Guido Kroemer

Summary

Affiliation: Institut Gustave Roussy
Country: France

Publications

  1. ncbi request reprint Lysosomes and autophagy in cell death control
    Guido Kroemer
    CNRS UMR8125, Institut Gustave Roussy, 38 rue Camille Desmoulins, F 94805 Villejuif, France
    Nat Rev Cancer 5:886-97. 2005
  2. ncbi request reprint Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells
    Ilio Vitale
    INSERM, U848, Unit Apoptosis, Cancer and Immunity, Villejuif, France
    Cell Cycle 7:1956-61. 2008
  3. ncbi request reprint Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
    G Kroemer
    CNRS UMR8125, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Cell Death Differ 12:1463-7. 2005
  4. pmc Apoptosis regulation in tetraploid cancer cells
    Maria Castedo
    CNRS, UMR8125, Institut Gustave Roussy, Villejuif, France
    EMBO J 25:2584-95. 2006
  5. pmc Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA
    Delphine Poncet
    Centre National de la Recherche Scientifique, FRE2939, Institut Gustave Roussy, F 94805 Villejuif, France
    J Cell Biol 174:985-96. 2006
  6. pmc Mitochondrial apoptosis and the peripheral benzodiazepine receptor: a novel target for viral and pharmacological manipulation
    Maria Castedo
    Centre National de la Recherche Scientifique, UMR 1599, Institut Gustave Roussy, F 94805 Villejuif, France
    J Exp Med 196:1121-5. 2002
  7. pmc Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion
    Patricia Boya
    Centre National de la Recherche Scientifique, UMR 8125, Institut Gustave Roussy, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    J Exp Med 197:1323-34. 2003
  8. pmc Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
    Jean Luc Perfettini
    Centre National Recherche Scientifique UMR8125, Institut Gustave Roussy, F 94805 Villejuif, France
    J Exp Med 201:279-89. 2005
  9. pmc Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
    Noelia Casares
    Centre National de la Recherche Scientifique UMR8125, Institut Gustave Roussy, F 94805 Villejuif, France
    J Exp Med 202:1691-701. 2005
  10. pmc NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope
    Jean Luc Perfettini
    Centre National de la Recherche Scientifique, UMR 8125, Institut Gustave Roussy, F 94805 Villejuif, France
    J Exp Med 199:629-40. 2004

Detail Information

Publications165 found, 100 shown here

  1. ncbi request reprint Lysosomes and autophagy in cell death control
    Guido Kroemer
    CNRS UMR8125, Institut Gustave Roussy, 38 rue Camille Desmoulins, F 94805 Villejuif, France
    Nat Rev Cancer 5:886-97. 2005
    ..Similarly, alterations in the autophagic compartment are linked to carcinogenesis and resistance to chemotherapy. Targeting these pathways might constitute a novel approach to cancer therapy...
  2. ncbi request reprint Chk1 inhibition activates p53 through p38 MAPK in tetraploid cancer cells
    Ilio Vitale
    INSERM, U848, Unit Apoptosis, Cancer and Immunity, Villejuif, France
    Cell Cycle 7:1956-61. 2008
    ..These results underscore the role of p38 MAPK as a pro-apoptotic kinase in the p53-dependant pathway for the therapeutic elimination of polyploidy cells...
  3. ncbi request reprint Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
    G Kroemer
    CNRS UMR8125, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Cell Death Differ 12:1463-7. 2005
  4. pmc Apoptosis regulation in tetraploid cancer cells
    Maria Castedo
    CNRS, UMR8125, Institut Gustave Roussy, Villejuif, France
    EMBO J 25:2584-95. 2006
    ..Tetraploid cells were also more resistant against UVC and gamma-irradiation. These data indicate the existence of p53-dependent alterations in apoptosis regulation in tetraploid cells...
  5. pmc Cytopathic effects of the cytomegalovirus-encoded apoptosis inhibitory protein vMIA
    Delphine Poncet
    Centre National de la Recherche Scientifique, FRE2939, Institut Gustave Roussy, F 94805 Villejuif, France
    J Cell Biol 174:985-96. 2006
    ..Similarly, knockdown of the phosphate carrier reduced cell size. Our data suggest that the cytopathic effect of CMV can be explained by vMIA effects on mitochondrial bioenergetics...
  6. pmc Mitochondrial apoptosis and the peripheral benzodiazepine receptor: a novel target for viral and pharmacological manipulation
    Maria Castedo
    Centre National de la Recherche Scientifique, UMR 1599, Institut Gustave Roussy, F 94805 Villejuif, France
    J Exp Med 196:1121-5. 2002
  7. pmc Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion
    Patricia Boya
    Centre National de la Recherche Scientifique, UMR 8125, Institut Gustave Roussy, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    J Exp Med 197:1323-34. 2003
    ..Altogether, our data indicate that mitochondria are indispensable for cell death initiated by lysosomal destabilization...
