Robert G Kelly

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint T-box genes in vertebrate development
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Annu Rev Genet 39:219-39. 2005
  2. ncbi request reprint The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm
    R G Kelly
    Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
    Dev Cell 1:435-40. 2001
  3. ncbi request reprint The anterior heart-forming field: voyage to the arterial pole of the heart
    Robert G Kelly
    CNRS URA 1947, Dept of Developmental Biology, Pasteur Institute, 28 rue du Dr Roux, Paris, France
    Trends Genet 18:210-6. 2002
  4. ncbi request reprint Cell history determines the maintenance of transcriptional differences between left and right ventricular cardiomyocytes in the developing mouse heart
    Robert G Kelly
    CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 25 rue du Dr Roux, Paris 75015, France
    J Cell Sci 116:5005-13. 2003
  5. pmc Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium
    Yusuke Watanabe
    Department of Developmental Biology, Centre National de la Recherche Scientifique CNRS Unité de Recherche Associée 2578, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 109:18273-80. 2012
  6. ncbi request reprint Right ventricular myocardium derives from the anterior heart field
    Stephane Zaffran
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 25 rue du Dr Roux, Paris, 75015, France
    Circ Res 95:261-8. 2004
  7. ncbi request reprint The clonal origin of myocardial cells in different regions of the embryonic mouse heart
    Sigolène M Meilhac
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Cell 6:685-98. 2004
  8. ncbi request reprint Myocardium at the base of the aorta and pulmonary trunk is prefigured in the outflow tract of the heart and in subdomains of the second heart field
    Fanny Bajolle
    Department of Developmental Biology, URA 2578 CNRS, Pasteur Institute, 25 rue du Dr Roux, 75724 Paris, France
    Dev Biol 313:25-34. 2008
  9. pmc Relationship between neural crest cells and cranial mesoderm during head muscle development
    Julien Grenier
    CNRS, UMR 7622 Biologie Moléculaire et Cellulaire du Développement, Universite Pierre et Marie Curie, Paris, France
    PLoS ONE 4:e4381. 2009
  10. doi request reprint Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates
    Ramkumar Sambasivan
    Institut Pasteur, Stem Cells and Development, CNRS URA 2578, Universite de la Mediterranee, Campus de Luminy, Marseille, France
    Dev Cell 16:810-21. 2009

