Patrick Forterre

Summary

Affiliation: Institut Pasteur
Country: France

Publications

  1. ncbi request reprint The origin of viruses
    Patrick Forterre
    Institut de Genetique et Microbiologie, Universite Paris Sud, CNRS UMR 8621, 91405 Orsay Cedex, France
    Res Microbiol 160:466-72. 2009
  2. ncbi request reprint The two ages of the RNA world, and the transition to the DNA world: a story of viruses and cells
    Patrick Forterre
    Institut Pasteur, Département de Microbiologie Fondamentale et Médicale, 25, rue du Docteur Roux, 75015 Paris, France
    Biochimie 87:793-803. 2005
  3. ncbi request reprint [Luca: the last universal common ancestor]
    Patrick Forterre
    Biologie Moléculaire du gène chez les extrêmophiles BMGE, Département de Microbiologie Fondamentale et Médicale, Institut Pasteur, Paris, France
    Med Sci (Paris) 21:860-5. 2005
  4. ncbi request reprint Origin and evolution of DNA topoisomerases
    Patrick Forterre
    Institut de Genetique et Microbiologie, UMR8621, Universite Paris Sud 11, Bat 400 409, 91405 Orsay Cedex, France
    Biochimie 89:427-46. 2007
  5. ncbi request reprint The virophage as a unique parasite of the giant mimivirus
    Bernard La Scola
    URMITE, Centre National de la Recherche Scientifique UMR IRD 6236, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Nature 455:100-4. 2008
  6. pmc Darwin's goldmine is still open: variation and selection run the world
    Patrick Forterre
    Institut Pasteur Paris, France patrick forterre igmors u psud fr
    Front Cell Infect Microbiol 2:106. 2012
  7. pmc Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol
    D Gadelle
    Institut de Genetique et Microbiologie, UMR CNRS 8621 Batiment 409, 91405 Orsay, France
    Nucleic Acids Res 33:2310-7. 2005
  8. pmc The common ancestor of archaea and eukarya was not an archaeon
    Patrick Forterre
    Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris, France Université Paris Sud, Institut de Genetique et Microbiologie, CNRS UMR 8621, 91405 Orsay Cedex, France
    Archaea 2013:372396. 2013
  9. doi request reprint The major role of viruses in cellular evolution: facts and hypotheses
    Patrick Forterre
    Institut Pasteur, 25 rue du Docteur Roux, Paris 75015, France Univ Paris Sud, CNRS UMR8621, Orsay Cedex 91405, France Electronic address
    Curr Opin Virol 3:558-65. 2013
  10. pmc Crystal structure of AFV3-109, a highly conserved protein from crenarchaeal viruses
    Jenny Keller
    Institut de Biochimie et de Biophysique Moleculaire et Cellulaire, CNRS UMR 8619, Université Paris 11, IFR115, Batiment 430, 91405 Orsay, France
    Virol J 4:12. 2007

Detail Information

Publications94

  1. ncbi request reprint The origin of viruses
    Patrick Forterre
    Institut de Genetique et Microbiologie, Universite Paris Sud, CNRS UMR 8621, 91405 Orsay Cedex, France
    Res Microbiol 160:466-72. 2009
    ..Although several hypotheses have been recently proposed to explain the origin of viruses, the emergence of virions, as a specific mechanism for gene dissemination, remains unexplained...
  2. ncbi request reprint The two ages of the RNA world, and the transition to the DNA world: a story of viruses and cells
    Patrick Forterre
    Institut Pasteur, Département de Microbiologie Fondamentale et Médicale, 25, rue du Docteur Roux, 75015 Paris, France
    Biochimie 87:793-803. 2005
    ....
  3. ncbi request reprint [Luca: the last universal common ancestor]
    Patrick Forterre
    Biologie Moléculaire du gène chez les extrêmophiles BMGE, Département de Microbiologie Fondamentale et Médicale, Institut Pasteur, Paris, France
    Med Sci (Paris) 21:860-5. 2005
    ....
  4. ncbi request reprint Origin and evolution of DNA topoisomerases
    Patrick Forterre
    Institut de Genetique et Microbiologie, UMR8621, Universite Paris Sud 11, Bat 400 409, 91405 Orsay Cedex, France
    Biochimie 89:427-46. 2007
    ....
  5. ncbi request reprint The virophage as a unique parasite of the giant mimivirus
    Bernard La Scola
    URMITE, Centre National de la Recherche Scientifique UMR IRD 6236, Faculte de Medecine, Universite de la Mediterranee, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Nature 455:100-4. 2008
    ..Considering its functional analogy with bacteriophages, we classify this virus as a virophage. The virophage could be a vehicle mediating lateral gene transfer between giant viruses...
  6. pmc Darwin's goldmine is still open: variation and selection run the world
    Patrick Forterre
    Institut Pasteur Paris, France patrick forterre igmors u psud fr
    Front Cell Infect Microbiol 2:106. 2012
    ..However, it remains for evolutionists to acknowledge interactions between cells and viruses (unknown for Darwin) as a major driving force in life evolution...
  7. pmc Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol
    D Gadelle
    Institut de Genetique et Microbiologie, UMR CNRS 8621 Batiment 409, 91405 Orsay, France
    Nucleic Acids Res 33:2310-7. 2005
    ..In contrast, the bacteria E.coli was resistant to this drug. Radicicol thus appears to be a very promising compound to study the mechanism of Topo IIB in vitro, as well as the biological roles of these enzymes in vivo...
