Denis Hudrisier

Summary

Affiliation: Institut de Pharmacologie et de Biologie Structurale
Country: France

Publications

  1. ncbi Capture of target cell membrane components via trogocytosis is triggered by a selected set of surface molecules on T or B cells
    Denis Hudrisier
    Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5089, 205 route de Narbonne, 31077 Toulouse Cedex 3, France
    J Immunol 178:3637-47. 2007
  2. doi Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis
    Denis Hudrisier
    Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    J Immunol 183:6102-13. 2009
  3. ncbi Chemical labels metabolically installed into the glycoconjugates of the target cell surface can be used to track lymphocyte/target cell interplay via trogocytosis: comparisons with lipophilic dyes and biotin
    Sandrine Daubeuf
    IPBS, UMR5089 CNRS, Toulouse, France
    Immunol Invest 36:687-712. 2007
  4. doi The direction of plasma membrane exchange between lymphocytes and accessory cells by trogocytosis is influenced by the nature of the accessory cell
    Sandrine Daubeuf
    Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    J Immunol 184:1897-908. 2010
  5. pmc Capture of plasma membrane fragments from target cells by trogocytosis requires signaling in T cells but not in B cells
    Anne Aucher
    Institut de Pharmacologie et de Biologie Structurale, Centre National de Recherche Scientifique, Unité Mixte de Recherche 5089, Toulouse, France
    Blood 111:5621-8. 2008
  6. doi Suitability of various membrane lipophilic probes for the detection of trogocytosis by flow cytometry
    Sandrine Daubeuf
    CNRS, IPBS Institut de Pharmacologie et de Biologie Structurale, 205 route de Narbonne, Toulouse F 31077, France
    Cytometry A 75:380-9. 2009
  7. ncbi Acquisition of viral receptor by NK cells through immunological synapse
    Julie Tabiasco
    Département Oncogénèse and Signalisation dans les Cellules Hématopoiétiques, Unité 563 de l Institut National de la Santé et de la Recherche Médicale, BP3028 Centre Hospitalier Universitaire Purpan, Toulouse, France
    J Immunol 170:5993-8. 2003
  8. ncbi T cell activation correlates with an increased proportion of antigen among the materials acquired from target cells
    Denis Hudrisier
    CPTP, INSERM U563, Institut Claude de Preval, Toulouse, France
    Eur J Immunol 35:2284-94. 2005
  9. pmc Molecular signature of recent thymic selection events on effector and regulatory CD4+ T lymphocytes
    Paola Romagnoli
    Institut National de la Sante et de la Recherche Medicale, Unite 563, Centre de Physiopathologie Toulouse Purpan, Toulouse, France
    J Immunol 175:5751-8. 2005
  10. ncbi A very rapid and simple assay based on trogocytosis to detect and measure specific T and B cell reactivity by flow cytometry
    Anne Laure Puaux
    CPTP, INSERM U563, Institut Claude de Preval, Toulouse, France
    Eur J Immunol 36:779-88. 2006

Collaborators

  • Paola Romagnoli
  • Xavier Preville
  • Isabel Puigdomènech
  • Jan Bauer
  • Joelle Riond
  • Bonaventura Clotet
  • Pierre Brousset
  • Pierre Bruhns
  • Sandrine Daubeuf
  • Etienne Joly
  • Anne Aucher
  • Olivier Joffre
  • Julie Tabiasco
  • Joost P M van Meerwijk
  • Anne Laure Puaux
  • Christine Bordier
  • Jean Jacques Fournie
  • Eric Espinosa
  • Audrey Salles
  • Lennart T Mars
  • Julie Ribot
  • Alain Vercellone
  • Gilles Favre
  • Laurent Serre
  • Ronald P Taylor
  • Gerald Gaibelet
  • Margaret A Lindorfer
  • Julia Blanco
  • Jean Charles Faye
  • Eddy Magdeleine
  • Thibault Santolaria
  • Talal Al Saati
  • Denis Calise
  • Florence Bucciarelli
  • Sylvie Pilipenko
  • Kostas Kosmatopoulos
  • Anne Huchenq
  • Huseyin Firat
  • Francois Lemonnier
  • Geneviève Enault
  • David A Gross
  • Kevin J Yarema
  • Roland S Liblau
  • Srinivasa Gopalan Sampathkumar
  • Maryline Calise
  • Julie Campanaud
  • Benedikt Timmerman
  • Nathalie Gorsse
  • Fabienne Meggetto

