Jean Charles Lambert

Summary

Affiliation: Institut Pasteur de Lille
Country: France

Publications

  1. pmc Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease
    J C Lambert
    INSERM, U744, Lille, France
    Mol Psychiatry 18:461-70. 2013
  2. pmc Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease
    J C Lambert
    Unité INSERM 508, Institut Pasteur de Lille, BP 245, 1 rue du Professeur Calmette, 59019 Lille Cedex, France
    J Med Genet 40:424-30. 2003
  3. doi request reprint Association of plasma amyloid beta with risk of dementia: the prospective Three-City Study
    J C Lambert
    Unité INSERM 744, Institut Pasteur de Lille, BP 245, 1, rue du Professeur Calmette, F 59019 Lille cedex, France
    Neurology 73:847-53. 2009
  4. doi request reprint Genetics of Alzheimer's disease: new evidences for an old hypothesis?
    Jean Charles Lambert
    INSERM U744, Institut Pasteur de Lille, Université de Lille Nord de France, F 59000 Lille, France
    Curr Opin Genet Dev 21:295-301. 2011
  5. doi request reprint Implication of the immune system in Alzheimer's disease: evidence from genome-wide pathway analysis
    Jean Charles Lambert
    INSERM U744, Lille, France
    J Alzheimers Dis 20:1107-18. 2010
  6. ncbi request reprint Genetic heterogeneity of Alzheimer's disease: complexity and advances
    Jean Charles Lambert
    Institut Pasteur de Lille, INSERM U744, Universite de Lille II, 1, rue du Professeur Calmette, 59019 Lille Cedex, France
    Psychoneuroendocrinology 32:S62-70. 2007
  7. doi request reprint Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations
    Jean Charles Lambert
    INSERM U744, Lille, France
    Neurobiol Aging 32:756.e11-5. 2011
  8. ncbi request reprint Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly
    J C Lambert
    INSERM U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Mol Psychiatry 12:870-80. 2007
  9. pmc Association of plasma Aß peptides with blood pressure in the elderly
    Jean Charles Lambert
    INSERM U744, Lille, France
    PLoS ONE 6:e18536. 2011
  10. ncbi request reprint Association study of the PIN1 gene with Alzheimer's disease
    Jean Charles Lambert
    INSERM U744, Institut Pasteur de Lille, Universite de Lille 2, France
    Neurosci Lett 402:259-61. 2006

Collaborators

Detail Information

Publications44

  1. pmc Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease
    J C Lambert
    INSERM, U744, Lille, France
    Mol Psychiatry 18:461-70. 2013
    ..4 × 10(-7)). In conclusion, combining both GWHA study and a conservative three-stage replication approach, we characterised FRMD4A as a new genetic risk factor of AD...
  2. pmc Association of 3'-UTR polymorphisms of the oxidised LDL receptor 1 (OLR1) gene with Alzheimer's disease
    J C Lambert
    Unité INSERM 508, Institut Pasteur de Lille, BP 245, 1 rue du Professeur Calmette, 59019 Lille Cedex, France
    J Med Genet 40:424-30. 2003
    ..The OLR1 expression was significantly lower in AD cases bearing the CC and CT genotypes compared with controls with the same genotypes. In conclusion, our data suggest that genetic variation in the OLR1 gene may modify the risk of AD...
  3. doi request reprint Association of plasma amyloid beta with risk of dementia: the prospective Three-City Study
    J C Lambert
    Unité INSERM 744, Institut Pasteur de Lille, BP 245, 1, rue du Professeur Calmette, F 59019 Lille cedex, France
    Neurology 73:847-53. 2009
    ..We also assessed the association between plasma concentrations of truncated Abeta (Abeta(n-40) and Abeta(n-42)) and the risk of dementia...
  4. doi request reprint Genetics of Alzheimer's disease: new evidences for an old hypothesis?
    Jean Charles Lambert
    INSERM U744, Institut Pasteur de Lille, Université de Lille Nord de France, F 59000 Lille, France
    Curr Opin Genet Dev 21:295-301. 2011
    ....