  8. pmc The common ancestor of archaea and eukarya was not an archaeon
    Patrick Forterre
    Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris, France Université Paris Sud, Institut de Genetique et Microbiologie, CNRS UMR 8621, 91405 Orsay Cedex, France
    Archaea 2013:372396. 2013
    ..Eukarya probably evolved toward complexity with the help of retroviruses and large DNA viruses, whereas similar selection pressure (thermoreduction) could explain why the archaeal and bacterial mobilomes somehow resemble each other. ..
  9. doi request reprint The major role of viruses in cellular evolution: facts and hypotheses
    Patrick Forterre
    Institut Pasteur, 25 rue du Docteur Roux, Paris 75015, France Univ Paris Sud, CNRS UMR8621, Orsay Cedex 91405, France Electronic address
    Curr Opin Virol 3:558-65. 2013
    ..Several documented cases show that viruses have been involved in the emergence of evolutionary innovations. This gives credit to hypotheses suggesting that viruses have played an important role in the formation of modern cells. ..
  10. pmc Crystal structure of AFV3-109, a highly conserved protein from crenarchaeal viruses
    Jenny Keller
    Institut de Biochimie et de Biophysique Moleculaire et Cellulaire, CNRS UMR 8619, Université Paris 11, IFR115, Batiment 430, 91405 Orsay, France
    Virol J 4:12. 2007
    ..Fluorescence quenching titrations also showed that AFV3-109 interacts with dsDNA. Genomic sequence analysis revealed bacterial homologs of AFV3-109 as a part of a putative previously unidentified prophage sequences in some Firmicutes...
  11. pmc Nanoarchaea: representatives of a novel archaeal phylum or a fast-evolving euryarchaeal lineage related to Thermococcales?
    Celine Brochier
    EA EGEE Evolution, Genomique, Environnement Université Aix Marseille I, Centre Saint Charles, 3 Place Victor Hugo, 13331 Marseille, Cedex 3, France
    Genome Biol 6:R42. 2005
    ..Confirming the phylogenetic position of N. equitans is thus crucial for deciphering the history of the archaeal domain...
  12. pmc A DNA topoisomerase IB in Thaumarchaeota testifies for the presence of this enzyme in the last common ancestor of Archaea and Eucarya
    Celine Brochier-Armanet
    Laboratoire de Chimie Bacterienne, Universite de Provence, Aix Marseille I, CNRS UPR9043, IFR88, Marseille, France
    Biol Direct 3:54. 2008
    ..Phylogenetic analyses suggest that a TopoIB was present in the last common ancestor of Archaea and Eucarya. This finding indicates that the last common ancestor of Archaea and Eucarya may have harboured a DNA genome...
  13. pmc An emerging phylogenetic core of Archaea: phylogenies of transcription and translation machineries converge following addition of new genome sequences
    Celine Brochier
    Laboratoire Evolution, Genomique, Environnement, Université Aix Marseille I, Centre Saint Charles, Case 36, 3 Place Victor Hugo, 13331 Marseille, Cedex 3, France
    BMC Evol Biol 5:36. 2005
    ..However, some incongruence remained between the two phylogenies. This may be due either to undetected LGT and/or to a lack of sufficient phylogenetic signal in the datasets...
  14. pmc Defining life: the virus viewpoint
    Patrick Forterre
    CNRS UMR 8621 Institut de Génétique et Microbiologie, Univ Paris Sud, 91405 Orsay Cedex, France
    Orig Life Evol Biosph 40:151-60. 2010
    ..The origin of life on our planet would correspond to the establishment of the first organism corresponding to this definition...
  15. ncbi request reprint The origin of viruses and their possible roles in major evolutionary transitions
    Patrick Forterre
    Institut de Genetique et Microbiologie, CNRS UMR 8621, Universite Paris Sud, 91405 Orsay Cedex, France
    Virus Res 117:5-16. 2006
    ....
  16. ncbi request reprint In a world of microbes, where should microbiology stand?
    Patrick Forterre
    Institut Pasteur, Batiment Fernbach, 75724 Paris Cedex 15, France
    Res Microbiol 159:74-80. 2008
  17. pmc Happy together: genomic insights into the unique Nanoarchaeum/Ignicoccus association
    Patrick Forterre
    Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris, France
    J Biol 8:7. 2009
    ....
  18. ncbi request reprint DNA topoisomerase V: a new fold of mysterious origin
    Patrick Forterre
    Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur, 25 rue du Dr Roux, 75015, Paris, France
    Trends Biotechnol 24:245-7. 2006
    ..So, where did it come from? It is my contention that Topo V, and many other orphan proteins, could have a viral origin...
  19. ncbi request reprint Giant viruses: conflicts in revisiting the virus concept
    Patrick Forterre
    Unité de Biologie du Gène chez les Extrêmophiles, Institut Pasteur, Paris, France
    Intervirology 53:362-78. 2010
    ..I briefly review here the history of these debates and how they lead to new proposals, such as the definition of viruses as capsid-encoding organisms or else the recognition of their fundamentally cellular nature, the virocell concept...
  20. doi request reprint A new fusion hypothesis for the origin of Eukarya: better than previous ones, but probably also wrong
    Patrick Forterre
    Institut Pasteur, 25 rue du Docteur Roux, 75015 Paris, France
    Res Microbiol 162:77-91. 2011
    ..I conclude that Eukarya and their viruses more probably evolved from a specific lineage, according to the three domains scenario originally proposed by Carl Woese...
  21. ncbi request reprint The great billion-year war between ribosome- and capsid-encoding organisms (cells and viruses) as the major source of evolutionary novelties
    Patrick Forterre
    Institut Pasteur, 75015 Paris, France
    Ann N Y Acad Sci 1178:65-77. 2009
    ....