Detail Information

Publications23

  1. ncbi Capture of target cell membrane components via trogocytosis is triggered by a selected set of surface molecules on T or B cells
    Denis Hudrisier
    Institut de Pharmacologie et de Biologie Structurale, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5089, 205 route de Narbonne, 31077 Toulouse Cedex 3, France
    J Immunol 178:3637-47. 2007
    ..This could therefore account for the different biological consequences of Ag capture via trogocytosis proposed for different types of cells...
  2. doi Ligand binding but undetected functional response of FcR after their capture by T cells via trogocytosis
    Denis Hudrisier
    Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    J Immunol 183:6102-13. 2009
    ..Thus, our study demonstrates that T cells capture FcgammaR that can efficiently exert ligand-binding activity, which, per se, could have functional consequences in T cell-B cell cooperation...
  3. ncbi Chemical labels metabolically installed into the glycoconjugates of the target cell surface can be used to track lymphocyte/target cell interplay via trogocytosis: comparisons with lipophilic dyes and biotin
    Sandrine Daubeuf
    IPBS, UMR5089 CNRS, Toulouse, France
    Immunol Invest 36:687-712. 2007
    ..More generally, we believe that the ever-growing ability to employ chemistry in living systems to label particular compounds will be powerful in unraveling the contributions of glycosylation to various aspects of T and B cells biology...
  4. doi The direction of plasma membrane exchange between lymphocytes and accessory cells by trogocytosis is influenced by the nature of the accessory cell
    Sandrine Daubeuf
    Centre National de la Recherche Scientifique, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    J Immunol 184:1897-908. 2010
    ..Our observations open new perspectives to understand the mechanisms involved in trogocytosis and may contribute to optimization of Ab-based immunotherapeutic approaches...
  5. pmc Capture of plasma membrane fragments from target cells by trogocytosis requires signaling in T cells but not in B cells
    Anne Aucher
    Institut de Pharmacologie et de Biologie Structurale, Centre National de Recherche Scientifique, Unité Mixte de Recherche 5089, Toulouse, France
    Blood 111:5621-8. 2008
    ..Trogocytosis thus has different requirements in different cell types. Moreover, the capture of membrane antigen by B cells is identified as a novel signaling-independent event of B-cell biology...
  6. doi Suitability of various membrane lipophilic probes for the detection of trogocytosis by flow cytometry
    Sandrine Daubeuf
    CNRS, IPBS Institut de Pharmacologie et de Biologie Structurale, 205 route de Narbonne, Toulouse F 31077, France
    Cytometry A 75:380-9. 2009
    ..We have identified a set of new lipophilic fluorescent probes suitable for TRAP assays in combination with intracellular staining...
  7. ncbi Acquisition of viral receptor by NK cells through immunological synapse
    Julie Tabiasco
    Département Oncogénèse and Signalisation dans les Cellules Hématopoiétiques, Unité 563 de l Institut National de la Santé et de la Recherche Médicale, BP3028 Centre Hospitalier Universitaire Purpan, Toulouse, France
    J Immunol 170:5993-8. 2003
    ..Hence, trans-synaptic acquisition of viral receptor from target cells might constitute an unsuspected mode of infection for otherwise unreachable lymphoid hosts...
  8. ncbi T cell activation correlates with an increased proportion of antigen among the materials acquired from target cells
    Denis Hudrisier
    CPTP, INSERM U563, Institut Claude de Preval, Toulouse, France
    Eur J Immunol 35:2284-94. 2005
    ..Taken together, our results show that the different thresholds that govern the elicitation of different CTL functions correlate with different proportions of antigen among the target cell components being captured via trogocytosis...
  9. pmc Molecular signature of recent thymic selection events on effector and regulatory CD4+ T lymphocytes
    Paola Romagnoli
    Institut National de la Sante et de la Recherche Medicale, Unite 563, Centre de Physiopathologie Toulouse Purpan, Toulouse, France
    J Immunol 175:5751-8. 2005
    ..e., those specifically expressed by thymic epithelial cells...
  10. ncbi A very rapid and simple assay based on trogocytosis to detect and measure specific T and B cell reactivity by flow cytometry
    Anne Laure Puaux
    CPTP, INSERM U563, Institut Claude de Preval, Toulouse, France
    Eur J Immunol 36:779-88. 2006
    ..Altogether, our method offers a simple and general alternative to other methods previously described to detect and quantify lymphocyte reactivity, and it can also be used in combination with those...
  11. pmc Shaping of the autoreactive regulatory T cell repertoire by thymic cortical positive selection
    Julie Ribot
    Institut National de la Santé et de la Recherche Médicale Unité 563, Toulouse, France
    J Immunol 179:6741-8. 2007
