Friedrich Frischknecht

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. pmc The history of biological warfare. Human experimentation, modern nightmares and lone madmen in the twentieth century
    Friedrich Frischknecht
    Friedrich Frischknecht is at the Malaria Biology and Genetics Unit, Department of Parasitology, Institut Pasteur, 25 28 Rue du Dr Roux, 75015 Paris, France
    EMBO Rep 4:S47-52. 2003
  2. ncbi request reprint Imaging movement of malaria parasites during transmission by Anopheles mosquitoes
    Friedrich Frischknecht
    Unité de Biologie et Génétique du Paludisme and Grand Programme Horizontal Anopheles, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Cell Microbiol 6:687-94. 2004
  3. ncbi request reprint In vivo imaging of malaria parasites in the murine liver
    Sabine Thiberge
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Nat Protoc 2:1811-8. 2007
  4. doi request reprint Independent roles of apical membrane antigen 1 and rhoptry neck proteins during host cell invasion by apicomplexa
    Donatella Giovannini
    Institut Pasteur, Unité de Biologie et Génétique du Paludisme, 75724 Paris, France
    Cell Host Microbe 10:591-602. 2011
  5. pmc Development of the malaria parasite in the skin of the mammalian host
    Pascale Gueirard
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 107:18640-5. 2010
  6. ncbi request reprint [A new view of malaria provided by parasite imaging]
    Robert Menard
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, Cedex 15, France
    Bull Acad Natl Med 191:1261-70; discussion 1271. 2007
  7. pmc Role of host cell traversal by the malaria sporozoite during liver infection
    Joana Tavares
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, F 75015 Paris, France
    J Exp Med 210:905-15. 2013
  8. ncbi request reprint Imaging malaria sporozoites in the dermis of the mammalian host
    Rogerio Amino
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, Paris, France
    Nat Protoc 2:1705-12. 2007
  9. ncbi request reprint Quantitative imaging of Plasmodium sporozoites in the mammalian host
    Rogerio Amino
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 25 28, rue du Docteur Roux, 75724 Paris Cedex 15, France
    C R Biol 329:858-62. 2006
  10. doi request reprint FLP/FRT-mediated conditional mutagenesis in pre-erythrocytic stages of Plasmodium berghei
    Celine Lacroix
    Institut Pasteur, Unité de Biologie et Génétique du Paludisme, Paris, France
    Nat Protoc 6:1412-28. 2011

