Antoine Gessain

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. doi request reprint HTLV-3/4 and simian foamy retroviruses in humans: discovery, epidemiology, cross-species transmission and molecular virology
    Antoine Gessain
    Institut Pasteur, Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, France, Departement de Virologie, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris, Cedex 15, France
    Virology 435:187-99. 2013
  2. doi request reprint Tropical spastic paraparesis and HTLV-1 associated myelopathy: clinical, epidemiological, virological and therapeutic aspects
    A Gessain
    CNRS URA 1930, Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Department of Virology, Institut Pasteur, 28, rue du Dr Roux, 75724 Paris Cedex 15, France
    Rev Neurol (Paris) 168:257-69. 2012
  3. pmc Two distinct variants of simian foamy virus in naturally infected mandrills (Mandrillus sphinx) and cross-species transmission to humans
    Augustin Mouinga-Ondeme
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Retrovirology 7:105. 2010
  4. pmc Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo
    Linda Zane
    CNRS UMR5239, Universite de Lyon, Oncovirologie et Biothérapies, Centre Leon Berard, 69008 Lyon, France
    Retrovirology 7:17. 2010
  5. pmc Intrahost variations in the envelope receptor-binding domain (RBD) of HTLV-1 and STLV-1 primary isolates
    Felix J Kim
    Institut de Génétique Moléculaire de Montpellier IGMM, 1919 Rte de Mende, F 34293 Montpellier cedex 5, France
    Retrovirology 3:29. 2006
  6. pmc The imprint of the Slave Trade in an African American population: mitochondrial DNA, Y chromosome and HTLV-1 analysis in the Noir Marron of French Guiana
    Nicolas Brucato
    Laboratoire d Anthropobiologie Moléculaire et Imagerie de Synthèse, CNRS and Université Paul Sabatier, FRE2960, Toulouse, France
    BMC Evol Biol 10:314. 2010
  7. ncbi request reprint Human herpesvirus 8 primary infection occurs during childhood in Cameroon, Central Africa
    A Gessain
    Departement des Retrovirus, Institut Pasteur, Paris, France
    Int J Cancer 81:189-92. 1999
  8. ncbi request reprint Spindle cells and their role in Kaposi's sarcoma
    Antoine Gessain
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département des Ecosytèmes et Epidémiologie des Maladies Infectieuses, Paris Cedex 15, France
    Int J Biochem Cell Biol 37:2457-65. 2005
  9. ncbi request reprint [A virus called HTLV-1. Virological and molecular aspects]
    A Gessain
    Unité d Oncologie Virale, Departement du SIDA et des Retrovirus, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris
    Presse Med 29:2228-32. 2000
  10. ncbi request reprint [A virus called HTLV-1. Epidemiological aspects]
    A Gessain
    Unité d Oncologie Virale, Departement du SIDA et des Retrovirus, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris
    Presse Med 29:2233-9. 2000

Detail Information

Publications127 found, 100 shown here

  1. doi request reprint HTLV-3/4 and simian foamy retroviruses in humans: discovery, epidemiology, cross-species transmission and molecular virology
    Antoine Gessain
    Institut Pasteur, Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, France, Departement de Virologie, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris, Cedex 15, France
    Virology 435:187-99. 2013
    ..In Central Africa, the increase of the bushmeat trade during the last decades has opened new possibilities for retroviral emergence in humans, especially in immuno-compromised persons...
  2. doi request reprint Tropical spastic paraparesis and HTLV-1 associated myelopathy: clinical, epidemiological, virological and therapeutic aspects
    A Gessain
    CNRS URA 1930, Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Department of Virology, Institut Pasteur, 28, rue du Dr Roux, 75724 Paris Cedex 15, France
    Rev Neurol (Paris) 168:257-69. 2012
    ..TSP/HAM can be associated with other HTLV-1 associated symptoms (uveitis, myositis, infective dermatitis). Therapy of TSP/HAM remains disappointing and symptomatic treatment remains still the mainstay of therapy...
  3. pmc Two distinct variants of simian foamy virus in naturally infected mandrills (Mandrillus sphinx) and cross-species transmission to humans
    Augustin Mouinga-Ondeme
    Unité de Rétrovirologie, Centre International de Recherches Medicales de Franceville, Franceville, Gabon
    Retrovirology 7:105. 2010
    ..We evaluated the natural history of the virus in a free-ranging colony of mandrills and investigated possible transmission of mandrill SFV to humans...
  4. pmc Tax gene expression and cell cycling but not cell death are selected during HTLV-1 infection in vivo
    Linda Zane
    CNRS UMR5239, Universite de Lyon, Oncovirologie et Biothérapies, Centre Leon Berard, 69008 Lyon, France
    Retrovirology 7:17. 2010
    ..HTLV-1 expression is cancer-prone in vitro, but in vivo numerous selection forces act to maintain T cell homeostasis and are possibly involved in clonal selection...
  5. pmc Intrahost variations in the envelope receptor-binding domain (RBD) of HTLV-1 and STLV-1 primary isolates
    Felix J Kim
    Institut de Génétique Moléculaire de Montpellier IGMM, 1919 Rte de Mende, F 34293 Montpellier cedex 5, France
    Retrovirology 3:29. 2006
    ..The new highly sensitive env PCR described here appears suitable for the screening of all known variants of the different PTLV types and should, therefore, be useful for the analysis of seroindeterminate samples...
  6. pmc The imprint of the Slave Trade in an African American population: mitochondrial DNA, Y chromosome and HTLV-1 analysis in the Noir Marron of French Guiana
    Nicolas Brucato
    Laboratoire d Anthropobiologie Moléculaire et Imagerie de Synthèse, CNRS and Université Paul Sabatier, FRE2960, Toulouse, France
    BMC Evol Biol 10:314. 2010
    ..Uniparental markers (mtDNA and NRY) coupled with HTLV-1 sequences (env and LTR) were studied to establish the genetic relationships linking them to African American and African populations...
