A Italiano

Summary

Affiliation: Institut Bergoni
Country: France

Publications

  1. pmc SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors
    Antoine Italiano
    Departments of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    BMC Cancer 12:408. 2012
  2. pmc Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Cancer 118:5878-87. 2012
  3. pmc Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Eur J Cancer 48:3215-22. 2012
  4. doi request reprint Advanced well-differentiated/dedifferentiated liposarcomas: role of chemotherapy and survival
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 23:1601-7. 2012
  5. doi request reprint Comparison of doxorubicin and weekly paclitaxel efficacy in metastatic angiosarcomas
    Antoine Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Cancer 118:3330-6. 2012
  6. doi request reprint Patterns of care, prognosis, and survival in patients with metastatic gastrointestinal stromal tumors (GIST) refractory to first-line imatinib and second-line sunitinib
    Antoine Italiano
    Institut Bergonie, Bordeaux, France
    Ann Surg Oncol 19:1551-9. 2012
  7. pmc The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Genes Chromosomes Cancer 51:569-78. 2012
  8. doi request reprint "Metronomic" chemotherapy in advanced soft tissue sarcomas
    Antoine Italiano
    Department of Medical Oncology, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Cancer Chemother Pharmacol 66:197-202. 2010
  9. ncbi request reprint Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: a multivariate analysis of the French Sarcoma Group Database
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 21:2436-41. 2010
  10. ncbi request reprint Clinical outcome of leiomyosarcomas of vascular origin: comparison with leiomyosarcomas of other origin
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 21:1915-21. 2010

Detail Information

Publications49

  1. pmc SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors
    Antoine Italiano
    Departments of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    BMC Cancer 12:408. 2012
    ..A recent report identified four non-syndromic, KIT/PDGFRA WT GIST harboring compound heterozygous or homozygous mutations in SDHA encoding the main subunit of the SDH complex II...
  2. pmc Alterations of the p53 and PIK3CA/AKT/mTOR pathways in angiosarcomas: a pattern distinct from other sarcomas with complex genomics
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Cancer 118:5878-87. 2012
    ..The scale of genetic abnormalities in these pathways remains unknown in angiosarcoma (AS)...
  3. pmc Patterns of deregulation of insulin growth factor signalling pathway in paediatric and adult gastrointestinal stromal tumours
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Eur J Cancer 48:3215-22. 2012
    ..Data regarding the patterns and the mechanisms of deregulation of the insulin growth factor (IGF) pathway in adult and paediatric gastrointestinal stromal tumours (GISTs) are limited...
  4. doi request reprint Advanced well-differentiated/dedifferentiated liposarcomas: role of chemotherapy and survival
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 23:1601-7. 2012
    ..Data regarding the role of systemic therapy in patients with advanced well-differentiated/dedifferentiated liposarcomas (WDLPS/DDLPS) are limited...
  5. doi request reprint Comparison of doxorubicin and weekly paclitaxel efficacy in metastatic angiosarcomas
    Antoine Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Cancer 118:3330-6. 2012
    ..Data regarding the role of anthracyclines and taxanes as first-line treatments of metastatic angiosarcoma are limited...
  6. doi request reprint Patterns of care, prognosis, and survival in patients with metastatic gastrointestinal stromal tumors (GIST) refractory to first-line imatinib and second-line sunitinib
    Antoine Italiano
    Institut Bergonie, Bordeaux, France
    Ann Surg Oncol 19:1551-9. 2012
    ..Data regarding the management and outcome of patients with metastatic gastrointestinal stromal tumors (GIST) refractory to 1st-line imatinib and 2nd-line sunitinib are limited...
  7. pmc The miR-17-92 cluster and its target THBS1 are differentially expressed in angiosarcomas dependent on MYC amplification
    Antoine Italiano
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Genes Chromosomes Cancer 51:569-78. 2012
    ..Thus, MYC amplification may play a crucial role in the angiogenic phenotype of AS through upregulation of the miR-17-92 cluster, which subsequently downregulates THBS1, a potent endogenous inhibitor of angiogenesis...
  8. doi request reprint "Metronomic" chemotherapy in advanced soft tissue sarcomas
    Antoine Italiano
    Department of Medical Oncology, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Cancer Chemother Pharmacol 66:197-202. 2010
    ..Endothelial cells are the primary target of metronomic chemotherapy. We report the safety and the efficacy of metronomic chemotherapy in metastatic STS patients...
