Research Topics
Species | I LandrieuSummaryAffiliation: Institut Pasteur de Lille Country: France Publications
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Detail Information
Publications
p13(SUC1) and the WW domain of PIN1 bind to the same phosphothreonine-proline epitopeI Landrieu
CNRS UMR 8525, Institut de Biologie de Lille Pasteur Institute of Lille, 59019 Lille Cedex, France
J Biol Chem 276:1434-8. 2001....- Solution structure of the single-domain prolyl cis/trans isomerase PIN1At from Arabidopsis thalianaIsabelle Landrieu
UMR 8525 CNRS Lille2, Institut de Biologie de Lille Pasteur Institute of Lille, 59019 Lille Cedex, France
J Mol Biol 320:321-32. 2002..Based on our experimental results and the molecular specificities of the PIN1At enzyme, functional implications of the lack of WW domains in this plant PIN-type PPIase will be discussed... - 1H NMR study on the binding of Pin1 Trp-Trp domain with phosphothreonine peptidesR Wintjens
Institut de Biologie de Lille, Institut Pasteur de Lille, CNRS UMR 8525, 1 rue du Professeur Calmette, BP 447, Lille 59021, France
J Biol Chem 276:25150-6. 2001.... - High-resolution magic angle spinning NMR of the neuronal tau protein integrated in Alzheimer's-like paired helical fragmentsAlain Sillen
, Institut Pasteur de Lille, BP 245 - F-59019 Lille Cedex, France
J Am Chem Soc 127:10138-9. 2005..HRMAS NMR of tau paired helical fragments assembled with heparin show an intensity decrease for those amino acids that are incorporated into the rigid core region, whereas the N-terminal amino acids maintain their full mobility... - Control of protein-protein interactions: structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 WW domain and phosphopeptidesCaroline Smet
CNRS-University of Lille 2 UMR 8525, Institut Pasteur de Lille, Molecular Drug Discovery, 3 rue du Professeur Laguesse, 59000 Lille, France
J Med Chem 48:4815-23. 2005..Our structure-based strategy implies the synthesis of analogues of the Ac-Thr(PO(3)H(2))-Pro-NH(2) dipeptide and relies on high resolution NMR spectroscopy to accurately measure the affinity constants even in the high micromolar range... - Studying the natively unfolded neuronal Tau protein by solution NMR spectroscopyGuy Lippens
CNRS Université de Lille2 UMR 8525, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex France
Protein Pept Lett 13:235-46. 2006..Preliminary NMR data on the fibers show that the assignment enables a precise mapping of the rigid core. Future NMR experiments should allow one to gain more insight into the conformational aspects of this intriguing protein... - NMR analysis of a Tau phosphorylation patternIsabelle Landrieu
CNRS UMR 8525, Institut Pasteur de Lille, 59019 Lille Cedex, France
J Am Chem Soc 128:3575-83. 2006..We finally demonstrate that the NMR approach can equally be used to evaluate potential kinase inhibitors in a straightforward manner... 
Arabidopsis PASTICCINO2 is an antiphosphatase involved in regulation of cyclin-dependent kinase AMarco da Costa
Laboratoire de Biologie Cellulaire, Institut National de la Recherche Agronomique, F 78026 Versailles Cedex, France
Plant Cell 18:1426-37. 2006....- Exploring the molecular function of PIN1 by nuclear magnetic resonanceIsabelle Landrieu
CNRS UMR 8576, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq, France
Curr Protein Pept Sci 7:179-94. 2006..Finally, isomerization catalysis is thought to regulate the (de)phosphorylation of specific pThr/pSer-Pro motifs, exemplified by the stimulation of the dephosphorylation of pThr231 of Tau by the PP2A phosphatase... - Structural impact of heparin binding to full-length Tau as studied by NMR spectroscopyNathalie Sibille
CNRS UMR 8576, Unite de Glycobiologie Structurale et Fonctionnelle, Université des Sciences et Technologies de Lille 1, 59655, Villeneuve d Ascq Cedex, France
Biochemistry 45:12560-72. 2006..Heparin thus becomes integrated into the rigid core region of the PHF, probably providing the charge compensation for the lysine-rich stretches that form upon the in-register, parallel stacking of the repeat regions... - NMR investigation of the interaction between the neuronal protein tau and the microtubulesAlain Sillen
CNRS UMR 8576 Unité de Glycobiologie Structurale et Fonctionnelle, Université des Sciences et Technologies de Lille 1, 59655, Villeneuve d Ascq Cedex, France
Biochemistry 46:3055-64. 2007..The presence of an intramolecular disulfide bridge, on the contrary, does lead to a partial detachment of the C-terminus of Tau, and decreases significantly the overloading of Tau on the MT surface... - Structural and functional characterization of the interaction between cyclophilin B and a heparin-derived oligosaccharideXavier Hanoulle
Structural and Functional Glycobiology Unit, UMR 8576 CNRS, University of Sciences and Technologies of Lille, 59655 Villeneuve d Ascq, France
J Biol Chem 282:34148-58. 2007..We thus conclude that the glycanic moiety of HSPG serves as anchor for CypB at the cell surface, and that the signal could be transduced by CypB via its PPIase activity toward CD147... 