  7. ncbi request reprint Human herpesvirus 8 primary infection occurs during childhood in Cameroon, Central Africa
    A Gessain
    Departement des Retrovirus, Institut Pasteur, Paris, France
    Int J Cancer 81:189-92. 1999
    ..We hypothesize that the lymphadenopathic form of KS seen in African children is related to an early and massive infection by HHV-8 in susceptible individuals...
  8. ncbi request reprint Spindle cells and their role in Kaposi's sarcoma
    Antoine Gessain
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département des Ecosytèmes et Epidémiologie des Maladies Infectieuses, Paris Cedex 15, France
    Int J Biochem Cell Biol 37:2457-65. 2005
    ....
  9. ncbi request reprint [A virus called HTLV-1. Virological and molecular aspects]
    A Gessain
    Unité d Oncologie Virale, Departement du SIDA et des Retrovirus, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris
    Presse Med 29:2228-32. 2000
    ..Specifically leukernogeneic or neurotrophic strains are unlikely to exist. However, despite this genetic stability, there are molecular variants related to the geographical origin of the virus...
  10. ncbi request reprint [A virus called HTLV-1. Epidemiological aspects]
    A Gessain
    Unité d Oncologie Virale, Departement du SIDA et des Retrovirus, Institut Pasteur, 28 rue du Dr Roux, F 75724 Paris
    Presse Med 29:2233-9. 2000
    ....
  11. ncbi request reprint [Human herpesvirus 8 and associated diseases: Kaposi's sarcoma, body cavity based lymphoma and multicentric Castleman disease: clinical and molecular epidemiology]
    A Gessain
    Departement des Retrovirus, Institut Pasteur, Paris
    Bull Acad Natl Med 181:1023-34. 1997
    ..Preliminary data indicate the existence of a low genetic variability of HHV8 in several regions of its genome, with however the presence of molecular subtypes linked possibly to the geographical origin of the infected patients...
  12. ncbi request reprint [Human herpesvirus 8 (HHV-8): clinical and epidemiological aspects and clonality of associated tumors]
    Antoine Gessain
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, URA CNRS 3015, Departement de Virologie, Batiment Lwoff, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Bull Acad Natl Med 192:1189-204; discussion 1204-6. 2008
    ....
  13. ncbi request reprint [Epidemiology, origin and genetic diversity of HTLV-1 retrovirus and STLV-1 simian affiliated retrovirus]
    A Gessain
    Departement du SIDA et des Retrovirus, Institut Pasteur, Paris
    Bull Soc Pathol Exot 93:163-71. 2000
    ..g., the slave trade from Africa to the New World...
  14. doi request reprint New strain of human T lymphotropic virus (HTLV) type 3 in a Pygmy from Cameroon with peculiar HTLV serologic results
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, URA CNRS 3015, Departement de Virologie, and Institut de Recherche pour le Développement, Musée de l Homme, Paris, France
    J Infect Dis 199:561-4. 2009
    ..These results were different from those for the 2 previously reported HTLV-3 strains, raising questions about serological confirmation of infection with such retroviruses...
  15. ncbi request reprint Detection and molecular characterization of foamy viruses in Central African chimpanzees of the Pan troglodytes troglodytes and Pan troglodytes vellerosus subspecies
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département EEMI, Institut Pasteur, Paris, France
    J Med Primatol 35:59-66. 2006
    ..This zoonotic infection was demonstrated mainly after bites by chimpanzees [Pan troglodytes (P. t.)] of the West African P. t. verus subspecies in primatology centers or zoos in the USA...
  16. pmc Discovery of a new human T-cell lymphotropic virus (HTLV-3) in Central Africa
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    Retrovirology 2:30. 2005
    ....
  17. doi request reprint HTLV-2B strains, similar to those found in several Amerindian tribes, are endemic in central African Bakola Pygmies
    Philippe Mauclere
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut National de la Santéet de la Recherche Médicale, Paris, France
    J Infect Dis 203:1316-23. 2011
    ..The presence and origin of endemic foci of human T-lymphotropic virus type 2 (HTLV2) infection in Africa remain a matter of debate...
  18. ncbi request reprint In primary effusion lymphoma cells, MYB transcriptional repression is associated with v-FLIP expression during latent KSHV infection while both v-FLIP and v-GPCR become involved during the lytic cycle
    Vincent Lacoste
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris, France
    Br J Haematol 138:487-501. 2007
    ..Taken together, our results demonstrate that, contrary to a number of other haematological malignancies, MYB expression is not required for PEL cell proliferation. Repressing MYB expression also helps in maintaining the virus in latency...
  19. pmc Modes of transmission and genetic diversity of foamy viruses in a Macaca tonkeana colony
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Departement de Virologie, Institut Pasteur, Paris, France
    Retrovirology 3:23. 2006
    ..Furthermore, all the serological and molecular data, obtained in this free-breeding colony, argue against a significant transmission of SFVs from mother or father to infants as well as between siblings...
  20. ncbi request reprint Molecular epidemiology of the HHV-8 K1 gene from Moroccan patients with Kaposi's sarcoma
    Renan Duprez
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Departement de Virologie, Institut Pasteur, 25 28 Rue du Dr Roux, 75724, Paris, Cedex 15, France
    Virology 353:121-32. 2006
    ..e., North African vs. sub-Saharan African vs. West Eurasian linages) and any HHV-8 strain because both C' and C'' strains were randomly distributed among the different patients' population backgrounds...