  22. pmc Two novel families of plasmids from hyperthermophilic archaea encoding new families of replication proteins
    Nicolas Soler
    Institut de Genetique et Microbiologie, Univ Paris Sud, Orsay, France
    Nucleic Acids Res 38:5088-104. 2010
    ..This strengthens the idea that plasmids and viruses are a reservoir of novel protein families involved in DNA replication...
  23. pmc Insights into dynamics of mobile genetic elements in hyperthermophilic environments from five new Thermococcus plasmids
    Mart Krupovic
    Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Departement de Microbiologie, Institut Pasteur, Paris, France
    PLoS ONE 8:e49044. 2013
    ..Finally, the plasmids described here might prove to be useful in developing new genetic tools for hyperthermophiles...
  24. pmc Evidence for a Xer/dif system for chromosome resolution in archaea
    Diego Cortez
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Paris, France
    PLoS Genet 6:e1001166. 2010
    ..Whereas Archaea and Bacteria use a completely different set of proteins for chromosome replication, our data strongly suggest that XerA is most likely used for chromosome resolution in Archaea...
  25. pmc Genomics and genetics of Sulfolobus islandicus LAL14/1, a model hyperthermophilic archaeon
    Carole Jaubert
    Departement de Microbiologie, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur, Paris, France
    Open Biol 3:130010. 2013
    ..Thus, LAL14/1 is a promising model to study virus-host interactions and the CRISPR/Cas defence mechanism in Archaea...
  26. ncbi request reprint Extracellular membrane vesicles harbouring viral genomes
    Marie Gaudin
    CNRS UMR 8621, Institut de Genetique et Microbiologie, Univ Paris Sud, 91405, Orsay Cedex, France
    Environ Microbiol 16:1167-75. 2014
    ..Our results suggest that MVs can serve as vehicles for the intercellular transport of viral genomes and facilitate recombination between viral, plasmid and/or cellular chromosomes in the absence of viral infection. ..
  27. pmc Unification of the globally distributed spindle-shaped viruses of the Archaea
    Mart Krupovic
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Departement de Microbiologie, Paris, France
    J Virol 88:2354-8. 2014
    ..Our results illuminate the utility of structure-based virus classification and bring additional order to the virosphere. ..
  28. pmc The Mre11 protein interacts with both Rad50 and the HerA bipolar helicase and is recruited to DNA following gamma irradiation in the archaeon Sulfolobus acidocaldarius
    Achim Quaiser
    Univ Paris Sud, Institut de Genetique et Microbiologie, CNRS UMR 8621, Batiment 409, F 91405 Orsay cedex, France
    BMC Mol Biol 9:25. 2008
    ..Since genetic tools for hyperthermophilic archaea are just emerging, we utilized immuno-detection approaches to get the first in vivo data on the role(s) of these proteins in the hyperthermophilic crenarchaeon Sulfolobus acidocaldarius...
  29. pmc Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: a hypothesis for the origin of cellular domain
    Patrick Forterre
    Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur, 25, rue du Dr Roux, 75015 Paris, France
    Proc Natl Acad Sci U S A 103:3669-74. 2006
    ....
  30. doi request reprint The universal Kae1 protein and the associated Bud32 kinase (PRPK), a mysterious protein couple probably essential for genome maintenance in Archaea and Eukarya
    Arnaud Hecker
    Universite Paris Sud, Institut de Genetique et Microbiologie, IFR115, UMR8621 CNRS, 91405 Orsay Cedex, France
    Biochem Soc Trans 37:29-35. 2009
    ..Understanding the precise biochemical function and biological role of these two proteins (which are probably essential for genome maintenance) remains a major challenge...
  31. pmc An archaeal orthologue of the universal protein Kae1 is an iron metalloprotein which exhibits atypical DNA-binding properties and apurinic-endonuclease activity in vitro
    Arnaud Hecker
    Institut de Genetique et Microbiologie, Univ Paris Sud, IFR115, UMR8621 CNRS, 91405 Orsay, France
    Nucleic Acids Res 35:6042-51. 2007
    ..Kae1 is thus a novel and atypical universal DNA interacting protein whose importance could rival those of RecA (RadA/Rad51) in the maintenance of genome integrity in all living cells...
  32. pmc A hidden reservoir of integrative elements is the major source of recently acquired foreign genes and ORFans in archaeal and bacterial genomes
    Diego Cortez
    Institut Pasteur, Departement de Microbiologie, Unite de Biologie Moleculaire du Gene chez les Extremophiles, Paris, France
    Genome Biol 10:R65. 2009
    ....
  33. doi request reprint Crystal structure of an intact type II DNA topoisomerase: insights into DNA transfer mechanisms
    Marc Graille
    Institut de Biochimie et de Biophysique Moleculaire et Cellulaire, UMR8619 CNRS, Universite Paris Sud, IFR115, F 91405 Orsay, France
    Structure 16:360-70. 2008
    ..This structure, combined with a wealth of experimental data gathered on these enzymes, allows us to propose a structural model for the two-gate DNA transfer mechanism...
  34. pmc In vitro biosynthesis of a universal t6A tRNA modification in Archaea and Eukarya
    Ludovic Perrochia
    Institut de Genetique et Microbiologie, Universite Paris Sud, IFR115, UMR8621 CNRS, 91405 Orsay, France
    Nucleic Acids Res 41:1953-64. 2013
    ..These findings shed light on the reaction mechanism of t(6)A synthesis and evolution of molecular systems that promote translation fidelity in present-day cells...
