Nicholas D Huntington

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7
    Nicholas D Huntington
    Cytokines and Lymphoid Development Unit, Institut Pasteur, 25 rue du Docteur Roux, Paris, France
    Int Immunol 21:715-25. 2009
  2. pmc Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 8:856-63. 2007
  3. doi request reprint Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice
    Nicholas D Huntington
    Innate Immunity Unit, Immunology Department, Institut Pasteur, Paris, France
    Eur J Immunol 41:2883-93. 2011
  4. pmc IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo
    Nicholas D Huntington
    Innate Immunity Unit, Immunology Department, Institut Pasteur, 75724 Paris, France
    Proc Natl Acad Sci U S A 108:6217-22. 2011
  5. ncbi request reprint NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation
    Nicholas D Huntington
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 178:4764-70. 2007
  6. pmc IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
    Nicholas D Huntington
    Immunology Department, 2 Institut National de la Santé et de la Recherche Médicale U668, 3 INSERM U883, Unite de Regulation Immunitaire et Vaccinologie, Institut Pasteur, Paris 75724, France
    J Exp Med 206:25-34. 2009
  7. ncbi request reprint 10th Meeting of the Society for Natural Immunity, Cambridge, UK, 11-14 April 2007
    Nicholas D Huntington
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Inserm U668, Paris, France
    Immunol Cell Biol 85:508-10. 2007
  8. pmc A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 201:1421-33. 2005
  9. doi request reprint Cutting Edge: a thymocyte-thymic epithelial cell cross-talk dynamically regulates intrathymic IL-7 expression in vivo
    Nuno L Alves
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France
    J Immunol 184:5949-53. 2010
  10. doi request reprint CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism
    Ana Inés Lalanne
    Unité du Développement des Lymphocytes, Departement d Immunologie, Institut Pasteur, Paris, France
    J Immunol 184:5678-85. 2010