  21. doi request reprint Multiple retroviral infection by HTLV type 1, 2, 3 and simian foamy virus in a family of Pygmies from Cameroon
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, URA CNRS 3015, Departement de Virologie, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris, Cedex 15, France
    Virology 410:48-55. 2011
    ....
  22. ncbi request reprint Human blood-brain barrier disruption by retroviral-infected lymphocytes: role of myosin light chain kinase in endothelial tight-junction disorganization
    Philippe Vicente Afonso
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département de Virologie and Centre National de la Recherche Scientifique Unité de Recherche Associée 3015, Institut Pasteur, Paris, France
    J Immunol 179:2576-83. 2007
    ..Based on this BBB model, the present data indicate that HTLV-1-infected lymphocytes can induce BBB breakdown and may be responsible for the CNS infiltration that occurs in the early steps of retroviral-associated neuromyelopathies...
  23. pmc Construction and characterization of a full-length infectious simian T-cell lymphotropic virus type 3 molecular clone
    Sébastien Alain Chevalier
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 3015, Departement de Virologie, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Virol 81:6276-85. 2007
    ..This clone will give us a unique opportunity to study in vitro the different pX transcripts and the putative presence of antisense transcripts and to evaluate the PTLV-3 pathogenicity in vivo...
  24. pmc Frequent and recent human acquisition of simian foamy viruses through apes' bites in central Africa
    Edouard Betsem
    Unit of Epidemiology and Pathophysiology of Oncogenic Viruses, Department of Virology, Institut Pasteur, Paris, France
    PLoS Pathog 7:e1002306. 2011
    ..The virus was found to persist over several years, with low SFV loads in infected persons. Secondary transmission remains an open question...
  25. ncbi request reprint Cutaneous disseminated endemic Kaposi's sarcoma in a Polynesian man infected with a new divergent human herpesvirus 8 subtype D
    Renan Duprez
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris, France
    J Clin Virol 37:222-6. 2006
  26. ncbi request reprint Respective roles of serological status and blood specific antihuman herpesvirus 8 antibody levels in human herpesvirus 8 intrafamilial transmission in a highly endemic area
    Sabine Plancoulaine
    Universite Rene Descartes, INSERM U 550, Faculte de Medecine Necker, Paris, France
    Cancer Res 64:8782-7. 2004
    ....
  27. pmc Alteration of blood-brain barrier integrity by retroviral infection
    Philippe V Afonso
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA3015, Institut Pasteur, Paris, France
    PLoS Pathog 4:e1000205. 2008
    ....
  28. pmc Construction and characterization of a human T-cell lymphotropic virus type 3 infectious molecular clone
    Sébastien Alain Chevalier
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 3015, Departement de Virologie, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, France
    J Virol 82:6747-52. 2008
    ..Viral particles are visible by electron microscopy. These particles are infectious, as demonstrated by infection experiments with purified virions...
  29. pmc Human herpesvirus 8 genotype E in patients with Kaposi sarcoma, Peru
    Olivier Cassar
    Institut Pasteur, Paris, France
    Emerg Infect Dis 16:1459-62. 2010
    ..Our findings of 8 A, 1 B, 14 C, and 2 E subtypes showed high HHV-8 diversity in these patients and association between E genotype and KS development...
  30. ncbi request reprint Natural simian foamy virus infection in wild-caught gorillas, mandrills and drills from Cameroon and Gabon
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département EMMI, Institut Pasteur, Paris, France
    J Gen Virol 85:3313-7. 2004
    ....
  31. pmc A major locus on chromosome 3p22 conferring predisposition to human herpesvirus 8 infection
    Vincent Pedergnana
    Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale U980, Paris, France
    Eur J Hum Genet 20:690-5. 2012
    ..83, P=2.0 × 10(-5)). This study provides the first evidence that HHV-8 infection in children in endemic areas has a strong genetic basis involving at least one recessive major locus on chromosome 3p22...
  32. ncbi request reprint A major susceptibility locus for HTLV-1 infection in childhood maps to chromosome 6q27
    Sabine Plancoulaine
    Laboratoire de Genetique Humaine des Maladies Infectieuses, université Paris René Descartes, INSERM, U550, Faculte de Medecine Necker, 156 rue de Vaugirard, Paris, France
    Hum Mol Genet 15:3306-12. 2006
    ....
  33. pmc Human herpesvirus 8 serological markers and viral load in patients with AIDS-associated Kaposi's sarcoma in Central African Republic
    Renan Duprez
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département Ecosytèmes et Epidémiologie des Maladies Infectieuses Batiment Lwoff, Institut Pasteur, Paris, France
    J Clin Microbiol 43:4840-3. 2005
    ..07 log copies/mug DNA) than in unaffected skin (2.93 log copies/mug DNA) or in PBMCs (2.55 log copies/mug DNA)...
  34. pmc Seroprevalence and molecular epidemiology of human T-Cell leukemia virus type 1 (HTLV-1) and HTLV-2 in blood donors from Dakar, Senegal
    Saliou Diop
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département Ecosytèmes et Epidémiologie des Maladies Infectieuses, Batiment Lwoff, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris, Cedex 15, France
    J Clin Microbiol 44:1550-4. 2006
    ..These data highlight the problem of transfusion safety in this area where HTLV-1-associated lymphoproliferative and neurological diseases are endemic...
  35. ncbi request reprint Kaposi's sarcoma in Morocco: a pathological study with immunostaining for human herpesvirus-8 LNA-1
    Oumkaltoum Hbid
    Unité de Recherche et d Expertise en Histotechnologie et Pathologie, Institut Pasteur, Paris, France
    Pathology 37:288-95. 2005
    ..We report here the clinical, virological and pathological features of 26 KS cases, including 17 classic forms, eight epidemic forms and one case of post-transplant KS...
