Serge Hercberg

Summary

Affiliation: Institut Scientifique et Technique de la Nutrition et de l'Alimentation
Country: France

Publications

  1. ncbi request reprint Iron deficiency in Europe
    S Hercberg
    Unité de Surveillance et d Epidémiologie Nutritionnelle, InVS Institut Scientifique et Technique de la Nutrition et de l Alimentation, CNAM, Paris, France
    Public Health Nutr 4:537-45. 2001
  2. pmc Impact of cancer occurrence on health-related quality of life: a longitudinal pre-post assessment
    Stephanie Boini
    EA 3444 Ecole de Santé Publique, Faculte de Medecine, Université Henry Poincaré de Nancy, 9 Avenue de la Forêt de Haye, BP 184, 54500 Vandoeuvre les Nancy, France
    Health Qual Life Outcomes 2:4. 2004
  3. ncbi request reprint Interventional studies concerning the role of antioxidant vitamins in cardiovascular diseases: a review
    S Czernichow
    U 557 INSERM UMR INSERM INRA CNAM, Institut Scientifique et Technique de la Nutrition et de l Alimentation, CNAM 5, rue Vertbois, F 75003 Paris
    J Nutr Health Aging 5:188-95. 2001
  4. ncbi request reprint Relationship between soup consumption, folate, beta-carotene, and vitamin C status in a French adult population
    Pilar Galan
    UMR 557 Inserm Inra Cnam, Institut Scientifique et Technique de la Nutrition et de l Alimentation, Conservatoire National des Arts et Metiers, 5 rue Vertbois, F 75003 Paris
    Int J Vitam Nutr Res 73:315-21. 2003
  5. doi request reprint Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults
    Sebastien Czernichow
    Nutritional Epidemiology Research Unit UMR U557 INSERM, U1125 Inra, CNAM, Paris 13 University, 93017 Bobigny, France
    Am J Clin Nutr 90:329-35. 2009
  6. ncbi request reprint Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels?
    Pilar Galan
    U557 INSERM UMR INSERM INRA CNAM, Institute Scientifique et Technique de la Nutrition et de l Alimentation CNAM, F 75003 Paris, France
    Br J Nutr 94:125-32. 2005
  7. ncbi request reprint Intake of added oils and fats among middle-aged French adults: relationships with educational level and region of residence
    Sebastien Czernichow
    Department of Nutrition, Hotel Dieu Hospital, University Pierre et Marie Curie, Paris, France
    J Am Diet Assoc 105:1889-94. 2005
  8. doi request reprint Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
  9. ncbi request reprint The French National Nutrition and Health Program score is associated with nutritional status and risk of major chronic diseases
    Carla Estaquio
    UMR U557 INSERM, U1125 INRA and Paris 13 University, CNAM, Centre de Recherche en Nutrition Humaine IdF, 93017 Bobigny, France
    J Nutr 138:946-53. 2008
  10. doi request reprint Long-term antioxidant supplementation has no effect on health-related quality of life: the randomized, double-blind, placebo-controlled, primary prevention SU.VI.MAX trial
    Serge Briancon
    Nancy University, P Verlaine, Metz University, Paris, Descartes University, EA 4360 Apemac, Nancy, France
    Int J Epidemiol 40:1605-16. 2011

Detail Information

Publications99

  1. ncbi request reprint Iron deficiency in Europe
    S Hercberg
    Unité de Surveillance et d Epidémiologie Nutritionnelle, InVS Institut Scientifique et Technique de la Nutrition et de l Alimentation, CNAM, Paris, France
    Public Health Nutr 4:537-45. 2001
    ..Increased knowledge and increased information about factors may be important tools in the prevention of iron deficiency in Europe...
  2. pmc Impact of cancer occurrence on health-related quality of life: a longitudinal pre-post assessment
    Stephanie Boini
    EA 3444 Ecole de Santé Publique, Faculte de Medecine, Université Henry Poincaré de Nancy, 9 Avenue de la Forêt de Haye, BP 184, 54500 Vandoeuvre les Nancy, France
    Health Qual Life Outcomes 2:4. 2004
    ..The objective of the present study was to investigate the impact of new cancer on HRQoL...
  3. ncbi request reprint Interventional studies concerning the role of antioxidant vitamins in cardiovascular diseases: a review
    S Czernichow
    U 557 INSERM UMR INSERM INRA CNAM, Institut Scientifique et Technique de la Nutrition et de l Alimentation, CNAM 5, rue Vertbois, F 75003 Paris
    J Nutr Health Aging 5:188-95. 2001
    ..A single antioxidant vitamin given at high doses in subjects with high risk of pathologies may not have substantial benefits and could even have negative consequences...
  4. ncbi request reprint Relationship between soup consumption, folate, beta-carotene, and vitamin C status in a French adult population
    Pilar Galan
    UMR 557 Inserm Inra Cnam, Institut Scientifique et Technique de la Nutrition et de l Alimentation, Conservatoire National des Arts et Metiers, 5 rue Vertbois, F 75003 Paris
    Int J Vitam Nutr Res 73:315-21. 2003
    ....
  5. doi request reprint Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults
    Sebastien Czernichow
    Nutritional Epidemiology Research Unit UMR U557 INSERM, U1125 Inra, CNAM, Paris 13 University, 93017 Bobigny, France
    Am J Clin Nutr 90:329-35. 2009
    ..Limited observational evidence suggests lower antioxidant concentrations in individuals with the metabolic syndrome (MetS); few randomized controlled trials have addressed the effect of multiple antioxidants on the risk of MetS...
  6. ncbi request reprint Antioxidant status and risk of cancer in the SU.VI.MAX study: is the effect of supplementation dependent on baseline levels?
    Pilar Galan
    U557 INSERM UMR INSERM INRA CNAM, Institute Scientifique et Technique de la Nutrition et de l Alimentation CNAM, F 75003 Paris, France
    Br J Nutr 94:125-32. 2005
    ..VI.MAX study...
