Research Topics
Genomes and Genes | E FabreSummaryAffiliation: Institut Pasteur Country: France Publications
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Publications
Transcription and nuclear transport of CAG/CTG trinucleotide repeats in yeastEmmanuelle Fabre
Unité de Génétique Moléculaire des Levures URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Nucleic Acids Res 30:3540-7. 2002..CAG- or CUG-containing transcripts show a non-homogeneous cellular localization. We propose that long mRNAs result from transcription slippage, and discuss the possible implications for human diseases...
Genome-wide nuclear morphology screen identifies novel genes involved in nuclear architecture and gene-silencing in Saccharomyces cerevisiaeMaria Teresa Teixeira
Département de Structure et Dynamique des Génomes, Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927 Univ P M Curie, Institut Pasteur, 25 rue du Docteur Roux, 75724 Cedex 15, Paris, France
J Mol Biol 321:551-61. 2002..Interestingly, these nuclear morphology alterations were associated with chromatin-silencing defects. These genes provide a molecular context to explore the functional link between nuclear architecture and gene silencing...- Large-scale exploration of growth inhibition caused by overexpression of genomic fragments in Saccharomyces cerevisiaeJeanne Boyer
Unité de Génétique Moléculaire des Levures, URA2171 CNRS and UFR 927 Université Pierre et Marie Curie, Paris Cedex 15, France
Genome Biol 5:R72. 2004.... - Yeast genetics to dissect the nuclear pore complex and nucleocytoplasmic traffickingE Fabre
Institut Pasteur, Departement des Biotechnologies, Paris, France
Annu Rev Genet 31:277-313. 1997..We review here our current knowledge on the role of nucleoporins, and on the mechanism of nucleocytoplasmic transport, with emphasis on the yeast Saccharomyces cerevisiae... - Comparative genomics in hemiascomycete yeasts: evolution of sex, silencing, and subtelomeresEmmanuelle Fabre
Unité de Génétique Moléculaire des Levures, URA2171 CNRS, UFR Université Pierre et Marie Curie, Département Structure et Dynamique des Génomes, Institut Pasteur, 75724 Cedex Paris, France
Mol Biol Evol 22:856-73. 2005..We have also found that in all species studied, subtelomeric gene families exist and are specific to each species... - Two functionally distinct domains generated by in vivo cleavage of Nup145p: a novel biogenesis pathway for nucleoporinsM T Teixeira
Unité de Génétique Moléculaire des levures URA 1300 CNRS and UPR 927 Univ P M Curie, Institut Pasteur, Departement des Biotechnologies, Paris, France
EMBO J 16:5086-97. 1997..These data suggest that N- and C-domains of Nup145p perform independent functions, and that the in vivo cleavage observed is of functional importance... - Self-catalyzed cleavage of the yeast nucleoporin Nup145p precursorM T Teixeira
Unité de Génétique Moléculaire des Levures, Institut Pasteur, Departement des Biotechnologies, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France
J Biol Chem 274:32439-44. 1999..Taken altogether, our data are consistent with a proteolytic mechanism involving an N>O acyl rearrangement and a subsequent ester intermediate uncovered in other self-processing proteins... - Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric regionPierre Therizols
Unité de Génétique Moléculaire des Levures URA 2171 Centre National de la Recherche Scientifique, UFR 927 Université Pierre et Marie Curie, Département Structure et Dynamique des Génomes, Institut Pasteur, 75724 Paris Cedex, France
J Cell Biol 172:189-99. 2006..They also indicate that anchoring of telomeres is essential for efficient repair of DSBs occurring therein and is important for preserving genome integrity... - Genome evolution in yeastsBernard Dujon
Unité de Génétique Moléculaire des Levures, URA 2171 CNRS and UFR 927 Université Pierre et Marie Curie
Nature 430:35-44. 2004.... - Chromosome arm length and nuclear constraints determine the dynamic relationship of yeast subtelomeresPierre Therizols
Unité de Génétique Moléculaire des Levures, Centre National de la Recherche Scientifique, Institut Pasteur, Université Pierre et Marie Curie 75724 Paris, France
Proc Natl Acad Sci U S A 107:2025-30. 2010..Our results suggest that interactions between subtelomeres are nonspecific and instead governed by physical constraints, including chromosome structure, attachment to the SPB, and nuclear crowding... 
High-resolution statistical mapping reveals gene territories in live yeastAxel B Berger
Institut Pasteur, Unité de Biologie Cellulaire du Noyau, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2582, 25 28 Rue du Docteur Roux, 75015 Paris, France
Nat Methods 5:1031-7. 2008..The technique can be used to visualize and quantify territory positions relative to each other and to nuclear landmarks, and should advance studies of nuclear architecture and function...- Plasmid DNA electrotransfer for intracellular and secreted proteins expression: new methodological developments and applicationsCarole Bloquel
, U266 INSERM FRE 2463 CNRS, , 4 avenue de l'Observatoire, 75270 Paris Cedex 06, France
J Gene Med 6:S11-23. 2004..DNA electrotransfer is also a powerful laboratory tool to study gene function in a given tissue... - [Nuclear pore and functional organization of chromatin]Emmanuelle Fabre
Med Sci (Paris) 22:483-4. 2006