Collaborators

Detail Information

Publications30

  1. ncbi request reprint T-box genes in vertebrate development
    L A Naiche
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA
    Annu Rev Genet 39:219-39. 2005
    ..The few downstream target genes that have been identified indicate a wide range of downstream effectors...
  2. ncbi request reprint The arterial pole of the mouse heart forms from Fgf10-expressing cells in pharyngeal mesoderm
    R G Kelly
    Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
    Dev Cell 1:435-40. 2001
    ..25 and 10.5. These data suggest that arterial pole myocardium originates outside the classical heart field...
  3. ncbi request reprint The anterior heart-forming field: voyage to the arterial pole of the heart
    Robert G Kelly
    CNRS URA 1947, Dept of Developmental Biology, Pasteur Institute, 28 rue du Dr Roux, Paris, France
    Trends Genet 18:210-6. 2002
    ..Discovery of the anterior heart-forming field has important implications for the interpretation of cardiac defects in mouse mutants and for the study of human congenital heart disease...
  4. ncbi request reprint Cell history determines the maintenance of transcriptional differences between left and right ventricular cardiomyocytes in the developing mouse heart
    Robert G Kelly
    CNRS URA 2578, Department of Developmental Biology, Pasteur Institute, 25 rue du Dr Roux, Paris 75015, France
    J Cell Sci 116:5005-13. 2003
    ..Epigenetic mechanisms may therefore be involved in maintaining patterning of the mammalian myocardium...
  5. pmc Fibroblast growth factor 10 gene regulation in the second heart field by Tbx1, Nkx2-5, and Islet1 reveals a genetic switch for down-regulation in the myocardium
    Yusuke Watanabe
    Department of Developmental Biology, Centre National de la Recherche Scientifique CNRS Unité de Recherche Associée 2578, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 109:18273-80. 2012
    ..Our findings provide a paradigm for transcriptional mechanisms that underlie the changes in regulatory networks during the transition from progenitor state to that of the differentiated tissue...
  6. ncbi request reprint Right ventricular myocardium derives from the anterior heart field
    Stephane Zaffran
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 25 rue du Dr Roux, Paris, 75015, France
    Circ Res 95:261-8. 2004
    ..This study demonstrates the differences in the embryological origin of right and left ventricular myocardium, which has important implications for congenital heart disease...
  7. ncbi request reprint The clonal origin of myocardial cells in different regions of the embryonic mouse heart
    Sigolène M Meilhac
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Cell 6:685-98. 2004
    ..These results are not consistent with the prespecification of the cardiac tube as a segmented structure. They are discussed in the context of different heart fields and of the evolution of the heart...
  8. ncbi request reprint Myocardium at the base of the aorta and pulmonary trunk is prefigured in the outflow tract of the heart and in subdomains of the second heart field
    Fanny Bajolle
    Department of Developmental Biology, URA 2578 CNRS, Pasteur Institute, 25 rue du Dr Roux, 75724 Paris, France
    Dev Biol 313:25-34. 2008
    ....
  9. pmc Relationship between neural crest cells and cranial mesoderm during head muscle development
    Julien Grenier
    CNRS, UMR 7622 Biologie Moléculaire et Cellulaire du Développement, Universite Pierre et Marie Curie, Paris, France
    PLoS ONE 4:e4381. 2009
    ..Tendons constitute one of the neural crest derivatives likely to interact with muscle formation. However, head tendon formation has not been studied, nor have tendon and muscle interactions in the head...
  10. doi request reprint Distinct regulatory cascades govern extraocular and pharyngeal arch muscle progenitor cell fates
    Ramkumar Sambasivan
    Institut Pasteur, Stem Cells and Development, CNRS URA 2578, Universite de la Mediterranee, Campus de Luminy, Marseille, France
    Dev Cell 16:810-21. 2009
    ..These findings identify novel genetic networks that may provide insights into myopathies which often affect only subsets of muscles...
  11. pmc Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries
    Yusuke Watanabe
    Department of Developmental Biology, URA CNRS 2578, Institut Pasteur, 25 rue du Dr Roux 75015 Paris, France
    Circ Res 106:495-503. 2010
    ..Previous studies of hypomorphic and conditional Fgf8 mutants show disrupted outflow tract (OFT) and right ventricle (RV) development, whereas Fgf10 mutants do not have detectable OFT defects...
  12. doi request reprint Clonal analysis reveals common lineage relationships between head muscles and second heart field derivatives in the mouse embryo
    Fabienne Lescroart
    Institut Pasteur, Unité de Génétique Moléculaire du Développement, CNRS URA 2578, 28 rue du Dr Roux, Paris, France
    Development 137:3269-79. 2010
    ....
  13. ncbi request reprint Integration of embryonic and fetal skeletal myogenic programs at the myosin light chain 1f/3f locus
    Peter S Zammit
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Dev Biol 313:420-33. 2008
    ..Together our observations provide insights into the regulation of fetal myogenesis and the mechanisms by which temporally distinct genetic programs are integrated at a single locus...
  14. ncbi request reprint Rotation of the myocardial wall of the outflow tract is implicated in the normal positioning of the great arteries
    Fanny Bajolle
    Department of Developmental Biology, CNRS URA 2578, Pasteur Institute, Paris, France
    Circ Res 98:421-8. 2006
    ..We propose that failure of normal rotation of OFT myocardium may underlie major forms of congenital heart disease...
  15. ncbi request reprint A retrospective clonal analysis of the myocardium reveals two phases of clonal growth in the developing mouse heart