  7. ncbi request reprint Intake of added oils and fats among middle-aged French adults: relationships with educational level and region of residence
    Sebastien Czernichow
    Department of Nutrition, Hotel Dieu Hospital, University Pierre et Marie Curie, Paris, France
    J Am Diet Assoc 105:1889-94. 2005
    ..To describe the relative contribution of 10 created food groups to total fat intake in middle-aged subjects. The relationship of added oil and fat intake with region of residence and educational level was also assessed...
  8. doi request reprint Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02)
    Sophie Limou
    Conservatoire National des Arts et Metiers, Universite Paris 7, Paris, France
    J Infect Dis 199:419-26. 2009
    ..The present study, the first GWAS of HIV-1 nonprogressors, underscores the potential for some HLA genes to control disease progression soon after infection...
  9. ncbi request reprint The French National Nutrition and Health Program score is associated with nutritional status and risk of major chronic diseases
    Carla Estaquio
    UMR U557 INSERM, U1125 INRA and Paris 13 University, CNAM, Centre de Recherche en Nutrition Humaine IdF, 93017 Bobigny, France
    J Nutr 138:946-53. 2008
    ..64; 95% CI: 0.44-0.96). No association was found in women. Healthy diet and lifestyle were associated with a lower risk of chronic diseases, particularly in men, thereby underlying relevance of the French nutritional recommendations...
  10. doi request reprint Long-term antioxidant supplementation has no effect on health-related quality of life: the randomized, double-blind, placebo-controlled, primary prevention SU.VI.MAX trial
    Serge Briancon
    Nancy University, P Verlaine, Metz University, Paris, Descartes University, EA 4360 Apemac, Nancy, France
    Int J Epidemiol 40:1605-16. 2011
    ..Our objective was to investigate the effect of nutritional doses of a combination of antioxidant vitamins and minerals on health-related quality of life (HRQoL) in a sample of healthy French adults...
  11. doi request reprint Association between the French nutritional guideline-based score and 6-year anthropometric changes in a French middle-aged adult cohort
    Emmanuelle Kesse-Guyot
    INSERMU557, INRAU1125, CNAM, Paris 13 University, Human Nutrition Research Center, Bobigny, France
    Am J Epidemiol 170:757-65. 2009
    ..89, 95% confidence interval: 0.80, 0.99) after a 6-year follow-up period. These observations support the role of nutritional guidelines in prevention of age-related weight increase and development of obesity...
  12. ncbi request reprint Iron status and risk of cancers in the SU.VI.MAX cohort
    Serge Hercberg
    U557 INSERM UMR INSERM INRA CNAM, Institut Scientifique et Technique de la Nutrition et de l Alimentation CNAM, F 75003 Paris, France
    J Nutr 135:2664-8. 2005
    ..Our results suggest that iron status is not a predictor of cancer risk in men, whereas a serum ferritin concentration > 160 microg/L may be associated with an increase in cancer risk in women...
  13. ncbi request reprint Relation between homocysteine concentrations and the consumption of different types of alcoholic beverages: the French Supplementation with Antioxidant Vitamins and Minerals Study
    Louise I Mennen
    UMR INSERM unit 557 INRA unit 1125, Institut Scientifique et Technique de la Nutrition et de l Alimentation, Paris, France
    Am J Clin Nutr 78:334-8. 2003
    ..Previous studies on the effects of alcohol consumption on total plasma homocysteine (tHcy) concentrations showed contradictory results. The conflicting results may derive in part from confounding by the type of alcoholic beverage consumed...
  14. doi request reprint Associations between dietary patterns, physical activity (leisure-time and occupational) and television viewing in middle-aged French adults
    Hélène Charreire
    INSERM U557, INRA U1125, CNAM, EA 3200, CRNH IdF, University Paris 13, 93017 Bobigny, France
    Br J Nutr 105:902-10. 2011
    ....
  15. doi request reprint Trends in the prevalence of obesity in employed adults in central-western France: a population-based study, 1995-2005
    Sebastien Czernichow
    Unite de Recherche en Epidemiologie Nutritionnelle, Faculté de medicine SMBH, INSERM U557, INRA U1125, CNAM, UP13, CRNH IdF, 93017 Bobigny, France
    Prev Med 48:262-6. 2009
    ..The aim of this study was to assess, according to socioeconomic status (SES), whether a shift in the obesity prevalence trends could be observed since the French National Nutrition and Public Health Program was implemented in 2001...
  16. pmc Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk
    Mathilde Touvier
    INSERM U557 National Institute of Health and Medical Research, INRA, CNAM, University of Paris 13 UREN, SMBH, 74 rue Marcel Cachin, F 93017 Bobigny, France
    World J Gastroenterol 18:2805-12. 2012
    ..To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models...
  17. doi request reprint Modulation of the association between plasma intercellular adhesion molecule-1 and cancer risk by n-3 PUFA intake: a nested case-control study
    Mathilde Touvier
    INSERM U557, National Institute of Health and Medical Research, INRA, CNAM, Paris 13 University, Bobigny, France
    Am J Clin Nutr 95:944-50. 2012
    ..Mechanistic data suggest that n-3 PUFAs and endothelial function may interact and play a role in carcinogenesis, but epidemiologic evidence is lacking...
  18. doi request reprint Effect of B-vitamins and n-3 PUFA supplementation for 5 years on blood pressure in patients with CVD
    Fabien Szabo de Edelenyi
    UMR U557 INSERM, U1125 Inra, CNAM, Universite Paris 13, CRNH IdF, SMBH, 74, rue Marcel Cachin, F 93017 Bobigny, France
    Br J Nutr 107:921-7. 2012
    ..Change in BP was not associated with change in homocysteine. In conclusion, the present results do not support the routine use of dietary supplements containing B-vitamins, or of n-3 fatty acids, to reduce BP in people with prior CVD...
  19. ncbi request reprint Consumption of foods rich in flavonoids is related to a decreased cardiovascular risk in apparently healthy French women
    Louise I Mennen
    UMR INSERM unit 557 INRA unit 1125, Institut Scientifique et Technique de la Nutrition et de l Alimentation, ISTNA CNAM, Paris, France
    J Nutr 134:923-6. 2004
    ..31; 95%CI: 0.14, 0.68], whereas a positive tendency was seen in men (OR: 1.38; 95%CI: 0.96, 2.00). These results indicate that in women, a high consumption of flavonoid-rich foods may prevent cardiovascular disease...
