Research Topics
Genomes and Genes | Sandrine Etienne-MannevilleSummaryAffiliation: Institut Pasteur Country: France Publications
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Publications
Polarity proteins in glial cell functionsSandrine Etienne-Manneville
Cell Polarity and Migration Group, Institut Pasteur and CNRS URA, Paris, France
Curr Opin Neurobiol 18:488-94. 2008..A general picture of the intracellular signalling pathways controlling polarity in glial cells is also emerging and shows that highly conserved and ubiquitously expressed polarity proteins are involved...
Adherens junctions during cell migrationSandrine Etienne-Manneville
Institut Pasteur, Cell Polarity and Migration Group and CNRS URA 2582, 25 rue du Dr Roux, 75724, Paris Cedex 15, France
Subcell Biochem 60:225-49. 2012..In addition, adherens junctions transduce signals that actively participate in the control of directed cell migration, by providing polarity cues and also participating in contact inhibition of motility...
Scribble at the crossroadsSandrine Etienne-Manneville
Institut Pasteur, Cell Polarity and Migration Group and CNRS URA 2582, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
J Biol 8:104. 2009..A recent report in BMC Biology clarifies the signaling pathways that control cell polarity, proliferation and apoptosis downstream of the tumor suppressor and apical-basal polarity determinant Scribble...
Polarity proteins in migration and invasionS Etienne-Manneville
Cell Polarity and Migration Group, Institut Pasteur and CNRS URA 2582, Paris Cedex 15, France
Oncogene 27:6970-80. 2008..The aim of this review is to highlight the molecular relationship between the control of cell polarity and the regulation of cell motility during oncogenesis...
From signaling pathways to microtubule dynamics: the key playersSandrine Etienne-Manneville
Institut Pasteur, Cell Polarity and Migration Group and CNRS URA 2582, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Curr Opin Cell Biol 22:104-11. 2010..I review here how modifications of the tubulin dimer, tubulin modifying enzymes, and microtubule-associated proteins are directly involved in the regulation of microtubule behavior and functions...
APC in cell migrationSandrine Etienne-Manneville
Institut Pasteur CNRS URA, Paris, France
Adv Exp Med Biol 656:30-40. 2009....
Cdc42 localization and cell polarity depend on membrane trafficNaël Osmani
Cell Polarity and Migration Group, Institut Pasteur, and Centre National de la Recherche Scientifique URA 2582, 75724 Paris, Cedex 15, France
J Cell Biol 191:1261-9. 2010..Our results demonstrate influence of membrane dynamics on the localization and activation of Cdc42 and consequently on directed cell migration...
N-cadherin expression level modulates integrin-mediated polarity and strongly impacts on the speed and directionality of glial cell migrationEmeline Camand
Institut Pasteur CNRS URA 2582, Cell Polarity, Migration and Cancer Unit, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
J Cell Sci 125:844-57. 2012..Re-expression of N-cadherin in gliomas restores cell polarity and strongly reduces cell velocity, suggesting that loss of N-cadherin could contribute to the invasive capacity of tumour astrocytes...
APC binds intermediate filaments and is required for their reorganization during cell migrationYasuhisa Sakamoto
Cell Polarity, Migration and Cancer Unit, Institut Pasteur, 75724 Paris, Cedex 15, France
J Cell Biol 200:249-58. 2013..These results point to APC as a crucial regulator of IF organization and confirm its fundamental role in the coordinated regulation of cytoskeletons...
N-cadherin expression level as a critical indicator of invasion in non-epithelial tumorsFlorent Peglion
Institut Pasteur, CNRS URA 2582, Cell Polarity and Migration Group, Paris, France
Cell Adh Migr 6:327-32. 2012..Re-expression of N-cadherin in glioma cells restores cell polarity and limits glioma cell migration, providing a potential therapeutic tool for diffuse glioma...
