of the phosphorylation of Tau by NMR spectroscopy...
  20. ncbi The peptidyl prolyl cis/trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on Tau
    Caroline Smet
    Institut de Biologie de Lille, Institut Pasteur de Lille, UMR CNRS 8525, BP 245, F 59019 Lille cedex, France
    Biochemistry 43:2032-40. 2004
    ....
  21. ncbi Structural analysis of Escherichia coli OpgG, a protein required for the biosynthesis of osmoregulated periplasmic glucans
    Xavier Hanoulle
    UMR 8525 CNRS, Institut de Biologie de Lille, Universite de Lille II, 1 rue du Professeur Calmette, BP447, 59021, France
    J Mol Biol 342:195-205. 2004
    ..The structural data suggest that OpgG is an OPG branching enzyme in which the catalytic activity is located in the large N-terminal domain and controlled via the smaller C-terminal domain...
  22. ncbi Accepting its random coil nature allows a partial NMR assignment of the neuronal Tau protein
    Caroline Smet
    CNRS Université de Lille 2, UMR 8525, Institut Pasteur de Lille, B P 245, 59019 Lille, France
    Chembiochem 5:1639-46. 2004
    ..The obtained assignments equally confirm the absence of regular secondary structure in the isolated protein...
  23. ncbi Characterization of the Arabidopsis thaliana Arath;CDC25 dual-specificity tyrosine phosphatase
    Isabelle Landrieu
    UMR 8525 CNRS Lille2, Institut de Biologie de Lille Pasteur Institute of Lille, 59019 Lille Cedex, France
    Biochem Biophys Res Commun 322:734-9. 2004
    ..The presence of a metal ion in the C-terminus of this new protein points to a zinc finger, and sequence homology indicates that this new structural element might be conserved in related plant homologs...
  24. pmc A small CDC25 dual-specificity tyrosine-phosphatase isoform in Arabidopsis thaliana
    Isabelle Landrieu
    Unité Mixte de Recherche 8525 Centre National de la Recherche Scientifique Lille2, Institut de Biologie de Lille Pasteur Institute of Lille, 59019 Lille Cedex, France
    Proc Natl Acad Sci U S A 101:13380-5. 2004
    ..We conclude that despite sequence divergence, Arath;CDC25 is structurally and functionally an isoform of the CDC25 superfamily, which is conserved in yeast and in plants, including Arabidopsis and rice...
  25. ncbi Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteria
    Xavier Hanoulle
    UMR 8525 CNRS Universíté de Lille 2 Lille, F 59021, France
    J Antimicrob Chemother 58:768-72. 2006
    ..Activation pathways of prodrugs are generally problematic to uncover as they produce intermediates potentially difficult to characterize, to purify and that might prove unstable outside of their cellular context...
  26. ncbi Regions of tau implicated in the paired helical fragment core as defined by NMR
    Alain Sillen
    CNRS Université de Lille 2 UMR 8525, Institut Pasteur de Lille, B P 245, 59019 Lille Cedex, France
    Chembiochem 6:1849-56. 2005
    ..Hence, our data give a more precise picture of the dynamics of tau when it is integrated into mature filaments and should provide further understanding of the molecular processes that govern aggregation...
  27. ncbi Assignment of the 1H, 13C and 15N resonances and secondary structure of the monomeric p13suc1 protein of Saccharomyces pombe
    Benoit Odaert
    J Biomol NMR 23:155-6. 2002
  28. ncbi ELISE NMR: experimental liquid sealing of NMR samples
    Jean Michel Wieruszeski
    CNRS Université de Lille 1 UMR 8576, USTL, Villeneuve d Ascq, France
    J Magn Reson 181:199-202. 2006
    ..For chloroform samples, a simple drop of water allows to efficiently seal the sample, avoiding solvent evaporation even over lengthy time periods...
  29. doi Microinjection of recombinant O-GlcNAc transferase potentiates Xenopus oocytes M-phase entry
    Vanessa Dehennaut
    UMR CNRS 8576, UGSF, USTL, IFR 147, 59655 Villeneuve d Ascq, France
    Biochem Biophys Res Commun 369:539-46. 2008
    ..Microinjection of anti-OGT antibodies leads to a delay of the GVBD kinetics. Our results hence demonstrate that OGT is a key molecule for the timely progression of the cell cycle...
  30. doi NMR observation of Tau in Xenopus oocytes
    Jean Francois Bodart
    Laboratoire de Régulation des Signaux de Division, EA4020, Building SN3, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq, France
    J Magn Reson 192:252-7. 2008
    ..When injecting Tau protein into immature oocytes, we show that both its microtubule association and different phosphorylation events can be detected...
  31. ncbi Monitoring of the ethionamide pro-drug activation in mycobacteria by (1)H high resolution magic angle spinning NMR
    Xavier Hanoulle
    CNRS, Université de Lille 2 UMR 8525, Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP447, 59021 Lille Cedex, France
    Biochem Biophys Res Commun 331:452-8. 2005
    ..The comparison of the metabolite NMR signature with that of synthetic molecules proves the non-identity of ETH* with the ETH derivatives described previously in the literature...