  36. pmc Human T-cell lymphotropic virus type 3: complete nucleotide sequence and characterization of the human tax3 protein
    Sara Calattini
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 1930, Departement de Virologie, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    J Virol 80:9876-88. 2006
    ..Altogether, these results demonstrate that although HTLV-3 and HTLV-1 have only 60% identity, Tax3Pyl43 is functionally closely related to the transforming protein Tax1 and suggest that HTLV-3, like HTLV-1, might be pathogenic in vivo...
  37. ncbi request reprint Evolutionary inferences of novel simian T lymphotropic virus type 1 from wild-caught chacma (Papio ursinus) and olive baboons (Papio anubis)
    R Mahieux
    , Institut Pasteur, 28 rue du Dr Roux, Paris, Cedex 15, 75724, France
    Virology 251:71-84. 1998
    ..anubis, corroborates the hypothesis of cross-species transmissions of STLV-1 in the wild. Further, phylogenetic analyses indicate that the known HTLV-1 strains do not share a common origin with nonhuman primates STLV in South Africa...
  38. pmc A new and frequent human T-cell leukemia virus indeterminate Western blot pattern: epidemiological determinants and PCR results in central African inhabitants
    Claudia Filippone
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Departement de Virologie, Institut Pasteur, Paris, France
    J Clin Microbiol 50:1663-72. 2012
    ..Moreover, this new pattern persists over time...
  39. doi request reprint Transcytosis of HTLV-1 across a tight human epithelial barrier and infection of subepithelial dendritic cells
    Sandra Martin-Latil
    Unité Epidémiologie et Physiopathologie des Virus Oncogènes, URA Centre National de la Recherche Scientifique 3015, Institut Pasteur, Paris, France
    Blood 120:572-80. 2012
    ..The present study provides the first data pertaining to the mode of HTLV-1 transport across a tight epithelial barrier, as can occur during mother-to-child HTLV-1 transmission during breastfeeding...
  40. ncbi request reprint A 10-amino acid domain within human T-cell leukemia virus type 1 and type 2 tax protein sequences is responsible for their divergent subcellular distribution
    Laurent Meertens
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, 75724 Paris Cedex 15, France
    J Biol Chem 279:43307-20. 2004
    ..Finally, we show a high correlation between intracellular localization of Tax and their NF-kappaB or CREB transactivating ability...
  41. doi request reprint Highly active antiretroviral treatment against STLV-1 infection combining reverse transcriptase and HDAC inhibitors
    Philippe V Afonso
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Centre National de la Recherche Scientifique CNRS URA 3015, Institut Pasteur, Paris, France
    Blood 116:3802-8. 2010
    ..Such treatments may be useful to reduce the risk of HAM/TSP in asymptomatic carriers with a high PVL...
  42. ncbi request reprint Evidence for a multiclonal origin of multicentric advanced lesions of Kaposi sarcoma
    Renan Duprez
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Departement de Virologie, Institut Pasteur, Paris, France
    J Natl Cancer Inst 99:1086-94. 2007
    ....
  43. pmc Simian foamy virus transmission from apes to humans, rural Cameroon
    Sara Calattini
    Institut Pasteur, Paris, France
    Emerg Infect Dis 13:1314-20. 2007
    ..6%) of those who had had contact with monkeys. These data demonstrate efficient transmission of SFVs to humans in natural settings in central Africa, specifically following ape bites, and viral persistence in the human host...
  44. pmc DC-SIGN facilitates fusion of dendritic cells with human T-cell leukemia virus type 1-infected cells
    Pierre Emmanuel Ceccaldi
    Unité Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris Cedex 15, France
    J Virol 80:4771-80. 2006
    ..Altogether, our results indicate that DC-SIGN facilitates HTLV-1 infection and fusion of DCs through an ICAM-dependent mechanism...
  45. pmc Simian T-cell lymphotropic virus type 1 from Mandrillus sphinx as a simian counterpart of human T-cell lymphotropic virus type 1 subtype D
    R Mahieux
    , Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 72:10316-22. 1998
    ..Due to the quasi-identity of both human and monkey viruses, interspecies transmission episodes leading to such a clade may have occurred recently...
  46. pmc Genetic characterization of simian foamy viruses infecting humans
    Rejane Rua
    Unit of Epidemiology and Physiopathology of Oncogenic Viruses, Department of Virology, Institut Pasteur, Paris, France
    J Virol 86:13350-9. 2012
    ..Our study reveals that natural polymorphism of SFV strains does exist at both the intersubspecies level (gag, bet) and the intrasubspecies (U3, tas) levels but does not seem to reflect a viral adaptation specific to zoonotic SFV strains...
  47. ncbi request reprint Evidence for a recessive major gene predisposing to human herpesvirus 8 (HHV-8) infection in a population in which HHV-8 is endemic
    Sabine Plancoulaine
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Université René Descartes INSERM U 550, Faculte de Medecine Necker, Paris, France
    J Infect Dis 187:1944-50. 2003
    ....
  48. doi request reprint Divergent KSHV/HHV-8 subtype D strains in New Caledonia and Solomon Islands, Melanesia
    Olivier Cassar
    Institut Pasteur, Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Departement de Virologie, F 75015 Paris, France
    J Clin Virol 53:214-8. 2012
    ..KSHV exhibits a high genetic variability comprising five genotypes (A-E). Few data are yet available concerning the situation of KSHV, its genetic variability and the associated diseases in Melanesia...
