M Lafon

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint Bat rabies--the Achilles heel of a viral killer?
    Monique Lafon
    Neuro immuno Virology, Institut Pasteur, 75724 Paris Cedex 15, France
    Lancet 366:876-7. 2005
  2. ncbi request reprint Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseases
    Alan C Jackson
    Unité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur, Paris, France
    J Neurovirol 12:229-34. 2006
  3. ncbi request reprint Immune evasion, a critical strategy for rabies virus
    M Lafon
    NeuroImmunologie Virale, Departement de Virologie, Institut Pasteur, Paris, France
    Dev Biol (Basel) 131:413-9. 2008
  4. ncbi request reprint Modulation of the immune response in the nervous system by rabies virus
    M Lafon
    Unité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Curr Top Microbiol Immunol 289:239-58. 2005
  5. ncbi request reprint Rabies virus receptors
    Monique Lafon
    Unité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur, 75724 Paris Cedex 15, France
    J Neurovirol 11:82-7. 2005
  6. pmc Modulation of HLA-G expression in human neural cells after neurotropic viral infections
    Monique Lafon
    Unité de Neuroimmunologie Virale, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 79:15226-37. 2005
  7. ncbi request reprint The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA
    Monique Lafon
    Unité de Neuroimmunologie Virale, Department of Neuroscience, Institut Pasteur, 75724 Paris, France
    J Mol Neurosci 29:185-94. 2006
  8. ncbi request reprint Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis
    Monique Lafon
    Viral Neuroimmunology, Institut Pasteur, Paris, France
    J Immunol 180:7506-15. 2008
  9. ncbi request reprint Selective role for the p55 Kd TNF-alpha receptor in immune unresponsiveness induced by an acute viral encephalitis
    S Camelo
    , Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    J Neuroimmunol 113:95-108. 2001
  10. ncbi request reprint Modulation of HLA-G and HLA-E expression in human neuronal cells after rabies virus or herpes virus simplex type 1 infections
    Françoise Mégret
    Laboratoire de Neuroimmunologie Virale, Institut Pasteur, Paris, France
    Hum Immunol 68:294-302. 2007

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Bat rabies--the Achilles heel of a viral killer?
    Monique Lafon
    Neuro immuno Virology, Institut Pasteur, 75724 Paris Cedex 15, France
    Lancet 366:876-7. 2005
  2. ncbi request reprint Expression of Toll-like receptor 3 in the human cerebellar cortex in rabies, herpes simplex encephalitis, and other neurological diseases
    Alan C Jackson
    Unité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur, Paris, France
    J Neurovirol 12:229-34. 2006
    ..This study has provided evidence that human brain neurons can express TLR-3 in vivo and suggests that neurons may play an important role in initiating an inflammatory reaction in a variety of neurological diseases...
  3. ncbi request reprint Immune evasion, a critical strategy for rabies virus
    M Lafon
    NeuroImmunologie Virale, Departement de Virologie, Institut Pasteur, Paris, France
    Dev Biol (Basel) 131:413-9. 2008
    ..Implications of these findings for rabies treatment are discussed...
  4. ncbi request reprint Modulation of the immune response in the nervous system by rabies virus
    M Lafon
    Unité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Curr Top Microbiol Immunol 289:239-58. 2005
    ..This strategy includes protection against virus-mediated apoptosis and destruction of T cells that invade the CNS in response to infection...
  5. ncbi request reprint Rabies virus receptors
    Monique Lafon
    Unité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur, 75724 Paris Cedex 15, France
    J Neurovirol 11:82-7. 2005
    ..However, little is known of the role of these molecules in vivo. This review proposes a speculative model that accounts for the role of these different molecules in entry and trafficking of rabies virus into the nervous system...
  6. pmc Modulation of HLA-G expression in human neural cells after neurotropic viral infections
    Monique Lafon
    Unité de Neuroimmunologie Virale, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Virol 79:15226-37. 2005
    ..HLA-G may therefore be involved in the escape of certain viruses from the immune response in the nervous system...
