Dominique M Elias

..The number, size, and localization of the tumor sites are less important than performing a complete (or near-complete) resection...

..However, this approach has not yet been evaluated for isolated peritoneal re-recurrences after previous IPC. The aim of this study was to evaluate the postoperative course and long-term outcome after repeat (re-)CCRS + IPC...

..The prognostic impact of a complete resection is high, but that of HIPEC per se is more hypothetical. The presence of a few resectable liver metastases associated with PC is not a contraindication to surgery plus HIPEC...

..This raises the question of the concordance between the PCI scores calculated by different surgeons, and a possible variation before and after CRS...

..We report preliminary results on survival in a phase II study using oxaliplatin (LOHP)...

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..Firstly, the ill-sited LM, which is located in the only feasible future hepatectomy plane, is ablated using RF; the hepatectomy is then performed through this ablated LM...

..New modalities will undoubtedly be necessary with the development of future technologies...

..After resection, the prognosis is based more on the total number of resected metastases (located inside and outside the liver) than on the site of these metastases (only inside the liver or not)...

..A third pharmacokinetic study was to determine the appropriate dose of intraperitoneal oxaliplatin combined with intraperitoneal irinotecan: the recommended dosage was 360 mg/m2 for each of the chemotherapy agents...

..The aim of our study was to investigate whether surgery alone had an impact on the hematological toxicity associated with the standardized drug protocol that we routinely prescribed...

..This would result in a reduced cure rate. Our purpose was to discover the incidence of unsuspected and surgically treatable intrahepatic and extrahepatic metastases discovered at laparotomy...

..The aim of the study was to appreciate the local recurrence rate of RFA in comparison with anatomic and wedge resection...

..This study was aimed at assessing the actual prognostic impact of PC and to evaluate a new treatment with respect to survival times...

..Results and indications of intra-operative radiofrequency (RF) ablation of liver metastases (LM) are not well defined in the literature...

..This article details the technical aspect of intraperitoneal chemohyperthermia. These techniques involve specific and important features. At these conditions, peritoneal carcinomatosis can be cured in two-thirds of cases...

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..This article details the technical aspect of peritonectomy...

..Colorectal peritoneal carcinomatosis (PC) is a frequent and very lethal event. However, cure may be possible with maximal cytoreductive surgery associated with early postoperative intraperitoneal chemotherapy (EPIC)...

..To analyse the causes of non resectability of peritoneal carcinomatosis (PC) of non-appendiceal colorectal carcinomas, discovered only at the time of the laparotomy...

..Two mains issues are discussed: advances in terms of the molecular basis of GI oncogenesis, and the data on molecular targeted agents for which the cost/efficacity balance needs to be addressed...

..To report our experience of peritoneal carcinomatosis (PC) discovered during abdominal exploration in patients with liver metastases (LM)...

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..To analyze a large series of patients with pseudomyxoma peritonei (PMP) treated with cytoreductive surgery associated with perioperative intraperitoneal chemotherapy (PIC) in 18 French-speaking centers...

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..These results should improve in the future, because the different teams involved will gain experience. This approach, when feasible, is now considered the gold standard in the French guidelines...

..It is an extensive application of the current guidelines...

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..Treatment based on complete cytoreductive surgery (CCRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) is gaining support. The aim of this study was to identify pre- and perioperative factors of prognostic value...

..This aggressive treatment is frequently followed by a complicated or an unusual postoperative course, that has yet to be described...

..quot; The aim of our study was to assess the long-term outcome of such "missing LMs."..

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..To date, the results of these procedures have never been compared...

..We report long-term results concerning survival of a phase II study using oxaliplatin (LOHP)...

..At last, considering the future technologies, we must elaborate the future modalities of the oncological surgery...

..And yet, to date this rate, the time of onset of these abscesses, and the prior status of the bile ducts have never been reported in the literature...

..At the same time, resectability rates are increasing with the assistance of local ablative physical treatments such as radiofrequency, resulting in an improvement of patients' median survival rates and quality of life...

..The goal of this review was to discuss the risk associated with this technique, and the way to minimize it...

..Systematic routine en bloc lymphadenectomy currently has no prognostic value and no known therapeutic effects...

..The present study reports the long-term outcome and prognostic factors of patients undergoing resection of extrahepatic disease simultaneously with hepatectomy for liver metastases...

..The objective of this retrospective study was to assess the long-term survival of this unusual therapeutic approach...

..p.) oxaliplatin (LOHP) solution and its safety profile in increasingly hypotonic solutions. This is the first clinical study of i.p. chemohyperthermia with hypotonic solutions...

..radiofrequency, like other tools for local tumor destruction, will greatly change our therapeutic strategies in the neat future...

..These simple, reproducible guidelines offer a basis for the standardization of procedures used for the treatment and classification of gastric carcinomas...

..This study assessed whether percutaneous RF ablation is a useful and safe technique for the treatment of liver tumour recurrence after hepatectomy...

..To elaborate a therapeutic scheme for desmoid tumors developing within the mesenteric root. These uncommon and often unrecognized tumors are difficult to treat as they lie very close to the superior mesenteric vessels...

..Oxaliplatin has demonstrated significant activity in advanced colorectal cancer, and this is the first publication concerning its intraperitoneal administration...

