Michel Feletou

Summary

Affiliation: Institut de Recherches Servier
Country: France

Publications

  1. ncbi request reprint NPY receptors as drug targets for the central regulation of body weight
    Michel Feletou
    Department of Angiology, Suresnes and Croissy Sur Seine, France
    CNS Neurol Disord Drug Targets 5:263-74. 2006
  2. doi request reprint Vasoconstrictor prostanoids
    Michel Feletou
    Institut Recherches Servier, Suresnes, France
    Pflugers Arch 459:941-50. 2010
  3. doi request reprint Nitric oxide: orchestrator of endothelium-dependent responses
    Michel Feletou
    Institut Recherches Servier, Suresnes, France
    Ann Med 44:694-716. 2012
  4. pmc Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptors
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Br J Pharmacol 156:563-74. 2009
  5. pmc Calcium-activated potassium channels and endothelial dysfunction: therapeutic options?
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Br J Pharmacol 156:545-62. 2009
  6. doi request reprint EDHF: an update
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Clin Sci (Lond) 117:139-55. 2009
  7. ncbi request reprint EDHF: new therapeutic targets?
    Michel Feletou
    Département Diabète et Maladies Métaboliques, Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France
    Pharmacol Res 49:565-80. 2004
  8. pmc Endothelium-mediated control of vascular tone: COX-1 and COX-2 products
    Michel Feletou
    Institut Recherches Servier, Suresnes, France
    Br J Pharmacol 164:894-912. 2011
  9. ncbi request reprint [Communication between endothelial and smooth muscle cells]
    Michel Feletou
    Institut de Recherches Servier, 92150 Suresnes, France
    Med Sci (Paris) 19:1242-50. 2003
  10. doi request reprint Aging and prostacyclin responses in aorta and platelets from WKY and SHR rats
    Elodie Gomez
    Départment d Angiologie, Institut de Recherches Servier, 11 rue des Moulineaux 92150 Suresnes, France
    Am J Physiol Heart Circ Physiol 295:H2198-211. 2008