  20. doi request reprint Incidence of cancers, ischemic cardiovascular diseases and mortality during 5-year follow-up after stopping antioxidant vitamins and minerals supplements: a postintervention follow-up in the SU.VI.MAX Study
    Serge Hercberg
    Unite de Recherche en Epidemiologie Nutritionnelle, UMR U557 INSERM, U 1125 INRA, CNAM, Université de Paris 13, Bobigny, France
    Int J Cancer 127:1875-81. 2010
    ..98 (95% CI, 0.75-1.26) for men receiving antioxidants compared to nonrecipients. In conclusion, beneficial effects of antioxidant supplementation in men disappeared during postintervention follow-up...
  21. ncbi request reprint Alcohol and atherosclerotic vascular disease risk factors in French men: relationships are linear, J-shaped, and U-shaped
    Philippe Rouillier
    INSERM U557, ISTNA, CNAM, Paris, France
    Alcohol Clin Exp Res 29:84-8. 2005
    ....
  22. doi request reprint Dietary intake, physical activity and nutritional status in adults: the French nutrition and health survey (ENNS, 2006-2007)
    Katia Castetbon
    Unité de Surveillance et d Epidémiologie Nutritionnelle, Institut de Veille Sanitaire, Université de Paris 13, Conservatoire National des Arts et Metiers, Bobigny, France
    Br J Nutr 102:733-43. 2009
    ..Based on the ENNS survey, overall nutrition remains a problem in France. Comparison of these data with those of other countries could contribute to a better understanding of variations in nutrition-related diseases...
  23. ncbi request reprint Effect of supplementation with antioxidants upon long-term risk of hypertension in the SU.VI.MAX study: association with plasma antioxidant levels
    Sebastien Czernichow
    Nutritional Epidemiology Unit, French Institute of Health and Medical Research, UMR INSERM INRA CNAM, Paris, France
    J Hypertens 23:2013-8. 2005
    ..5-year risk of hypertension in the SU.VI.MAX trial. To describe the association between baseline plasma antioxidant levels and the same long-term risk using observational data from the study...
  24. doi request reprint Energy density and 6-year anthropometric changes in a middle-aged adult cohort
    Anne Claire Vergnaud
    Centre de Recherche en Nutrition Humaine Ile de France, UMR U557 INSERM, U1125 Inra, CNAM, SMBH Université Paris 13, 74 rue Marcel Cachin, F 93017 Bobigny Cedex, France
    Br J Nutr 102:302-9. 2009
    ..This relationship could be mediated by physical activity level. Further research needs to be performed in other populations to determine whether ED could be effective strategies to prevent weight gain...
  25. doi request reprint Control of baseline cardiovascular risk factors in the SU-FOL-OM3 study cohort: does the localization of the arterial event matter?
    Claire Vesin
    Paris Descartes University, Faculty of Medicine, AP HP, Hotel Dieu Hospital, Diagnosis and Therapeutic Center, Paris, France
    Eur J Cardiovasc Prev Rehabil 17:541-8. 2010
    ....
  26. ncbi request reprint Sedentary behaviors, physical activity, and metabolic syndrome in middle-aged French subjects
    Sandrine Bertrais
    UMR INSERM U557 INRA U1125 CNAM EA 3200 MR, 5 rue du Vertbois, F 75003 Paris, France
    Obes Res 13:936-44. 2005
    ..To study the relationships of time spent in sedentary occupations with the National Cholesterol Education Program-defined metabolic syndrome (MS), taking into account the habitual level of physical activity (PA)...
  27. ncbi request reprint Consumption of antioxidant-rich beverages and risk for breast cancer in French women
    Tero Hirvonen
    UMR Institut Nationale de la Santé et de la Recherche Médicale Unit 557 INRA Unit 1125, L Institut Scientifique et Technique de la Nutrition et de l Alimentation Conservatoire National des Arts et Métiers, Paris, France
    Ann Epidemiol 16:503-8. 2006
    ..The objective of the study is to evaluate the relation between antioxidant-rich beverages and the incidence of breast cancer...
  28. pmc Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial
    Pilar Galan
    UMR U557 INSERM, U1125 Inra, CNAM, Universite Paris 13, CRNH IdF, F 93017 Bobigny, France
    BMJ 341:c6273. 2010
    ..To investigate whether dietary supplementation with B vitamins or omega 3 fatty acids, or both, could prevent major cardiovascular events in patients with a history of ischaemic heart disease or stroke...
  29. ncbi request reprint The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals
    Serge Hercberg
    Institut National de la Sante et de la Recherche Medicale, Unité de Recherche Médicale INSERM Institut National de la Recherche Agronomique Conservatoire National des Ants et Métiers CNAM, Paris, France
    Arch Intern Med 164:2335-42. 2004
    ..We tested the efficacy of nutritional doses of supplementation with a combination of antioxidant vitamins and minerals in reducing the incidence of cancer and ischemic cardiovascular disease in the general population...
  30. doi request reprint Adherence to French nutritional guidelines is associated with lower risk of metabolic syndrome
    Emmanuelle Kesse-Guyot
    Unite de Recherche en Epidemiologie Nutritionnelle, UMR U557 INSERM, U1125 Inra, CNAM, Paris 13, CRNH IdF, Bobigny, France
    J Nutr 141:1134-9. 2011
    ..Improvement in compliance with nutritional recommendations may help to reduce the burden of CVD disease in the general population...
  31. ncbi request reprint Metabolic syndrome in relation to structure and function of large arteries: a predominant effect of blood pressure. A report from the SU.VI.MAX. Vascular Study
    Sebastien Czernichow
    Nutritional Epidemiology Unit INSERM Unit 557, UMR INSERM INRA CNAM, 5 rue Vertbois, 75003 Paris, France
    Am J Hypertens 18:1154-60. 2005
    ..Metabolic syndrome (MetS) is associated with increased risk of cardiovascular disease. However, the contribution of MetS to intermediate cardiovascular endpoints such as structure and function alterations of large arteries is still unclear...