  9. ncbi request reprint Effect of adjuvant chemotherapy on survival in FNCLCC grade 3 soft tissue sarcomas: a multivariate analysis of the French Sarcoma Group Database
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 21:2436-41. 2010
    ..The predictive value of grade for benefit from adjuvant chemotherapy (AC) in soft tissue sarcoma (STS) patients has never been explored...
  10. ncbi request reprint Clinical outcome of leiomyosarcomas of vascular origin: comparison with leiomyosarcomas of other origin
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 21:1915-21. 2010
    ..There are no data about the natural history of leiomyosarcoma of vascular origin (vLMS) in comparison with leiomyosarcoma (LMS) of other origin and about the management of advanced disease...
  11. ncbi request reprint [Chemotherapy options for patients with advanced soft-tissue sarcoma beyond anthracyclines]
    A Italiano
    Institut Bergonie, Departement d Oncologie Medicale, 229, cours de l Argonne, 33076 Bordeaux Cedex, France
    Bull Cancer 97:679-86. 2010
    ..Further studies are needed in order to identify predictive factors of clinical benefit in advanced soft-tissue sarcoma patients treated with cytotoxic agents in combination or not with targeted therapies...
  12. doi request reprint Temsirolimus in advanced leiomyosarcomas: patterns of response and correlation with the activation of the mammalian target of rapamycin pathway
    Antoine Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, Cedex, France
    Anticancer Drugs 22:463-7. 2011
    ..Further investigations of the phosphoinositide 3-kinases/PTEN/Akt/mTOR pathway are needed to explore the role of mTOR inhibitors, either alone or in combination, in patients with advanced sarcoma...
  13. doi request reprint KRAS and BRAF mutational status in primary colorectal tumors and related metastatic sites: biological and clinical implications
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Ann Surg Oncol 17:1429-34. 2010
    ..The question of primary resistance to anti-EGFR treatment as a result of the presence of KRAS or BRAF mutations only in metastases has been raised but not resolved...
  14. ncbi request reprint Neo/adjuvant chemotherapy does not improve outcome in resected primary synovial sarcoma: a study of the French Sarcoma Group
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 20:425-30. 2009
    ..There are only scarce data about the benefit of adjunctive chemotherapy in patients with localized synovial sarcoma (SS)...
  15. doi request reprint Trends in survival for patients with metastatic soft-tissue sarcoma
    Antoine Italiano
    Department of Medical Oncology, Bergonie Institute, Bordeaux, France
    Cancer 117:1049-54. 2011
    ..The objective of this study was to determine whether the overall survival of patients with metastatic soft tissue sarcoma (STS) has improved over the last 20 years...
  16. ncbi request reprint Clinical and biological significance of CDK4 amplification in well-differentiated and dedifferentiated liposarcomas
    Antoine Italiano
    Laboratory of Solid Tumors Genetics and Department of Pathology, Nice University Hospital, Nice, France
    Clin Cancer Res 15:5696-703. 2009
    ..Our goal was to determine whether the absence of CDK4 amplification was (a) correlated to a specific clinico-histopathologic profile; and (b) compensated by another genomic anomaly involving the CCND1/CDK4/P16INK4a/RB1/E2F pathway...
  17. doi request reprint High-dose chemotherapy consolidation for chemosensitive advanced soft tissue sarcoma patients: an open-label, randomized controlled trial
    B Bui-Nguyen
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 23:777-84. 2012
    ..This randomized open phase III study examines whether high-dose (HD) chemotherapy with peripheral blood stem cells (PBSCs) could improve overall survival (OS) of chemosensitive patients...
  18. doi request reprint Chemotherapy in patients with desmoid tumors: a study from the French Sarcoma Group (FSG)
    D Garbay
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 23:182-6. 2012
    ..Data regarding the role of chemotherapy (CT) in patients with recurrent and/or unresectable desmoid tumors (DTs) are scarce...
  19. ncbi request reprint [Helical tomotherapy for axial and paraspinal tumours: experience of Institut Bergonié (14 cases)]
    H Haddad
    Departement de Radiotherapie, Institut Bergonie, Centre Régional de Lutte Contre le Cancer de Bordeaux et du Sud Ouest, 229 Cours de l Argonne, Bordeaux Cedex, France
    Cancer Radiother 15:404-12. 2011
    ..To evaluate the feasibility of helical tomotherapy intensity-modulated radiotherapy for the treatment of axial and paraspinal tumours...
