Alain Israel

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain
    E Laplantine
    Unite de Signalisation Moleculaire et Activation Cellulaire, Institut Pasteur, URA 2582 CNRS, Paris, France
    EMBO J 28:2885-95. 2009
  2. ncbi request reprint The IKK complex: an integrator of all signals that activate NF-kappaB?
    A Israel
    Unité de Biologie Moléculaire de l Expression Génique, URA 1773 CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Trends Cell Biol 10:129-33. 2000
  3. ncbi request reprint NF-kappaB activation: Nondegradative ubiquitination implicates NEMO
    Alain Israel
    Unite de Signalisation Moleculaire et Activation Cellulaire, URA 2582 CNRS Institut Pasteur, 75015 Paris, France
    Trends Immunol 27:395-7. 2006
  4. pmc The IKK complex, a central regulator of NF-kappaB activation
    Alain Israel
    Unite de Signalisation Moleculaire et Activation Cellulaire, URA 2582 CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Cold Spring Harb Perspect Biol 2:a000158. 2010
  5. ncbi request reprint The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration
    Emmanuelle M Six
    Unité de Biologie Moléculaire de l Expression Génique, URA 2582 CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 279:55818-26. 2004
  6. pmc Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor
    Neetu Gupta-Rossi
    Unité de Biologie Moléculaire de l Expression Génique, URA 2582, CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Cell Biol 166:73-83. 2004
  7. pmc AIP4/Itch regulates Notch receptor degradation in the absence of ligand
    Patricia Chastagner
    Unite de Signalisation Moleculaire et Activation Cellulaire, URA 2582, CNRS, Institut Pasteur, Paris, France
    PLoS ONE 3:e2735. 2008
  8. ncbi request reprint The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains
    Fabrice Agou
    Unité de Régulation Enzymatique des Activités Cellulaires, CNRS URA 2185, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 279:27861-9. 2004
  9. doi request reprint DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding
    Olivera Grubisha
    Unité de Biochimie Structurale et Cellulaire, Institut Pasteur, CNRS, URA 2185, Paris, France
    J Mol Biol 395:89-104. 2010
  10. pmc The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity
    Sara Farrah Heuss
    Unite de Signalisation Moleculaire et Activation Cellulaire, Unité de Recherche Associées 2582, Centre National de la Recherche Scientifique, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 105:11212-7. 2008

Collaborators

Detail Information

Publications34

  1. pmc NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain
    E Laplantine
    Unite de Signalisation Moleculaire et Activation Cellulaire, Institut Pasteur, URA 2582 CNRS, Paris, France
    EMBO J 28:2885-95. 2009
    ..We also demonstrate that the recently described binding of NEMO to linear poly-ubiquitin chains is dependent on the NOA alone and does not require the presence of the ZF...
  2. ncbi request reprint The IKK complex: an integrator of all signals that activate NF-kappaB?
    A Israel
    Unité de Biologie Moléculaire de l Expression Génique, URA 1773 CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Trends Cell Biol 10:129-33. 2000
    ....
  3. ncbi request reprint NF-kappaB activation: Nondegradative ubiquitination implicates NEMO
    Alain Israel
    Unite de Signalisation Moleculaire et Activation Cellulaire, URA 2582 CNRS Institut Pasteur, 75015 Paris, France
    Trends Immunol 27:395-7. 2006
    ....
  4. pmc The IKK complex, a central regulator of NF-kappaB activation
    Alain Israel
    Unite de Signalisation Moleculaire et Activation Cellulaire, URA 2582 CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Cold Spring Harb Perspect Biol 2:a000158. 2010
    ..I will review here the genetic, biochemical, and structural data accumulated during the last 10 yr regarding the function of the three IKK subunits...
  5. ncbi request reprint The notch ligand Delta1 recruits Dlg1 at cell-cell contacts and regulates cell migration
    Emmanuelle M Six
    Unité de Biologie Moléculaire de l Expression Génique, URA 2582 CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 279:55818-26. 2004
    ..These results point to a new, probably cell-autonomous function of Delta1, which is independent of its activity as a Notch ligand...
  6. pmc Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor
    Neetu Gupta-Rossi
    Unité de Biologie Moléculaire de l Expression Génique, URA 2582, CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Cell Biol 166:73-83. 2004
    ..We propose a new model where monoubiquitination and endocytosis of Notch are a prerequisite for its PS-dependent cleavage, and discuss its relevance for other gamma-secretase substrates...
