Research Topics
Genomes and Genes
| Nicholas D HuntingtonSummaryAffiliation: Institut Pasteur Country: France Publications
| Collaborators
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Detail Information
Publications
Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7Nicholas D Huntington
Cytokines and Lymphoid Development Unit, Institut Pasteur, 25 rue du Docteur Roux, Paris, France
Int Immunol 21:715-25. 2009..Our data highlight the role of Bim as a key regulator of cell survival during B lymphocyte development in vivo...- Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1Nicholas D Huntington
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Nat Immunol 8:856-63. 2007..Thus, IL-15 regulates the survival of NK cells at multiple steps, with Bim and Noxa being key antagonists of Mcl-1, the critical survivor factor in this process... 
Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) miceNicholas D Huntington
Innate Immunity Unit, Immunology Department, Institut Pasteur, Paris, France
Eur J Immunol 41:2883-93. 2011..As IL-15 immunotherapy promotes early thymopoiesis, this novel approach could be used to reduce the period of T-cell immunodeficiency in the post-transplant clinical setting...- IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivoNicholas D Huntington
Innate Immunity Unit, Immunology Department, Institut Pasteur, 75724 Paris, France
Proc Natl Acad Sci U S A 108:6217-22. 2011.... 
NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulationNicholas D Huntington
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
J Immunol 178:4764-70. 2007..These data indicate that NK cells acquire KLRG1 on their surface during development, and this expression correlates with functional distinctions from other peripheral NK cells in vivo...- IL-15 trans-presentation promotes human NK cell development and differentiation in vivoNicholas D Huntington
Immunology Department, 2 Institut National de la Santé et de la Recherche Médicale U668, 3 INSERM U883, Unite de Regulation Immunitaire et Vaccinologie, Institut Pasteur, Paris 75724, France
J Exp Med 206:25-34. 2009.... - 10th Meeting of the Society for Natural Immunity, Cambridge, UK, 11-14 April 2007Nicholas D Huntington
Cytokines and Lymphoid Development Unit, Institut Pasteur, Inserm U668, Paris, France
Immunol Cell Biol 85:508-10. 2007.... - A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cellsNicholas D Huntington
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
J Exp Med 201:1421-33. 2005..Thus we identify CD45 as a pivotal enzyme in eliciting a precise subset of NK cell responses... - Cutting Edge: a thymocyte-thymic epithelial cell cross-talk dynamically regulates intrathymic IL-7 expression in vivoNuno L Alves
Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France
J Immunol 184:5949-53. 2010..Although thymocyte-derived signals are often considered stimulatory for TEC maturation, our findings identify a negative feedback mechanism in which signals derived from TCRbeta-selected thymocytes modulate TEC-dependent IL-7 expression... - CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanismAna Inés Lalanne
Unité du Développement des Lymphocytes, Departement d Immunologie, Institut Pasteur, Paris, France
J Immunol 184:5678-85. 2010..Thus, TLR9 signals can regulate B lymphopoiesis in vivo... - A role for Blimp1 in the transcriptional network controlling natural killer cell maturationAxel Kallies
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
Blood 117:1869-79. 2011..We have identified NK cells as the first hematopoietic cell type in which the IRF4-Blimp1-Bcl6 regulatory axis is not in operation, highlighting the distinct nature of the NK-cell gene-regulatory network... - CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centersNicholas D Huntington
The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
Nat Immunol 7:190-8. 2006..These results show mechanistic differences in B cell survival during germinal center initiation and propagation; CD40 signaling is sufficient for the former, whereas the latter requires signaling from the BCR... - ER stress triggers apoptosis by activating BH3-only protein BimHamsa Puthalakath
The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
Cell 129:1337-49. 2007..These results define the molecular mechanisms of ER stress-induced apoptosis and identify targets for therapeutic intervention in ER stress-related diseases... - Phosphatidylinositol-3 kinase activity in B cells is negatively regulated by Lyn tyrosine kinaseYuekang Xu
The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
Immunol Cell Biol 90:903-11. 2012..Regulating SFK activity may thus be a central mechanism by which Lyn regulates PI3K activity in B cells. This study defines the molecular connection between the BCR and PI3K and reveals this to be a point of Lyn-mediated regulation... - Characterization of the thymic IL-7 niche in vivoNuno L Alves
Cytokines and Lymphoid Development Unit, Lymphocyte Development Unit, Plate Forme Technologique Centre d Ingénierie Génétique Murine, and Laboratory of Lymphoid Tissue Development, Institut Pasteur, Paris, France
Proc Natl Acad Sci U S A 106:1512-7. 2009..This IL-7 reporter mouse provides a valuable tool to further dissect the mechanisms that govern thymic IL-7 expression in vivo... - Different kinetics of blimp-1 induction in B cell subsets revealed by reporter geneKirsten A Fairfax
Immunology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia
J Immunol 178:4104-11. 2007..Transferred naive Blimp-1(GFP/+) B1 and B2 cells both gave rise to ASCs in the bone marrow, suggesting no intrinsic barriers to B1 cell entry into the long-lived ASC compartment... - Thymic epithelial cells: the multi-tasking framework of the T cell "cradle"Nuno L Alves
Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France
Trends Immunol 30:468-74. 2009..Thus, the division of labour among TECs may be coordinated directly by local cellular feedback mechanisms operating within distinct thymic niches... - Developmental pathways that generate natural-killer-cell diversity in mice and humansNicholas D Huntington
Cytokines and Lymphoid Development Unit and Inserm Unit 668, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, Cedex 15, France
Nat Rev Immunol 7:703-14. 2007.... - Lyn tyrosine kinase: accentuating the positive and the negativeYuekang Xu
The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
Immunity 22:9-18. 2005..Here, we review the outcomes of altered Lyn activity within the framework of B cell development and differentiation and the circumstances that appear to dictate the outcome... - Functional subsets of mouse natural killer cellsYoshihiro Hayakawa
Cancer Immunology Program, Sir Donald and Lady Trescowick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
Immunol Rev 214:47-55. 2006..Extending our knowledge of mature NK cell heterogeneity between the species will be critical to further our understanding of the pathological role of NK cells in immune responses... - CD45: direct and indirect government of immune regulationNicholas D Huntington
The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
Immunol Lett 94:167-74. 2004....