  49. doi request reprint The human HTLV-3 and HTLV-4 retroviruses: new members of the HTLV family
    R Mahieux
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 3015, Departement de Virologie, Institut Pasteur, 28, rue du Dr Roux, 75015 Paris, France
    Pathol Biol (Paris) 57:161-6. 2009
    ..Furthermore, molecular characterization of their viral transactivator Tax is ongoing in order to look for possible oncogenic properties...
  50. pmc Restriction of foamy viruses by APOBEC cytidine deaminases
    Frédéric Delebecque
    Virus and Immunity Group, URA CNRS 1930, Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 80:605-14. 2006
    ..In infected hosts, the persistence strategy employed by FV might be based on low levels of replication, as well as avoidance of cells expressing large amounts of active cytidine deaminases...
  51. ncbi request reprint Mono/oligoclonal pattern of Kaposi Sarcoma-associated herpesvirus (KSHV/HHV-8) episomes in primary effusion lymphoma cells
    Emmanuelle Boulanger
    Unité d Epidémiologie et de Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris, France
    Int J Cancer 115:511-8. 2005
    ..Several of these mechanisms, not mutually exclusive, might coexist in a single tumor...
  52. pmc Maternal traces of deep common ancestry and asymmetric gene flow between Pygmy hunter-gatherers and Bantu-speaking farmers
    Lluis Quintana-Murci
    Human Evolutionary Genetics Unit, Centre National de la Recherche Scientifique URA3012, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 105:1596-601. 2008
    ....
  53. pmc Direct evidence for a chronic CD8+-T-cell-mediated immune reaction to tax within the muscle of a human T-cell leukemia/lymphoma virus type 1-infected patient with sporadic inclusion body myositis
    Simona Ozden
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Paris, France
    J Virol 78:10320-7. 2004
    ....
  54. pmc Inferring the demographic history of African farmers and pygmy hunter-gatherers using a multilocus resequencing data set
    Etienne Patin
    Institut Pasteur, Human Evolutionary Genetics, CNRS, URA3012, Paris, France
    PLoS Genet 5:e1000448. 2009
    ..An appreciation of the demographic and adaptive history of African populations with different modes of subsistence should improve our understanding of the influence of human lifestyles on genome diversity...
  55. doi request reprint Inhibition of Chikungunya virus infection in cultured human muscle cells by furin inhibitors: impairment of the maturation of the E2 surface glycoprotein
    Simona Ozden
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 3015, Institut Pasteur, 75724 Paris, France
    J Biol Chem 283:21899-908. 2008
    ..Our results demonstrate the role of furin-like proteases in the processing of CHIKV particles and point out new approaches to inhibit this infection...
  56. ncbi request reprint Seroepidemiological and molecular studies of human T cell lymphotropic virus type II, subtype b, in isolated groups of Mataco and Toba Indians of northern Argentina
    M Biglione
    Unité d Epidémiologie des Virus Oncogènes, Institut Pasteur, Paris, France
    AIDS Res Hum Retroviruses 15:407-17. 1999
    ..Such data help to make a phylogenetic atlas of HTLV-II among Amerindian tribes and are crucial to gain new insights into the origin and modes of dissemination of this human retrovirus in the Americas...
  57. ncbi request reprint HTLV-I infection in squirrel monkeys (Saïmiri sciureus) using autologous, homologous, or heterologous HTLV-I-transformed cell lines
    M Kazanji
    Unité d Epidémiologie des Virus Oncogènes, Institut Pasteur, Paris, France
    Virology 231:258-66. 1997
    ..The squirrel monkey, which is naturally free of simian T-cell leukemia/ lymphoma virus, thus appears to be a suitable model for evaluating HTLV-I candidate vaccines and for studying the pathogenesis of HTLV-I...
  58. ncbi request reprint High titers of anti-human herpesvirus 8 antibodies in elderly males in an endemic population
    Sabine Plancoulaine
    Laboratoire de Genetique Humaine des Maladies Infectieuses, Institut National de la Sante et de la Recherche Medicale, Unité 550, Faculte de Medecine Necker, Paris, France
    J Natl Cancer Inst 94:1333-5. 2002
    ..Our results suggest that the role of gender should also be considered in evaluating the association between anti-HHV8 antibody titers in people aged 40 years and older and the risk of developing KS...
  59. pmc Innate sensing of foamy viruses by human hematopoietic cells
    Rejane Rua
    Institut Pasteur, Virus and Immunity Unit, URA CNRS 3015, Paris, France
    J Virol 86:909-18. 2012
    ..Therefore, FV are potent inducers of type I IFN by pDCs and by PBMCs. This previously underestimated activation of the innate immune response may be involved in the control of viral replication in humans...
  60. pmc Presence of a functional but dispensable nuclear export signal in the HTLV-2 Tax protein
    Sébastien A Chevalier
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris, France
    Retrovirology 2:70. 2005
    ..We have recently demonstrated that Tax1 and Tax2 display different subcellular localization and that residues 90-100 are critical for this process. We investigate in the present report, whether Tax2 also possesses a functional NES...
  61. pmc Human muscle satellite cells as targets of Chikungunya virus infection
    Simona Ozden
    Unité Epidémiologie et Physiopathologie des Virus Oncogènes CNRS URA1930, Institut Pasteur, Paris, France
    PLoS ONE 2:e527. 2007
    ..7% of cases. Since the cellular targets of CHIK virus in humans are unknown, we studied the pathogenic events and targets of CHIK infection in skeletal muscle...