..A new approach that combines maximal surgery with maximal regional chemotherapy has potential to cure selected patients who have colorectal PC. The authors have reported the oncologic results of this combined treatment...

..The complete or almost complete resection of peritoneal carcinomatosis (PC) followed by intraperitoneal chemohyperthermia (IPCH) is potentially capable of curing some patients presenting with disease confined to the peritoneum...

..To analyze the results of surgery for macroscopically or radiologically obvious (i.e., easily detectable by computed tomography scan or by palpation) synchronous or metachronous lateroaortic lymph node metastases from colorectal primaries...

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..The purpose of this study is to report tolerance and preliminary results in patients with liver metastases synchronous to moderate PC, treated with hepatectomy, complete cytoreductive surgery, and IPIC...

..The aim of this prospective study was to evaluate this treatment strategy...

..The true impact of the width of the margin on the prognosis is unclear...

..Prospective studies must be conducted in the prevention of carcinomatosis in well-defined high-risk patients...

..A pharmacokinetic study using intraperitoneal oxaliplatin at the same dose but in various hypotonic solutions did not show any specific pharmacologic advantage and was associated with excessive postoperative bleeding...

..If these conditions can be met, peritoneal metastases can be definitively cured in two thirds of colorectal PC and pseudomyxoma peritonei, and in nearly half of mesotheliomas...

..Intraoperative radiofrequency (RF) can be used to treat multiple small pancreatic tumours...

..This study reports the long-term outcome and prognostic factors of patients undergoing extrahepatic disease resection simultaneously with hepatectomy for liver metastases...

..Our study was aimed at assessing the evolution of these metastases when they were also not found during liver surgery...

..The adjunction of an intraperitoneal chemo-hyperthermia is logical for these two types of disease and probably increases the survival rate...

..A local recurrence is thus possible. New clinical presentations such as this one have first to be described in order to improve patient follow-up...

..Whether this regimen could be beneficial after systemic chemotherapy failure is unknown...

..The benefit seems considerably lower for the other groups of high-risk patients...

..This technique thus increases the suitability of resection as a treatment choice for patients with liver metastases. PVE should number among the therapeutic options available to every hepatic surgeon...

..The decision is simple for young patients but more difficult for older patients in whom a negative hormone receptor status appears to be a contraindication...

..CONCLUSION: Chemotherapy with 5-FU and platinum compounds seems effective and well-tolerated in patients with advanced SBA. 5-FU-irinotecan combination chemotherapy deserves further investigation in the first-line setting...

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..Hyperthermic intraperitoneal chemotherapy (HIPEC) after complete surgical resection is currently accepted as a therapeutic option for peritoneal carcinomatosis. However, considerable morbidity is reported after HIPEC...

..To analyze predictive factors of hypertrophy of the nonembolized future remnant liver (FRL) after transhepatic preoperative portal vein embolization (PVE) of the liver to be resected...

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..To evaluate the feasibility, functionality, and dysfunctions of an arterial port catheter implanted via the femoral artery...

..For advanced disease, chemotherapy alone has given very disappointing results. A multidisciplinary approach combining biological assessment of targets with clinical trials to evaluate new targeted drugs should be considered...

..This study enables the stratification of metastatic GEP WDEC patients into distinct risk groups. These risk categories can be used to tailor therapeutic approaches and also to design and interpret clinical trials...

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..The aim of this study was to analyze the impact of hepatic arterial infusion (HAI) of oxaliplatin with systemic 5-Fluorouracil and leucovorin on patients with isolated unresectable liver metastases...

..To define predictive factors for "high-sensitivity SRS."..

..Our purpose was to assess the cost-effectiveness of intraperitoneal chemohyperthermia (IPCH) compared to palliative chemotherapy (STANDARD) against peritoneal carcinomatosis arising from colorectal cancer...

..The objective of our study was to compare the usefulness of contrast-enhanced sonography with baseline sonography in detecting malignant liver lesions...

..The purpose of this work was to describe the computed tomography (CT) features of peritoneal carcinomatosis after surgery combined with intraperitoneal chemohyperthermia (IPCH)...

..Classic analysis using H&E remains the gold standard. However, SLNs detection can change the tumor stage by upstaging nearly 15% of the tumors from T2-3N0 to T2-3 N+...

..Long-term palliation is possible in unresectable liver metastases from digestive neuroendocrine tumors with a few sessions of TACE as first-line and eventually exclusive treatment...

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..To evaluate the usefulness of a guiding needle for radiofrequency (RF) ablative treatment of liver tumors...

..To assess and compare the performance of CT and 18F-FDG-PET/CT in the evaluation of peritoneal carcinomatosis (PC)...

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..Our primary objective was to assess the cost of radio-frequency ablation (RFA) of hepatic malignancies and to compare it to hospital reimbursement paid in the French Prospective Payment System (PPS)...

..If the SLN is proven disease free, only very limited and microinvasive resections would be required to treat some digestive cancers with a curative intent...

..The surgical excision of metastatic inguinal nodes, followed by radiotherapy, is an alternative to radiotherapy alone. Surgery can also be performed after failure of radiotherapy, at the cost of an increased morbidity...

..To determine the utility of hepatic resection (HR) in the treatment of patients with noncolorectal nonendocrine liver metastases (NCNELM)...