  20. pmc Advanced chondrosarcomas: role of chemotherapy and survival
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux
    Ann Oncol 24:2916-22. 2013
    ..There are limited data about the role of chemotherapy in patients with advanced chondrosarcomas...
  21. pmc GDC-0449 in patients with advanced chondrosarcomas: a French Sarcoma Group/US and French National Cancer Institute Single-Arm Phase II Collaborative Study
    A Italiano
    Department of Medical Oncology, Institut Bergonie, Bordeaux
    Ann Oncol 24:2922-6. 2013
    ..Pre-clinical data have suggested a therapeutic role of Hedgehog (Hh) pathway inhibitors in chondrosarcoma...
  22. ncbi request reprint Retroperitoneal sarcomas: patterns of care at diagnosis, prognostic factors and focus on main histological subtypes: a multicenter analysis of the French Sarcoma Group
    M Toulmonde
    Department of Medical Oncology, Institut Bergonie, Bordeaux
    Ann Oncol 25:735-42. 2014
    ..This study addresses these specific points in a homogeneous cohort of patients with completely resected primary RPS...
  23. ncbi request reprint Retroperitoneal sarcomas: patterns of care in advanced stages, prognostic factors and focus on main histological subtypes: a multicenter analysis of the French Sarcoma Group
    M Toulmonde
    Department of Medical Oncology, Institut Bergonie, Bordeaux
    Ann Oncol 25:730-4. 2014
    ..There is no available report assessing palliative chemotherapy in advanced RPS. This study analyzes management and outcome in a large cohort of patients with advanced RPS, considering main histological subtypes separately...
  24. doi request reprint Advanced soft-tissue sarcoma in elderly patients: patterns of care and survival
    D Garbay
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Ann Oncol 24:1924-30. 2013
    ..There are no data regarding the management of advanced soft-tissue sarcoma (STS) in elderly patients...
  25. ncbi request reprint Aromatase inhibition in male breast cancer patients: biological and clinical implications
    J Doyen
    Department of Medical Oncology, Centre Antoine Lacassagne, Nice, France
    Ann Oncol 21:1243-5. 2010
    ..The role of aromatase inhibitors (AIs) and their impact on estradiol (E(2)) levels remain unknown in male breast cancer (MBC) patients...
  26. ncbi request reprint [Surgical margins in soft tissue sarcoma]
    E Stoeckle
    Institut Bergonie, Centre Regional de Lutte Contre le Cancer, Bordeaux, France
    Bull Cancer 95:1199-204. 2008
    ..To state about adequacy of surgery margins in soft tissue sarcoma (STS)...
  27. ncbi request reprint [Adjuvant chemotherapy of adults soft tissue sarcomas]
    B Bui-Nguyen
    Institut Bergonie, Departement d Oncologie Medicale, 229, cours de l Argonne, 33076 Bordeaux Cedex, France
    Bull Cancer 97:673-8. 2010
    ..This needs a better understanding of the biology of those tumors, of metastases risk factors and of the determinants of systemic therapies efficacy in these tumors...
  28. doi request reprint Quality of randomized controlled trials reporting in the treatment of sarcomas
    Maud Toulmonde
    Institut Bergonie, Bordeaux, France
    J Clin Oncol 29:1204-9. 2011
    ..Randomized controlled trials (RCTs) represent the best evidence in oncology practice. The aim of this study was to assess the reporting quality of sarcoma RCTs and to identify significant predictors of quality...
  29. pmc Adherence to consensus-based diagnosis and treatment guidelines in adult soft-tissue sarcoma patients: a French prospective population-based study
    S Mathoulin-Pelissier
    Clinical and Epidemiological Research Unit, Institut Bergonie, Comprehensive Cancer Centre, Bordeaux
    Ann Oncol 25:225-31. 2014
    ..Management and treatment are thus complex, but crucial for patient outcomes. We assess adherence to adult STS management guidelines across two French regions (10% of the French population). We also report standardized incidence...