  32. doi request reprint Sex and dieting modify the association between emotional eating and weight status
    Sandrine Peneau
    Nutritional Epidemiology Research Unit, Universite Paris 13, Sorbonne Paris Cité, Institut National de la Santé et de la Recherche Médicale U557, Institut National de la Recherche Agronomiqu U1125, Conservatoire National des Arts et Metiers, Bobigny, France
    Am J Clin Nutr 97:1307-13. 2013
    ..Unlike other psychological correlates of weight status, emotional eating (EmE) has received relatively limited attention in the literature...
  33. doi request reprint Physical activity patterns in the French 18-74-year-old population: French Nutrition and Health Survey (Etude Nationale Nutrition Santé, ENNS) 2006-2007
    Benoit Salanave
    Université Paris 13 Sorbonne Paris Cité, Unité de Surveillance et d Epidémiologie Nutritionnelle, Bobigny Cedex, France
    Public Health Nutr 15:2054-9. 2012
    ..To describe detailed physical activity and sedentary behaviour in French adults across physical activity categories...
  34. doi request reprint Macrovascular and microvascular dysfunction in the metabolic syndrome
    Sebastien Czernichow
    Nutritional Epidemiology Research Unit, UMR U557 INSERM, U1125 Inra, CNAM, Paris 13, CRNH IdF, Bobigny, France
    Hypertens Res 33:293-7. 2010
    ..The common mechanism linking MetS components to CVD risk through small- and large-artery dysfunctions may be mediated through metabolic factors related to insulin resistance, not to increased BP...
  35. ncbi request reprint Drinking patterns in French adult men--a cluster analysis of alcoholic beverages and relationship with lifestyle
    Philippe Rouillier
    ISTNA, CNAM, 5 rue Vertbois, 75003 Paris, France
    Eur J Nutr 43:69-76. 2004
    ..Establishing patterns of alcohol consumption may be useful for investigating the relationship between alcohol and diseases...
  36. ncbi request reprint Effects of light to moderate alcohol consumption on thyroid volume and thyroid function
    Pierre Valeix
    National Institute for Health and Medical Research, Nutritional Epidemiology Unit, U557 INSERM, U1125 Inra, CNAM, Universite Paris 13, CRNH Ile de France, Bobigny, France
    Clin Endocrinol (Oxf) 68:988-95. 2008
    ..To examine a possible relationship between alcohol consumption and thyroid volume and function...
  37. pmc Cross-sectional and longitudinal associations of different sedentary behaviors with cognitive performance in older adults
    Emmanuelle Kesse-Guyot
    UMR INSERM U557, INRA U1125, CNAM, University Paris 13 Paris cité Sorbonne, Centre of Research on Human Nutrition Ile de France, Bobigny, France
    PLoS ONE 7:e47831. 2012
    ..The deleterious health effects of sedentary behaviors, independent of physical activity, are increasingly being recognized. However, associations with cognitive performance are not known...
  38. doi request reprint Serum thyrotropin and free thyroxine reference ranges as defined in a disease-free sample of French middle-aged adults
    Carla Estaquio
    Unité de Surveillance et d Epidémiologie Nutritionnelle, Institut de Veille Sanitaire, Universite Paris 13, CNAM, Centre de Recherche en Nutrition Humaine Ile de France, Bobigny, France
    Clin Chem Lab Med 47:1497-505. 2009
    ..The goal of this study was to provide reference ranges for thyrotropin (TSH) and free thyroxine (fT(4)) based on data collected from a disease-free sample of French middle-aged adults...
  39. doi request reprint Relative validity and reproducibility of a food frequency questionnaire designed for French adults
    Emmanuelle Kesse-Guyot
    INSERM U, INRA U, CNAM, Human Nutrition Research Center of Ile de France, UFR SMBH, Paris, France
    Ann Nutr Metab 57:153-62. 2010
    ..We tested the reproducibility and relative validity of a French self-administered food frequency questionnaire (FFQ) against 24-hour dietary records (DRs)...
  40. doi request reprint Microvascular dysfunction in healthy insulin-sensitive overweight individuals
    Sebastien Czernichow
    Nutritional Epidemiology Research Unit UMR U557 INSERM, U1125 Inra, CNAM, CRNH IdF, France
    J Hypertens 28:325-32. 2010
    ..In the present study, we measured skin capillary density and endothelial function in a group of normotensive overweight/obese nondiabetic individuals and healthy lean controls...
  41. doi request reprint Beta-carotene supplementation and cancer risk: a systematic review and metaanalysis of randomized controlled trials
    Nathalie Druesne-Pecollo
    UMR U 557 INSERM, U 1125 INRA, CNAM, Universite Paris 13, F 93017 Bobigny, France
    Int J Cancer 127:172-84. 2010
    ..This study adds to the evidence that nutritional prevention of cancer through beta-carotene supplementation should not be recommended...
  42. doi request reprint Low total and nonheme iron intakes are associated with a greater risk of hypertension
    Pilar Galan
    UMR U557 INSERM, U1125 Inra, CNAM, Universite Paris 13, CRNH IdF, F 93017 Bobigny, France
    J Nutr 140:75-80. 2010
    ..Our data support a possible role of low nonheme iron intake, independent of heme iron intake, in the development of hypertension...
  43. ncbi request reprint Alterations of the lipid profile after 7.5 years of low-dose antioxidant supplementation in the SU.VI.MAX Study
    Serge Hercberg
    U557 Institut National de la Santé et de la Recherche Médicale INSERM, Institut Scientifique et Technique de la Nutrition et de l Alimentation, Paris, France
    Lipids 40:335-42. 2005
    ....
  44. ncbi request reprint Association of selenium with thyroid volume and echostructure in 35- to 60-year-old French adults
    Hélène Derumeaux
    UMR INSERM U557 INRA U1125 CNAM, Institut Scientifique et Technique de la Nutrition et de l Alimentation, CNAM, Paris, France
    Eur J Endocrinol 148:309-15. 2003
    ..To investigate the relationship between selenium status, thyroid Volume and gland echostructure...
