Yves L Janin

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?
    Yves L Janin
    URA 2128 CNRS Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Med Chem 48:7503-12. 2005
  2. ncbi request reprint Antituberculosis drugs: ten years of research
    Yves L Janin
    URA 2128 CNRS Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Bioorg Med Chem 15:2479-513. 2007
  3. doi request reprint ATPase inhibitors of heat-shock protein 90, second season
    Yves L Janin
    Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Drug Discov Today 15:342-53. 2010
  4. doi request reprint Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity
    Luke Alvey
    Institut Pasteur, URA 2128 CNRS Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Eur J Med Chem 44:2497-505. 2009
  5. doi request reprint A new synthetic access to furo[3,2-f]chromene analogues of an antimycobacterial
    Luke Alvey
    Laboratoire de Chimie Organique, URA 2128 CNRS Institut Pasteur, 25 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France
    Bioorg Med Chem 16:8264-72. 2008
  6. doi request reprint 5-Iodo-3-ethoxypyrazoles: an entry point to new chemical entities
    Sandrine Guillou
    Institut Pasteur, URA 2128 CNRS Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15 France, Fax 33 145688404
    Chemistry 16:4669-77. 2010
  7. ncbi request reprint Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues
    Soizic Prado
    Laboratoire de Chimie Organique, URA 2128 CNRS Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Bioorg Med Chem 15:2177-86. 2007
  8. pmc Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis
    Jana Kordulakova
    Unite de Genetique Mycobacterienne, URA 2128 CNRS Institute Pasteur, Paris, France
    Antimicrob Agents Chemother 51:3824-9. 2007

Collaborators

  • S T Cole
  • Avraham Liav
  • Mary Jackson
  • Luke Alvey
  • Soizic Prado
  • Michel Koch
  • Brigitte Saint-Joanis
  • Sylvie Michel
  • Francois Tillequin
  • Sandrine Guillou
  • Jana Kordulakova
  • Valerie Huteau
  • Patrick J Brennan
  • Priscille Brodin
  • Jean Rauzier
  • Pierre Etienne Bost
  • Tiago Dos Vultos
  • Brigitte Gicquel
  • Nathalie Barilone

Detail Information

Publications8

  1. ncbi request reprint Heat shock protein 90 inhibitors. A text book example of medicinal chemistry?
    Yves L Janin
    URA 2128 CNRS Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Med Chem 48:7503-12. 2005
  2. ncbi request reprint Antituberculosis drugs: ten years of research
    Yves L Janin
    URA 2128 CNRS Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Bioorg Med Chem 15:2479-513. 2007
    ..This is followed by other inhibitors of M. tuberculosis growth, including recently reported compounds devoid of a reported mechanism of action...
  3. doi request reprint ATPase inhibitors of heat-shock protein 90, second season
    Yves L Janin
    Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Drug Discov Today 15:342-53. 2010
    ..On the medicinal chemistry side, a second wave of inhibitors has been reported. This review attempts to describe all the ATPase inhibitors of HSP90 reported since our last survey...
  4. doi request reprint Diversity-oriented synthesis of furo[3,2-f]chromanes with antimycobacterial activity
    Luke Alvey
    Institut Pasteur, URA 2128 CNRS Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Eur J Med Chem 44:2497-505. 2009
    ..However, the many analogues which inhibited the growth of M. tuberculosis in the 0.6-5 microg/mL range turned out to be also cytotoxic on VERO cells growth at the same concentration range...
  5. doi request reprint A new synthetic access to furo[3,2-f]chromene analogues of an antimycobacterial
    Luke Alvey
    Laboratoire de Chimie Organique, URA 2128 CNRS Institut Pasteur, 25 28 Rue du Docteur Roux, 75724 Paris Cedex 15, France
    Bioorg Med Chem 16:8264-72. 2008
    ..Their biological evaluation on the growth of Mycobacterium smegmatis as well as Mycobacterium tuberculosis pointed out that some analogues were four times more active than the initial hit...
  6. doi request reprint 5-Iodo-3-ethoxypyrazoles: an entry point to new chemical entities
    Sandrine Guillou
    Institut Pasteur, URA 2128 CNRS Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15 France, Fax 33 145688404
    Chemistry 16:4669-77. 2010
    ..As a conclusion of this work, we conducted an investigation into the regiochemistry of the condensation between diethyl 2-(ethoxymethylene)malonate and the hydrochloride salts of methyl, benzyl, or phenyl hydrazine. ..
  7. ncbi request reprint Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues
    Soizic Prado
    Laboratoire de Chimie Organique, URA 2128 CNRS Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Bioorg Med Chem 15:2177-86. 2007
    ..We wish to report here the preparation of some structural analogues along with their biological effect on the growth of Mycobacterium smegmatis, M. tuberculosis, as well as on VERO cells for the most active compound...
  8. pmc Isoxyl activation is required for bacteriostatic activity against Mycobacterium tuberculosis
    Jana Kordulakova
    Unite de Genetique Mycobacterienne, URA 2128 CNRS Institute Pasteur, Paris, France
    Antimicrob Agents Chemother 51:3824-9. 2007
    ....