Mirdad Kazanji

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Effectiveness of two antifolate prophylactic strategies against malaria in HIV-positive pregnant women in Bangui, Central African Republic: study protocol for a randomized controlled trial (MACOMBA)
    Alexandre Manirakiza
    Institut Pasteur of Bangui, International Network of Instituts Pasteur, PO Box 923, Pasteur Avenue, Bangui, Central African Republic
    Trials 14:255. 2013
  2. pmc Entomological profile of yellow fever epidemics in the Central African Republic, 2006-2010
    Carine Ngoagouni
    Institut Pasteur de Bangui, PO Box 923, Bangui, Central African Republic
    Parasit Vectors 5:175. 2012
  3. pmc First introduction of pandemic influenza A/H1N1 and detection of respiratory viruses in pediatric patients in Central African Republic
    Emmanuel Nakoune
    Virology Department, Institut Pasteur de Bangui, Bangui, Central African Republic
    Virol J 10:49. 2013
  4. pmc Acute risk for hepatitis E virus infection among HIV-1-positive pregnant women in central Africa
    Melanie Caron
    Unité de Rétrovirologie, Centre International de Recherches Medicales, Franceville, BP 769, Gabon
    Virol J 9:254. 2012
  5. pmc Prevalence and molecular diversity of hepatitis B virus and hepatitis delta virus in urban and rural populations in northern Gabon in central Africa
    Maria Makuwa
    Unité de virologie, Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    J Clin Microbiol 47:2265-8. 2009
  6. pmc New insights into prevalence, genetic diversity, and proviral load of human T-cell leukemia virus types 1 and 2 in pregnant women in Gabon in equatorial central Africa
    Sonia Lekana Douki Etenna
    Département de Rétrovirologie, Centre International de Recherches Medicales, BP 769 Franceville, Gabon
    J Clin Microbiol 46:3607-14. 2008
  7. doi Simian immunodeficiency virus types 1 and 2 (SIV mnd 1 and 2) have different pathogenic potentials in rhesus macaques upon experimental cross-species transmission
    Sandrine Souquiere
    Laboratoire de Retrovirologie, Centre International de Recherches Médicales CIRMF, Franceville, Gabon
    J Gen Virol 90:488-99. 2009
  8. doi High HIV Type 1 prevalence and wide genetic diversity with dominance of recombinant strains but low level of antiretroviral drug-resistance mutations in untreated patients in northeast Gabon, Central Africa
    Armel Mintsa-Ndong
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    AIDS Res Hum Retroviruses 25:411-8. 2009
  9. pmc Phylogeography, risk factors and genetic history of hepatitis C virus in Gabon, central Africa
    Richard Njouom
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    PLoS ONE 7:e42002. 2012
  10. pmc Prevalence and genetic diversity of hepatitis B and delta viruses in pregnant women in Gabon: molecular evidence that hepatitis delta virus clade 8 originates from and is endemic in central Africa
    Maria Makuwa
    Laboratoire de Virologie, Centre International de Recherches Medicales, BP 769, Franceville, Gabon
    J Clin Microbiol 46:754-6. 2008

Collaborators

Detail Information

Publications29

  1. pmc Effectiveness of two antifolate prophylactic strategies against malaria in HIV-positive pregnant women in Bangui, Central African Republic: study protocol for a randomized controlled trial (MACOMBA)
    Alexandre Manirakiza
    Institut Pasteur of Bangui, International Network of Instituts Pasteur, PO Box 923, Pasteur Avenue, Bangui, Central African Republic
    Trials 14:255. 2013
    ..falciparum infections among HIV-infected pregnant women in Bangui, the capital of the Central African Republic...
  2. pmc Entomological profile of yellow fever epidemics in the Central African Republic, 2006-2010
    Carine Ngoagouni
    Institut Pasteur de Bangui, PO Box 923, Bangui, Central African Republic
    Parasit Vectors 5:175. 2012
    ..As the presence of a vector of yellow fever virus (YFV) represents a risk for spread of the disease, we undertook entomological investigations at these sites to identify potential vectors of YFV and their abundance...