  45. pmc Sociodemographic and geographic correlates of meeting current recommendations for physical activity in middle-aged French adults: the Supplémentation en Vitamines et Minéraux Antioxydants (SUVIMAX) Study
    Sandrine Bertrais
    Unite Mixte de Recherche, Institut National de la Santé et de la Recherche Médicale INSERM U557, Institut National de la Recherche Agronomique INRA U1125, Conservatoire National des Arts et Métiers CNAM EA 3200 MR, Paris, France
    Am J Public Health 94:1560-6. 2004
    ..We evaluated the characteristics of French subjects meeting current public health recommendations for physical activity...
  46. pmc Participant profiles according to recruitment source in a large web-based prospective study: experience from the nutrinet-santé study
    Emmanuelle Kesse-Guyot
    Universite Paris 13, Sorbonne Paris Cité, UREN, Inserm U557 Inra U1125, CNAM, Bobigny, France
    J Med Internet Res 15:e205. 2013
    ..Interest in Internet-based epidemiologic research is growing given the logistic and cost advantages. Cohort recruitment to maximally diversify the sociodemographic profiles of participants, however, remains a contentious issue...
  47. ncbi request reprint Antioxidant vitamins and minerals in prevention of cancers: lessons from the SU.VI.MAX study
    Serge Hercberg
    U557 INSERM UMR INSERM INRA CNAM, Institut Scientifique et Technique de la Nutrition et de l Alimentation CNAM, 5 rue Vertbois, F 75003 Paris, France
    Br J Nutr 96:S28-30. 2006
    ..High doses of antioxidant supplementation may be deleterious in subjects in whom the initial phase of cancer development has already started, and they could be ineffective in well-nourished subjects with adequate antioxidant status...
  48. ncbi request reprint Homocysteine, cardiovascular disease risk factors, and habitual diet in the French Supplementation with Antioxidant Vitamins and Minerals Study
    Louise I Mennen
    UMR INSERM unit 557 INRA unit 1125, Institut Scientifique et Technique de la Nutrition et de l Alimentation, ISTNA, Paris, France
    Am J Clin Nutr 76:1279-89. 2002
    ..An elevated plasma total homocysteine (tHcy) concentration seems to increase the risk of cardiovascular disease...
  49. doi request reprint Prognostic value of multiple emerging biomarkers in cardiovascular risk prediction in patients with stable cardiovascular disease
    Namanjeet Ahluwalia
    UMR U557 INSERM, U1125 Inra, CNAM, UFR SMBH, Universite Paris 13, CRNH IdF, 74 rue Marcel Cachin, F 93017 Bobigny, France
    Atherosclerosis 228:478-84. 2013
    ....
  50. doi request reprint Total and specific polyphenol intakes in midlife are associated with cognitive function measured 13 years later
    Emmanuelle Kesse-Guyot
    Unite de Recherche en Epidemiologie Nutritionnelle, U557 INSERM, U1125 Inra, CNAM, Universite Paris 13, CRNH IdF, Bobigny, France
    J Nutr 142:76-83. 2012
    ..Further investigations are needed to clarify the observed negative associations regarding executive functioning...
  51. ncbi request reprint The French National Nutrition and Health Program: 2001-2006-2010
    Serge Hercberg
    U557 INSERM, CNAM, Paris 13, F 93017 Bobigny, France
    Int J Public Health 53:68-77. 2008
    ....
  52. pmc Validity of web-based self-reported weight and height: results of the nutrinet-santé study
    Camille Lassale
    Universite Paris 13, Sorbonne Paris Cité, UREN Nutritional Epidemiology Research Unit, INSERM U557, INRA U1125, CNAM, Bobigny, France
    J Med Internet Res 15:e152. 2013
    ..With the growing scientific appeal of e-epidemiology, concerns arise regarding validity and reliability of Web-based self-reported data...
  53. doi request reprint A genome-wide association study in Caucasian women points out a putative role of the STXBP5L gene in facial photoaging
    Sigrid Le Clerc
    Chaire de Bioinformatique, Conservatoire National des Arts et Metiers, Paris, France
    J Invest Dermatol 133:929-35. 2013
    ..These two genes, which were not previously described in the context of aging, may constitute good candidates for the investigation of molecular mechanisms of skin photoaging...
  54. doi request reprint Cardiovascular effects of B-vitamins and/or N-3 fatty acids: the SU.FOL.OM3 trial
    Jacques Blacher
    Universite Paris Descartes, Faculte de Medecine, AP HP, Hotel Dieu, Centre de Diagnostic et Thérapeutique, Paris, France
    Int J Cardiol 167:508-13. 2013
    ..Because of differential vascular effects, N-3 polyunsatured fatty acids (PUFA) and B vitamins could have differential effects on different types of cardiovascular clinical events in high-risk patients...
  55. ncbi request reprint Dietary intakes and food sources of n-6 and n-3 PUFA in French adult men and women
    Pierre Astorg
    UMR Inserm 557 INRA CNAM Epidémiologie nutritionnelle, Institut Scientifique et Technique de la Nutrition et de I Alimentatio, Conservatoire National des Arts et Metiers, Paris, France
    Lipids 39:527-35. 2004
    ..Fish and seafood consumption showed very large interindividual variations, the low consumers being at risk of insufficient n-3 PUFA intake...
  56. ncbi request reprint Antioxidant vitamins and blood pressure
    Sebastien Czernichow
    French Institute of Health and Medical Research INSERM, Unit 557, UMR INSERM INRA CNAM, 5 rue Vertbois, 75003 Paris, France
    Curr Hypertens Rep 6:27-30. 2004
    ..Additional large studies should be conducted to determine the effect on BP of antioxidant supplementation at nutritional doses...
  57. ncbi request reprint The history of beta-carotene and cancers: from observational to intervention studies. What lessons can be drawn for future research on polyphenols?
    Serge Hercberg
    U557 INSERM and Unité de Surveillance et d Epidémiologie Nutritionnelle, InVS CNAM, Institut Scientifique et Technique de la Nutrition et de l Alimentation CNAM, Paris, France
    Am J Clin Nutr 81:218S-222S. 2005
    ..If these questions are not answered, then we run the risk of needing to renounce recommendations regarding polyphenols in the future, damaging the credibility of nutritional recommendations for public health...