  7. ncbi request reprint The innate immune facet of brain: human neurons express TLR-3 and sense viral dsRNA
    Monique Lafon
    Unité de Neuroimmunologie Virale, Department of Neuroscience, Institut Pasteur, 75724 Paris, France
    J Mol Neurosci 29:185-94. 2006
    ..This work firmly establishes that human neurons, in absence of glia, have the intrinsic machinery to trigger robust inflammatory, chemoattractive, and antiviral responses...
  8. ncbi request reprint Detrimental contribution of the immuno-inhibitor B7-H1 to rabies virus encephalitis
    Monique Lafon
    Viral Neuroimmunology, Institut Pasteur, Paris, France
    J Immunol 180:7506-15. 2008
    ..They show that the B7-H1/PD-1 pathway can be exploited locally and in an organ specific manner--here the nervous system--by a neurotropic virus to promote successful host invasion...
  9. ncbi request reprint Selective role for the p55 Kd TNF-alpha receptor in immune unresponsiveness induced by an acute viral encephalitis
    S Camelo
    , Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    J Neuroimmunol 113:95-108. 2001
    ....
  10. ncbi request reprint Modulation of HLA-G and HLA-E expression in human neuronal cells after rabies virus or herpes virus simplex type 1 infections
    Françoise Mégret
    Laboratoire de Neuroimmunologie Virale, Institut Pasteur, Paris, France
    Hum Immunol 68:294-302. 2007
    ..Thus, neurotropic viruses that escape the host immune response totally (RABV) or partially (HSV-1) regulate HLA-G expression on human neuronal cells differentially...
  11. pmc Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferon
    Christophe Prehaud
    Unité de Neuroimmunologie Virale, Institut Pasteur, Paris, France
    J Virol 79:12893-904. 2005
    ..Thus, human neurons can mount an innate immunity response to double-stranded RNA. These observations firmly establish that human neurons, in absence of glia, have the intrinsic machinery to sense virus infection...
  12. doi request reprint Latent viral infections of the nervous system: role of the host immune response
    M Lafon
    URA CNRS 3015, unité de neuro immunologie virale, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    Rev Neurol (Paris) 165:1039-44. 2009
    ..The recent observation that herpes virus latency may confer protection against experimental bacterial infection suggests that unexpected symbiosis may exist between latent viruses and the infected nervous system of its host...
  13. ncbi request reprint Up-regulation of Fas ligand (FasL) in the central nervous system: a mechanism of immune evasion by rabies virus
    Leïla Baloul
    Unité de Neuroimmunologie Virale, Institut Pasteur, Paris, France
    J Neurovirol 10:372-82. 2004
    ..Thus, rabies virus seems to use an immunosubversive strategy that takes advantage of the immune privilege status of the CNS...
  14. ncbi request reprint Apoptosis and rabies virus neuroinvasion
    Leïla Baloul
    Unité de Neuroimmunologie Virale, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    Biochimie 85:777-88. 2003
    ....
  15. pmc Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies
    Pauline Ménager
    NeuroImmunologie Virale, Institut Pasteur, Paris, France
    PLoS Pathog 5:e1000315. 2009
    ..This study shows how viruses can exploit cellular proteins and compartmentalisation for their own benefit...
  16. doi request reprint Attenuation of rabies virulence: takeover by the cytoplasmic domain of its envelope protein
    Christophe Prehaud
    Institut Pasteur, 75724 Paris, France
    Sci Signal 3:ra5. 2010
    ..Thus, we propose that attenuation of rabies virus requires expansion of the set of host PDZ proteins with which G interacts, which interferes with the finely tuned homeostasis required for survival of the infected neuron...
  17. pmc Rabies virus ocular disease: T-cell-dependent protection is under the control of signaling by the p55 tumor necrosis factor alpha receptor, p55TNFR
    S Camelo
    , Institut Pasteur, Paris, France
    J Virol 75:3427-34. 2001
    ..In conclusion, rabies virus-mediated eye disease provides a new model for studying mechanisms regulating immune privilege during viral infection...