    ..Our data therefore demonstrate that thymic cortical positive selection of regulatory and Tconv precursors is governed by distinct rules and that it plays an important role in shaping the autoreactive Treg repertoire...
  12. pmc In vivo maintenance of T-lymphocyte unresponsiveness induced by thymic medullary epithelium requires antigen presentation by radioresistant cells
    Denis Hudrisier
    Institut National de la Santé et de la Recherche Médicale INSERM Centre de Physiopathologie de Toulouse Purpan, Institut Claude de Preval, Toulouse, France
    Immunology 108:24-31. 2003
    ..Our data may therefore have important consequences for tolerance to tissue-specific and inducible self-antigens...
  13. ncbi Synaptic transfer by human gamma delta T cells stimulated with soluble or cellular antigens
    Eric Espinosa
    Institut National de la Sante et de la Recherche Medicale, Centre Hospitalier Universitaire Purpan, Toulouse, France
    J Immunol 168:6336-43. 2002
    ....
  14. pmc Preferential transfer of certain plasma membrane proteins onto T and B cells by trogocytosis
    Sandrine Daubeuf
    CNRS, Institut de Pharmacologie et de Biologie Structurale, Toulouse, France
    PLoS ONE 5:e8716. 2010
    ..The preferential transfer documented here should prove useful in deciphering the cellular structures involved in trogocytosis...
  15. ncbi CD8 T cell responses to myelin oligodendrocyte glycoprotein-derived peptides in humanized HLA-A*0201-transgenic mice
    Lennart T Mars
    Institut National de la Sante et de la Recherche Medicale, Unite 563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France
    J Immunol 179:5090-8. 2007
    ..Therefore, this detailed in vivo characterization provides a hierarchy of candidate epitopes for MOG-specific CD8(+) T cell responses in HLA-A*0201 MS patients identifying the encephalitogenic MOG(181) epitope as a primary candidate...
  16. pmc Could CD4 capture by CD8+ T cells play a role in HIV spreading?
    Anne Aucher
    Institut de Pharmacologie et de Biologie Structurale CNRS, IPBS, 205 route de Narbonne, 31077 Toulouse, France
    J Biomed Biotechnol 2010:907371. 2010
    ..Our results show that acquisition of CD4 by CD8(+) T cells via trogocytosis could play a previously unappreciated role for CD8(+) T cells in HIV spreading possibly without leading to their infection...
  17. ncbi A simple trogocytosis-based method to detect, quantify, characterize and purify antigen-specific live lymphocytes by flow cytometry, via their capture of membrane fragments from antigen-presenting cells
    Sandrine Daubeuf
    IPBS, CNRS UMR5089, Toulouse, France
    Nat Protoc 1:2536-42. 2006
    ..Furthermore, cells can be recovered alive and active after detection of trogocytosis, and are therefore available for further characterization or even conceivably for therapeutic purposes...
  18. ncbi Active trans-synaptic capture of membrane fragments by natural killer cells
    Julie Tabiasco
    Centre de Physiopathologie de Toulouse Purpan, Institut National de la Sante et de la Recherche Medicale, Toulouse, France
    Eur J Immunol 32:1502-8. 2002
    ..Furthermore, this process is down-regulated by signals emanating from inhibitory NK receptors recognizing protective MHC class I alleles...
  19. ncbi Preferential recognition of self antigens despite normal thymic deletion of CD4(+)CD25(+) regulatory T cells
    Paola Romagnoli
    Institut National de la Sante et de la Recherche Medicale, Claude de Preval Institute, Purpan Hospital, Toulouse, France
    J Immunol 168:1644-8. 2002
    ..Combined, our data firmly establish that the repertoire of regulatory T cells is specifically enriched in autospecific cells despite the fact that their precursors are normally susceptible to thymic deletion...
  20. pmc Prevention of acute and chronic allograft rejection with CD4+CD25+Foxp3+ regulatory T lymphocytes
    Olivier Joffre
    Institut National de la Sante et de la Recherche Medicale, U563, Tolerance and Autoimmunity section, Toulouse, F 31300 France
    Nat Med 14:88-92. 2008
    ..Our findings demonstrate the potential of appropriately stimulated regulatory T cells for future cell-based therapeutic approaches to induce lifelong immunological tolerance to allogeneic transplants...
  21. pmc Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes
    Olivier Joffre
    Tolerance and Autoimmunity section, Institut National de la Sante et de la Recherche Medicale, Centre de Physiopathologie de Toulouse Purpan, Institut de Preval, France
    Blood 103:4216-21. 2004
    ..Our results suggest that CD4(+)CD25(+) regulatory T cells could in the future be used in clinical settings to induce specific immunosuppression...
  22. ncbi What is trogocytosis and what is its purpose?
    Etienne Joly
    Nat Immunol 4:815. 2003
  23. ncbi Intercellular transfer of antigen-presenting cell determinants onto T cells: molecular mechanisms and biological significance
    Denis Hudrisier
    INSERM U 395, CHU Purpan and Paul Sabatier University, BP3028 31024 Toulouse Cedex 3, France
    FASEB J 16:477-86. 2002
    ....