  8. pmc Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
    Jean Luc Perfettini
    Centre National Recherche Scientifique UMR8125, Institut Gustave Roussy, F 94805 Villejuif, France
    J Exp Med 201:279-89. 2005
    ..Dominant-negative MKK3 or MKK6 inhibited syncytial activation of p38, p53S46P, and apoptosis. Altogether, these findings indicate that p38 MAPK-mediated p53 phosphorylation constitutes a critical step of Env-induced apoptosis...
  9. pmc Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death
    Noelia Casares
    Centre National de la Recherche Scientifique UMR8125, Institut Gustave Roussy, F 94805 Villejuif, France
    J Exp Med 202:1691-701. 2005
    ..These results delineate a procedure for the generation of cancer vaccines and the stimulation of anti-neoplastic immune responses in vivo...
  10. pmc NF-kappaB and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope
    Jean Luc Perfettini
    Centre National de la Recherche Scientifique, UMR 8125, Institut Gustave Roussy, F 94805 Villejuif, France
    J Exp Med 199:629-40. 2004
    ..Altogether, these data indicate that NF-kappaB and p53 cooperate as the dominant proapoptotic transcription factors participating in HIV-1 infection...
  11. pmc Inhibition of Chk1 kills tetraploid tumor cells through a p53-dependent pathway
    Ilio Vitale
    INSERM, U848, Cancer and Immunity, Villejuif, France
    PLoS ONE 2:e1337. 2007
    ..Altogether, our results demonstrate that, in tetraploid tumor cells, the inhibition of Chk1 sequentially triggers aberrant mitosis, p53 activation and Puma/BBC3-dependent mitochondrial apoptosis...
  12. pmc Human immunodeficiency virus 1 envelope glycoprotein complex-induced apoptosis involves mammalian target of rapamycin/FKBP12-rapamycin-associated protein-mediated p53 phosphorylation
    M Castedo
    Centre National de la Recherche Scientifique, UMR1599, Institut Gustave Roussy, F 94805 Villejuif, France
    J Exp Med 194:1097-110. 2001
    ..In summary, we demonstrate that phosphorylation of p53S15 by mTOR/FRAP plays a critical role in syncytial apoptosis driven by HIV-1 Env...
  13. pmc Mitochondrial control of cell death induced by hyperosmotic stress
    Alfredo Criollo
    Institut Gustave Roussy 39 rue Camille Desmoulins, F 94805, Villejuif, France
    Apoptosis 12:3-18. 2007
    ..Thus, hyperosmotic stress kills cells by triggering different molecular pathways, which converge at mitochondria where pro- and anti-apoptotic members of the Bcl-2 family exert their control...
  14. ncbi request reprint Introduction: mitochondrial control of apoptosis
    Guido Kroemer
    Centre National de la Recherche Scientifique, UMR1599, Institut Gustave Roussy, 39, rue Camille Desmoulins, 94805 Villejuif, France
    Biochimie 84:103-4. 2002
  15. ncbi request reprint Heat shock protein 70 neutralizes apoptosis-inducing factor
    G Kroemer
    Centre National de la Recherche Scientifique, UMR, Institut Gustave Roussy, Villejuif, France
    ScientificWorldJournal 1:590-2. 2001
    ..Another example concerns the so-called apoptosis-inducing factor (AIF), another mitochondrial intermembrane protein which can translocate to the nucleus where it induces chromatin condensation and DNA fragmentation...
  16. ncbi request reprint The mitochondrial permeability transition pore complex as a pharmacological target. An introduction
    Guido Kroemer
    Centre National de la Recherche Scientifique, UMR 8125, Villejuif, France
    Curr Med Chem 10:1469-72. 2003
  17. ncbi request reprint Cancer: defeating the immortal
    Guido Kroemer
    INSERM, U898, Villejuif, France, Institut Gustave Roussy, Villejuif, France, Universite Paris Sud, Villejuif, France
    Cancer Biol Ther 6:1324-8. 2007
    ..So instead of an auto-apotheosis, this piece will simply translate what I could tell a friend during an after-dinner conversation, knowing that the plans for the future (optimistically) outnumber the experiences in the past...
  18. ncbi request reprint Death, danger, and immunity: an infernal trio
    Guido Kroemer
    INSERM, U805, Villejuif, France
    Immunol Rev 220:5-7. 2007
  19. ncbi request reprint Caspase-independent cell death
    Guido Kroemer
    Centre National de la Recherche Scientifique, UMR8125, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Nat Med 11:725-30. 2005
    ..Such alternative strategies may either target catabolic hydrolases or be aimed at preventing mitochondrial membrane permeabilization and its upstream triggers...