  7. pmc AIP4/Itch regulates Notch receptor degradation in the absence of ligand
    Patricia Chastagner
    Unite de Signalisation Moleculaire et Activation Cellulaire, URA 2582, CNRS, Institut Pasteur, Paris, France
    PLoS ONE 3:e2735. 2008
    ..The mammalian ortholog of Su(dx), Itch/AIP4, has been shown to have multiple substrates, including Notch, but the precise events regulated by Itch/AIP4 in the Notch pathway have not been identified yet...
  8. ncbi request reprint The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains
    Fabrice Agou
    Unité de Régulation Enzymatique des Activités Cellulaires, CNRS URA 2185, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 279:27861-9. 2004
    ..This model is discussed in relation to the mechanism of activation of the IKK complex by upstream activators...
  9. doi request reprint DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding
    Olivera Grubisha
    Unité de Biochimie Structurale et Cellulaire, Institut Pasteur, CNRS, URA 2185, Paris, France
    J Mol Biol 395:89-104. 2010
    ..Collectively, these data provide structural insights into how several pathological mutations within and outside of the CC2-LZ's NOA ubiquitin binding site affect IkappaB kinase activation in the NF-kappaB signaling pathway...
  10. pmc The intracellular region of Notch ligands Dll1 and Dll3 regulates their trafficking and signaling activity
    Sara Farrah Heuss
    Unite de Signalisation Moleculaire et Activation Cellulaire, Unité de Recherche Associées 2582, Centre National de la Recherche Scientifique, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 105:11212-7. 2008
    ....
  11. ncbi request reprint Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein
    Annie Olry
    Unite de Signalisation Moleculaire et Activation Cellulaire, URA 2582, CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 280:28564-71. 2005
    ..The first mutation abolishes nicastrin production, and the second mutation, a point mutation in the ectodomain, abolishes nicastrin maturation. In both cases, gamma-secretase activity on Notch and APP is impaired...
  12. ncbi request reprint Combined deficiency in IkappaBalpha and IkappaBepsilon reveals a critical window of NF-kappaB activity in natural killer cell differentiation
    Sandrine I Samson
    Unité des Cytokines et Développement Lymphoide, Institut Pasteur, 25 rue du Dr Roux, 75742 Paris, France
    Blood 103:4573-80. 2004
    ..These results define a critical window in NK cell development in which NF-kappaB levels may be tightly controlled...
  13. doi request reprint Plk1-dependent phosphorylation of optineurin provides a negative feedback mechanism for mitotic progression
    David Kachaner
    Unite de Signalisation Moleculaire et Activation Cellulaire, Institut Pasteur, CNRS URA 2582, 75724 Paris Cedex 15, France
    Mol Cell 45:553-66. 2012
    ..Overall, these results highlight an important role of Optn in the spatial and temporal coordination of Plk1 activity...
  14. ncbi request reprint T-cell-receptor- and B-cell-receptor-mediated activation of NF-kappaB in lymphocytes
    Robert Weil
    Unité de Biologie Moléculaire de l Expression Génique, Unite de Recherche Associee, 2582 Centre National de la Recherche Scientifique, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Curr Opin Immunol 16:374-81. 2004
    ....
  15. doi request reprint Α-arrestin 1 (ARRDC1) and β-arrestins cooperate to mediate Notch degradation in mammals
    Loredana Puca
    Institut Pasteur and CNRS URA 2582, Signalisation Moléculaire et Activation Cellulaire, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Cell Sci 126:4457-68. 2013
    ..Our data show for the first time that ARRDC1 and β-arrestins heterodimerize and cooperate in the same complex to promote non-activated Notch receptor degradation, thus acting as negative regulators of Notch signaling...
  16. pmc The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation
    Julien Moretti
    Institut Pasteur, Unité de Signalisation Moléculaire et Activation Cellulaire and CNRS URA 2582, rue du Dr Roux, Paris, France
    PLoS Biol 8:e1000545. 2010
    ..These data improve our knowledge of Notch signaling but also open new avenues of research on the Zomes family and the translation initiation factors...