Collaborators

Detail Information

Publications33

  1. ncbi request reprint NPY receptors as drug targets for the central regulation of body weight
    Michel Feletou
    Department of Angiology, Suresnes and Croissy Sur Seine, France
    CNS Neurol Disord Drug Targets 5:263-74. 2006
    ..Whether this will be the long awaited therapy based on manipulation of NPY receptors will await further studies of long term efficacy and more importantly a favorable side effect profile...
  2. doi request reprint Vasoconstrictor prostanoids
    Michel Feletou
    Institut Recherches Servier, Suresnes, France
    Pflugers Arch 459:941-50. 2010
    ..TP receptor antagonists curtail endothelial dysfunction in diseases such as hypertension and diabetes, are potent antithrombotic agents, and prevent vascular inflammation...
  3. doi request reprint Nitric oxide: orchestrator of endothelium-dependent responses
    Michel Feletou
    Institut Recherches Servier, Suresnes, France
    Ann Med 44:694-716. 2012
    ....
  4. pmc Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptors
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Br J Pharmacol 156:563-74. 2009
    ..Nevertheless, because EDCFs converge to activate TP receptors, selective antagonists of this receptor, by preventing endothelium-dependent contractions, curtail the endothelial dysfunction in diseases such as hypertension and diabetes...
  5. pmc Calcium-activated potassium channels and endothelial dysfunction: therapeutic options?
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Br J Pharmacol 156:545-62. 2009
    ..Conversely, blockers of IK(Ca) may prevent restenosis and that of BK(Ca) channels sepsis-dependent hypotension...
  6. doi request reprint EDHF: an update
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Clin Sci (Lond) 117:139-55. 2009
    ..A better characterization of EDHF-mediated responses should allow the determination of whether or not new drugable targets can be identified for the treatment of cardiovascular diseases...
  7. ncbi request reprint EDHF: new therapeutic targets?
    Michel Feletou
    Département Diabète et Maladies Métaboliques, Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France
    Pharmacol Res 49:565-80. 2004
    ..Activating endothelial IK(Ca) and/or SK(Ca) or increasing their expression as well as improving myo-endothelial communication, for instance by increasing the expression of connexin(s), could become interesting therapeutic targets...
  8. pmc Endothelium-mediated control of vascular tone: COX-1 and COX-2 products
    Michel Feletou
    Institut Recherches Servier, Suresnes, France
    Br J Pharmacol 164:894-912. 2011
    ....
  9. ncbi request reprint [Communication between endothelial and smooth muscle cells]
    Michel Feletou
    Institut de Recherches Servier, 92150 Suresnes, France
    Med Sci (Paris) 19:1242-50. 2003
    ..The discovery of specific inhibitors of the endothelial cell hyperpolarization allows the assessment of the contribution of EDHF-mediated responses in the control of vascular tone...
  10. doi request reprint Aging and prostacyclin responses in aorta and platelets from WKY and SHR rats
    Elodie Gomez
    Départment d Angiologie, Institut de Recherches Servier, 11 rue des Moulineaux 92150 Suresnes, France
    Am J Physiol Heart Circ Physiol 295:H2198-211. 2008
    ..In aorta from WKY those responses are reduced by aging and, in SHR, are already compromised at 3 mo. This dysfunction of the IP receptor is only partially explained by a general dysfunction of the adenylate cyclase pathway...
  11. pmc KCa 3.1 channels maintain endothelium-dependent vasodilatation in isolated perfused kidneys of spontaneously hypertensive rats after chronic inhibition of NOS
    Serge Simonet
    Institut de Recherches Servier, Suresnes, France
    Br J Pharmacol 167:854-67. 2012
    ..The purpose of the study was to investigate renal endothelium-dependent vasodilatation in a model of severe hypertension associated with kidney injury...
  12. ncbi request reprint In SHR aorta, calcium ionophore A-23187 releases prostacyclin and thromboxane A2 as endothelium-derived contracting factors
    Pascale Gluais
    Département Angiologie, Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France
    Am J Physiol Heart Circ Physiol 291:H2255-64. 2006
    ..These results indicate that in the aorta of SHR and WKY, the endothelium-dependent contractions elicited by A-23187 involve the release of thromboxane A(2) and prostacyclin with a most likely concomitant contribution of PGH(2)...
  13. doi request reprint Anti-aggregating effect of BAY 58-2667, an activator of soluble guanylyl cyclase
    Séverine Roger
    Institut Recherches Servier, Suresnes, France
    Vascul Pharmacol 53:281-7. 2010
    ..When the sGC is oxidized, BAY 58-2667 becomes a relevant anti-aggregating agent, which synergizes with the cAMP-dependent pathway...
  14. pmc Role of SK(Ca) and IK(Ca) in endothelium-dependent hyperpolarizations of the guinea-pig isolated carotid artery
    Pascale Gluais
    Institut de Recherches Servier, Suresnes, France
    Br J Pharmacol 144:477-85. 2005
    ..Furthermore, the EDHF-mediated response involves the activation of both endothelial IK(Ca) and SK(Ca) channels, the activation of either one being able to produce a true hyperpolarization...
  15. ncbi request reprint Mechanisms underlying ATP-induced endothelium-dependent contractions in the SHR aorta
    Pascale Gluais
    Institut de Recherches Servier, 92150 Suresnes, France
    Eur J Pharmacol 556:107-14. 2007
    ..Thus, in the aorta of SHR, endothelium-dependent contractions elicited by ATP involve the release of thromboxane A(2) and prostacyclin with a possible contribution of PGH(2)...
  16. ncbi request reprint Hydrogen peroxide and endothelium-dependent hyperpolarization in the guinea-pig carotid artery
    Pascale Gluais
    Institut Recherches, Servier, Suresnes, France
    Eur J Pharmacol 513:219-24. 2005
    ..These data indicate that, in the guinea-pig isolated carotid artery, hydrogen peroxide is unlikely to contribute to the endothelium-dependent hyperpolarization evoked by acetylcholine...
  17. doi request reprint Mechanisms of the vasorelaxing effects of CORM-3, a water-soluble carbon monoxide-releasing molecule: interactions with eNOS
    Ali Alshehri
    Institut Recherches Servier, Suresnes, France