  30. ncbi request reprint [Normal tissue tolerance to external beam radiation therapy: adult bone]
    P Sargos
    Departement de Radiotherapie, Centre Regional de Lutte Contre le Cancer, Institut Bergonie, 229 Cours de l Argonne, 33076 Bordeaux Cedex, France
    Cancer Radiother 14:386-91. 2010
    ..Dose-effect relations are difficult to qualify in older series. Recent models evaluating radiations toxicity on diaphysa suggest an important risk after 60 Gy, for high dose-fraction and for a large volume...
  31. doi request reprint Treatment of advanced gastrointestinal stromal tumors in patients over 75 years old: clinical and pharmacological implications
    A Italiano
    Department of Medical Oncology, Institut Bergonie, 229 Cours de l Argonne, 33076, Bordeaux Cedex, France
    Target Oncol 8:295-300. 2013
    ..Overall survival is similar to that of younger patients. Comorbidities did not result in increased incidence of toxicity. Careful follow-up regarding tolerance issues should be considered in elderly patients with poor PS...
  32. doi request reprint Sarcoma lung metastases treated with percutaneous radiofrequency ablation: results from 29 patients
    J Palussiere
    Department of Radiology, Institut Bergonie, Regional Cancer Center, Bordeaux, France
    Ann Surg Oncol 18:3771-7. 2011
    ..We aimed to determine safety and efficacy of radiofrequency ablation (RFA) in the treatment of lung metastases arising from sarcoma...
  33. ncbi request reprint Comparison of the epidermal growth factor receptor gene and protein in primary non-small-cell-lung cancer and metastatic sites: implications for treatment with EGFR-inhibitors
    A Italiano
    Department of Medical Oncology, Centre Antoine Lacassagne, Nice, France
    Ann Oncol 17:981-5. 2006
    ..However, it is still not known whether EGFR expression differs in metastases compared to primary non-small cell lung cancer (NSCLC)...
  34. ncbi request reprint Targeting the epidermal growth factor receptor in colorectal cancer: advances and controversies
    Antoine Italiano
    Department of Medical Oncology, Centre Regional de Lutte Contre le Cancer Antoine Lacassagne, Canceropôle PACA, Nice, France
    Oncology 70:161-7. 2006
    ..However, expression of EGFR did not correlate with clinical benefit. Clearly, the search for markers of response to treatment against EGFR must go on...
  35. doi request reprint EGFR and KRAS status of primary sarcomatoid carcinomas of the lung: implications for anti-EGFR treatment of a rare lung malignancy
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, Nice, France
    Int J Cancer 125:2479-82. 2009
    ..The rare incidence of increased EGFR gene copy number, the lack of EGFR mutation and the high rate of KRAS mutation observed in our series also suggest that most patients with lung SC are not likely to benefit from anti-EGFR therapies...
  36. doi request reprint Bone marrow metastases in a patient with primary mediastinal non-seminomatous germ cell tumor - an unusual pattern of relapse
    Delphine Garbay
    Department of Medical Oncology, Institut Bergonie, Bordeaux, France
    Onkologie 35:40-2. 2012
    ..Bone marrow is a very unusual site of metastasis for germ cell tumors...
  37. ncbi request reprint Linea alba tumoral (sarcomatous) hernia
    P Y Marcy
    Radiology Department, Centre Antoine Lacassagne, Nice, France
    JBR-BTR 89:103. 2006
  38. ncbi request reprint Home infusions of biphosphonate in cancer patients: a prospective study
    A Italiano
    Centre Regional de Lutte Contre le Cancer Antoine Lacassagne Canceropôle PACA, Nice, France
    J Chemother 18:217-20. 2006
    ....
  39. doi request reprint [Multifocal Langerhans cell histiocytosis of bone: indications for radiotherapy]
    G L Gaundong Mbéthé
    Service de Radiotherapie, Centre Regional de Lutte Contre le Cancer, Institut Bergonie, 229, cours de l Argonne, 33076 Bordeaux Cedex, France
    Cancer Radiother 14:759-62. 2010
    ..The decision of radiotherapy must be weighed against the risk of the disease. Caution should be the rule in this non-malignant tumour pathology...