  5. doi request reprint Implication of the immune system in Alzheimer's disease: evidence from genome-wide pathway analysis
    Jean Charles Lambert
    INSERM U744, Lille, France
    J Alzheimers Dis 20:1107-18. 2010
    ..In conclusion, a systematic search for biological pathways using GWAS data set seems to comfort the primary causes already suspected but may specifically highlight the importance of the immune system in AD...
  6. ncbi request reprint Genetic heterogeneity of Alzheimer's disease: complexity and advances
    Jean Charles Lambert
    Institut Pasteur de Lille, INSERM U744, Universite de Lille II, 1, rue du Professeur Calmette, 59019 Lille Cedex, France
    Psychoneuroendocrinology 32:S62-70. 2007
    ..However, recent methodologies allowing new strategies may allow important breakthrough...
  7. doi request reprint Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations
    Jean Charles Lambert
    INSERM U744, Lille, France
    Neurobiol Aging 32:756.e11-5. 2011
    ..0 × 10(-3)). However, this signal did not appear to be independent of APOE. In conclusion, we confirmed that BIN1 and PICALM are genetic determinants of AD, whereas the potential involvement of EXOC3L2 requires further investigation...
  8. ncbi request reprint Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly
    J C Lambert
    INSERM U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Mol Psychiatry 12:870-80. 2007
    ..Therefore, this genetic variant in S100beta increases the risk of low cognitive performance and dementia, possibly by favouring a splicing event increasing S100beta2 isoform expression in the brain...
  9. pmc Association of plasma Aß peptides with blood pressure in the elderly
    Jean Charles Lambert
    INSERM U744, Lille, France
    PLoS ONE 6:e18536. 2011
    ..We assess whether plasma Aß peptide levels might be associated with systolic and diastolic blood pressure values (SBP and DBP, respectively)...
  10. ncbi request reprint Association study of the PIN1 gene with Alzheimer's disease
    Jean Charles Lambert
    INSERM U744, Institut Pasteur de Lille, Universite de Lille 2, France
    Neurosci Lett 402:259-61. 2006
    ..No association of these polymorphisms or haplotypes with the disease was observed in a large French case-control population. Our data suggest that these genetic variants in PIN1 do not make a significant contribution to AD risk...
  11. ncbi request reprint Relevance and limitations of public databases for microarray design: a critical approach to gene predictions
    J C Lambert
    1Unité INSERM 508, Institut Pasteur de Lille, 1 rue du Professeur Calmette, Lille Cedex, France
    Pharmacogenomics J 3:235-41. 2003
    ..These observations have led us to exclude these ORFs from our study, decreasing their number from 5849 to 2748. Microarrays may be only 'snapshots' of our current knowledge of the human genome...
  12. pmc Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease?
    J C Lambert
    Unité INSERM 508, Institut Pasteur de Lille, BP 245, 1 rue du Professeur Calmette, 59019 Lille Cedex, France
    J Neurol Neurosurg Psychiatry 76:928-33. 2005
    ..It has been proposed that, independent of the epsilon4 allele, APOE promoter polymorphisms (-491 A/T and -219 G/T) may be risks factor for Alzheimer's disease by modulating APOE expression...
  13. pmc Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    Karolien Bettens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
    Mol Neurodegener 7:3. 2012
    ....
  14. doi request reprint Is the ornithine transcarbamylase gene a genetic determinant of Alzheimer's disease?
    Franck Hansmannel
    INSERM, U744, Institut Pasteur de Lille, Universite de Lille, Lille, France
    Neurosci Lett 449:76-80. 2009
    ..19, p=0.004). This association was independent of age and ApoE status. Our results support that the OTC gene may be a minor genetic determinant of AD...
  15. doi request reprint Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study
    Geoffroy Laumet
    INSERM U744, Lille, France
    J Alzheimers Dis 20:1181-8. 2010
    ..Of the genes showing nominal association in our cohorts, TFAM and CHRNB2 appear particularly interesting and warrant further genetic and functional follow-up analyses...