  35. ncbi request reprint The rolling-circle plasmid pTN1 from the hyperthermophilic archaeon Thermococcus nautilus
    Nicolas Soler
    Institut de Genetique et Microbiologie, Univ Paris Sud, CNRS UMR 8621 and 8619, 91405 Orsay Cedex, France
    Mol Microbiol 66:357-70. 2007
    ....
  36. doi request reprint A thaumarchaeal provirus testifies for an ancient association of tailed viruses with archaea
    Mart Krupovic
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, 28 rue du Dr Roux, 75015 Paris, France
    Biochem Soc Trans 39:82-8. 2011
    ....
  37. ncbi request reprint Four newly isolated fuselloviruses from extreme geothermal environments reveal unusual morphologies and a possible interviral recombination mechanism
    Peter Redder
    Unite de Biologie Moleculaire du Gene chez les Extremophiles, Institut Pasteur, 25, rue du Dr Roux, F 75015 Paris, France
    Environ Microbiol 11:2849-62. 2009
    ..We propose a fuselloviral specific mechanism for interviral recombination, and show that the spacers of the Sulfolobus CRISPR antiviral system are not biased to the highly similar regions of the fusellovirus genomes...
  38. ncbi request reprint The role played by viruses in the evolution of their hosts: a view based on informational protein phylogenies
    Jonathan Filee
    Institut de Genetique et Microbiologie, Bat 409, CNRS UMR 8621, Universite Paris Sud XI, 91405 Cedex, Orsay, France
    Res Microbiol 154:237-43. 2003
    ..Thus, viruses have definitively to be considered as major players in the evolution of cellular genomes...
  39. pmc Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex
    Arnaud Hecker
    Institut de Genetique et Microbiologie, Universite Paris Sud, IFR115 UMR8621 CNR, Orsay, France
    EMBO J 27:2340-51. 2008
    ..Direct interaction between Kae1p and Bud32p in yeast is required both for the transcription and the telomere homeostasis function of EKC/KEOPS...
  40. pmc A highly divergent archaeo-eukaryotic primase from the Thermococcus nautilus plasmid, pTN2
    Sukhvinder Gill
    Institut Pasteur Unité Biologie Moléculaire du Gène chez les Extrêmophiles, 25 rue du Docteur Roux, 75015 Paris, France, CNRS UMR 7138 Systématique, Adaptation, Evolution, Université Paris 6 quai Saint Bernard, 75252 Paris Cedex 05, France and Univ Paris Sud Institut de Génétique et Microbiologie, CNRS UMR 8621, Orsay 91406, France
    Nucleic Acids Res 42:3707-19. 2014
    ..Surprisingly, the N-terminal domain possesses reverse transcriptase activity. We speculate that this activity could reflect an ancestral function of AEP proteins in the transition from the RNA to the DNA world. ..
  41. pmc First insights into the entry process of hyperthermophilic archaeal viruses
    Emmanuelle R J Quemin
    Institut Pasteur, Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Departement de Microbiologie, Paris, France
    J Virol 87:13379-85. 2013
    ..Finally, we also show that SIRV2 establishes superinfection exclusion, a phenomenon not previously described for archaeal viruses. ..
  42. ncbi request reprint An integrated analysis of the genome of the hyperthermophilic archaeon Pyrococcus abyssi
    Georges N Cohen
    Institut Pasteur, 25, 28 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Mol Microbiol 47:1495-512. 2003
    ..However, proteins probably from bacterial origin, including some from mesophilic bacteria, are also present in the P. abyssi genome...
  43. ncbi request reprint Phylogenomics of type II DNA topoisomerases
    Danièle Gadelle
    Institut de Genetique et Microbiologie, CNRS, UMR 8621, Universite Paris Sud, France
    Bioessays 25:232-42. 2003
    ..However, plants and some Archaea contain Topo II from both families. We confront this atypical distribution with current hypotheses on the evolution of the three domains of life and origin of DNA genomes...
  44. doi request reprint Postcards from the edge: structural genomics of archaeal viruses
    Mart Krupovic
    Department of Microbiology, Institut Pasteur, Molecular Biology of the Gene in Extremophiles Unit, Paris, France
    Adv Virus Res 82:33-62. 2012
    ..Structural studies, discussed here, have advanced our understanding of the archaeal virosphere and provided precious information on different aspects of biology of archaeal viruses and evolution of viruses in general...
  45. doi request reprint Plasmids, viruses and virus-like membrane vesicles from Thermococcales
    Nicolas Soler
    Institut de Genetique et Microbiologie, Univ Paris Sud 11, UMR 8621, CNRS 91405, Orsay, France
    Biochem Soc Trans 39:36-44. 2011
    ..Some membrane vesicles of Thermococcus nautilus harbour the plasmid pTN1, suggesting that vesicles can be involved in plasmid transfer between species...
  46. doi request reprint When DNA replication and protein synthesis come together
    Jonathan Berthon
    Universite Paris Sud 11, CNRS UMR 8621, Institut de Genetique et Microbiologie, 91405 Orsay Cedex, France
    Trends Biochem Sci 34:429-34. 2009
    ..We believe that this gene organization is biologically relevant and, moreover, that it suggests the existence of a mechanism coupling DNA replication and translation in Archaea and Eukarya...
  47. ncbi request reprint The HSP90 and DNA topoisomerase VI inhibitor radicicol also inhibits human type II DNA topoisomerase
    Danièle Gadelle
    Institut de Genetique et Microbiologie, UMR CNRS 8621, France
    Biochem Pharmacol 72:1207-16. 2006
    ..The finding that radicicol can inhibit at least two different antitumoral drug targets in human, and interferes with drugs currently used in cancer treatment, could have implications in cancer therapy...