  62. ncbi request reprint Evolutionary insights into the high worldwide prevalence of MBL2 deficiency alleles
    Paul Verdu
    CNRS FRE 2849, Unit of Molecular Prevention and Therapy of Human Diseases, Institut Pasteur, Paris, France
    Hum Mol Genet 15:2650-8. 2006
    ..The evolutionary neutrality of MBL2 strongly supports the notion that MBL2 variation does not have strong effects on population fitness, suggesting, therefore, that this lectin is largely redundant in host human defences...
  63. pmc Divergent simian T-cell lymphotropic virus type 3 (STLV-3) in wild-caught Papio hamadryas papio from Senegal: widespread distribution of STLV-3 in Africa
    Laurent Meertens
    , , Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 77:782-9. 2003
    ....
  64. ncbi request reprint Utilization of the CBP but not the p300 co-activator by human T-lymphotropic virus type-2 Tax for p53 inhibition
    Laurent Meertens
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Oncogene 23:5447-58. 2004
    ..Given the similarities between the functional domains of CBP and p300, these results are intriguing and suggest that Tax-2B must bind the CR2 domain of CBP, but not that of p300 in order to repress p53...
  65. doi request reprint Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses
    Ana Monica Pais-Correia
    Institut Pasteur, Unite de Biologie Cellulaire des Lymphocytes, Centre National de Recherche Scientifique CNRS, Unité de Recherche Associée 1961, Paris, France
    Nat Med 16:83-9. 2010
    ..HTLV-1 biofilm-like structures represent a major route for virus transmission from cell to cell...
  66. ncbi request reprint Complete nucleotide sequence of an African human T-lymphotropic virus type II subtype b isolate (HTLV-II-Gab): molecular and phylogenetic analysis
    F Letourneur
    GENSET, Paris, France
    J Gen Virol 79:269-77. 1998
    ..Nevertheless, the very low genetic divergence observed between this new African strain and the American strains raises several questions on the origins and level of genetic variability over time of this human retrovirus...
  67. ncbi request reprint Infection of rats with human T-cell leukemia virus type-I: susceptibility of inbred strains, antibody response and provirus location
    F Ibrahim
    , Institut Pasteur, Paris, France
    Int J Cancer 58:446-51. 1994
    ..It is concluded that HTLV-I infection occurs in adult rats, but is suppressed with time...
  68. pmc Isolation and characterization of a new simian T-cell leukemia virus type 1 from naturally infected celebes macaques (Macaca tonkeana): complete nucleotide sequence and phylogenetic relationship with the Australo-Melanesian human T-cell leukemia virus typ
    F Ibrahim
    , Institut Pasteur, France
    J Virol 69:6980-93. 1995
    ....
  69. ncbi request reprint Comparative trends of seroprevalence and seroincidence rates of human T cell lymphotropic virus type I and human immunodeficiency virus 1 in pregnant women of various ethnic groups sharing the same environment in French Guiana
    Patricia Tortevoye
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département d Ecosystème et Epidémiologie des Maladies Infectieuses, Institut Pasteur, Paris, France
    Am J Trop Med Hyg 73:560-5. 2005
    ..While HTLV-I, which is highly endemic in groups of African origin, showed a slight decrease over time in a suspected cohort effect, HIV-1 spread rapidly in an epidemic mode, especially in the groups of the lowest socioeconomic levels...
  70. ncbi request reprint Efficient transfer of HTLV-1 tax gene in various primary and immortalized cells using a flap lentiviral vector
    Christelle Royer-Leveau
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris, Cedex 15 France
    J Virol Methods 105:133-40. 2002
    ..Therefore, this vector provides a useful tool for investigating the role of the Tax viral protein in the pathogenesis of diseases linked to HTLV-1 infection...
  71. pmc Muscle wasting induced by HTLV-1 tax-1 protein: an in vitro and in vivo study
    Simona Ozden
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département Ecosystèmes et Epidémiologie des Maladies Infectieuses, Institut Pasteur, Paris, France
    Am J Pathol 167:1609-19. 2005
    ..The present data indicate that the myocytotoxicity that is observed in HTLV-1-associated myopathies can be due to a direct effect of the Tax-1 protein expressed in infected inflammatory cells, in the absence of muscle cell infection...
  72. ncbi request reprint A novel homologue of Human herpesvirus 6 in chimpanzees
    Vincent Lacoste
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Département EEMI, Batiment Lwoff, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Gen Virol 86:2135-40. 2005
    ..Characterization of this virus represents a great potential to gain a better understanding of the diseases associated with HHV-6...
  73. pmc Human herpesvirus 8, southern siberia
    Olivier Cassar
    Institut Pasteur, Paris, France O Cassar, S Bassot, S Plancoulaine, L Quintana Murci, G de The, C Harmant, A Gessain Institut National de la Sante et de la Recherche Medicale INSERM, Paris S Plancoulaine Centre National de la Recherche Scientifique CNRS, Paris L Quintana Murci and Blokhin Cancer Research Center, Moscow, Russia V Gurtsevitch, N B Senyuta, L S Yakovleva
    Emerg Infect Dis 16:580-2. 2010
    ....
  74. pmc Characterization of reemerging chikungunya virus
    Marion Sourisseau
    Department of Virology, Unité Virus et Immunite, Institut Pasteur, Paris, France
    PLoS Pathog 3:e89. 2007
    ..CHIKV was highly sensitive to the antiviral activity of type I and II interferons. These results provide a general insight into the interaction between CHIKV and its mammalian host...
  75. ncbi request reprint Serological and molecular evidence that human herpesvirus 8 is endemic among Amerindians in French Guiana
    Mirdad Kazanji
    Laboratoire de Retrovirologie, Institut Pasteur de la Guyane, Cayenne, French Guiana
    J Infect Dis 192:1525-9. 2005
    ..Analysis of a 725-base pair fragment of the K1 gene amplified from DNA from a Wayampi Amerindian showed that the virus belonged to molecular subtype E, which has hitherto been found in only a few Amerindians in Brazil and Ecuador...