  17. pmc The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation
    Julien Moretti
    Institut Pasteur and CNRS Unité de Recherche Associée URA 2582, Signalisation Moléculaire et Activation Cellulaire, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Biol Chem 287:29429-41. 2012
    ..These results characterize a new level of conserved regulation of Notch signaling by the ubiquitin system...
  18. pmc Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10
    Camille Lobry
    Unite de Signalisation Moleculaire et Activation Cellulaire, Unité de Recherche Associée 2582, Centre National de la Recherche Scientifique, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 104:908-13. 2007
    ..Mutants of Bcl10 in the IKK phosphorylation site are resistant to degradation, accumulate in the nucleus, and lead to an increase in IL-2 production after T cell antigen receptor stimulation...
  19. pmc NRP/Optineurin Cooperates with TAX1BP1 to potentiate the activation of NF-kappaB by human T-lymphotropic virus type 1 tax protein
    Chloé Journo
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 3015, Institut Pasteur, Paris, France
    PLoS Pathog 5:e1000521. 2009
    ..Our data strongly suggest for the first time that NRP is a critical adaptor that regulates the assembly of TAX1BP1 and post-translationally modified forms of Tax1, leading to sustained NF-kappaB activation...
  20. pmc The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway
    Neetu Gupta-Rossi
    Unite de Signalisation Moleculaire et Activation Cellulaire, CNRS URA 2582, CNRS URA 2582, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Biol Chem 286:18720-30. 2011
    ..These results suggest that after ligand-induced activation of Notch, the membrane-tethered form can be directed to different endocytic pathways leading to distinct fates...
  21. pmc Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains
    Patricia Chastagner
    Unite de Signalisation Moleculaire et Activation Cellulaire, URA 2582, CNRS, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    EMBO Rep 7:1147-53. 2006
    ..Furthermore, AIP4-generated polyubiquitin chains are mainly conjugated through lysine 29 of ubiquitin in vivo, indicating a link between this type of chain and lysosomal degradation...
  22. pmc IkappaBalpha/IkappaBepsilon deficiency reveals that a critical NF-kappaB dosage is required for lymphocyte survival
    Bertrand Goudeau
    Unité de Biologie Moléculaire de l Expression Génique, Unite de Recherche Associee, Centre National de la Recherche Scientifique 2582, Unité de Biologie Moléculaire du Gène, Paris Cedex 15, France
    Proc Natl Acad Sci U S A 100:15800-5. 2003
    ..Because reduction or rise of NF-kappaB activity leads to similar dysfunction, they also reveal that only a narrow window of NF-kappaB activity is tolerated by lymphocytes...
  23. pmc A glycosphingolipid binding domain controls trafficking and activity of the mammalian notch ligand delta-like 1
    Sara Farrah Heuss
    Unite de Signalisation Moleculaire et Activation Cellulaire, URA CNRS 2582, Institut Pasteur, Paris, France
    PLoS ONE 8:e74392. 2013
    ..Our data indicate that glycosphingolipids, by interacting with Dll1, may act as functional co-factors to promote its biological activity. ..
  24. pmc The NEMO mutation creating the most-upstream premature stop codon is hypomorphic because of a reinitiation of translation
    Anne Puel
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Faculte de Medecine Necker Enfants Malades, 75015 Paris, France
    Am J Hum Genet 78:691-701. 2006
    ..The residual production of an NH(2)-truncated NEMO protein was sufficient for normal fetal development and for the subsequent normal development of skin appendages but was insufficient for the development of protective immune responses...
  25. ncbi request reprint Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection
    Valérie Fridmacher
    Unité de Biologie Moléculaire de l Expression Génique, Centre National de la Recherche Scientifique 2582, Institut Pasteur, Paris Cedex 15, France
    J Neurosci 23:9403-8. 2003
    ..These data demonstrate for the first time that neuron-restricted ablation of NF-kappaB-driven gene expression increases neurodegeneration. This might lead to the path for new treatments of neurodegenerative diseases...
  26. ncbi request reprint Inhibition of NF-kappa B activation by peptides targeting NF-kappa B essential modulator (nemo) oligomerization
    Fabrice Agou
    Unité de Régulation Enzymatique des Activités Cellulaires, CNRS URA 2185, 75724 Paris, France
    J Biol Chem 279:54248-57. 2004
    ..Our results provide the "proof of concept" for a new and promising strategy for the inhibition of NF-kappa B pathway activation through targeting the oligomerization state of the NEMO protein...
