Marie Lise Gougeon

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. doi Suppression by Thimerosal of Ex-Vivo CD4+ T Cell Response to Influenza Vaccine and Induction of Apoptosis in Primary Memory T Cells
    Emily Loison
    Antiviral Immunity Biotherapy and Vaccine Unit, Institut Pasteur, Paris, France
    PLoS ONE 9:e92705. 2014
  2. doi IFN-α and TRAIL: a double edge sword in HIV-1 disease?
    Marie Lise Gougeon
    Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Paris, France
    Exp Cell Res 318:1260-8. 2012
  3. pmc HMGB1, an alarmin promoting HIV dissemination and latency in dendritic cells
    M L Gougeon
    Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
    Cell Death Differ 19:96-106. 2012
  4. doi Natural killer cells, dendritic cells, and the alarmin high-mobility group box 1 protein: a dangerous trio in HIV-1 infection?
    Marie Lise Gougeon
    Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
    Curr Opin HIV AIDS 6:364-72. 2011
  5. pmc Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk--a pivotal role of HMGB1
    Marie Thérèse Melki
    Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Paris, France
    PLoS Pathog 6:e1000862. 2010
  6. ncbi Multiparametric flow cytometric analysis of biochemical and functional events associated with apoptosis and oncosis using the 7-aminoactinomycin D assay
    Hervé Lecoeur
    Département de Médecine Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Immunol Methods 265:81-96. 2002
  7. ncbi The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver
    Olivier Terradillos
    Unite de Recombinaison et Expression Genetique, INSERM U163, Institut Pasteur, Paris, France
    Oncogene 21:377-86. 2002
  8. ncbi Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3
    Luzia Maria de Oliveira Pinto
    Department of AIDS and Retroviruses, URA CNRS 1930, Institut Pasteur, Paris, Cedex 15, France
    Blood 99:1666-75. 2002
  9. ncbi A nonsecreted variant of interleukin-4 is associated with apoptosis: implication for the T helper-2 polarization in HIV infection
    Eric Ledru
    Antiviral Immunity, Biotherapy, and Vaccines Unit and the Viral Immunopathology Laboratory Unité de Recherche Associée Centre National de la Scientifique 1930, Molecular Medicine Department, Institut Pasteur, Paris, France
    Blood 101:3102-5. 2003
  10. pmc HMGB1-dependent triggering of HIV-1 replication and persistence in dendritic cells as a consequence of NK-DC cross-talk
    Hela Saidi
    Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Inserm U668, Paris, France
    PLoS ONE 3:e3601. 2008