  16. ncbi request reprint Association study of the Ubiquilin gene with Alzheimer's disease
    Faiza Bensemain
    INSERM U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, BP 245, 5019 Lille Cédex, France
    Neurobiol Dis 22:691-3. 2006
    ..Furthermore, no relationship between this polymorphism and Abeta load or degree of neurofibrillary degeneration in the brains of 114 patients with AD was detected...
  17. doi request reprint Association study of the GAB2 gene with the risk of developing Alzheimer's disease
    Julien Chapuis
    INSERM, U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Neurobiol Dis 30:103-6. 2008
    ..3, 95%CI 1.0-1.6, p=0.05) in varepsilon4-carriers. In addition, the rs2373115 did not modulate the extent of tau phosphorylation in the brain of 89 AD cases. The GAB2 gene is at best a minor genetic determinant of AD...
  18. doi request reprint Association study of the CFH Y402H polymorphism with Alzheimer's disease
    Isabelle Le Fur
    INSERM U744, Institut Pasteur de Lille, Universite de Lille 2, France
    Neurobiol Aging 31:165-6. 2010
    ..We were not able to detect such an association whatever the studied population, suggesting that the CFH gene is not a genetic determinant of AD...
  19. doi request reprint A study of the association between the ADAM12 and SH3PXD2A (SH3MD1) genes and Alzheimer's disease
    Geoffroy Laumet
    INSERM, U744, Universite de Lille 2, Institut Pasteur de Lille, BP 245, 1, rue du Professeur Calmette, F 59019 Lille cedex, France
    Neurosci Lett 468:1-2. 2010
    ..With a view to replicating this observation, we genotyped the two SNPs in four European case-control cohorts of Caucasian origin (1913 cases and 1468 controls) but were unable to confirm the initial results...
  20. doi request reprint Study of thyroid hormone receptor alpha gene polymorphisms on Alzheimer's disease
    Louisa Goumidi
    INSERM, U744, Lille, France
    Neurobiol Aging 32:624-30. 2011
    ..19 [0.97-1.45], p=0.10). The relationship between the genetic variability of the THRA gene and AD risk remains uncertain but cannot be entirely excluded...
  21. ncbi request reprint Association study of the vascular endothelial growth factor gene with the risk of developing Alzheimer's disease
    Julien Chapuis
    Unité INSERM 508, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex, France
    Neurobiol Aging 27:1212-5. 2006
    ..Our data indicate that although this polymorphism is functional, it does not confer greater risk for AD, nor modulate the extent of vascular pathology...
  22. ncbi request reprint APOE promoter polymorphisms and dementia in the elderly
    Jean Charles Lambert
    INSERM U508, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, 59019 Lille Cedex, France
    Neurosci Lett 365:116-9. 2004
    ..6-2.1)). Similar results were observed when restricted to Alzheimer's disease. In conclusion, these data indicate that the -219 G/T polymorphism is a genetic determinant of dementia in the elderly, independently of the 4 allele...
  23. doi request reprint Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease
    Jean Charles Lambert
    INSERM U744, Lille, France
    Nat Genet 41:1094-9. 2009
    ..Previous biological studies support roles of CLU and CR1 in the clearance of beta amyloid (Abeta) peptide, the principal constituent of amyloid plaques, which are one of the major brain lesions of individuals with Alzheimer's disease...
  24. doi request reprint Association study of the NEDD9 gene with the risk of developing Alzheimer's and Parkinson's disease
    Julien Chapuis
    INSERM, U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Hum Mol Genet 17:2863-7. 2008
    ..In conclusion, these data indicate that the rs760678 SNP of the NEDD9 gene is at best a weak genetic determinant of AD or PD...
  25. pmc Is the urea cycle involved in Alzheimer's disease?
    Franck Hansmannel
    INSERM U744, Lille, France
    J Alzheimers Dis 21:1013-21. 2010
    ..None of the other genes in the pathway appeared to be differentially expressed in the AD brain or act as genetic determinants of the disease...