    Naunyn Schmiedebergs Arch Pharmacol 386:185-96. 2013
    ....
  18. ncbi request reprint Endothelial dysfunction: a multifaceted disorder (The Wiggers Award Lecture)
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Am J Physiol Heart Circ Physiol 291:H985-1002. 2006
    ..Therapeutic interventions do not necessarily restore a proper endothelial function and, when they do, may improve only part of these variables...
  19. ncbi request reprint Nitric oxide the gatekeeper of endothelial vasomotor control
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Front Biosci 13:4198-217. 2008
    ..Among the diffusible endothelial factors nitric oxide (NO) plays a key role, particularly in large blood vessels. This chapter briefly reviews the interactions between NO and the other vasomotor signals released by the endothelial cells...
  20. pmc Acetylcholine-induced endothelium-dependent contractions in the SHR aorta: the Janus face of prostacyclin
    Pascale Gluais
    Institut de Recherches Servier, 92150 Suresnes, France
    Br J Pharmacol 146:834-45. 2005
    ..Thus, in the aorta of SHR and aging WKY, the endothelium-dependent contractions elicited by acetylcholine most likely involve the release of PGI2 with a concomitant contribution of PGH2...
  21. ncbi request reprint Endothelium-dependent hyperpolarization to acetylcholine in carotid artery of guinea pig: role of lipoxygenase
    Jean François Quignard
    Département Diabète et Maladies Métaboliques, Institut de Recherches Servier, Suresnes, France
    J Cardiovasc Pharmacol 40:467-77. 2002
    ....
  22. pmc Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Curr Hypertens Rep 12:267-75. 2010
    ..This brief review highlights these different endothelial pathways as potential drug targets for novel treatments in hypertension and the associated endothelial dysfunction and end-organ damage...
  23. pmc The anti-aggregating effect of BAY 41-2272, a stimulator of soluble guanylyl cyclase, requires the presence of nitric oxide
    Séverine Roger
    Département Angiologie, Institut de Recherches Servier, 11 rue des Moulineaux, Suresnes, France
    Br J Pharmacol 161:1044-58. 2010
    ..The purpose of the present study was to determine whether a stimulator of soluble guanylyl cyclase, BAY 41-2272, inhibits platelet aggregation and to clarify its interaction with nitric oxide (NO)...
  24. ncbi request reprint Endothelium-dependent hyperpolarizations: past beliefs and present facts
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Ann Med 39:495-516. 2007
    ..These various mechanisms are not necessarily mutually exclusive and, depending on the vascular bed and the experimental conditions, can occur simultaneously or sequentially, or also may act synergistically...
  25. doi request reprint Role of thromboxane TP and angiotensin AT1 receptors in lipopolysaccharide-induced arterial dysfunction in the rabbit: an in vivo study
    Christine Vayssettes-Courchay
    Division of Angiology, Servier Research Institute, 11 rue des Moulineaux, 92150 Suresnes, France
    Eur J Pharmacol 634:113-20. 2010
    ....
  26. pmc Characterization of a charybdotoxin-sensitive intermediate conductance Ca2+-activated K+ channel in porcine coronary endothelium: relevance to EDHF
    Rostislav Bychkov
    Département Diabète et Maladies Métaboliques, Institut de Recherches Servier, 11 rue des Molineaux, 92150 Suresnes, France
    Br J Pharmacol 137:1346-54. 2002
    ..This channel is opened by activation of the EDHF pathway and likely mediates the charybdotoxin-sensitive component of the EDHF response...
  27. pmc Endothelin-1 inhibits TNF alpha-induced iNOS expression in 3T3-F442A adipocytes
    Christelle Merial-Kieny
    Département Diabète et Maladies Métaboliques, Institut de Recherche Servier, Suresnes 92150, France
    Br J Pharmacol 139:935-44. 2003
    ..6. Thus, these results confirm that adipocytes are a target for circulating ET-1 and demonstrate that the activation of the ETA receptor subtype can prevent TNFalpha-induced iNOS expression...
  28. ncbi request reprint Altered TP receptor function in isolated, perfused kidneys of nondiabetic and diabetic ApoE-deficient mice
    Frederic Michel
    Institut de Recherches Servier, 11 rue des Moulineaux, 92150 Suresnes, France
    Am J Physiol Renal Physiol 294:F120-9. 2008
    ..Increased responsiveness of TP receptors occurs in diabetic ApoE-KO mouse kidneys. Thus early changes in TP receptor-mediated vasoconstrictor activity may participate in the development of kidney disease in atherosclerosis and diabetes...
  29. ncbi request reprint The thromboxane/endoperoxide receptor (TP): the common villain
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    J Cardiovasc Pharmacol 55:317-32. 2010
    ..Therefore, TP antagonists, because of this triple activity, may have a unique potential for the treatment of cardiovascular disorders...
  30. ncbi request reprint K+ channels in cultured bovine retinal pericytes: effects of beta-adrenergic stimulation
    Jean François Quignard
    Département Diabète et Maladies Métaboliques, Institut de Recherches Servier, Suresnes, France
    J Cardiovasc Pharmacol 42:379-88. 2003
    ....
  31. ncbi request reprint Endothelium-derived hyperpolarizing factor: where are we now?
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Arterioscler Thromb Vasc Biol 26:1215-25. 2006
    ..Additionally, the endothelium can produce other factors such as lipoxygenases derivatives or hydrogen peroxide (H2O2). These different mechanisms are not necessarily exclusive and can occur simultaneously...
  32. ncbi request reprint Neuropeptide Y2 receptors as drug targets for the central regulation of body weight
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Curr Opin Investig Drugs 6:1002-11. 2005
    ..The possibility that long-term NPY Y2 agonism could cause bone thinning and retinal angiogenesis are of particular concern and will need to be investigated as drug discovery moves forward...
  33. pmc TP receptors and oxidative stress hand in hand from endothelial dysfunction to atherosclerosis
    Michel Feletou
    Department of Angiology, Institut de Recherches Servier, Suresnes, France
    Adv Pharmacol 60:85-106. 2010
    ..TP receptor antagonists represent a promising avenue for the prevention of vascular disease in part because of these pleiotropic actions that extend beyond their antithrombotic properties...