The peptidyl-prolyl isomerase and chaperone Par27 of Bordetella pertussis as the prototype for a new group of parvulinsHélène Hodak
INSERM U629, Lille, France
J Mol Biol 376:414-26. 2008..Par27 displays both PPIase and chaperone activities in vitro. In vivo, Par27 might function as a general periplasmic chaperone in B. pertussis...- Regulation of Pin1 peptidyl-prolyl cis/trans isomerase activity by its WW binding module on a multi-phosphorylated peptide of Tau proteinCaroline Smet
UMR CNRS 8525 - Structure et fonction des Biomolecules, Institut de Biologie de Lille, Institut Pasteur de Lille, BP 245 - F-59019 Lille Cedex, France
FEBS Lett 579:4159-64. 2005..We therefore conclude that the WW domain can act as a negative regulator of enzymatic activity when multiple phosphorylation is present, thereby suggesting a subtle mechanism of its functional regulation... - The talin rod IBS2 alpha-helix interacts with the beta3 integrin cytoplasmic tail membrane-proximal helix by establishing charge complementary salt bridgesSophie Rodius
Laboratoire de Biologie et Physiologie Intégrée CNRS GDRE ITI, Université du Luxembourg, L 1511 Luxembourg, Grand Duchy of Luxembourg
J Biol Chem 283:24212-23. 2008.... - Solution NMR study of the monomeric form of p13suc1 protein sheds light on the hinge region determining the affinity for a phosphorylated substrateBenoit Odaert
CNRS Université de Lille 2 UMR 8525, Institut Pasteur de Lille Institut de Biologie de Lille, 59019 Lille Cedex, France
J Biol Chem 277:12375-81. 2002.... - Pin1: a therapeutic target in Alzheimer neurodegenerationMalika Hamdane
INSERM U422, IMPRT, Place de Verdun, Lille, France
J Mol Neurosci 19:275-87. 2002..The involvement of Pin1 in the G0/G1 transition in neurons points to its function as a good target for the development of new therapeutic strategies in neurodegenerative disorders... - Neurofibrillary degeneration of the Alzheimer-type: an alternate pathway to neuronal apoptosis?Malika Hamdane
INSERM U422, Institut de Médecine Prédictive et Recherche Thérapeutique, Place de Verdun, F 59045 Lille Cedex, France
Biochem Pharmacol 66:1619-25. 2003.... - Proline-directed random-coil chemical shift values as a tool for the NMR assignment of the tau phosphorylation sitesGuy Lippens
CNRS Université de Lille 2 UMR 8525, Institut Pasteur de Lille, BP 245 59019 Lille Cedex, France
Chembiochem 5:73-8. 2004..This is a first step toward the study of the phosphorylation of Tau by NMR spectroscopy... - The peptidyl prolyl cis/trans-isomerase Pin1 recognizes the phospho-Thr212-Pro213 site on TauCaroline Smet
Institut de Biologie de Lille, Institut Pasteur de Lille, UMR CNRS 8525, BP 245, F 59019 Lille cedex, France
Biochemistry 43:2032-40. 2004.... - Structural analysis of Escherichia coli OpgG, a protein required for the biosynthesis of osmoregulated periplasmic glucansXavier Hanoulle
UMR 8525 CNRS, Institut de Biologie de Lille, Universite de Lille II, 1 rue du Professeur Calmette, BP447, 59021, France
J Mol Biol 342:195-205. 2004..The structural data suggest that OpgG is an OPG branching enzyme in which the catalytic activity is located in the large N-terminal domain and controlled via the smaller C-terminal domain... - Accepting its random coil nature allows a partial NMR assignment of the neuronal Tau proteinCaroline Smet
, UMR 8525, Institut Pasteur de Lille, B. P. 245, 59019 Lille, France
Chembiochem 5:1639-46. 2004..The obtained assignments equally confirm the absence of regular secondary structure in the isolated protein... - Characterization of the Arabidopsis thaliana Arath;CDC25 dual-specificity tyrosine phosphataseIsabelle Landrieu