Collaborators

Detail Information

Publications19

  1. pmc The history of biological warfare. Human experimentation, modern nightmares and lone madmen in the twentieth century
    Friedrich Frischknecht
    Friedrich Frischknecht is at the Malaria Biology and Genetics Unit, Department of Parasitology, Institut Pasteur, 25 28 Rue du Dr Roux, 75015 Paris, France
    EMBO Rep 4:S47-52. 2003
  2. ncbi request reprint Imaging movement of malaria parasites during transmission by Anopheles mosquitoes
    Friedrich Frischknecht
    Unité de Biologie et Génétique du Paludisme and Grand Programme Horizontal Anopheles, Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Cell Microbiol 6:687-94. 2004
    ..These observations suggest that sporozoite gliding allows not only for cell invasion but also for parasite locomotion in host tissues, and that it may control parasite transmission...
  3. ncbi request reprint In vivo imaging of malaria parasites in the murine liver
    Sabine Thiberge
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, France
    Nat Protoc 2:1811-8. 2007
    ....
  4. doi request reprint Independent roles of apical membrane antigen 1 and rhoptry neck proteins during host cell invasion by apicomplexa
    Donatella Giovannini
    Institut Pasteur, Unité de Biologie et Génétique du Paludisme, 75724 Paris, France
    Cell Host Microbe 10:591-602. 2011
    ..We propose that while the RON proteins act at the TJ, AMA1 mainly functions on the zoite surface to permit correct attachment to the cell, which may facilitate invasion depending on the zoite-cell combination...
  5. pmc Development of the malaria parasite in the skin of the mammalian host
    Pascale Gueirard
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 107:18640-5. 2010
    ..Therefore, during malaria in rodents, the skin is not just the route to the liver but is also the final destination for many inoculated parasites, where they can differentiate into merozoites and possibly persist...
  6. ncbi request reprint [A new view of malaria provided by parasite imaging]
    Robert Menard
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, Cedex 15, France
    Bull Acad Natl Med 191:1261-70; discussion 1271. 2007
    ..In particular, it includes a component of lymphatic infection, thus altering our representation of how an immune response can be mounted against these parasite stages...
  7. pmc Role of host cell traversal by the malaria sporozoite during liver infection
    Joana Tavares
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, F 75015 Paris, France
    J Exp Med 210:905-15. 2013
    ..By being involved in multiple steps of the sporozoite journey from the skin to the final hepatocyte, the parasite proteins mediating host CT emerge as ideal antibody targets for vaccination against the parasite...
  8. ncbi request reprint Imaging malaria sporozoites in the dermis of the mammalian host
    Rogerio Amino
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris Cedex 15, Paris, France
    Nat Protoc 2:1705-12. 2007
    ..Applied to genetically modified parasites and/or mice, these imaging techniques should be useful for studying the cellular and molecular bases of Plasmodium sporozoite infection in vivo...
  9. ncbi request reprint Quantitative imaging of Plasmodium sporozoites in the mammalian host
    Rogerio Amino
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 25 28, rue du Docteur Roux, 75724 Paris Cedex 15, France
    C R Biol 329:858-62. 2006
    ..We describe previously unrecognized steps in the parasite's journey to the liver of the host, which are likely to play an important role in the host immune response...
  10. doi request reprint FLP/FRT-mediated conditional mutagenesis in pre-erythrocytic stages of Plasmodium berghei
    Celine Lacroix
    Institut Pasteur, Unité de Biologie et Génétique du Paludisme, Paris, France
    Nat Protoc 6:1412-28. 2011
    ..The protocol should allow the functional analysis of any essential protein in the sporozoite, liver stage or hepatic merozoite stages of rodent Plasmodium parasites...
  11. doi request reprint Host cell traversal is important for progression of the malaria parasite through the dermis to the liver
    Rogerio Amino
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Cell Host Microbe 3:88-96. 2008
    ..We propose that the cell traversal activity of the sporozoite must be turned on for progression to the liver parenchyma, where it must be switched off for infection of a final hepatocyte...
  12. doi request reprint TREP, a novel protein necessary for gliding motility of the malaria sporozoite
    Audrey Combe
    Institut Pasteur, Unité de Biologie et Génétique du Paludisme, Paris, France
    Int J Parasitol 39:489-96. 2009
    ..We conclude that the gliding motility of the Plasmodium sporozoite in the mosquito depends on at least two proteins, TRAP and TREP...
  13. pmc Using green fluorescent malaria parasites to screen for permissive vector mosquitoes
    Friedrich Frischknecht
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 25 28 Rue du Dr Roux, 75015 Paris, France
    Malar J 5:23. 2006
    ..However, it was reported that P. yoelii can infect the South American mosquito, Anopheles albimanus, while P. berghei cannot...
  14. doi request reprint Clonal conditional mutagenesis in malaria parasites
    Audrey Combe
    Institut Pasteur, Unité de Biologie et Génétique du Paludisme, 28 rue du Dr Roux, Paris Cedex 15, Paris 75724, France
    Cell Host Microbe 5:386-96. 2009
    ..Silencing MSP1 in sporozoites impaired subsequent merozoite formation in the liver. Therefore, MSP1 plays a dual role in the parasite life cycle, acting both in liver and erythrocytic parasite stages...
  15. ncbi request reprint Quantitative imaging of Plasmodium transmission from mosquito to mammal
    Rogerio Amino
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 25 28 Rue du Dr Roux, 75724 Paris, Cedex 15, Paris, France
    Nat Med 12:220-4. 2006
    ..This previously unrecognized step of the parasite life cycle could influence the immune response of the host, and may have implications for vaccination strategies against the preerythrocytic stages of the parasite...
  16. pmc Bordetella bronchiseptica persists in the nasal cavities of mice and triggers early delivery of dendritic cells in the lymph nodes draining the lower and upper respiratory tract
    Pascale Gueirard
    Unité des Bordetella, Institut Pasteur, Paris, France
    Infect Immun 71:4137-43. 2003
    ..Later during the infectious process, the bacteria persist mainly in the nasal cavity...
  17. ncbi request reprint Calcium dynamics of Plasmodium berghei sporozoite motility
    Allison F Carey
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, Paris, France
    Cell Microbiol 16:768-83. 2014
    ....
  18. pmc Towards systematic identification of Plasmodium essential genes by transposon shuttle mutagenesis
    Hiroshi Sakamoto
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Nucleic Acids Res 33:e174. 2005
    ..The procedure opens the way to the systematic identification of essential genes in Plasmodium...
  19. pmc Conditional mutagenesis using site-specific recombination in Plasmodium berghei
    Teresa Gil Carvalho
    Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 101:14931-6. 2004
    ..e., during infection of salivary glands in the mosquito and infection of both the liver and red blood cells in the mammal...