  48. pmc Functional assignment of KEOPS/EKC complex subunits in the biosynthesis of the universal t6A tRNA modification
    Ludovic Perrochia
    Institut de Genetique et Microbiologie, Universite Paris Sud, IFR115, UMR8621 CNRS, 91405 Orsay, France and Université de Lorraine, UMR 1136 INRA Université de Lorraine Interactions Arbres Microorganismes, Labex ARBRE, FR EFABA, Faculte des Sciences, 54500 Vandoeuvre, France
    Nucleic Acids Res 41:9484-99. 2013
    ..Overall, our data support a mechanistic model in which the final step in the biosynthesis of t(6)A relies on a strictly catalytic component, Kae1, and three partner proteins necessary for dimerization, tRNA binding and regulation. ..
  49. doi request reprint Hyperthermophilic archaea produce membrane vesicles that can transfer DNA
    Marie Gaudin
    Institut de Genetique et Microbiologie, Univ Paris Sud, CNRS UMR8621, 91405 Orsay Cedex, France
    Environ Microbiol Rep 5:109-16. 2013
    ..Notably, these MVs can be used to transfer pLC70 into plasmid-free cells, suggesting that MVs could be involved in DNA transfer between cells at high temperature...
  50. ncbi request reprint Evolution of DNA polymerase families: evidences for multiple gene exchange between cellular and viral proteins
    Jonathan Filee
    Institut de Genetique et Microbiologie, Bat 409, CNRS UMR 8621, Universite Paris Sud XI, F 91405 Orsay cedex, France
    J Mol Evol 54:763-73. 2002
    ..Taken together, these findings suggest a complex evolutionary history of the DNA replication apparatus that involved significant exchanges between viruses, plasmids, and their hosts...
  51. pmc Simple and elegant design of a virion egress structure in Archaea
    Tessa E F Quax
    Institut Pasteur, Biologie Moléculaire du Gène chez les Extrêmophiles, 75015 Paris, France
    Proc Natl Acad Sci U S A 108:3354-9. 2011
    ....
  52. pmc Genomic context analysis in Archaea suggests previously unrecognized links between DNA replication and translation
    Jonathan Berthon
    Univ Paris Sud 11, CNRS, UMR8621, Institut de Genetique et Microbiologie, 91405 Orsay Cedex, France
    Genome Biol 9:R71. 2008
    ..Here, we have systematically analyzed the genomic environment of all known DNA replication genes in 27 archaeal genomes to infer new connections for DNA replication proteins from conserved genomic associations...
  53. ncbi request reprint Thermococcus nautili sp. nov., a hyperthermophilic archaeon isolated from a hydrothermal deep-sea vent
    Aurore Gorlas
    Institut de Genetique et Microbiologie, Universite Paris Sud, CNRS UMR8621, 91405 Orsay Cedex, France
    Int J Syst Evol Microbiol 64:1802-10. 2014
    ..On the basis of the data presented, strain 30-1T is considered to represent a novel species of the genus Thermococcus, for which the name Thermococcus nautili sp. nov. is proposed. The type strain is 30-1T (=CNCM 4275=JCM 19601)...
  54. pmc Genomewide and biochemical analyses of DNA-binding activity of Cdc6/Orc1 and Mcm proteins in Pyrococcus sp
    Fujihiko Matsunaga
    Institut de Genetique et Microbiologie, UMR8621, Bat 409, Universite Paris Sud, 91405 Orsay Cedex, France
    Nucleic Acids Res 35:3214-22. 2007
    ..Our ChIP-chip analysis also revealed that Mcm alters the binding specificity to the oriC region according to the growth phase, consistent with its role as a licensing factor...
  55. pmc A unique virus release mechanism in the Archaea
    Ariane Bize
    Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
    Proc Natl Acad Sci U S A 106:11306-11. 2009
    ..The generation of specific cellular structures for a distinct step of virus life cycle is known in eukaryal virus-host systems but is unprecedented in cells from other domains...
  56. pmc Identification of short 'eukaryotic' Okazaki fragments synthesized from a prokaryotic replication origin
    Fujihiko Matsunaga
    Universite Paris Sud, Orsay, France
    EMBO Rep 4:154-8. 2003
    ..Short Okazaki fragments and a high replication speed imply a very efficient turnover of Okazaki fragments in Archaea. Archaea therefore have a unique replication system showing mechanistic similarities to both Bacteria and Eukarya...
  57. ncbi request reprint The great virus comeback-- from an evolutionary perspective
    Patrick Forterre
    Equipe Biologie Moléculaire du Gène chez les Extrêmophiles, Institut de Genetique et Microbiologie, Universite Paris Sud, Centre d Orsay, France
    Res Microbiol 154:223-5. 2003
  58. doi request reprint The archeoviruses
    Mery Pina
    Institut Pasteur, Molecular Biology of the Gene in Extremophiles Unit, Paris, France
    FEMS Microbiol Rev 35:1035-54. 2011
    ..In this review, we summarize the current knowledge of archeoviruses, their interaction with hosts and plasmids and their role in the evolution of life...
  59. pmc Archaeal virus with exceptional virion architecture and the largest single-stranded DNA genome
    Tomohiro Mochizuki
    Unite de Biologie Moleculaire du Gene chez les Extremophiles, Departement de Microbiologie, Institut Pasteur, 75015 Paris, France
    Proc Natl Acad Sci U S A 109:13386-91. 2012
    ..pernix growth. The genome content of ACV is in line with its unique morphology and confirms that ACV is not closely related to any known virus...