  3. pmc First introduction of pandemic influenza A/H1N1 and detection of respiratory viruses in pediatric patients in Central African Republic
    Emmanuel Nakoune
    Virology Department, Institut Pasteur de Bangui, Bangui, Central African Republic
    Virol J 10:49. 2013
    ..Active surveillance is essential to identify the causative agents and to improve clinical management, especially in the context of possible circulation of pandemic viruses...
  4. pmc Acute risk for hepatitis E virus infection among HIV-1-positive pregnant women in central Africa
    Melanie Caron
    Unité de Rétrovirologie, Centre International de Recherches Medicales, Franceville, BP 769, Gabon
    Virol J 9:254. 2012
    ..In Gabon, a central African country, the prevalence of antibodies to HEV among pregnant women is 14.1%. Recent studies have demonstrated unusual patterns of hepatitis E (chronic hepatitis, cirrhosis) among immunodeficient patients...
  5. pmc Prevalence and molecular diversity of hepatitis B virus and hepatitis delta virus in urban and rural populations in northern Gabon in central Africa
    Maria Makuwa
    Unité de virologie, Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    J Clin Microbiol 47:2265-8. 2009
    ..Phylogenetic analysis showed the circulation of HBV-A3 and -E genotypes and the presence of HDV-1, HDV-7, and HDV-8 clades...
  6. pmc New insights into prevalence, genetic diversity, and proviral load of human T-cell leukemia virus types 1 and 2 in pregnant women in Gabon in equatorial central Africa
    Sonia Lekana Douki Etenna
    Département de Rétrovirologie, Centre International de Recherches Medicales, BP 769 Franceville, Gabon
    J Clin Microbiol 46:3607-14. 2008
    ..The sole HTLV-2 strain belonged to subtype B. In this study we showed that the prevalence of HTLV-1 in the southeast is one of the highest in the world for pregnant women...
  7. doi Simian immunodeficiency virus types 1 and 2 (SIV mnd 1 and 2) have different pathogenic potentials in rhesus macaques upon experimental cross-species transmission
    Sandrine Souquiere
    Laboratoire de Retrovirologie, Centre International de Recherches Médicales CIRMF, Franceville, Gabon
    J Gen Virol 90:488-99. 2009
    ..The demonstration of the ability of both SIVmnd types to induce persistent infections in rhesus macaques calls for a careful assessment of the potential of these two viruses to emerge as new human pathogens...
  8. doi High HIV Type 1 prevalence and wide genetic diversity with dominance of recombinant strains but low level of antiretroviral drug-resistance mutations in untreated patients in northeast Gabon, Central Africa
    Armel Mintsa-Ndong
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    AIDS Res Hum Retroviruses 25:411-8. 2009
    ..The wide diversity and the emergence of recombinant strains are in accordance with the rapid spread of new HIV strains in the population and, thus, the dynamic evolution of the epidemic...
  9. pmc Phylogeography, risk factors and genetic history of hepatitis C virus in Gabon, central Africa
    Richard Njouom
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    PLoS ONE 7:e42002. 2012
    ..The aim of this study was to determine the prevalence, genotype distribution and epidemic history of HCV in the Gabonese general population...
  10. pmc Prevalence and genetic diversity of hepatitis B and delta viruses in pregnant women in Gabon: molecular evidence that hepatitis delta virus clade 8 originates from and is endemic in central Africa
    Maria Makuwa
    Laboratoire de Virologie, Centre International de Recherches Medicales, BP 769, Franceville, Gabon
    J Clin Microbiol 46:754-6. 2008
    ..6% of the HBsAg-positive women. The HBV strains were of the A3 and E genotypes. The HDV strains belonged to HDV clades 1 and 8. These results provide clear evidence that HDV clade 8 is indigenous to Africa...