  26. doi request reprint A regulatory variant in CCR6 is associated with susceptibility to antitopoisomerase-positive systemic sclerosis
    Eugénie Koumakis
    INSERM, Institut Cochin, Cochin Hospital, AP HP, Inserm U1016, Sorbonne Paris Cité, and Paris Descartes University, Paris, France
    Arthritis Rheum 65:3202-8. 2013
    ..The present study was thus undertaken to investigate whether CCR6 polymorphisms could also be associated with susceptibility to SSc...
  27. doi request reprint Study of estrogen receptor-α and receptor-β gene polymorphisms on Alzheimer's disease
    Louisa Goumidi
    INSERM, U744 Institut Pasteur de Lille Univ Lille Nord de France UDSL, Lille, France
    J Alzheimers Dis 26:431-9. 2011
    ..Our results reinforce the notion that SNPs in the ESR1 or ESR2 genes do not seem to play a major role in the genetic susceptibility of AD...
  28. doi request reprint Associations of complement factor H and smoking with early age-related macular degeneration: the ALIENOR study
    Cécile Delcourt
    INSERM, U897, Bordeaux, France
    Invest Ophthalmol Vis Sci 52:5955-62. 2011
    ..To assess the associations of complement factor H (CFH) Y402H polymorphism and smoking with specific features of early AMD (type, location, and area)...
  29. ncbi request reprint Association study of the paraoxonase 1 gene with the risk of developing Alzheimer's disease
    Julien Chapuis
    INSERM U744, Institut Pasteur de Lille, Universite de Lille 2, Lille, France
    Neurobiol Aging 30:152-6. 2009
    ..We confirmed that the proximal promoter and 5' sequence of the PON1 gene may harbor unknown functional variant(s) associated with the risk of developing AD...
  30. pmc The CALHM1 P86L polymorphism is a genetic modifier of age at onset in Alzheimer's disease: a meta-analysis study
    Jean Charles Lambert
    Unité INSERM 744, Institut Pasteur de Lille BP 245, 1, rue du Professeur Calmette, F59019Lille cedex, France
    J Alzheimers Dis 22:247-55. 2010
    ..Our results indicate that the CALHM1 P86L polymorphism is likely not a genetic determinant of AD but may modulate age of onset by interacting with the effect of the ε4 allele of the APOE gene...
  31. pmc Association of HDL-related loci with age-related macular degeneration and plasma lutein and zeaxanthin: the Alienor study
    Bénédicte M J Merle
    INSERM, Institut National de la Sante et de la Recherche Medicale, ISPED Institut de Santé Publique d Épidémiologie et de Développement, Centre INSERM U897 Epidemiologie Biostatistique, Bordeaux, France Université de Bordeaux, Bordeaux, France
    PLoS ONE 8:e79848. 2013
    ..The objective is to confirm the associations of HDL-related loci with AMD and to assess their associations with plasma lutein and zeaxanthin concentrations...
  32. ncbi request reprint Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population
    Amro Kabbara
    Unité INSERM 508, Institut Pasteur de Lille, BP 245, 1 rue du Professeur Calmette, 59019 Lille Cedex, France
    Neurosci Lett 363:139-43. 2004
    ..We were unable to detect any polymorphisms in the coding and exon/intron sequences of the APOF. Finally, we excluded APOM as a genetic determinant of AD in our large French case control population...
  33. ncbi request reprint New insight into the association of apolipoprotein E genetic variants with carotid plaques and intima-media thickness
    Stephanie Debette
    Department of Neurology, University Hospital of Lille, Lille, France
    Stroke 37:2917-23. 2006
    ..Our aim was to test their association with 2 polymorphisms of the apolipoprotein E (apoE) gene, epsilon and -219G/T...
  34. doi request reprint Association of ornithine transcarbamylase gene polymorphisms with hypertension and coronary artery vasomotion
    Julie Dumont
    INSERM, U744, Lille, France
    Am J Hypertens 22:993-1000. 2009
    ..Our aim was to determine whether hypertension and coronary vasomotion could be associated with polymorphisms within the ornithine transcarbamylase (OTC) gene, located on chromosome X and coding for a key-enzyme of the urea cycle...