  76. ncbi request reprint Molecular characterization and phylogenetic analyses of a new simian T cell lymphotropic virus type 1 in a wild-caught african baboon (Papio anubis) with an indeterminate STLV type 2-like serology
    R Mahieux
    Unité d Oncologie Virale, Institut Pasteur, 75724 Paris Cedex 15, France
    AIDS Res Hum Retroviruses 16:2043-8. 2000
    ..The complete p19 sequence reveals amino acid changes at critical positions. This is the first report of an African STLV-1 virus leading to an STLV-2-like serological profile in its host...
  77. ncbi request reprint Genetic variability and molecular epidemiology of human and simian T cell leukemia/lymphoma virus type I
    A Gessain
    , Institut Pasteur, Paris, France
    J Acquir Immune Defic Syndr Hum Retrovirol 13:S132-45. 1996
    ..While geographical subtypes vary from 2 to 8% between themselves, HTLV-I quasi-species present within an individual appear to be much lower, with a variability of < 0.5%...
  78. ncbi request reprint Monoclonality or oligoclonality of human herpesvirus 8 terminal repeat sequences in Kaposi's sarcoma and other diseases
    J G Judde
    Unité d Oncologie Virale, Departement des Retrovirus, Institut Pasteur, Paris, France
    J Natl Cancer Inst 92:729-36. 2000
    ..The purpose of this study was to examine whether the number of terminal repeats (TRs) contained in the fused TR region of HHV8 could be used as a marker of clonality in HHV8-associated tumors...
  79. ncbi request reprint Arsenic trioxide induces apoptosis in human T-cell leukemia virus type 1- and type 2-infected cells by a caspase-3-dependent mechanism involving Bcl-2 cleavage
    R Mahieux
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris, France
    Blood 98:3762-9. 2001
    ..The antiapoptotic factor Bcl-2 was then cleaved, converting it to a Bax-like death effector. These results demonstrated that arsenic trioxide induces apoptosis in HTLV-1- and -2-infected cells through activation of the caspase pathway...
  80. pmc Isolation and molecular characterization of a human T-cell lymphotropic virus type II (HTLV-II), subtype B, from a healthy Pygmy living in a remote area of Cameroon: an ancient origin for HTLV-II in Africa
    A Gessain
    , Institut Pasteur, Paris, France
    Proc Natl Acad Sci U S A 92:4041-5. 1995
    ..The low genetic divergence of this African isolate from American isolates raises questions about the genetic variability over time and the origin and dissemination of HTLV-II, hitherto considered to be predominantly a New World virus...
  81. pmc Human T-cell lymphotropic virus type 1 gag indeterminate western blot patterns in Central Africa: relationship to Plasmodium falciparum infection
    R Mahieux
    Unité d Epidémiologie des Virus Oncogènes, CNRS URA 1960, Institut Pasteur, Paris, France
    J Clin Microbiol 38:4049-57. 2000
    ..These data suggest that in Central Africa, this frequent and specific Western blot is not caused by HTLV-1 infection but could instead be associated with P. falciparum infection...
  82. ncbi request reprint [New human retroviruses: HTLV-3 and HTLV-4]
    R Mahieux
    L Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, Paris, France
    Med Trop (Mars) 65:525-8. 2005
    ..In particular, the possible oncogenic properties of their viral transactivator Tax is being investigated, as well as their modes of transmission and their possible association with human diseases...
  83. ncbi request reprint Molecular and phylogenetic analyses of 16 novel simian T cell leukemia virus type 1 from Africa: close relationship of STLV-1 from Allenopithecus nigroviridis to HTLV-1 subtype B strains
    L Meertens
    , , Institut Pasteur, 25 28 Rue du Dr Roux, Paris Cedex 15, 75724, France
    Virology 287:275-85. 2001
    ....
  84. ncbi request reprint A novel, divergent simian T-cell lymphotropic virus type 3 in a wild-caught red-capped mangabey (Cercocebus torquatus torquatus) from Nigeria
    L Meertens
    , , Batiment Lwoff, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    J Gen Virol 84:2723-7. 2003
    ....
  85. pmc Multicentric Castleman disease in an HHV8-infected child born to consanguineous parents with systematic review
    Sandrine Leroy
    Department of Pediatric Immunology and Hematology, Necker Hospital, AP HP, Paris, France
    Pediatrics 129:e199-203. 2012
    ..Moreover, as previously suggested for Kaposi sarcoma, MCD in childhood may result from inborn errors of immunity to HHV-8 infection...
  86. pmc Novel gamma-2-herpesvirus of the Rhadinovirus 2 lineage in gibbons
    Renan Duprez
    Institut Pasteur, Paris, France
    Emerg Infect Dis 10:899-902. 2004
    ..The finding of this new gibbon virus, which clusters with a related chimpanzee virus in the rhadinovirus 2 genogroup, suggests the existence of a novel gamma-2-herpesvirus in humans...
  87. pmc Application of broad-spectrum resequencing microarray for genotyping rhabdoviruses
    Laurent Dacheux
    Institut Pasteur, Lyssavirus Dynamics and Host Adaptation Unit, Paris, France
    J Virol 84:9557-74. 2010
    ....
  88. ncbi request reprint Human herpesvirus 8 (HHV-8)-associated peritoneal primary effusion lymphoma (PEL) in two HIV-negative elderly patients
    Emmanuelle Boulanger
    Unit of Epidemiology and Physiopathology of Oncogenic Viruses, Institut Pasteur, Paris, France
    Am J Hematol 76:88-91. 2004
    ..Compared to AIDS-related PEL, these two cases displayed distinct features in particular the advanced age of patients, as observed for Mediterranean KS, and the absence of EBV coinfection...