  60. ncbi request reprint Genetic analysis of DNA repair in the hyperthermophilic archaeon, Thermococcus kodakaraensis
    Ryosuke Fujikane
    Institut de Genetique et Microbiologie, Universite Paris Sud 11, CNRS UMR 8621, 91405 Orsay Cedex, France
    Genes Genet Syst 85:243-57. 2010
    ....
  61. doi request reprint Novel archaeal plasmid pAH1 and its interactions with the lipothrixvirus AFV1
    Tamara Basta
    Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Mol Microbiol 71:23-34. 2009
    ..This mechanism of archaeal viral inhibition of plasmid propagation is not observed in bacteria where relevant bacteriophages either are dependent on a conjugative plasmid for successful infection or are excluded by a resident plasmid...
  62. ncbi request reprint Viruses in acidic geothermal environments of the Kamchatka Peninsula
    Ariane Bize
    Molecular Biology of the Gene in Extremophiles Unit, Institut Pasteur, rue du Dr Roux 25, 75724 Paris Cedex 15, France
    Res Microbiol 159:358-66. 2008
    ..One of the viruses, Acidianus filamentous virus 9, AFV9, was isolated and its structure and genome were studied in detail...
  63. pmc Qri7/OSGEPL, the mitochondrial version of the universal Kae1/YgjD protein, is essential for mitochondrial genome maintenance
    Jacques Oberto
    Universite Paris Sud 11, CNRS, UMR8621, Institut de Genetique et Microbiologie, 91405 Orsay, France
    Nucleic Acids Res 37:5343-52. 2009
    ..We suggest to name members of the Kae1(OSGEP)/YgjD family UGMP, for Universal Genome Maintenance Proteins...
  64. ncbi request reprint [The great virus comeback]
    Patrick Forterre
    Universite Paris Sud, Institut de Génétique Microbiologie, CNRS UMR 8621, 91405 Orsay Cedex, France Institut Pasteur, 25 rue du Dr Roux, 75015 Paris, France
    Biol Aujourdhui 207:153-68. 2013
    ..One can thus conclude that the continuous interaction between viruses and cells, all along the history of life, has been, and still is, a major engine of biological evolution. ..
  65. ncbi request reprint Unique genome replication mechanism of the archaeal virus AFV1
    Mery Pina
    Institut Pasteur, Departement de Microbiologie, 25 rue du Dr Roux, 75015, Paris, France
    Mol Microbiol 92:1313-25. 2014
    ..A terminal protein was found to be attached to the ends of the viral genome. The results allow us to postulate a model of genome replication that relies on recombination events for initiation and termination. ..
  66. pmc Microviridae goes temperate: microvirus-related proviruses reside in the genomes of Bacteroidetes
    Mart Krupovic
    Unité Biologie Moléculaire du Gène chez les Extrêmophiles, Department of Microbiology, Institut Pasteur, Paris, France
    PLoS ONE 6:e19893. 2011
    ....
  67. doi request reprint Membrane vesicles, nanopods and/or nanotubes produced by hyperthermophilic archaea of the genus Thermococcus
    Evelyne Marguet
    Institut de Genetique et Microbiologie, Universite Paris Sud, CNRS UMR8621, 91405 Orsay Cedex, France
    Biochem Soc Trans 41:436-42. 2013
    ..As suggested for bacteria, archaeal nanopods and/or nanotubes could be used to expand the metabolic sphere around cells and/or to promote intercellular communication...
  68. doi request reprint On the last common ancestor and early evolution of eukaryotes: reconstructing the history of mitochondrial ribosomes
    Elie Desmond
    Institut Pasteur, Unité BMGE, Department of Microbiology, 28 rue du Dr Roux, 75015 Paris, France
    Res Microbiol 162:53-70. 2011
    ..Intriguingly, archaeal ribosomes also show a very dynamic nature, with multiple independent losses among lineages...
  69. ncbi request reprint The origin of DNA genomes and DNA replication proteins
    Patrick Forterre
    Institut de Genetique et Microbiologie, Batiment 409, CNRS UMR 8621, Universite Paris Sud XI, F 91405 Orsay cedex, France
    Curr Opin Microbiol 5:525-32. 2002
    ..A hyperthermophilic LUCA would have suggested a circular, double-stranded DNA genome; however, recent data favor a mesophilic or moderately thermophilic LUCA...
  70. doi request reprint The origin of eukaryotes and their relationship with the Archaea: are we at a phylogenomic impasse?
    Simonetta Gribaldo
    Institut Pasteur, Department of Microbiology, Paris, France
    Nat Rev Microbiol 8:743-52. 2010
    ..We examine the reasons for such a lack of consensus and consider how alternative approaches may enable progress in answering this fascinating and as-yet-unresolved question...
  71. ncbi request reprint Evolution of the Archaea
    Patrick Forterre
    Institut de Genetique et Microbiologie, UMR 8621 CNRS, Bat 409, Universite Paris Sud, 91405 Orsay Cedex, France
    Theor Popul Biol 61:409-22. 2002
    ..The phenotypic and genotypic characterization of these new groups is now a top priority for further studies on archaeal evolution...
  72. pmc Phylogenomics of DNA topoisomerases: their origin and putative roles in the emergence of modern organisms
    Patrick Forterre
    Institut de Genetique et Microbiologie, Univ Paris Sud, 91405 Orsay Cedex, France
    Nucleic Acids Res 37:679-92. 2009
    ..We also proposed that topoisomerases have played a critical role in the origin of modern genomes and in the emergence of the three cellular domains...