  20. pmc Inhibition of macroautophagy triggers apoptosis
    Patricia Boya
    CNRS UMR 8125, Institut Gustave Roussy, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Mol Cell Biol 25:1025-40. 2005
    ..All together, these data indicate that autophagy may be cytoprotective, at least under conditions of nutrient depletion, and point to an important cross talk between type 1 and type 2 cell death pathways...
  21. ncbi request reprint Mitochondrial control of apoptosis: an introduction
    Guido Kroemer
    Centre National de la Recherche Scientifique, UMR 8125, Institut Gustave Roussy, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F 94805 Villejuif Cedex, France
    Biochem Biophys Res Commun 304:433-5. 2003
    ..The detailed investigation of the mechanisms of MMP will hopefully lead to the discovery of suitable drug targets for therapeutic intervention on cell death control...
  22. doi request reprint Tumor cell metabolism: cancer's Achilles' heel
    Guido Kroemer
    INSERM, U848, F 94805 Villejuif, France
    Cancer Cell 13:472-82. 2008
    ..Specifically, we discuss the alterations in signal transduction pathways and/or enzymatic machineries that account for metabolic reprogramming of transformed cells...
  23. pmc Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
    G Kroemer
    INSERM, U848, Villejuif F 94805, France
    Cell Death Differ 16:3-11. 2009
    ..This study details the 2009 recommendations of the NCCD on the use of cell death-related terminology including 'entosis', 'mitotic catastrophe', 'necrosis', 'necroptosis' and 'pyroptosis'...
  24. pmc Autophagic cell death: the story of a misnomer
    Guido Kroemer
    Institut Gustave Roussy, F 94805 Villejuif, France
    Nat Rev Mol Cell Biol 9:1004-10. 2008
    ..We also list the caveats that must be considered when deciding whether or not autophagy is an important effector mechanism of cell death...
  25. ncbi request reprint Preapoptotic chromatin condensation upstream of the mitochondrial checkpoint
    Karine Andreau
    CNRS UMR8125, Institut Gustave Roussy, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    J Biol Chem 279:55937-45. 2004
    ..In synthesis, our data reveal the unexpected capacity of STS to induce DNA lesions and suggest qualitative differences in the cytoprotective and DNA repair-inducing potential of different apoptosis inhibitors...
  26. ncbi request reprint Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy
    Maria Castedo
    CNRS UMR 8125, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Oncogene 23:4362-70. 2004
    ..Our findings delineate a molecular pathway through which DNA damage, failure to arrest the cell cycle and inhibition of apoptosis can favor the occurrence of cytogenetic abnormalities that are likely to participate in oncogenesis...
  27. ncbi request reprint Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine
    Patricia Boya
    Centre National de la Recherche Scientifique, UMR 8125, Institut Gustave Roussy, Pavillon de Recherche 1, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Oncogene 22:3927-36. 2003
    ..The data reported herein indicate that LMP does not suffice to trigger caspase activation and that Bax/Bak-dependent MMP is a critical step of LMP-induced cell death...
  28. ncbi request reprint Chemotherapy induces ATP release from tumor cells
    Isabelle Martins
    INSERM, U848, Villejuif, France Institut Gustave Roussy, Villejuif, France
    Cell Cycle 8:3723-8. 2009
    ..Hence, ATP release is a general correlate of apoptotic cell death induced by conventional anticancer therapies...
  29. ncbi request reprint Pro-apoptotic function of checkpoint kinase-2 in syncytia elicited by the HIV-1 envelope
    Claire Séror
    INSERM, U848, Villejuif, France
    Cell Cycle 8:438-42. 2009
    ..Altogether, these results indicate that Chk2 (but not Chk1) participates in the DNA damage-elicited pro-apoptotic cascade that leads to the demise of Env-elicited syncytia...
  30. ncbi request reprint The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe
    Maria Castedo
    CNRS UMR 8125, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Oncogene 23:4353-61. 2004
    ..Inhibition of Chk2 thus can sensitize proliferating cells to chemotherapy-induced apoptosis...
  31. ncbi request reprint Calreticulin exposure dictates the immunogenicity of cancer cell death
    Michel Obeid
    INSERM U848, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Nat Med 13:54-61. 2007
    ..These data identify CRT as a key feature determining anticancer immune responses and delineate a possible strategy for immunogenic chemotherapy...
  32. ncbi request reprint Mitochondrion-dependent caspase activation by the HIV-1 envelope
    Thomas Roumier
    Centre National de la Recherche Scientifique, UMR 8125, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Biochem Pharmacol 66:1321-9. 2003
    ..Conversely, inhibition of caspases did not prevent MMP. These results indicate that Env-elicited syncytial apoptosis involves the intrinsic (mitochondrial) pathway...
  33. pmc Sequential involvement of Cdk1, mTOR and p53 in apoptosis induced by the HIV-1 envelope
    Maria Castedo
    Centre National de la Recherche Scientifique, UMR1599, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    EMBO J 21:4070-80. 2002
    ..Cdk1 inhibition prevents the death of syncytia elicited by HIV-1 infection of primary CD4 lymphoblasts. Thus, HIV-1 elicits a pro-apoptotic signal transduction pathway relying on the sequential action of cyclin B-Cdk1, mTOR and p53...