  40. ncbi request reprint Cetuximab shows activity in colorectal cancer patients with tumors for which FISH analysis does not detect an increase in EGFR gene copy number
    Antoine Italiano
    Department of Medical Oncology, Centre Antoine Lacassagne, Canceropôle PACA, Nice, France
    Ann Surg Oncol 15:649-54. 2008
    ..The aim or our study was to relate the EGFR gene copy number to therapeutic results in patients with metastatic colorectal cancer (CRC) treated with a cetuximab-containing regimen...
  41. ncbi request reprint Molecular cytogenetic characterization of a metastatic lung sarcomatoid carcinoma: 9p23 neocentromere and 9p23-p24 amplification including JAK2 and JMJD2C
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Centre Hospitalier Universitaire de Nice and CNRS UMR 6543, Faculte de Medecine, 28 Avenue de Valombrose, 06107 Nice, France
    Cancer Genet Cytogenet 167:122-30. 2006
    ..The frequency of neocentromere formation in solid tumors may indeed be underestimated and may have a significant implication in chromosomal instability in tumor cells...
  42. doi request reprint HMGA2 is the partner of MDM2 in well-differentiated and dedifferentiated liposarcomas whereas CDK4 belongs to a distinct inconsistent amplicon
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital, and CNRS, UMR 6543, Faculty of Medicine, Nice, France
    Int J Cancer 122:2233-41. 2008
    ..We also found a frequent amplification and overexpression of YEATS4, an oncogene that inactivates P53, suggesting that YEATS4 might play an important role together with MDM2 in WDLPS/DDLPS oncogenesis...
  43. doi request reprint Quality of reporting of phase II trials: a focus on highly ranked oncology journals
    T Grellety
    Department of Medical Oncology, Institut Bergonie, Regional Comprehensive Cancer Centre, Bordeaux
    Ann Oncol 25:536-41. 2014
    ..This study assesses the quality of their reporting in highly ranked oncology journals, investigates predictive factors of quality, and proposes reporting guidelines...
  44. ncbi request reprint Dedifferentiated liposarcoma of the pleura mimicking a malignant solitary fibrous tumor and associated with dedifferentiated liposarcoma of the mediastinum: usefulness of cytogenetic and molecular genetic analyses
    Maxime Benchetritt
    Laboratory of Clinical and Experimental Pathology, 30 Avenue de la Voie Romaine, Louis Pasteur Hospital, 06002, Nice, France
    Cancer Genet Cytogenet 179:150-5. 2007
    ..Array comparative genomic hybridization showed amplifications of chromosome arms 6q, 12q, and 15q, shared by both tumors and strongly pointing to a common origin...
  45. doi request reprint Monosomy 7 and absence of 12q amplification in two cases of spindle cell liposarcomas
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Faculty of Medicine, Nice University Hospital, 28 Avenue de Valombrose, 06107 Nice, France
    Cancer Genet Cytogenet 184:99-104. 2008
    ..On the basis of cytogenetic and molecular findings, some SCL may constitute an independent entity rather than being regarded as variants of WDLPS...
  46. ncbi request reprint Gains and complex rearrangements of the 12q13-15 chromosomal region in ordinary lipomas: the "missing link" between lipomas and liposarcomas?
    Antoine Italiano
    Faculty of Medicine, Laboratory of Solid Tumors Genetics, Nice University Hospital and CNRS UMR 6543, Nice, France
    Int J Cancer 121:308-15. 2007
    ..Some of these intermediary forms may correspond to a genomic premalignant condition while some may have no malignant potential...
  47. ncbi request reprint [Gastrointestinal stromal tumors: molecular aspects and therapeutic implications]
    Antoine Italiano
    Centre Antoine Lacassagne, Departement d Oncologie Medicale, Nice, France
    Bull Cancer 95:107-16. 2008
    ....
  48. doi request reprint Variability of origin for the neocentromeric sequences in analphoid supernumerary marker chromosomes of well-differentiated liposarcomas
    Antoine Italiano
    Laboratory of Solid Tumors Genetics, Nice University Hospital and CNRS UMR 6543, Faculty of Medicine, 28 Avenue de Valombrose, 06107 Nice, France
    Cancer Lett 273:323-30. 2009
    ..These sequences might be activated for centromeric function by epigenetic mechanisms...
  49. ncbi request reprint Tumour response to paclitaxel in an adult with relapsed nephroblastoma
    Antoine Italiano
    Antoine Lacassagne Centre, Department of Medical Oncology, Nice, France
    Lancet Oncol 6:252-3. 2005