  73. ncbi request reprint The Sulfolobus rod-shaped virus 2 encodes a prominent structural component of the unique virion release system in Archaea
    Tessa E F Quax
    Institut Pasteur, Molecular Biology of the Gene in Extremophiles Unit, 75724 Paris Cedex 15, France
    Virology 404:1-4. 2010
    ....
  74. ncbi request reprint An alternative flavin-dependent mechanism for thymidylate synthesis
    Hannu Myllykallio
    Institut de Genetique et Microbiologie, CNRS UMR 8621, Universite Paris Sud, Orsay, France
    Science 297:105-7. 2002
    ..Our findings reveal complexity in the evolution of thymidine in present-day DNA. Because ThyX proteins are found in many pathogenic microbes, they present a previously uncharacterized target for antimicrobial compounds...
  75. pmc Pyrococcus genome comparison evidences chromosome shuffling-driven evolution
    Yvan Zivanovic
    Institut de Genetique et Microbiologie, Universite de Paris Sud, UMR C8621 Centre Universitaire d Orsay, Batiment 409, 91405 Orsay Cedex, France
    Nucleic Acids Res 30:1902-10. 2002
    ..furiosus. We discuss the implications of genomic rearrangements on gene orientation and composition biases, and their consequences on sequence evolution...
  76. pmc Massive activation of archaeal defense genes during viral infection
    Tessa E F Quax
    Biologie Moléculaire du Gène chez les Extrêmophiles, Institut Pasteur, Paris, France or
    J Virol 87:8419-28. 2013
    ..The information on individual gene expression and activation of antiviral defense systems is expected to aid future studies aimed at detailed understanding of the functions and interplay of these systems in vivo. ..
  77. doi request reprint Fake virus particles generated by fluorescence microscopy
    Patrick Forterre
    Institut de Genetique et Microbiologie, Universite Paris Sud, CNRS UMR 8621, 91405 Orsay Cedex, France
    Trends Microbiol 21:1-5. 2013
    ..Besides trying to improve discrimination between virions and MVs, we suggest adopting less holistic approaches, focusing on the detection of known virus groups and the isolation of new viruses from a broader range of hosts...
  78. ncbi request reprint Viruses of the Archaea: a unifying view
    David Prangishvili
    Molecular Biology of the Gene in Extremophiles Unit, Institut Pasteur, rue du Docteur Roux 25, F 75724 Paris Cedex 15, France
    Nat Rev Microbiol 4:837-48. 2006
    ..Here, we provide a unifying view on archaeal viruses, and present them as a particular assemblage that is fundamentally different in morphotype and genome from the DNA viruses of the other two domains of life, the Bacteria and Eukarya...
  79. ncbi request reprint A hot story from comparative genomics: reverse gyrase is the only hyperthermophile-specific protein
    Patrick Forterre
    Institut de Genetique et Microbiologie, CNRS UMR 8621, Bat 409, Universite Paris Sud, 91405 Orsay Cedex, France
    Trends Genet 18:236-7. 2002
    ..This result emphasizes the importance of reverse gyrase in the adaptation of life to very high temperatures, and strengthens the idea that evolution of this enzyme was crucial in the origin of hyperthermophiles...
  80. ncbi request reprint Virus-like vesicles and extracellular DNA produced by hyperthermophilic archaea of the order Thermococcales
    Nicolas Soler
    Univ Paris Sud, Institut de Genetique et Microbiologie, CNRS, UMR 8621, F 91405 Orsay cedex, France
    Res Microbiol 159:390-9. 2008
    ..DNA in vesicle preparations is remarkably resistant to DNase treatment and thermodenaturation, indicating that association with vesicles could be an important factor determining DNA stability in natural environments...
  81. pmc Construction of a shuttle vector for, and spheroplast transformation of, the hyperthermophilic archaeon Pyrococcus abyssi
    Soizick Lucas
    LEMAR, UMR CNRS 6539, IUEM, Universite de Bretagne Occidentale, Technopole Brest Iroise, 29280 Plouzané Institut de Génétique et Microbiologie, Universite Paris Sud, 91405 Orsay Cedex, France
    Appl Environ Microbiol 68:5528-36. 2002
    ..Vector pYS2 proved to be very stable and was maintained at high copy number under selective conditions in both Escherichia coli and P. abyssi...
  82. doi request reprint Diversity of virus-host systems in hypersaline Lake Retba, Senegal
    Télesphore Sime-Ngando
    Laboratoire Microorganismes Génome et Environnement, Université Blaise Pascal Clermont Ferrand II, UMR CNRS 6023, F 63177, Aubiere Cedex, France
    Environ Microbiol 13:1956-72. 2011
    ..A large proportion of the sequences had similarity to previously sequenced viral metagenomes from solar salterns...
  83. ncbi request reprint Archaeal phylogeny based on ribosomal proteins
    Oriane Matte-Tailliez
    Institut de Genetique et Microbiologie, Universite Paris Sud, Orsay, France
    Mol Biol Evol 19:631-9. 2002
    ..The major difference involves organisms living in similar environments, suggesting that LGTs are mainly directed by the physical proximity of the organisms rather than by their phylogenetic proximity...
  84. pmc Archaeal phylogeny based on proteins of the transcription and translation machineries: tackling the Methanopyrus kandleri paradox
    Celine Brochier
    Equipe Phylogénomique, Université Aix Marseille I, Centre Saint Charles, 13331 Marseille Cedex 3, France
    Genome Biol 5:R17. 2004
    ..We analyzed archaeal phylogeny using two concatenated datasets consisting of 14 proteins involved in transcription and 53 ribosomal proteins (3,275 and 6,377 positions, respectively)...