  34. ncbi request reprint Contagious apoptosis facilitated by the HIV-1 envelope: fusion-induced cell-to-cell transmission of a lethal signal
    Karine Andreau
    CNRS UMR8125, France
    J Cell Sci 117:5643-53. 2004
    ..Contagious apoptosis could be induced in primary human T cells, as well as in vivo, in T cells exposed to dying Env-expressing cells. Altogether, these data point to a novel mechanism through which HIV-1 can induce bystander killing...
  35. pmc Multipolar mitosis of tetraploid cells: inhibition by p53 and dependency on Mos
    Ilio Vitale
    INSERM, Villejuif, France
    EMBO J 29:1272-84. 2010
    ..In the absence of p53, Mos knockdown prevents multipolar mitoses and exerts genome-stabilizing effects. These results elucidate the mechanisms through which asymmetric cell division drives chromosomal instability in tetraploid cells...
  36. ncbi request reprint [Immunological aspects of anticancer chemotherapy]
    Laurence Zitvogel
    Institut Gustave Roussy, F 94805 Villejuif, 39, rue Camille Desmoulins, France
    Bull Acad Natl Med 192:1469-87; discussion 1487-9. 2008
    ..The response to chemotherapy and/or radiotherapy may thus combine both direct cytotoxic effects and the development of long-term antitumor immunity. We anticipate that these new results will have major impact on cancer management...
  37. ncbi request reprint Longevity-relevant regulation of autophagy at the level of the acetylproteome
    Guillermo Mariño
    INSERM, U, Institut Gustave Roussy, Universite Paris Sud, Villejuif, France
    Autophagy 7:647-9. 2011
    ..We surmise that subtle and concerted alterations in the acetylproteome regulate autophagy at multiple levels...
  38. ncbi request reprint Disruption of the PP1/GADD34 complex induces calreticulin exposure
    Oliver Kepp
    INSERM, U848, Villejuif, France
    Cell Cycle 8:3971-7. 2009
    ..These results suggest that the PP1/GADD34 complex plays a major role in the regulation of CRT exposure...
  39. doi request reprint CCL2/CCR2-dependent recruitment of functional antigen-presenting cells into tumors upon chemotherapy
    Yuting Ma
    Authors Affiliations INSERM, U848 Institut Gustave Roussy INSERM, U1015, CBT1017 Metabolomics and Cell Biology Platforms, Institut Gustave Roussy, Villejuif, France Université Paris Descartes Paris V, Sorbonne Paris Cité Equipe 11 labellisée par la Ligue Nationale contre le Cancer, Centre de Recherche des Cordeliers, Paris Université Paris Sud Paris XI Le Kremlin Bicêtre Pôle de Biologie, Hopital Europeen Georges Pompidou, AP HP Paris INSERM, UMR 996, LabEx LERMIT, Clamart, France Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria Diamantina Institute School of Medicine, University of Queensland Immunology in Cancer and Infection Laboratory, QIMR Berghofer Medical Research Institute Cancer Immunoregulation and Immunotherapy Laboratory, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia Laboratorio de Vetores Virais, Instituto do Coracao, FM USP, Sao Paulo, Brazil and Genomics and Immunoregulation, LIMES Institute, University of Bonn, Bonn, Germany
    Cancer Res 74:436-45. 2014
    ..Altogether, our results underscore the importance of the CCL2/CCR2 signaling axis for therapeutic anticancer immune responses as elicited by immunogenic chemotherapy...
  40. pmc Synergistic interaction between cisplatin and PARP inhibitors in non-small cell lung cancer
    Judith Michels
    U848, INSERM, Villejuif, France
    Cell Cycle 12:877-83. 2013
    ..Combined treatment with CDDP and PARP inhibitors elicits the intrinsic pathway of apoptosis...
  41. doi request reprint miR-181a and miR-630 regulate cisplatin-induced cancer cell death
    Lorenzo Galluzzi
    Institut National de la Sante et de la Recherche Medicale, U848, Villejuif, France
    Cancer Res 70:1793-803. 2010
    ..Altogether, these results identify miR-181a and miR-630 as novel modulators of the CDDP response in NSCLC...
  42. ncbi request reprint Involvement of p38alpha in the mitotic progression of p53(-/-) tetraploid cells
    Ilio Vitale
    INSERM, U848, Villejuif, France
    Cell Cycle 9:2823-9. 2010
    ..We conclude that the mitotic progression of p53(-/-) (but not p53(+/+)) tetraploids heavily relies on p38alpha, revealing a novel function for this protein in the context of aneuploidizing cell divisions...