UMR 8525 CNRS Lille2, Institut de Biologie de Lille Pasteur Institute of Lille, 59019 Lille Cedex, France
Biochem Biophys Res Commun 322:734-9. 2004..The presence of a metal ion in the C-terminus of this new protein points to a zinc finger, and sequence homology indicates that this new structural element might be conserved in related plant homologs... - A small CDC25 dual-specificity tyrosine-phosphatase isoform in Arabidopsis thalianaIsabelle Landrieu
Unité Mixte de Recherche 8525 Centre National de la Recherche Scientifique Lille2, Institut de Biologie de Lille Pasteur Institute of Lille, 59019 Lille Cedex, France
Proc Natl Acad Sci U S A 101:13380-5. 2004..We conclude that despite sequence divergence, Arath;CDC25 is structurally and functionally an isoform of the CDC25 superfamily, which is conserved in yeast and in plants, including Arabidopsis and rice... - Selective intracellular accumulation of the major metabolite issued from the activation of the prodrug ethionamide in mycobacteriaXavier Hanoulle
, F-59021, France
J Antimicrob Chemother 58:768-72. 2006..CONCLUSIONS: These results strongly suggest that ETH* is the active antimycobacterial ethionamide derivative and open new perspectives for the understanding of the mode of action of prodrugs... - Regions of tau implicated in the paired helical fragment core as defined by NMRAlain Sillen
, Institut Pasteur de Lille, B.P. 245, 59019 Lille Cedex, France
Chembiochem 6:1849-56. 2005..Hence, our data give a more precise picture of the dynamics of tau when it is integrated into mature filaments and should provide further understanding of the molecular processes that govern aggregation... - Assignment of the 1H, 13C and 15N resonances and secondary structure of the monomeric p13suc1 protein of Saccharomyces pombeBenoit Odaert
J Biomol NMR 23:155-6. 2002 - ELISE NMR: experimental liquid sealing of NMR samplesJean-Michel Wieruszeski
, USTL, Villeneuve d'Ascq, France
J Magn Reson 181:199-202. 2006..For chloroform samples, a simple drop of water allows to efficiently seal the sample, avoiding solvent evaporation even over lengthy time periods... - Microinjection of recombinant O-GlcNAc transferase potentiates Xenopus oocytes M-phase entryVanessa Dehennaut
UMR CNRS 8576, UGSF, USTL, IFR 147, 59655 Villeneuve d Ascq, France
Biochem Biophys Res Commun 369:539-46. 2008..Microinjection of anti-OGT antibodies leads to a delay of the GVBD kinetics. Our results hence demonstrate that OGT is a key molecule for the timely progression of the cell cycle... - NMR observation of Tau in Xenopus oocytesJean Francois Bodart
Laboratoire de Régulation des Signaux de Division, EA4020, Building SN3, Universite des Sciences et Technologies de Lille, 59655 Villeneuve d Ascq, France
J Magn Reson 192:252-7. 2008..When injecting Tau protein into immature oocytes, we show that both its microtubule association and different phosphorylation events can be detected... - Monitoring of the ethionamide pro-drug activation in mycobacteria by (1)H high resolution magic angle spinning NMRXavier Hanoulle
CNRS, , Institut de Biologie de Lille, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP447, 59021 Lille Cedex, France
Biochem Biophys Res Commun 331:452-8. 2005..The comparison of the metabolite NMR signature with that of synthetic molecules proves the non-identity of ETH* with the ETH derivatives described previously in the literature...