    Sigolène M Meilhac
    CNRS URA 2578, Departement de Biologie du Developpement, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Development 130:3877-89. 2003
    ..We discuss how the characteristics of myocardial cell growth, which we describe, underlie the formation of the heart tube and its subsequent regionalised expansion...
  16. ncbi request reprint Dynamic left/right regionalisation of endogenous myosin light chain 3F transcripts in the developing mouse heart
    R G Kelly
    CNRS URA 1947, Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
    J Mol Cell Cardiol 30:1067-81. 1998
    ..MLC3F transgenes, however, maintain an embryonic-like distribution throughout development suggesting that myocardial gene expression is controlled by distinct temporal, as well as spatial, regulatory modules...
  17. ncbi request reprint Embryonic and fetal myogenic programs act through separate enhancers at the MLC1F/3F locus
    R G Kelly
    CNRS URA 1947, Departement de Biologie Moleculaire, Institut Pasteur, Paris, France
    Dev Biol 187:183-99. 1997
    ..These results suggest that temporal regulation of transcription at the MLC1F/3F locus is controlled by separate enhancers which are differentially activated during embryonic and fetal development...
  18. ncbi request reprint Modular regulation of the MLC1F/3F gene and striated muscle diversity
    R G Kelly
    CNRS URA 1947, Departement de Biologie Moleculaire, Institut Pasteur, 75724 Paris Cedex 15, France
    Microsc Res Tech 50:510-21. 2000
    ..How each of these regulatory modules acts and how their individual activites are integrated to coordinate transcription at this locus are discussed...
  19. pmc Tbx3 is required for outflow tract development
    Karim Mesbah
    Developmental Biology Institute of Marseilles Luminy, France
    Circ Res 103:743-50. 2008
    ....
  20. doi request reprint The del22q11.2 candidate gene Tbx1 controls regional outflow tract identity and coronary artery patterning
    Magali Théveniau-Ruissy
    Developmental Biology Institute of Marseilles Luminy, Inserm Avenir Group, UMR 6216 CNRS Université de la Méditerrané, Campus de Luminy, Marseille Cedex 9, France
    Circ Res 103:142-8. 2008
    ..Our results implicate second heart field development in coronary artery patterning and provide new insights into the association between conotruncal defects and coronary artery anomalies...
  21. ncbi request reprint Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles
    Chiara Prunotto
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Torino, Corso Massimo d Azeglio 52, 10126 Turin, Italy
    Dev Dyn 231:582-91. 2004
    ..Surprisingly, however, X-gal staining showed that, in this mutant, hyoid arch-derived facial muscles were either reduced or absent, thus revealing that Met also contributes to the development of muscles in the head...
  22. ncbi request reprint The del22q11.2 candidate gene Tbx1 regulates branchiomeric myogenesis
    Robert G Kelly
    Department of Genetics and Development, Columbia University, New York, NY 10032, USA
    Hum Mol Genet 13:2829-40. 2004
    ..While no abnormalities in branchiomeric myogenesis were detected in Tbx1(+/-) mice, reduced TBX1 levels may contribute to pharyngeal hypotonia in del22q11.2 patients...
  23. ncbi request reprint Heartening news for head muscle development
    Raphaelle Grifone
    Developmental Biology Institute of Marseilles Luminy, Inserm Avenir Group, UMR 6216 CNRS Université de la Méditerranée, Campus de Luminy Case 907, 13288 Marseilles Cedex 9, France
    Trends Genet 23:365-9. 2007
    ..The divergent myogenic fates of adjacent progenitor cells revealed by these data provide a new framework for the study of craniofacial myogenesis...
  24. ncbi request reprint Visualization of outflow tract development in the absence of Tbx1 using an FgF10 enhancer trap transgene
    Robert G Kelly
    Department of Genetics and Development, Columbia University, New York, NY, USA
    Dev Dyn 236:821-8. 2007
    ..Furthermore, although normal Fgf10 levels are dependent on Tbx1, loss of Fgf10 alleles does not significantly modify the cardiac phenotype of Tbx1 heterozygous or homozygous mutant embryos...
  25. ncbi request reprint Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice
    Anita Marguerie
    Cancer Research UK, London Research Institute, 61 Lincoln s Inn Fields, London WC2A 3PX, UK
    Cardiovasc Res 71:50-60. 2006
    ..In order to define the role of fibroblast growth factor (FGF) signaling in this process we investigated whether Fgf10 or the major Fgf10 receptor Fgfr2-IIIb are required for normal heart development...
  26. ncbi request reprint Left and right ventricular contributions to the formation of the interventricular septum in the mouse heart
    Diego Franco
    Department of Experimental Biology, Faculty of Experimental Sciences, University of Jaen, 23071 Jaen, Spain
    Dev Biol 294:366-75. 2006
    ..Examination of the orientation as well as the distribution of labeled cells in clusters provides new insights into the morphogenesis of the septum...
  27. ncbi request reprint Tbx2 is essential for patterning the atrioventricular canal and for morphogenesis of the outflow tract during heart development
    Zachary Harrelson
    Department of Genetics and Development, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Development 131:5041-52. 2004
    ....
  28. ncbi request reprint Molecular inroads into the anterior heart field
    Robert G Kelly
    Developmental Biology Institute of Marseilles, Marseille, France
    Trends Cardiovasc Med 15:51-6. 2005
    ....
  29. ncbi request reprint Building the right ventricle
    Robert G Kelly
    Circ Res 100:943-5. 2007
  30. ncbi request reprint The mouse Ink4a/Arf locus: a p53 pile-up at a tumour surveillance crossroads?
    Robert G Kelly
    Trends Genet 19:81-3. 2003