  43. doi request reprint Witch hunt against tumor cells enhanced by dendritic cells
    Clara Locher
    Institut National de la Sante et de la Recherche Medicale, U805, Villejuif, France
    Ann N Y Acad Sci 1174:51-60. 2009
    ..We review these two molecular mechanisms that dictate the radio/chemotherapy-elicited antitumor immune response and discuss how this knowledge can be clinically exploited to predict and also ameliorate the success of chemo/radiotherapy...
  44. ncbi request reprint An anti-apoptotic viral protein that recruits Bax to mitochondria
    Delphine Poncet
    Centre National de la Recherche Scientifique, UMR 8125, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    J Biol Chem 279:22605-14. 2004
    ..vMIA neutralizes Bax by recruiting it to mitochondria and "freezing" its pro-apoptotic activity. These data unravel a novel strategy of subverting an intrinsic pathway of apoptotic signaling...
  45. pmc Direct interaction between STAT3 and EIF2AK2 controls fatty acid-induced autophagy
    Mireia Niso-Santano
    INSERM, U848, Villejuif, France
    Autophagy 9:415-7. 2013
    ..These results reveal an unsuspected crosstalk between cellular metabolism (fatty acids), pro-inflammatory signaling (STAT3), innate immunity (EIF2AK2), and translational control (EIF2S1) that regulates autophagy...
  46. ncbi request reprint Nonapoptotic role for Apaf-1 in the DNA damage checkpoint
    Yael Zermati
    INSERM, U848, 94805 Villejuif, France
    Mol Cell 28:624-37. 2007
    ..Hence, Apaf-1 exerts two distinct, phylogenetically conserved roles in response to mitochondrial membrane permeabilization and DNA damage. These data point to a role for Apaf-1 as a bona fide tumor suppressor...
  47. pmc Regulation of autophagy by cytoplasmic p53
    Ezgi Tasdemir
    INSERM, U848, France
    Nat Cell Biol 10:676-87. 2008
    ..These results provide evidence of a key signalling pathway that links autophagy to the cancer-associated dysregulation of p53...
  48. ncbi request reprint Erlotinib antagonizes constitutive activation of SRC family kinases and mTOR in acute myeloid leukemia
    Simone Boehrer
    INSERM U848, Villejuif, France
    Cell Cycle 10:3168-75. 2011
    ..Thus, combination therapies with erlotinib and rapamycin might be beneficial for MDS and AML patients...
  49. ncbi request reprint Molecular determinants of immunogenic cell death: surface exposure of calreticulin makes the difference
    Nathalie Chaput
    Centre d Investigation Clinique biothérapie, Institut Gustave Roussy, Villejuif, France
    J Mol Med (Berl) 85:1069-76. 2007
    ..The challenge will be to determine whether the exposure of calreticulin translocation on the tumour cell surface is linked to chemotherapy-induced anti-tumour immune responses and therapeutic efficacy in human cancer...
  50. ncbi request reprint Mitochondrial apoptosis induced by the HIV-1 envelope
    Maria Castedo
    Centre National de la Recherche Scientifique, UMR 8125, Institut Gustave Roussy, F 94805 Villejuif, France
    Ann N Y Acad Sci 1010:19-28. 2003
    ..The implications of these findings for the pathophysiology of HIV-1 infection is discussed...
  51. doi request reprint Crosstalk between ER stress and immunogenic cell death
    Oliver Kepp
    université Paris Sud Paris XI, Le Kremlin Bicetre, France INSERM, U848, Villejuif, France Institut Gustave Roussy, Villejuif, France
    Cytokine Growth Factor Rev 24:311-8. 2013
    ..In this review, we will summarize recent findings in the field of ICD research with a special focus on ER stress mechanisms and their implication for cancer therapy...
  52. pmc AIF deficiency compromises oxidative phosphorylation
    Nicola Vahsen
    CNRS UMR8125, Institut Gustave Roussy, Villejuif, France
    EMBO J 23:4679-89. 2004
    ..Altogether, these data point to a role of AIF in OXPHOS and emphasize the dual role of AIF in life and death...
  53. ncbi request reprint A novel epidermal growth factor receptor inhibitor promotes apoptosis in non-small cell lung cancer cells resistant to erlotinib
    Thibault de La Motte Rouge
    INSERM, U848, Villejuif, France
    Cancer Res 67:6253-62. 2007
    ..g., Puma, Bax, Bak, caspase-2, etc.) and DNA damage-related proteins (e.g., ERCC1, hTERT) exerted cytoprotective effects. BMS-690514 is a new pan-HER/VEGFR inhibitor that may become an alternative to erlotinib for the treatment of NSCLC...
  54. ncbi request reprint Enrichment of non-synchronized cells in the G1, S and G2 phases of the cell cycle for the study of apoptosis
    Arnaud Coquelle
    Centre National de la Recherche Scientifique, UMR8125, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Biochem Pharmacol 72:1396-404. 2006
    ..These results delineate a novel procedure for studying the intersection between cell cycle regulation and cell death mechanisms...