  85. ncbi request reprint Identification, purification, and characterization of an eukaryotic-like phosphopantetheine adenylyltransferase (coenzyme A biosynthetic pathway) in the hyperthermophilic archaeon Pyrococcus abyssi
    Jean Armengaud
    CEA VALRHO, DSV DIEP, SBTN, Service de Biochimie post génomique and Toxicologie Nucléaire, 30207 Bagnols sur Ceze, France
    J Biol Chem 278:31078-87. 2003
    ..The existence of operational proteins highly conserved between Archaea and Eukarya involved in a central metabolic pathway challenge evolutionary scenarios in which eukaryal operational proteins are strictly of bacterial origin...
  86. pmc Widespread distribution of archaeal reverse gyrase in thermophilic bacteria suggests a complex history of vertical inheritance and lateral gene transfers
    Celine Brochier-Armanet
    EA 3781 EGEE Evolution Génome Environnement, Université de Provence Aix Marseille I, Centre Saint Charles, 3 Place Victor Hugo 13331, Marseille Cedex 3, France
    Archaea 2:83-93. 2007
    ..However, it also questions the role of this enzyme in thermophilic bacteria and the selective advantage its presence could provide...
  87. pmc Structural insights into a new homodimeric self-activated GTPase family
    Stephanie Gras
    Laboratoire de Cristallographie et Cristallogenese des Proteines, Institut de Biologie Structurale J P Ebel, CEA CNRS UJF, UMR 5075, 41, rue Jules Horowitz, F 38027 Grenoble, France
    EMBO Rep 8:569-75. 2007
    ..Owing to this unique functional feature, we propose to call this family as GPN-loop GTPase...
  88. pmc Physiological responses of the hyperthermophilic archaeon "Pyrococcus abyssi" to DNA damage caused by ionizing radiation
    Edmond Jolivet
    Institut Universitaire Europeen de la Mer, Universite de Bretagne Occidentale, CNRS UMR 6539, Technopole Brest Iroise, 29 280 Plouzane, France
    J Bacteriol 185:3958-61. 2003
    ..Our cell fractionation assays further suggest that "P. abyssi" contains a highly efficient DNA repair system which is continuously ready to repair the DNA damage caused by high temperature and/or ionizing radiation...
  89. doi request reprint Mesophilic Crenarchaeota: proposal for a third archaeal phylum, the Thaumarchaeota
    Celine Brochier-Armanet
    Universite de Provence, Aix Marseille I, CNRS, UPR 9043, Laboratoire de Chimie Bacterienne, Institut de Biologie Structurale et de Microbiologie, 13402 Marseille, France
    Nat Rev Microbiol 6:245-52. 2008
    ..Our results indicate that C. symbiosum and its relatives are not Crenarchaeota, but should be considered as a third archaeal phylum, which we propose to name Thaumarchaeota (from the Greek 'thaumas', meaning wonder)...
  90. pmc DNA bending, compaction and negative supercoiling by the architectural protein Sso7d of Sulfolobus solfataricus
    Alessandra Napoli
    Institute of Protein Biochemistry and Enzymology, Consiglio Nazionale delle Ricerche, Via Pietro Castellino 111, 80131 Naples, Italy
    Nucleic Acids Res 30:2656-62. 2002
    ..The proposed biological relevance of these observations is that these proteins might model the behaviour of DNA in constrained chromatin environments...
  91. doi request reprint Redefining viruses: lessons from Mimivirus
    Didier Raoult
    Unite des Rickettsies, IRD CNRS UMR 6236, IFR 48, Faculte de Medecine, 27 Bd Jean Moulin, 13385 Marseille, France
    Nat Rev Microbiol 6:315-9. 2008
    ....
  92. ncbi request reprint Thermococcus marinus sp. nov. and Thermococcus radiotolerans sp. nov., two hyperthermophilic archaea from deep-sea hydrothermal vents that resist ionizing radiation
    Edmond Jolivet
    UMR 6539, Institut Universitaire Europeen de la Mer, Centre National de la Recherche Scientifique et Université de Bretagne Occidentale, Technopole Brest Iroise, Place Nicolas Copernic, 29280 Plouzane, France
    Extremophiles 8:219-27. 2004
    ..marinus sp. nov. and T. radiotolerans sp. nov. The type strain of T. marinus is strain EJ1T (= DSM 15227T = JCM 11825T) and the type strain of T. radiotolerans is strain EJ2T (= DSM 15228T = JCM 11826T)...
  93. pmc Molecular diversity of new Thermococcales isolates from a single area of hydrothermal deep-sea vents as revealed by randomly amplified polymorphic DNA fingerprinting and 16S rRNA gene sequence analysis
    Elodie Lepage
    Unité de Recherches Laitières et Génétique Appliquée, Institut National de la Recherche Agronomique, Domaine de Vilvert, 78352 Jouy en Josas, France
    Appl Environ Microbiol 70:1277-86. 2004
    ....
  94. ncbi request reprint Thermococcus gammatolerans sp. nov., a hyperthermophilic archaeon from a deep-sea hydrothermal vent that resists ionizing radiation
    Edmond Jolivet
    UMR 6539, Centre National de la Recherche Scientifique et Université de Bretagne Occidentale, Technopole Brest Iroise, Place Nicolas Copernic, 29280 Plouzane, France
    Int J Syst Evol Microbiol 53:847-51. 2003
    ..nov. The type strain is EJ3(T) (= DSM 15229(T) = JCM 11827(T))...