  58. ncbi request reprint Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies
    Luc Dauchet
    INSERM U557, INRA U1125, CNAM, University Paris 13, Centre de Recherche en Nutrition Humaine, 93017 Bobigny, France
    J Nutr 136:2588-93. 2006
    ..This meta-analysis of cohort studies shows that fruit and vegetable consumption is inversely associated with the risk of CHD. The causal mechanism of this association, however, remains to be demonstrated...
  59. ncbi request reprint Relationship between serum, red cell, urinary and dietary magnesium in a middle-aged French adult population
    Sebastien Czernichow
    Institut Scientifique et Technique de la Nutrition et de l Alimentation UMR INSERM INRA CNAM, Paris
    Int J Vitam Nutr Res 74:123-8. 2004
    ..Further investigations should be conducted in order to determine the role played by dietary Mg intake in the relationship between health status and several biological Mg measurements...
  60. ncbi request reprint Serum ferritin, cardiovascular risk factors and ischaemic heart diseases: a prospective analysis in the SU.VI.MAX (SUpplementation en VItamines et Minéraux AntioXydants) cohort
    Pilar Galan
    U557 INSERM UMR INSERM INRA CNAM, Centre de Recherche en Nutrition, Ile de France, Paris 13, Bobigny, France
    Public Health Nutr 9:70-4. 2006
    ..We therefore carried out a prospective study to evaluate the relationship between iron status and CVD in a middle-aged French population...
  61. ncbi request reprint Urinary flavonoids and phenolic acids as biomarkers of intake for polyphenol-rich foods
    Louise I Mennen
    UMR INSERM U557 INRA CNAM, ISTNA CNAM, 5 rue du Vertbois, 75003 Paris, France
    Br J Nutr 96:191-8. 2006
    ..37-0.54, P < 0.001). The present results suggest that several polyphenols measured in a spot urine sample can be used as biomarkers of polyphenol-rich food intake...
  62. ncbi request reprint Antioxidant supplementation increases the risk of skin cancers in women but not in men
    Serge Hercberg
    UMR U557 Inserm U1125 Inra EA3200 Cnam Univ Paris 13, Bobigny, France 93017
    J Nutr 137:2098-105. 2007
    ..37; P = 0.22 for women and adjusted HR = 0.72; P = 0.19 for men). Our findings suggest that antioxidant supplementation affects the incidence of SC differentially in men and women...
  63. pmc Socioeconomic, Lifestyle and Dietary Factors Associated with Dietary Supplement Use during Pregnancy
    Camille Pouchieu
    Nutritional Epidemiology Research Team, Sorbonne Paris Cité Research Center, INSERM U557, INRA, CNAM, Paris 13 University, SMBH Paris 13, Bobigny, France
    PLoS ONE 8:e70733. 2013
    ..Our aim was to evaluate DS use and its socioeconomic, lifestyle and dietary correlates among pregnant women participating in the French NutriNet-Santé cohort study...
  64. doi request reprint Distinctive unhealthy eating pattern in free-living middle-aged hypertensives when compared with dyslipidemic or overweight patients
    Pierre Meneton
    Inserm U872, Centre de Recherche des Cordeliers, Paris, France
    J Hypertens 31:1554-63. 2013
    ..To evaluate habitual dietary intakes in patients with established hypertension, dyslipidemia and/or overweight...
  65. doi request reprint Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03)
    Sigrid Le Clerc
    Conservatoire National des Arts et Metiers, Paris, France
    J Infect Dis 200:1194-201. 2009
    ..The discovery of genetic factors that predispose individuals to rapid progression to AIDS should also reveal new insights into the molecular etiology of the pathology...
  66. doi request reprint Maternal alcohol consumption during pregnancy and risk of childhood leukemia: systematic review and meta-analysis
    Paule Latino-Martel
    UMR U557 INSERM, U1125 Inra, CNAM, Universite Paris, France
    Cancer Epidemiol Biomarkers Prev 19:1238-60. 2010
    ..Among different potential risk factors, the possible role of maternal alcohol consumption during pregnancy has been questioned...
  67. ncbi request reprint [Food and cancer: state of the art about the protective effect of fruits and vegetables]
    Mariette Gerber
    INSERM CRLC, Groupe d Epidémiologie Métabolique, Val d Aurelle, 34298 Montpellier Cedex 05
    Bull Cancer 89:293-312. 2002
    ....
  68. ncbi request reprint Dietary fibre intake and clinical indices in the French Supplementation en Vitamines et Minéraux AntioXydants (SU.VI.MAX) adult cohort
    Denis Lairon
    Unité 476 Human Nutrition and Lipids at INSERM National Institute of Health and Medical Research, Faculty of Medecine, 27 Bd J Moulin, 13385 Marseille Cedex 5, France
    Proc Nutr Soc 62:11-5. 2003
    ..Overall, these data support the concept of a beneficial effect of a high dietary fibre intake on cardiovascular disease risk...
  69. ncbi request reprint Variation in FTO contributes to childhood obesity and severe adult obesity
    Christian Dina
    CNRS 8090 Institute of Biology, Pasteur Institute, Lille, France
    Nat Genet 39:724-6. 2007
    ..The at-risk haplotype yields a proportion of attributable risk of 22% for common obesity. We conclude that FTO contributes to human obesity and hence may be a target for subsequent functional analyses...
  70. ncbi request reprint Antioxidant vitamin and mineral supplementation and prostate cancer prevention in the SU.VI.MAX trial
    Francois Meyer
    Laval University Cancer Research Center, Quebec, Canada
    Int J Cancer 116:182-6. 2005
    ..54; 95% CI = 0.87-2.72). The supplementation had no effect on PSA or IGF levels. Our findings support the hypothesis that chemoprevention of prostate cancer can be achieved with nutritional doses of antioxidant vitamins and minerals...
  71. ncbi request reprint Leisure time physical activity and health-related quality of life
    Anne Vuillemin
    EA 3444 Ecole de Santé Publique, Faculte de Medecine, Universite Henri Poincare, 54505 Vandoeuvre Les Nancy Cedex, France
    Prev Med 41:562-9. 2005
    ..We investigated the relationships of meeting public health recommendations (PHR) for moderate and vigorous physical activity with HRQoL in French adult subjects...