  89. ncbi request reprint HTLV-1 and associated adult T-cell leukemia/lymphoma
    Renaud Mahieux
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Institut Pasteur, 28 rue du Dr Roux, 75724, Paris
    Rev Clin Exp Hematol 7:336-61. 2003
    ..The survival rate of ATLL patients, especially those who develop the acute leukemic or lymphomas forms, is very poor, and such clonal malignant CD4 expansion remains one of the most severe lymphoproliferations...
  90. pmc A novel gamma 2-herpesvirus of the Rhadinovirus 2 lineage in chimpanzees
    V Lacoste
    , , Institut Pasteur, 75724 Paris Cedex 15, France
    Genome Res 11:1511-9. 2001
    ..By demonstrating the existence of two distinct Rhadinovirus lineages in common chimpanzees, our finding indicates the possible existence of a novel human gamma2-herpesvirus belonging to the RV2 genogroup...
  91. pmc Simian homologues of human gamma-2 and betaherpesviruses in mandrill and drill monkeys
    V Lacoste
    Unité d Oncologie Virale, Departement du SIDA et des Retrovirus, Institut Pasteur, Paris, France
    J Virol 74:11993-9. 2000
    ..Moreover, mandrills, like macaques and African green monkeys, harbor also two distinct gamma-2 herpesviruses, thus strongly suggesting that a second gamma-2 herpesvirus, belonging to the RV2 genogroup, may exist in humans...
  92. pmc Molecular characterization and phylogenetic analyses of a new, highly divergent simian T-cell lymphotropic virus type 1 (STLV-1marc1) in Macaca arctoides
    R Mahieux
    , Institut Pasteur, Paris, France
    J Virol 71:6253-8. 1997
    ....
  93. ncbi request reprint Kaposi's sarcoma in a child with Wiskott-Aldrich syndrome
    Capucine Picard
    Unité d Immunologie et d Hématologie Pédiatriques AP HP, Hopital Necker Enfants Malades, 149 rue de Sevres, 75015, Paris, EU, France
    Eur J Pediatr 165:453-7. 2006
    ..Kaposi's sarcoma (KS) is rare in childhood. It may be favored by acquired immune deficiencies, but the predisposing factors to KS in other children are unclear...
  94. ncbi request reprint Severe demyelinating myelopathy with low human T cell lymphotropic virus type 1 expression after transfusion in an immunosuppressed patient
    Simona Ozden
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Departement des Retrovirus, Institut Pasteur, 75724 Paris Cedex 15, France
    Clin Infect Dis 34:855-60. 2002
    ....
  95. pmc Identification of a novel neuropathogenic Theiler's murine encephalomyelitis virus
    Matthew R Buckwalter
    Laboratory of Dendritic Cell Immunobiology, Department of Immunology, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris, Cedex 15, France
    J Virol 85:6893-905. 2011
    ....
  96. pmc Complete sequence of a novel highly divergent simian T-cell lymphotropic virus from wild-caught red-capped mangabeys (Cercocebus torquatus) from Cameroon: a new primate T-lymphotropic virus type 3 subtype
    Laurent Meertens
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, Departement du SIDA et des Retrovirus, Institut Pasteur, 75724 Paris Cedex 15, France
    J Virol 76:259-68. 2002
    ....
  97. ncbi request reprint Seroepidemiology, viral isolation, and molecular characterization of human T cell leukemia/lymphoma virus type I from La Réunion Island, Indian Ocean
    R Mahieux
    Unité d Epidémiologie des Virus Oncogènes, Institut Pasteur, Paris, France
    AIDS Res Hum Retroviruses 10:745-52. 1994
    ....
  98. pmc Lymphoid organs as a major reservoir for human T-cell leukemia virus type 1 in experimentally infected squirrel monkeys (Saimiri sciureus): provirus expression, persistence, and humoral and cellular immune responses
    M Kazanji
    Unité d Oncologie Virale, Institut Pasteur, Paris, France
    J Virol 74:4860-7. 2000
    ..Our results indicate that squirrel monkeys represent a promising animal model for studying the early events of HTLV-1 infection and for evaluating candidate vaccines against HTLV-1...
  99. ncbi request reprint [HTLV-I virus and associated chronic neuromyelopathies. Current data and hypotheses]
    A Gessain
    Laboratoire de Virologie des Leucémies, LOI CNRS, Hopital Saint Louis, Paris, France
    Nouv Rev Fr Hematol 30:15-20. 1988
    ..The possible neurotropism or neurovirulence of this retrovirus is discussed...
  100. ncbi request reprint Adult T-cell leukemia/lymphoma and HTLV-1
    Renaud Mahieux
    Unité d Epidémiologie et Physiopathologie des Virus Oncogènes, CNRS URA 3015, Department of Virology, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Curr Hematol Malig Rep 2:257-64. 2007
    ..This article discusses a number of recent treatments including antiretroviral therapy, aggressive chemotherapy, and allogeneic bone-marrow transplantation, as well as new drugs...
  101. ncbi request reprint Cell surface phenotype and human T lymphotropic virus type 1 antigen expression in 12 T cell lines derived from peripheral blood and cerebrospinal fluid of West Indian, Guyanese and African patients with tropical spastic paraparesis
    A Gessain
    , , Paris, France
    J Gen Virol 71:333-41. 1990
    ..Thus a signal of 62K was easily detectable in all the TSP lines, but not in the ATLL lines. In all cell lines bands corresponding to p53, p24 and p19 viral core polypeptides were present, as was the env gene-coded protein p46...