  11. pmc Cross-species transmission of simian foamy virus to humans in rural Gabon, Central Africa
    Augustin Mouinga-Ondeme
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    J Virol 86:1255-60. 2012
    ..All but one were infected with ape SFV. We thus found novel SFV strains in NHPs in Gabon and high cross-species transmission of SFVs from gorilla bites...
  12. doi Absence of intrafamilial transmission of hepatitis C virus and low risk for sexual transmission in rural central Africa indicate a cohort effect
    Guy Roger Ndong-Atome
    Departement de Virologie, Centre International de Recherches Medicales de Franceville CIRMF, BP 769, Franceville, Gabon
    J Clin Virol 45:349-53. 2009
    ..Intrafamilial and sexual transmission of hepatitis C virus (HCV) are still being debated, and little is known about such transmission in central Africa...
  13. pmc New strain of simian immunodeficiency virus identified in wild-born chimpanzees from central Africa
    Sandrine Souquiere
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    PLoS ONE 7:e44298. 2012
    ..Further field studies with non-invasive methods are needed to determine the prevalence, geographic distribution, species association, and natural history of SIVcpz strains in the chimpanzee habitat in Gabon...
  14. pmc High prevalence of both humoral and cellular immunity to Zaire ebolavirus among rural populations in Gabon
    Pierre Becquart
    Unité des Maladies Virales Emergentes, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    PLoS ONE 5:e9126. 2010
    ..These findings provide significant new insights into ZEBOV circulation and human exposure, and raise important questions as to the human pathogenicity of ZEBOV and the existence of natural protective immunization...
  15. doi Protective properties of non-nucleoside reverse transcriptase inhibitor (MC1220) incorporated into liposome against intravaginal challenge of Rhesus macaques with RT-SHIV
    Melanie Caron
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, BP 769, Gabon
    Virology 405:225-33. 2010
    ..The RNA viral load at necropsy was significantly lower (p=0.05) in treated-infected animals than in controls. In both protocols, the number of CD4+ T cells was lower at viremia peak in infected than in protected animals...
  16. doi Risk factors for Zaire ebolavirus--specific IgG in rural Gabonese populations
    Dieudonné Nkoghe
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    J Infect Dis 204:S768-75. 2011
    ..In Gabon, several Ebolavirus outbreaks have occurred exclusively in the northeastern region. We conducted a large serosurvey to identify areas and populations at risk and potential demographic, clinical, and behavioral risk factors...
  17. pmc Hepatitis E virus is highly prevalent among pregnant women in Gabon, central Africa, with different patterns between rural and urban areas
    Melanie Caron
    Departement de Virologie, Centre International de Recherches Médicales CIRMF, BP 769, Franceville, Gabon
    Virol J 5:158. 2008
    ..05) in seroprevalence was found between rural (6.4%) and urban (13.5%) areas. These data provide evidence of a high prevalence of HEV in Gabon, providing indirect evidence of past contact with this virus...
  18. doi Human immunodeficiency virus type 1 seroprevalence and antiretroviral drug resistance-associated mutations in miners in Gabon, central Africa
    Melanie Caron
    Unité de Rétrovirologie, Centre International de Recherches Medicales, Franceville, Gabon
    AIDS Res Hum Retroviruses 24:1225-8. 2008
    ..To avoid the rapid emergence of resistant viruses in this part of central Africa, continuous surveillance of the circulation of drug-resistant viruses must be maintained to guide treatment strategies...
  19. pmc Prevalence, genetic diversity and antiretroviral drugs resistance-associated mutations among untreated HIV-1-infected pregnant women in Gabon, central Africa
    Melanie Caron
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville BP 769, Gabon
    BMC Infect Dis 12:64. 2012
    ..In Africa, the wide genetic diversity of HIV has resulted in emergence of new strains, rapid spread of this virus in sub-Saharan populations and therefore spread of the HIV epidemic throughout the continent...
  20. pmc Dynamic interaction between STLV-1 proviral load and T-cell response during chronic infection and after immunosuppression in non-human primates
    Sandrine Souquiere
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    PLoS ONE 4:e6050. 2009
    ..Such studies would provide important information for the development of immune-based therapeutic strategies...