  27. ncbi request reprint NEMO trimerizes through its coiled-coil C-terminal domain
    Fabrice Agou
    Unité de Régulation Enzymatique des Activités Cellulaires, Paris Cedex 15, France
    J Biol Chem 277:17464-75. 2002
    ..We propose a model in which the activation of the IKK complex occurs through the trimerization of NEMO upon binding to a not yet identified upstream activator...
  28. doi request reprint TNF and IL-1 exhibit distinct ubiquitin requirements for inducing NEMO-IKK supramolecular structures
    Nadine Tarantino
    Unité de Signalisation Moléculaire et Activation Cellulaire and 2 Laboratoire Trafic Membranaire et Division Cellulaire, Institut Pasteur, Centre National de la Recherche Scientifique URA 2582, Paris 75015, France
    J Cell Biol 204:231-45. 2014
    ..Thus, different mechanisms are involved in the recruitment of NEMO into supramolecular complexes, which appear to be essential for NF-κB activation. ..
  29. ncbi request reprint Arachidonic acid differentially affects basal and lipopolysaccharide-induced sPLA(2)-IIA expression in alveolar macrophages through NF-kappaB and PPAR-gamma-dependent pathways
    Mounia Alaoui-El-Azher
    Unité de Défense Innée et Inflammation and Unité de Biologie Moléculaire de l Expression Génique, Institut Pasteur, Paris, France
    Mol Pharmacol 61:786-94. 2002
    ..In contrast, the inhibition of LPS-stimulated sPLA(2)-IIA expression is mediated by cyclooxygenase-derived metabolites of AA and involves a PPAR-gamma-dependent pathway. These findings provide new insights for the treatment of ALI...
  30. pmc A hypermorphic IkappaBalpha mutation is associated with autosomal dominant anhidrotic ectodermal dysplasia and T cell immunodeficiency
    Gilles Courtois
    Unité de Biologie Moléculaire de l Expression Génique, Centre National de la Recherche Scientifique URA 2582, Institut Pasteur, Paris, France
    J Clin Invest 112:1108-15. 2003
    ..Our report highlights both the diversity of genotypes associated with EDA-ID and the diversity of immunologic phenotypes associated with mutations in different components of the NF-kappaB signaling pathway...
  31. ncbi request reprint [Human pathologies associated with NF-kappaB defects]
    Gilles Courtois
    Unité de Biologie Moléculaire de l Expression Génique, URA 2582 CNRS, Institut Pasteur, 25, rue du Dr Roux, 75724 Paris Cedex 15, France
    J Soc Biol 198:93-6. 2004
    ..This gene encodes a protein which interacts with NEMO and exhibits deubiquitinase activity, therefore strengthening the recent hypothesis of the role of non-degradation-linked ubiquitination in NF-kappaB activation...
  32. pmc From calcium to NF-kappa B signaling pathways in neurons
    Alain Lilienbaum
    Unité de Biologie Moléculaire de l Expression Génique, URA 2582 CNRS, Institut Pasteur, 75724 Paris Cedex 15, France
    Mol Cell Biol 23:2680-98. 2003
    ..By using a global approach in studying signaling pathways in neurons, these results provide further evidence to validate the concept of networks of transducing cascades, specific to cells and to physiological situations...
  33. pmc The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and gamma-secretase
    Emmanuelle Six
    Unité de Biologie Moléculaire de l Expression Génique, Unité de Recherche Associée 2582, Centre National de la Recherche Scientifique, Institut Pasteur, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 100:7638-43. 2003
    ..Therefore Dll1 is a substrate for regulated intramembrane proteolysis, and its intracellular region possibly fulfills a specific function in the nucleus...
  34. ncbi request reprint Induction of the NF-kappaB cascade by recruitment of the scaffold molecule NEMO to the T cell receptor
    Robert Weil
    Unité de Biologie Moléculaire de l Expression Génique, FRE 2364 Centre National de la Recherche Scientifique CNRS, 75724 Paris Cedex 15, France
    Immunity 18:13-26. 2003
    ..This study shows that the localization of NEMO to the immunological synapse is important for TCR-induced NF-kappaB activation and offers a powerful system to dissect the NF-kappaB cascade in T cells...