Collaborators

Detail Information

Publications21

  1. pmc Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7
    Nicholas D Huntington
    Cytokines and Lymphoid Development Unit, Institut Pasteur, 25 rue du Docteur Roux, Paris, France
    Int Immunol 21:715-25. 2009
    ..Our data highlight the role of Bim as a key regulator of cell survival during B lymphocyte development in vivo...
  2. pmc Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 8:856-63. 2007
    ..Thus, IL-15 regulates the survival of NK cells at multiple steps, with Bim and Noxa being key antagonists of Mcl-1, the critical survivor factor in this process...
  3. doi request reprint Autonomous and extrinsic regulation of thymopoiesis in human immune system (HIS) mice
    Nicholas D Huntington
    Innate Immunity Unit, Immunology Department, Institut Pasteur, Paris, France
    Eur J Immunol 41:2883-93. 2011
    ..As IL-15 immunotherapy promotes early thymopoiesis, this novel approach could be used to reduce the period of T-cell immunodeficiency in the post-transplant clinical setting...
  4. pmc IL-15 transpresentation promotes both human T-cell reconstitution and T-cell-dependent antibody responses in vivo
    Nicholas D Huntington
    Innate Immunity Unit, Immunology Department, Institut Pasteur, 75724 Paris, France
    Proc Natl Acad Sci U S A 108:6217-22. 2011
    ....
  5. ncbi request reprint NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation
    Nicholas D Huntington
    Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    J Immunol 178:4764-70. 2007
    ..These data indicate that NK cells acquire KLRG1 on their surface during development, and this expression correlates with functional distinctions from other peripheral NK cells in vivo...
  6. pmc IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
    Nicholas D Huntington
    Immunology Department, 2 Institut National de la Santé et de la Recherche Médicale U668, 3 INSERM U883, Unite de Regulation Immunitaire et Vaccinologie, Institut Pasteur, Paris 75724, France
    J Exp Med 206:25-34. 2009
    ....
  7. ncbi request reprint 10th Meeting of the Society for Natural Immunity, Cambridge, UK, 11-14 April 2007
    Nicholas D Huntington
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Inserm U668, Paris, France
    Immunol Cell Biol 85:508-10. 2007
    ....
  8. pmc A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    J Exp Med 201:1421-33. 2005
    ..Thus we identify CD45 as a pivotal enzyme in eliciting a precise subset of NK cell responses...
  9. doi request reprint Cutting Edge: a thymocyte-thymic epithelial cell cross-talk dynamically regulates intrathymic IL-7 expression in vivo
    Nuno L Alves
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France
    J Immunol 184:5949-53. 2010
    ..Although thymocyte-derived signals are often considered stimulatory for TEC maturation, our findings identify a negative feedback mechanism in which signals derived from TCRbeta-selected thymocytes modulate TEC-dependent IL-7 expression...
  10. doi request reprint CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism
    Ana Inés Lalanne
    Unité du Développement des Lymphocytes, Departement d Immunologie, Institut Pasteur, Paris, France
    J Immunol 184:5678-85. 2010
    ..Thus, TLR9 signals can regulate B lymphopoiesis in vivo...
  11. doi request reprint A role for Blimp1 in the transcriptional network controlling natural killer cell maturation
    Axel Kallies
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia
    Blood 117:1869-79. 2011
    ..We have identified NK cells as the first hematopoietic cell type in which the IRF4-Blimp1-Bcl6 regulatory axis is not in operation, highlighting the distinct nature of the NK-cell gene-regulatory network...
  12. ncbi request reprint CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia
    Nat Immunol 7:190-8. 2006
    ..These results show mechanistic differences in B cell survival during germinal center initiation and propagation; CD40 signaling is sufficient for the former, whereas the latter requires signaling from the BCR...
  13. ncbi request reprint ER stress triggers apoptosis by activating BH3-only protein Bim
    Hamsa Puthalakath
    The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia
    Cell 129:1337-49. 2007
    ..These results define the molecular mechanisms of ER stress-induced apoptosis and identify targets for therapeutic intervention in ER stress-related diseases...
  14. doi request reprint Phosphatidylinositol-3 kinase activity in B cells is negatively regulated by Lyn tyrosine kinase
    Yuekang Xu
    The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia
    Immunol Cell Biol 90:903-11. 2012
    ..Regulating SFK activity may thus be a central mechanism by which Lyn regulates PI3K activity in B cells. This study defines the molecular connection between the BCR and PI3K and reveals this to be a point of Lyn-mediated regulation...
  15. pmc Characterization of the thymic IL-7 niche in vivo
    Nuno L Alves
    Cytokines and Lymphoid Development Unit, Lymphocyte Development Unit, Plate Forme Technologique Centre d Ingénierie Génétique Murine, and Laboratory of Lymphoid Tissue Development, Institut Pasteur, Paris, France
    Proc Natl Acad Sci U S A 106:1512-7. 2009
    ..This IL-7 reporter mouse provides a valuable tool to further dissect the mechanisms that govern thymic IL-7 expression in vivo...
  16. ncbi request reprint Different kinetics of blimp-1 induction in B cell subsets revealed by reporter gene
    Kirsten A Fairfax
    Immunology Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria, Australia
    J Immunol 178:4104-11. 2007
    ..Transferred naive Blimp-1(GFP/+) B1 and B2 cells both gave rise to ASCs in the bone marrow, suggesting no intrinsic barriers to B1 cell entry into the long-lived ASC compartment...
  17. doi request reprint Thymic epithelial cells: the multi-tasking framework of the T cell "cradle"
    Nuno L Alves
    Cytokines and Lymphoid Development Unit, Institut Pasteur, Paris, France
    Trends Immunol 30:468-74. 2009
    ..Thus, the division of labour among TECs may be coordinated directly by local cellular feedback mechanisms operating within distinct thymic niches...
  18. ncbi request reprint Developmental pathways that generate natural-killer-cell diversity in mice and humans
    Nicholas D Huntington
    Cytokines and Lymphoid Development Unit and Inserm Unit 668, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris, Cedex 15, France
    Nat Rev Immunol 7:703-14. 2007
    ....
  19. ncbi request reprint Lyn tyrosine kinase: accentuating the positive and the negative
    Yuekang Xu
    The Walter and Eliza Hall Institute of Medical Research, Melbourne 3050, Australia
    Immunity 22:9-18. 2005
    ..Here, we review the outcomes of altered Lyn activity within the framework of B cell development and differentiation and the circumstances that appear to dictate the outcome...
  20. ncbi request reprint Functional subsets of mouse natural killer cells
    Yoshihiro Hayakawa
    Cancer Immunology Program, Sir Donald and Lady Trescowick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia
    Immunol Rev 214:47-55. 2006
    ..Extending our knowledge of mature NK cell heterogeneity between the species will be critical to further our understanding of the pathological role of NK cells in immune responses...
  21. ncbi request reprint CD45: direct and indirect government of immune regulation
    Nicholas D Huntington
    The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3050, Australia
    Immunol Lett 94:167-74. 2004
    ....