  72. ncbi request reprint Effects of long-term daily low-dose supplementation with antioxidant vitamins and minerals on structure and function of large arteries
    Mahmoud Zureik
    National Institute of Health and Medical Research Unit 258, Villejuif, France
    Arterioscler Thromb Vasc Biol 24:1485-91. 2004
    ..Limited data exist from randomized trials evaluating, noninvasively, the impact of antioxidant supplementation on vascular structure and function...
  73. ncbi request reprint Changes in serum retinol, alpha-tocopherol, vitamin C, carotenoids, xinc and selenium after micronutrient supplementation during alcohol rehabilitation
    Sonia Gueguen
    INSERM U525 and Centre de Médecine Préventive, 2 avenue Jacques Parisot, F 54500 Vandoeuvre les Nancy, France
    J Am Coll Nutr 22:303-10. 2003
    ..To test the effect of a 21-day supplementation with moderate doses of antioxidant nutrients on biochemical indicators of vitamin, carotenoid and trace element levels in alcohol-dependent patients during a program of alcohol rehabilitation...
  74. ncbi request reprint Alcohol intake in relation to body mass index and waist-to-hip ratio: the importance of type of alcoholic beverage
    Esther Lukasiewicz
    UMR INSERM unit 557 INRA unit 1125, Institut Scientifique et Technique de la Nutrition et de l Alimentation, ISTNA CNAM, 5 rue du Vertbois, F 75003 Paris, France
    Public Health Nutr 8:315-20. 2005
    ....
  75. ncbi request reprint Parental longevity and 7-year changes in blood pressures in adult offspring
    Mahmoud Zureik
    Unit 508, National Institute of Health and Medical Research INSERM, Institut Pasteur de Lille, Lille, France
    Hypertension 46:287-94. 2005
    ..These results indicate that there are dynamic and continuous processes linking paternal longevity to blood pressure in adults...
  76. doi request reprint Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    Cristen J Willer
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:161-9. 2008
    ..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls...
  77. doi request reprint Relationships between selenium, lipids, iron status and hormonal therapy in women of the SU.VI.M.AX cohort
    Josiane Arnaud
    Département de Biologie Intégrée, pole de biologie, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    J Trace Elem Med Biol 21:66-9. 2007
    ..074, p<0.07 depending on groups) or ferritin in serum (r(2) from 0.032 to 0.075, p<0.07 depending on groups). These relationships could explain the differences observed according to hormonal treatment and age in the SU.VI.MAX study...
  78. ncbi request reprint Low iron stores: a risk factor for excessive hair loss in non-menopausal women
    Claire Deloche
    L Oreal Recherche, Clichy, France
    Eur J Dermatol 17:507-12. 2007
    ..Analysis of variance and logistic regression show that a low iron store represents a risk factor for hair loss in non-menopausal women...
  79. ncbi request reprint Effect of low dose antioxidant vitamin and trace element supplementation on the urinary concentrations of thromboxane and prostacyclin metabolites
    Josiane Arnaud
    Département de Biologie Intégrée, CHU de Grenoble, BP 217, 38043 Grenoble Cedex 9, France
    J Am Coll Nutr 26:405-11. 2007
    ..This trial evaluated the effect of antioxidant supplementation on the urinary excretion of 11-dehydro TXB(2)/2,3 dinor 6 keto PGF(1alpha) ratio, a marker of the pathogenesis of thrombosis and arteriosclerosis...
  80. ncbi request reprint Dietary patterns and blood pressure change over 5-y follow-up in the SU.VI.MAX cohort
    Luc Dauchet
    UMR U557 INSERM, France
    Am J Clin Nutr 85:1650-6. 2007
    ..Although short-term effects of the Dietary Approaches to Stop Hypertension (DASH) diet on blood pressure have been shown in intervention studies, less is known about the long-term effects...
  81. ncbi request reprint Dairy products, calcium and the risk of breast cancer: results of the French SU.VI.MAX prospective study
    Emmanuelle Kesse-Guyot
    INSERM U557, INRA U1125, CNAM EA3200, Universite Paris 13, CRNH IdF, Unite de Recherche en Epidemiologie Nutritionnelle, Bobigny, France
    Ann Nutr Metab 51:139-45. 2007
    ..01) respectively. Our data support the hypothesis that dairy products, through calcium content or a correlated component, might have a negative association with the risk of breast cancer, particularly among premenopausal women...
  82. ncbi request reprint Travellers to high UV-index countries: sun-exposure behaviour in 7822 French adults
    Khaled Ezzedine
    Department of Dermatology, ULB Erasme Hospital, Route de Lennik 808, B 1070 Brussels, Belgium
    Travel Med Infect Dis 5:176-82. 2007
    ..Travel health information includes warning on sun exposure, particularly for fair-skinned individuals travelling to tropical countries...
  83. ncbi request reprint Association between leisure-time physical activity and health-related quality of life changes over time
    Sabrina Tessier
    EA 4003, Nancy Universite, Ecole de Santé Publique, Faculte de Medecine, 9 Avenue de la Forêt de Haye, BP 184, 54500 Vandoeuvre les Nancy, France
    Prev Med 44:202-8. 2007
    ..This study aimed to assess whether changes in leisure-time physical activity over 3 years are associated with changes in health-related quality of life...
  84. pmc Evaluating the association of common PBX1 variants with type 2 diabetes
    Konsta Duesing
    Genomic Medicine, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 0NN, UK
    BMC Med Genet 9:14. 2008
    ..PBX1 is a biological candidate gene for type 2 diabetes at the 1q21-q24 susceptibility locus. The aim of this study was to evaluate the association of common PBX1 variants with type 2 diabetes in French Caucasian subjects...
  85. doi request reprint Association of fish and long-chain n-3 polyunsaturated fatty acid intakes with the occurrence of depressive episodes in middle-aged French men and women
    Pierre Astorg
    Unité Nutrition et Régulation Lipidique des Fonctions Cérébrales NuRéLiCe, UR 909, Institut National de la Recherche Agronomique INRA, Centre de Recherche de Jouy, Jouy en Josas, France
    Prostaglandins Leukot Essent Fatty Acids 78:171-82. 2008
    ..In contrast, smokers eating fatty fish had an increased risk of recurrent depression. These results suggest that a usual intake of fatty fish or long-chain n-3 PUFA may decrease the risk of recurrent depression in non-smokers...