  18. ncbi request reprint High level of Bcl-2 counteracts apoptosis mediated by a live rabies virus vaccine strain and induces long-term infection
    Maria Isabel Thoulouze
    NeuroImmunologie Virale, Institut Pasteur, Paris, France
    Virology 314:549-61. 2003
    ..Thus, in infections with live RV vaccine strains, infected cells may be productive reservoirs of virus in the long term. This may account for the high efficacy of live rabies vaccines...
  19. ncbi request reprint Dynamics of immune cell recruitment during West Nile encephalitis and identification of a new CD19+B220-BST-2+ leukocyte population
    Anne Claire Brehin
    Neuro Immunologie Virale, Institut Pasteur, Paris, France
    J Immunol 180:6760-7. 2008
    ..G8-ICs express high levels of MHC class II, stain for viral Ag, and are localized in the paracortical zone of lymph nodes, strongly suggesting they are previously unidentified APCs that appear in response to viral infection...
  20. pmc Glycoprotein of nonpathogenic rabies viruses is a key determinant of human cell apoptosis
    Christophe Prehaud
    Unité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur, Paris, France
    J Virol 77:10537-47. 2003
    ..Only RV containing the G protein from the nonpathogenic RV strain was able to trigger the apoptosis of human cells. Thus, the ability of RV strains to induce apoptosis is largely determined by the viral G protein...
  21. ncbi request reprint Glycoprotein of nonpathogenic rabies viruses is a major inducer of apoptosis in human jurkat T cells
    Stéphanie Lay
    Unité de Neuroimmunologie Virale, Département de Neuroscience, Institut Pasteur, Paris, France
    Ann N Y Acad Sci 1010:577-81. 2003
    ..No other virus proteins than G of nonpathogenic RV strains induce apoptosis, and the G polypeptide of RV is a critical determinant for apoptosis in human cells...
  22. ncbi request reprint Apoptosis inversely correlates with rabies virus neurotropism
    Maria Isabel Thoulouze
    NeuroImmunologie Virale, Institut Pasteur, Paris 75724, France
    Ann N Y Acad Sci 1010:598-603. 2003
    ....
  23. doi request reprint 1H, 13C and 15N resonance assignments of the PDZ of microtubule-associated serine/threonine kinase 205 (MAST205) in complex with the C-terminal motif from the rabies virus glycoprotein
    Elouan Terrien
    Unité de Résonance Magnétique Nucléaire des Biomolécules, Departement de Biologie Structurale et Chimie, CNRS URA 2185, Institut Pasteur, 28, rue du Docteur Roux, 75724, Paris Cedex 15, France
    Biomol NMR Assign 3:45-8. 2009
    ..The BMRB accession code is 155972...
  24. ncbi request reprint Studying neurotrophin antiviral effect on rabies-infected dorsal root ganglia cultures
    Jaime E Castellanos
    Laboratorio de Neurociencias, Instituto Nacional de Salud, Bogota, Colombia
    J Neurovirol 11:403-10. 2005
    ..Adult mouse dorsal root ganglion cultures can be regarded as being a useful model for detecting therapeutic targets and evaluating experimental antiviral drugs...
  25. doi request reprint Furious and paralytic rabies of canine origin: neuroimaging with virological and cytokine studies
    Jiraporn Laothamatas
    Department of Radiology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    J Neurovirol 14:119-29. 2008
    ..Paralytic rabies is characterized by delayed viral neuroinvasion and a more intense inflammation than furious rabies. Dogs may be a good model for study of the host inflammatory responses that may modulate rabies virus neuroinvasiveness...
  26. ncbi request reprint Human viral superantigens: to be or not to be transactivated?
    Monique Lafon
    Trends Immunol 23:238-9; author reply 239. 2002