  55. pmc Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
    M Chiara Maiuri
    INSERM U848, Villejuif, France
    EMBO J 26:2527-39. 2007
    ..BH3-only proteins and pharmacological BH3 mimetics induce autophagy by competitively disrupting the interaction between Beclin-1 and Bcl-2 or Bcl-X(L)...
  56. pmc Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death
    Theocharis Panaretakis
    INSERM, Unit 848, Villejuif, France
    EMBO J 28:578-90. 2009
    ..Depletion of PERK, caspase-8 or SNAREs had no effect on cell death induced by anthracyclines, yet abolished the immunogenicity of cell death, which could be restored by absorbing recombinant CRT to the cell surface...
  57. doi request reprint A chemical inhibitor of Apaf-1 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint
    Laura Mondragon
    U848, INSERM, 94805 Villejuif, France
    Apoptosis 14:182-90. 2009
    ..Moreover, QM31 can inhibit mitochondrial outer membrane permeabilization, an effect that is independent from its action on Apaf-1...
  58. doi request reprint Immunogenic cancer cell death: a key-lock paradigm
    Antoine Tesniere
    INSERM, U848, F 94805 Villejuif, France
    Curr Opin Immunol 20:504-11. 2008
    ..Nonetheless, numerous details on the molecular events that define immunogenicity remain to be defined, both at the level of the dying cancer cells and at the level of the responding innate effectors...
  59. pmc Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia
    Jean Luc Perfettini
    INSERM U848, Institut Gustave Roussy, Villejuif, France
    PLoS ONE 3:e2458. 2008
    ..Altogether these results indicate that apoptosis induced by a fusogenic HIV-1 Env follows a pro-apoptotic pathway involving the sequential activation of ATM, p38MAPK and p53...
  60. ncbi request reprint PK11195 potently sensitizes to apoptosis induction independently from the peripheral benzodiazepin receptor
    Rosa Ana Gonzalez-Polo
    1Centre National de la Recherche Scientifique, UMR8125, Institut Gustave Roussy, Pavillon de Recherche 1, 39 rue Camille Desmoulins, 94805 Villejuif, France
    Oncogene 24:7503-13. 2005
    ..Thus, PK11195 potently sensitizes to apoptosis via a pathway that involves mitochondria, yet does not involve the PBR...
  61. ncbi request reprint The chemopreventive agent N-(4-hydroxyphenyl)retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family
    Patricia Boya
    Centre National de la Recherche Scientifique, UMR8125, Institut Gustave Roussy, Villejuif, France
    Oncogene 22:6220-30. 2003
    ..Altogether, these data indicate that 4-HPR induces MMP through an ROS-mediated pathway that involves the obligatory contribution of the proapopotic Bcl-2 family members Bax and/or Bak...
  62. ncbi request reprint Selective resistance of tetraploid cancer cells against DNA damage-induced apoptosis
    Maria Castedo
    Centre National de la Recherche Scientifique, UMR8125, Villejuif, France
    Ann N Y Acad Sci 1090:35-49. 2006
    ..These data point to an intrinsic resistance of tetraploid cells against radiotherapy and DNA-targeted chemotherapy that may be linked to the status of the p53 system...
  63. ncbi request reprint [Antitumoral immunization during cancer chemotherapy]
    Laurence Zitvogel
    Institut Gustave Roussy, F 94805 Villejuif, France
    Bull Acad Natl Med 196:1075-86. 2012
    ..These findings will help to identify immune predictors of the response to conventional anticancer treatments and to design innovative combinatorial immunochemotherapy regimens...
  64. pmc Prognostic value of LIPC in non-small cell lung carcinoma
    Lorenzo Galluzzi
    Institut Gustave Roussy IGR, Villejuif, France
    Cell Cycle 12:647-54. 2013
    ..If these findings were confirmed by additional studies, LIPC expression levels might allow not only for NSCLC patient stratification, but also for the implementation of personalized therapeutic approaches...
  65. doi request reprint Autophagic removal of micronuclei
    Santiago Rello-Varona
    INSERM, U848, Orsay, Paris, France
    Cell Cycle 11:170-6. 2012
    ..These results indicate that micronuclei can be subjected to autophagic degradation. Moreover, it can be speculated that removal of micronuclei may contribute to the genome-stabilizing effects of autophagy...
  66. doi request reprint Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice
    Mickael Michaud
    INSERM, U848, Villejuif, France
    Science 334:1573-7. 2011
    ..Thus, autophagy is essential for the immunogenic release of ATP from dying cells, and increased extracellular ATP concentrations improve the efficacy of antineoplastic chemotherapies when autophagy is disabled...