  35. doi request reprint From genetics to dietetics: the contribution of epidemiology to understanding Alzheimer's disease
    Pascale Barberger-Gateau
    INSERM, U897, Bordeaux, France
    J Alzheimers Dis 33:S457-63. 2013
    ..Research should focus on sensitive instruments to capture early functional decline to improve the identification of elderly patients at high risk of conversion to dementia...
  36. doi request reprint Association between Parkinson's disease and the HLA-DRB1 locus
    Ismail Ahmed
    INSERM, U708, Neuroepidemiology, Paris, France
    Mov Disord 27:1104-10. 2012
    ..The highly polymorphic HLA-DRB1 locus contains rs660895, which represents a more legitimate candidate than previous ones. Our finding is in agreement with the hypothesis of an immune component in PD pathophysiology...
  37. doi request reprint Single polymorphism nucleotide rs1333049 on chromosome 9p21 is associated with carotid plaques but not with common carotid intima-media thickness in older adults. A combined analysis of the Three-City and the EVA studies
    Matthieu Plichart
    INSERM, U970, Paris Cardiovascular Research Centre, PARCC, University Paris Descartes, Sorbonne Paris Cité, UMR S970, Paris, France
    Atherosclerosis 222:187-90. 2012
    ....
  38. pmc A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis
    Nicolas Greliche
    INSERM, UMR_S 937 Institute of Cardiometabolism And Nutrition ICAN, Universite Pierre et Marie Curie Paris 6, Paris F 75013, France
    BMC Med Genet 14:36. 2013
    ..This study was aimed to investigate whether pair-wise interactions between common single nucleotide polymorphisms (SNPs) could exist and modulate the risk of VT...
  39. pmc Independent and joint effects of the MAPT and SNCA genes in Parkinson disease
    Alexis Elbaz
    INSERM, U708, Neuroepidemiology, F 75013, Paris, France
    Ann Neurol 69:778-92. 2011
    ....
  40. pmc Association between IgM anti-herpes simplex virus and plasma amyloid-beta levels
    Catherine Feart
    INSERM, U897, Bordeaux, France
    PLoS ONE 6:e29480. 2011
    ..The aim of our study was to investigate the association between anti-HSV antibodies and plasma Aβ levels...
  41. doi request reprint Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
    Jean Charles Lambert
    1 INSERM, U744, Lille, France 2 Université Lille 2, Lille, France 3 Institut Pasteur de Lille, Lille, France 4
    Nat Genet 45:1452-8. 2013
    ..In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10(-8)) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease. ..
  42. pmc Genome-wide scan identifies TNIP1, PSORS1C1, and RHOB as novel risk loci for systemic sclerosis
    Yannick Allanore
    Universite Paris Descartes, Rhumatologie A, INSERM, U1016, Hopital Cochin, APHP, Paris, France
    PLoS Genet 7:e1002091. 2011
    ..The genetic signal of association with TNIP1 variants, together with tissular and cellular investigations, suggests that this pathway has a critical role in regulating autoimmunity and SSc pathogenesis...
  43. doi request reprint TDP-43 loss-of-function causes neuronal loss due to defective steroid receptor-mediated gene program switching in Drosophila
    Lies Vanden Broeck
    Laboratory of Behavioral and Developmental Genetics, Center of Human Genetics, University of Leuven, B3000 Leuven, Belgium
    Cell Rep 3:160-72. 2013
    ..We propose that dTDP-43 neurotoxicity is caused by a loss of its normal function...
  44. ncbi request reprint Deciphering genetic susceptibility to frontotemporal lobar dementia
    Jean Charles Lambert
    Jean Charles Lambert and Philippe Amouyel are at Inserm U744, , Lille, France
    Nat Genet 42:189-90. 2010
    ..The work illustrates how high-quality phenotyping can increase power to detect risk alleles for rare heterogeneous diseases...