  86. ncbi request reprint Relationship between iron status and dietary fruit and vegetables based on their vitamin C and fiber content
    Sandrine Peneau
    INSERM U557, INRA U1125, CNAM EA3200, University 13 Paris, and Centre de Recherche en Nutrition Humaine Ile de France, Unite de Recherche en Epidemiologie Nutritionnelle, Bobigny, France
    Am J Clin Nutr 87:1298-305. 2008
    ..The potential association between iron status and intakes of specific fruits and vegetables, according to sex and menopausal status, must be investigated...
  87. ncbi request reprint Case for folic acid and vitamin B12 fortification in Europe
    Sebastien Czernichow
    Nutritional Epidemiology Unit French Institute of Health and Medical Research, INSERM U 557, Paris
    Semin Vasc Med 5:156-62. 2005
    ..This review advocates a proposal for combined fortification of folic acid and vitamin B (12) to address possible hazards of fortification with folic acid alone...
  88. ncbi request reprint Common polymorphisms in the USF1 gene are not associated with type 2 diabetes in French Caucasians
    Fernando Gibson
    Department of Genomic Medicine, Imperial College, London, UK
    Diabetes 54:3040-2. 2005
    ....
  89. ncbi request reprint Antioxidant supplementation does not affect fasting plasma glucose in the Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) study in France: association with dietary intake and plasma concentrations
    Sebastien Czernichow
    Nutritional Epidemiology Unit, French Institute of Health and Medical Research, CRNH Ile de France, Bobigny, France
    Am J Clin Nutr 84:395-9. 2006
    ..Observational data suggest a protective effect of several antioxidants on fasting plasma glucose (FPG) and type 2 diabetes. However, randomized trials have yielded inconsistent results...
  90. ncbi request reprint Dietary fiber intake and risk factors for cardiovascular disease in French adults
    Denis Lairon
    INSERM, U476, and INRA 1260, Universite de la Mediterranee, Marseille, France
    Am J Clin Nutr 82:1185-94. 2005
    ..Increased consumption of dietary fiber is widely recommended to maintain or improve health, but knowledge of the relation between dietary fiber sources and cardiovascular disease risk factors is limited...
  91. ncbi request reprint Homocysteine is not associated with arterial thickness and stiffness in healthy middle-aged French volunteers
    Angelika de Bree
    Unilever Food and Health Research Institute, Unilever Research and Development, Vlaardingen, The Netherlands
    Int J Cardiol 113:332-40. 2006
    ..To study the association between the total plasma homocysteine (tHcy) concentration and the carotid artery intima-medial wall thickness (IMT), pulse wave velocity (PWV) and the presence of arterial plaques in a French population...
  92. pmc Evaluation of the association of IGF2BP2 variants with type 2 diabetes in French Caucasians
    Konsta Duesing
    Section of Genomic Medicine, Imperial College London, Hammersmith Campus, London, U K
    Diabetes 57:1992-6. 2008
    ....
  93. ncbi request reprint Occurrence of coronary artery disease has an adverse impact on health-related quality of life: a longitudinal controlled study
    Stephanie Boini
    EA 4003 Ecole de Santé Publique, Faculte de Medecine, Université Henry Poincaré Nancy 1, 9 Avenue de la Forêt de Haye, BP 184, 54500 Vandoeuvre les Nancy, France
    Int J Cardiol 113:215-22. 2006
    ..The aim here was to investigate the impact of coronary artery disease occurrence on health-related quality of life...
  94. ncbi request reprint Vitamin supplementation in elderly persons
    Francois Girodon
    JAMA 289:173-4; author reply 174. 2003
  95. ncbi request reprint Genetic study of the melanin-concentrating hormone receptor 2 in childhood and adulthood severe obesity
    Maya Ghoussaini
    Centre National de la Recherche Scientifique Unité Mixte de Recherche 8090 Institute of Biology, Pasteur Institute, 59000 Lille, France
    J Clin Endocrinol Metab 92:4403-9. 2007
    ..MCHR2 maps on chromosome 6q16.3, in a susceptibility locus for childhood obesity...
  96. ncbi request reprint Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype-phenotype relationship, and lack of association with binge eating
    Cecile Lubrano-Berthelier
    Diabetes Center and Department of Medicine, University of California San Francisco, San Francisco, California 94143 0573, USA
    J Clin Endocrinol Metab 91:1811-8. 2006
    ..There are conflicting reports regarding the prevalence, nature, and pathogenic effects of MC4R mutations in adults with severe late-onset obesity...
  97. ncbi request reprint A synonymous coding polymorphism in the alpha2-Heremans-schmid glycoprotein gene is associated with type 2 diabetes in French Caucasians
    Afshan Siddiq
    Section of Genomic Medicine, 2nd Floor, 233 L Block, Imperial College, Hammersmith Campus, Du Cane Rd, London, W12 0NN UK
    Diabetes 54:2477-81. 2005
    ..A haplotype carrying the minor allele of SNP rs1071592 was protective against type 2 diabetes (P = 0.014). However, our analyses indicated that rs1071592 is not associated with the evidence for linkage of type 2 diabetes to 3q27...
  98. ncbi request reprint Expatriates in high-UV index and tropical countries: sun exposure and protection behavior in 9,416 French adults
    Khaled Ezzedine
    Department of Dermatology, Université Libre de Bruxelle, Erasmus Hospital, Brussels, Belgium
    J Travel Med 14:85-91. 2007
    ....
  99. ncbi request reprint [Iron deficiency in France: prevalence and prevention]
    Isabelle Hininger-Favier
    Laboratoire de Nutrition Vieillissement et Maladies Cardiovasculaires UFR de Pharmacie, Universite Joseph Fourier, 38700 Grenoble
    Bull Acad Natl Med 189:1623-30; discussion 1631-3. 2005
    ..The consequences of non anemic iron deficiency are unclear Conversely, excessive iron stores can be harmful, owing to the pro-oxidant imbalance they create...