  67. ncbi request reprint Ecto-calreticulin in immunogenic chemotherapy
    Michel Obeid
    INSERM, U848, Villejuif, France
    Immunol Rev 220:22-34. 2007
    ....
  68. ncbi request reprint Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints
    Yungan Tao
    UPRES EA27 10 Laboratoire Radiosensibilité des Tumeurs et Tissus Sains, University Paris Sud XI Kremlin Bicêtre and Institut Gustave Roussy, 39 rue Camille Desmoulins, Villejuif, France
    Cell Cycle 8:1196-205. 2009
    ..Altogether these results suggest that Chir-124-mediated radiosensitization is profoundly influenced by the p53 and cell cycle checkpoint system...
  69. ncbi request reprint Immunogenic tumor cell death for optimal anticancer therapy: the calreticulin exposure pathway
    Laurence Zitvogel
    INSERM, U1015, and CICBT507, Villejuif, France
    Clin Cancer Res 16:3100-4. 2010
    ..We speculate that human cancers that are incapable of activating the CRT exposure pathway are refractory to the immune-mediated component of anticancer therapies...
  70. doi request reprint Lysyl tRNA synthetase is required for the translocation of calreticulin to the cell surface in immunogenic death
    Oliver Kepp
    INSERM, U848, Villejuif, France
    Cell Cycle 9:3072-7. 2010
    ..Moreover, recombinant KARS protein was unable to stimulate macrophages in vitro. These results underscore the contribution of KARS to the emission of (one of) the principal signal(s) of immunogenic cell death, CRT exposure...
  71. pmc Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome
    Eugenia Morselli
    Institut National de la Santé et de la Recherche Medicale U848, Villejuif, France
    J Cell Biol 192:615-29. 2011
    ..Altogether, these data underscore the importance of an autophagy regulatory network of antagonistic deacetylases and acetylases that can be pharmacologically manipulated...
  72. ncbi request reprint Neuroendocrine regulation of autophagy by leptin
    Shoaib Ahmad Malik
    INSERM, U848, Institut Gustave Roussy, Universite Paris Sud, Villejuif, France
    Cell Cycle 10:2917-23. 2011
    ..These results suggest that leptin plays an important role in the neuroendocrine control of autophagy, underscoring the existence of novel links between metabolic control and autophagic flux that warrant further in-depth investigation...
  73. ncbi request reprint Tumor cells can escape DNA-damaging cisplatin through DNA endoreduplication and reversible polyploidy
    Pierre Emmanuel Puig
    INSERM, UMR 866, F 21079 Dijon, France
    Cell Biol Int 32:1031-43. 2008
    ..These data suggest that a multistep pathway, including DNA endoreduplication, polyploidy, then depolyploidization and generation of clonogenic escape cells can account for tumor relapse after initial efficient chemotherapy...
  74. ncbi request reprint Differentiating megakaryocytes in myelodysplastic syndromes succumb to mitochondrial derangement without caspase activation
    Thorsten Braun
    INSERM, Unit 848, F 94805 Villejuif, France
    Apoptosis 12:1101-8. 2007
    ..Thus, a stereotyped pattern of mitochondrial alterations accompanies differentiation-associated MK death in MDS...
  75. doi request reprint Premortem autophagy determines the immunogenicity of chemotherapy-induced cancer cell death
    Isabelle Martins
    INSERM, U848, Villejuif, France
    Autophagy 8:413-5. 2012
    ..Altogether, these results suggest that autophagy-incompetent tumor cells escape from chemotherapy-induced (and perhaps natural?) immunosurveillance because they are unable to release ATP...
  76. doi request reprint Cardiac glycosides exert anticancer effects by inducing immunogenic cell death
    Laurie Menger
    INSERM, U848, F 94805 Villejuif, France
    Sci Transl Med 4:143ra99. 2012
    ....
  77. ncbi request reprint An immunosurveillance mechanism controls cancer cell ploidy
    Laura Senovilla
    INSERM, U848, Villejuif, France
    Science 337:1678-84. 2012
    ..Our results unveil an immunosurveillance system that imposes immunoselection against hyperploidy in carcinogen- and oncogene-induced cancers...
  78. ncbi request reprint The aurora B kinase inhibitor AZD1152 sensitizes cancer cells to fractionated irradiation and induces mitotic catastrophe
    Yungan Tao
    UPRES EA27 10 Laboratoire Radiosensibilité des Tumeurs et Tissus Sains, Villejuif, France
    Cell Cycle 8:3172-81. 2009
    ..Altogether, these data support the contention that AZD1152 mediates radiosensitization in vivo by enhancing mitotic catastrophe, which can be used as a biomarker of treatment efficacy...
  79. doi request reprint Methods for assessing autophagy and autophagic cell death
    Ezgi Tasdemir
    INSERM, Unit Apoptosis, Cancer and Immunity, Villejuif, France
    Methods Mol Biol 445:29-76. 2008
    ..Accordingly, we describe a strategy for discriminating cell death with autophagy from cell death through autophagy...