  21. doi Prevention of vaginal simian immunodeficiency virus transmission in macaques by postexposure prophylaxis with zidovudine, lamivudine and indinavir
    Olivier Bourry
    Centre de Primatologie, Centre International de Recherches Medicales de Franceville, Franceville, France
    AIDS 23:447-54. 2009
    ..To evaluate the efficacy of postexposure prophylaxis with a combination of zidovudine (ZDV), lamivudine (3TC) and indinavir (IDV), after vaginal exposure to HIV...
  22. pmc Two distinct variants of simian foamy virus in naturally infected mandrills (Mandrillus sphinx) and cross-species transmission to humans
    Augustin Mouinga-Ondeme
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Retrovirology 7:105. 2010
    ..We evaluated the natural history of the virus in a free-ranging colony of mandrills and investigated possible transmission of mandrill SFV to humans...
  23. pmc One-step, multiplex, real-time PCR assay with molecular beacon probes for simultaneous detection, differentiation, and quantification of human T-cell leukemia virus types 1, 2, and 3
    Guillaume Besson
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    J Clin Microbiol 47:1129-35. 2009
    ..Our new method also could be used for epidemiological studies in Africa and in countries where HTLVs and STLVs are endemic...
  24. doi T-cell tropism of simian T-cell leukaemia virus type 1 and cytokine profiles in relation to proviral load and immunological changes during chronic infection of naturally infected mandrills (Mandrillus sphinx)
    Sandrine Souquiere
    Département de Rétrovirologie, Centre International de Recherches Medicales de Franceville CIRMF, Franceville, Gabon
    J Med Primatol 38:279-89. 2009
    ..Although a wide variety of non-human primates are susceptible to simian T-cell leukaemia virus type 1 (STLV-1), little is known about the virological or molecular determinants of natural STLV-1 infection...
  25. pmc Early introduction and delayed dissemination of pandemic influenza, Gabon
    Sonia Etenna Lekana-Douki
    Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Emerg Infect Dis 19:644-7. 2013
    ..We found that pH1N1 virus was introduced in mid-2009 but spread throughout the country in 2010. Thus, Gabon was also affected by pH1N1...
  26. ncbi Complete-genome analysis of hepatitis B virus from wild-born chimpanzees in central Africa demonstrates a strain-specific geographical cluster
    Maria Makuwa
    Centre International de Recherches Medicales de Franceville, Unité de Rétrovirologie et Centre de Primatologie, Franceville, Gabon
    J Gen Virol 88:2679-85. 2007
    ..The strong phylogenetic associations of ChHBV sequences with both chimpanzee subspecies and their geographical origin were therefore confirmed...
  27. pmc Hepatitis C virus prevalence and genetic diversity among pregnant women in Gabon, central Africa
    Guy Roger Ndong-Atome
    Laboratoire de Virologie, Centre International de Recherches Médicales CIRMF, BP 769, Franceville, Gabon
    BMC Infect Dis 8:82. 2008
    ..The prevalence and genetic diversity of HCV in pregnant women in Gabon, central Africa, is not known. We therefore evaluated the prevalence and the circulating genotypes of HCV in a large population cohort of pregnant women...
  28. pmc Simian foamy virus in non-human primates and cross-species transmission to humans in Gabon: an emerging zoonotic disease in central Africa?
    Augustin Mouinga-Ondeme
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville CIRMF, Franceville BP 769, Gabon
    Viruses 5:1536-52. 2013
    ..In this review, we summarize and discuss our five-year observations on the prevalence and dissemination of SFV in humans and non-human primates in Gabon...
  29. ncbi Identification of hepatitis B virus subgenotype A3 in rural Gabon
    Maria Makuwa
    Laboratoire de Retrovirologie, Centre International de Recherches Medicales, CIRMF, Franceville, Gabon
    J Med Virol 78:1175-84. 2006
    ..Two full genome sequences of two new Gabonese HBV isolates are also presented and confirm the distinctive HBV-Gab-A3 cluster...