Nuclear positioning: mechanisms and functionsIsabelle Dupin
Institut Pasteur, Cell Polarity, Migration and Cancer Unit and CNRS URA 2582, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Int J Biochem Cell Biol 43:1698-707. 2011....
Dlg1 binds GKAP to control dynein association with microtubules, centrosome positioning, and cell polarityJean Baptiste Manneville
UMR144 Centre National de la Recherche Scientifique Institut Curie, Paris, France
J Cell Biol 191:585-98. 2010....
Cytoplasmic intermediate filaments mediate actin-driven positioning of the nucleusIsabelle Dupin
Institut Pasteur, Cell Polarity and Migration Group and CNRS URA 2582, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
J Cell Sci 124:865-72. 2011..This function of intermediate filaments might be crucial for regulating cell motility, in particular in tumor cells expressing high levels of cytoplasmic intermediate filaments...
Ezrin tunes T-cell activation by controlling Dlg1 and microtubule positioning at the immunological synapseRémi Lasserre
Institut Pasteur, Department of Immunology, Lymphocyte Cell Biology Unit, Paris, France
EMBO J 29:2301-14. 2010..Moreover, they underscore the importance of ezrin and Dlg1 in the regulation of NF-AT activation through p38...
[Scrib, a tumor suppressor gene involved in cell polarity]Naël Osmani
Groupe Polarité et Migration Cellulaires, Institut Pasteur, 25 rue du Docteur Roux, Paris Cedex 15, France
Med Sci (Paris) 24:61-4. 2008..Scribble illustrates the more and more obvious link between regulation of cell polarity, cell transformation and tumor formation...
Scrib controls Cdc42 localization and activity to promote cell polarization during astrocyte migrationNaël Osmani
Cell Polarity and Migration Group, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
Curr Biol 16:2395-405. 2006..Cdc42 is, in particular, required for polarization and orientation of astrocytes in a scratch-induced polarized migration assay. Using this assay, we characterized Scrib function during polarized cell migration...
Control of polarized cell morphology and motility by adherens junctionsSandrine Etienne-Manneville
Institut Pasteur, Cell Polarity and Migration Group and CNRS URA 2582, Paris, France
Semin Cell Dev Biol 22:850-7. 2011..I review here the molecular mechanisms allowing control of polarized cell morphology and motility by AJs...
Classical cadherins control nucleus and centrosome position and cell polarityIsabelle Dupin
Institut Pasteur, Cell Polarity and Migration Group, and Centre National de la Recherche Scientifique Unité de Recherche Associée 2582, 75724 Paris, Cedex 15, France
J Cell Biol 185:779-86. 2009..Our results demonstrate that in addition to the specific function of E-cadherin in regulating baso-apical epithelial polarity, classical cadherins control cell polarization in otherwise nonpolarized cells...
In vitro assay of primary astrocyte migration as a tool to study Rho GTPase function in cell polarizationSandrine Etienne-Manneville
Morphogeneses et Signalisation Cellulaire, Institut Curie, Paris, France
Methods Enzymol 406:565-78. 2006..Here I describe the procedure by which we can obtain and purify primary rat astrocytes and the different assays we have previously used to analyze the role of Rho GTPases and their downstream targets in cell migration and polarization...
Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestinsEvelyne Lima-Fernandes
INSERM, U1016, Institut Cochin, Paris, France
EMBO J 30:2557-68. 2011..arrs can thus differentially control distinct functional outputs of PTEN important for cell proliferation and migration...
ICAM-1-coupled cytoskeletal rearrangements and transendothelial lymphocyte migration involve intracellular calcium signaling in brain endothelial cell linesS Etienne-Manneville
Centre National de la Recherche Scientifique, Unité Propre de Recherche 0415, Cell Biology Department, Institut Cochin de Genetique Moleculaire, Universite Paris VII, Paris, France
J Immunol 165:3375-83. 2000..Our results also indicate that these calcium-mediated intracellular events are essential for lymphocyte migration through the blood-brain barrier...