  80. doi request reprint How to improve the immunogenicity of chemotherapy and radiotherapy
    Yuting Ma
    INSERM, U1015, 94805 Villejuif, France
    Cancer Metastasis Rev 30:71-82. 2011
    ..Based on the recent clinical or experimental findings, several strategies have been suggested to improve the immunogenicity of cell death and augment antitumor immunity...
  81. doi request reprint The dendritic cell-like functions of IFN-producing killer dendritic cells reside in the CD11b+ subset and are licensed by tumor cells
    Magali Terme
    Institut National de la Sante et de la Recherche Medicale, Villejuif, France
    Cancer Res 69:6590-7. 2009
    ..Collectively, our data indicate that upon exposure to tumor cells, IKDC subserve DC-like functions...
  82. ncbi request reprint Cell death by mitotic catastrophe: a molecular definition
    Maria Castedo
    CNRS UMR 8125, Institut Gustave Roussy, Pavillon de Recherche 1, 39 rue Camille Desmoulins, Villejuif F 94805, France
    Oncogene 23:2825-37. 2004
    ....
  83. ncbi request reprint p53-A pro-apoptotic signal transducer involved in AIDS
    Maria Castedo
    CNRS UMR8125, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Biochem Biophys Res Commun 331:701-6. 2005
    ..Thus, p53 may constitute a novel therapeutic target for the treatment of AIDS...
  84. ncbi request reprint Erlotinib exhibits antineoplastic off-target effects in AML and MDS: a preclinical study
    Simone Boehrer
    INSERM, U848, Villejuif, France
    Blood 111:2170-80. 2008
    ..In summary, we here provide novel evidence in vitro, ex vivo, and in vivo for the potential therapeutic efficacy of erlotinib in the treatment of high-risk MDS and AML...
  85. doi request reprint Erlotinib and gefitinib for the treatment of myelodysplastic syndrome and acute myeloid leukemia: a preclinical comparison
    Simone Boehrer
    INSERM, U848, 94805 Villejuif, France
    Biochem Pharmacol 76:1417-25. 2008
    ..These results suggest that erlotinib and gefitinib share a mechanistically related off-target effect that may be taken advantage of for the therapy of MDS and AML...
  86. ncbi request reprint Platelet formation is the consequence of caspase activation within megakaryocytes
    Stephane De Botton
    Institut National de la Santé et de la Recherche Médicale U362 and the Centre National de la Recherche Scientifique Unité Mixte de Recherche 1599, Institut Gustave Roussy, Institut Fédératif de Recherche 54, Villejuif, France
    Blood 100:1310-7. 2002
    ..Thus, localized caspase activation is causal to proplatelet formation. We conclude that proplatelet formation is regulated by a caspase activation limited to only some cellular compartments...
  87. ncbi request reprint Immunological aspects of cancer chemotherapy
    Laurence Zitvogel
    INSERM, U805, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, Paris, France
    Nat Rev Immunol 8:59-73. 2008
    ..Here, we review the immunological aspects of conventional cancer treatments and propose that future successes in the fight against cancer will rely on the development and clinical application of combined chemo- and immunotherapies...
  88. doi request reprint Decoding cell death signals in inflammation and immunity
    Laurence Zitvogel
    INSERM, Villejuif, France
    Cell 140:798-804. 2010
    ..We speculate that combinations of these molecules determine the route by which dying cells are engulfed and the nature of the immune response that their death elicits...
  89. doi request reprint Tumor cell death and ATP release prime dendritic cells and efficient anticancer immunity
    Laetitia Aymeric
    U805 and CIC BT507 INSERM, Institut Gustave Roussy, 39 rue Camille Desmoulins, F 94805 Villejuif, France
    Cancer Res 70:855-8. 2010
    ..IL-1beta then is required for the adequate polarization of IFNgamma-producing CD8(+) T cells. These results imply a novel danger signal, ATP, and a novel receptor, P2RX7, in the chemotherapy-elicited anticancer immune response...
  90. ncbi request reprint NF-kappaB constitutes a potential therapeutic target in high-risk myelodysplastic syndrome
    Thorsten Braun
    Centre National de la Recherche Scientifique, Unite Mixté de Recherche UMR 8125, Institut Gustave Roussy, Villejuif, France
    Blood 107:1156-65. 2006
    ..NF-kappaB inhibition may constitute a novel therapeutic strategy if apoptosis induction of MDS stem cells is the goal...
  91. ncbi request reprint Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5
    Santiago Rello-Varona
    INSERM U848, Institut Gustave Roussy, and Université de Paris 11, Villejuif, France
    Cell Cycle 8:1030-5. 2009
    ..In conclusion, tetraploid cells are particular vulnerable to undergo mitotic catastrophe after genetic or pharmacological inhibition of Eg5...