Collaborators

Detail Information

Publications15

  1. doi Suppression by Thimerosal of Ex-Vivo CD4+ T Cell Response to Influenza Vaccine and Induction of Apoptosis in Primary Memory T Cells
    Emily Loison
    Antiviral Immunity Biotherapy and Vaccine Unit, Institut Pasteur, Paris, France
    PLoS ONE 9:e92705. 2014
    ....
  2. doi IFN-α and TRAIL: a double edge sword in HIV-1 disease?
    Marie Lise Gougeon
    Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Paris, France
    Exp Cell Res 318:1260-8. 2012
    ..In this review, we discuss our current understanding of the protective and pathogenic roles of both IFN-α and TRAIL in HIV-1 disease...
  3. pmc HMGB1, an alarmin promoting HIV dissemination and latency in dendritic cells
    M L Gougeon
    Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
    Cell Death Differ 19:96-106. 2012
    ....
  4. doi Natural killer cells, dendritic cells, and the alarmin high-mobility group box 1 protein: a dangerous trio in HIV-1 infection?
    Marie Lise Gougeon
    Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
    Curr Opin HIV AIDS 6:364-72. 2011
    ..Here we review the recent evidence suggesting that NK-dendritic cell crosstalk is disrupted during HIV-1 infection and we discuss the consequences on HIV persistence in dendritic cells...
  5. pmc Escape of HIV-1-infected dendritic cells from TRAIL-mediated NK cell cytotoxicity during NK-DC cross-talk--a pivotal role of HMGB1
    Marie Thérèse Melki
    Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Paris, France
    PLoS Pathog 6:e1000862. 2010
    ....
  6. ncbi Multiparametric flow cytometric analysis of biochemical and functional events associated with apoptosis and oncosis using the 7-aminoactinomycin D assay
    Hervé Lecoeur
    Département de Médecine Moléculaire, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Immunol Methods 265:81-96. 2002
    ..Finally, we show that this assay is not specific for apoptosis since it detects oncosis, the early stage of primary necrosis...
  7. ncbi The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver
    Olivier Terradillos
    Unite de Recombinaison et Expression Genetique, INSERM U163, Institut Pasteur, Paris, France
    Oncogene 21:377-86. 2002
    ..Our data indicate that the dominant function of HBx upon Bcl-2-regulated control of apoptosis might play an important role in the pathogenesis of chronic hepatitis B...
  8. ncbi Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3
    Luzia Maria de Oliveira Pinto
    Department of AIDS and Retroviruses, URA CNRS 1930, Institut Pasteur, Paris, Cedex 15, France
    Blood 99:1666-75. 2002
    ....
  9. ncbi A nonsecreted variant of interleukin-4 is associated with apoptosis: implication for the T helper-2 polarization in HIV infection
    Eric Ledru
    Antiviral Immunity, Biotherapy, and Vaccines Unit and the Viral Immunopathology Laboratory Unité de Recherche Associée Centre National de la Scientifique 1930, Molecular Medicine Department, Institut Pasteur, Paris, France
    Blood 101:3102-5. 2003
    ..The particular reactivity of apoptotic T cells to 8D4 mAb may explain some discordances among studies analyzing the Th1/Th2 balance in HIV infection and questions the function of this intracellular type 2 signal...
  10. pmc HMGB1-dependent triggering of HIV-1 replication and persistence in dendritic cells as a consequence of NK-DC cross-talk
    Hela Saidi
    Institut Pasteur, Antiviral Immunity, Biotherapy and Vaccine Unit, Inserm U668, Paris, France
    PLoS ONE 3:e3601. 2008
    ..Here, we investigate the impact of NK-DC cross-talk on maturation and functions of HIV-infected immature DCs...
  11. ncbi Apoptosis as an HIV strategy to escape immune attack
    Marie Lise Gougeon
    Antiviral Immunity, Biotherapy and Vaccine Unit, Department of Molecular Medicine, Pasteur Institute, 28 rue du Dr Roux, 75724 Cedex 15, Paris, France
    Nat Rev Immunol 3:392-404. 2003
    ..This review discusses the molecular mechanisms by which HIV manipulates the apoptotic machinery to its advantage, assesses the functional consequences of this process and evaluates how new therapeutics might counteract this strategy...
  12. doi Analysis of apoptotic pathways by multiparametric flow cytometry: application to HIV infection
    Hervé Lecoeur
    Unité d Immunophysiologie et Parasitisme Intracellulaire, Paris, France
    Methods Enzymol 442:51-82. 2008
    ..Several examples of combined staining of apoptotic cells are shown on peripheral blood lymphocytes from chronically HIV-infected patients, prone to undergo premature apoptosis...
  13. ncbi Adipocytes targets and actors in the pathogenesis of HIV-associated lipodystrophy and metabolic alterations
    Marie Lise Gougeon
    Unité d Immunité Anti virale, Biothérapie et Vaccins, Département de Médecine Moléculaire, Institut Pasteur, Paris, France
    Antivir Ther 9:161-77. 2004
    ....
  14. ncbi T cell repertoire diversity is required for relapses in myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis
    Nicolas Fazilleau
    Institut National de la Sante et de la Recherche Medicale, Unité 277, Institut Pasteur, Paris, France
    J Immunol 178:4865-75. 2007
    ..Thus, in addition to epitope spreading, a novel mechanism involving TCRalphabeta repertoire diversification contributes to autoimmune progression...
  15. ncbi Human TCR alpha/beta+ CD4-CD8- double-negative T cells in patients with autoimmune lymphoproliferative syndrome express restricted Vbeta TCR diversity and are clonally related to CD8+ T cells
    Anne Bristeau-Leprince
    Antiviral Immunity, Biotherapy and Vaccine Unit, Infection and Epidemiology Department, Institut Pasteur, Paris, France
    J Immunol 181:440-8. 2008
    ..CDR3 sequencing of matching clonotypes revealed a significant sharing of CDR3 sequences from selected Vbeta-Jbeta transcripts between DN and CD8+ T cells. Altogether, these data strongly argue for a CD8 origin of DN T cells in ALPS...