Dominique M Elias


Affiliation: Institut Gustave Roussy
Country: France


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    Elias D, Goharin A, El Otmany A, Taieb J, Duvillard P, Lasser P, et al. Usefulness of intraoperative radiofrequency thermoablation of liver tumours associated or not with hepatectomy. Eur J Surg Oncol. 2000;26:763-9 pubmed
    ..7% and 22%, respectively. Intraoperative use of RF to destroy unresectable liver tumours increases the rate of curative resections. Future progress in RF technology and adequate vascular clamping during RF should increase this rate. ..
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    Elias D, El Otmany A, Bonnay M, Paci A, Ducreux M, Antoun S, et al. Human pharmacokinetic study of heated intraperitoneal oxaliplatin in increasingly hypotonic solutions after complete resection of peritoneal carcinomatosis. Oncology. 2002;63:346-52 pubmed
    ..p. hypotonic solutions (200, 150 or 100 mosm/l) during IPCH. A high incidence of i.p. hemorrhage and thrombocytopenia was observed. ..
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    Elias D, Laurent S, Antoun S, Duvillard P, Ducreux M, Pocard M, et al. [Pseudomyxoma peritonei treated with complete resection and immediate intraperitoneal chemotherapy]. Gastroenterol Clin Biol. 2003;27:407-12 pubmed
    ..This treatment is more easily performed, more well-tolerated, and more efficient when performed early. ..
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    Elias D, Di Pietroantonio D, Gachot B, Menegon P, Hakime A, de Baere T. Liver abscess after radiofrequency ablation of tumors in patients with a biliary tract procedure. Gastroenterol Clin Biol. 2006;30:823-7 pubmed
    ..When RFA is performed synchronously with a biliary diversion, the risk of a liver abscess seems to disappear. ..
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    Elias D, Goere D, Blot F, Billard V, Pocard M, Kohneh Shahri N, et al. Optimization of hyperthermic intraperitoneal chemotherapy with oxaliplatin plus irinotecan at 43 degrees C after compete cytoreductive surgery: mortality and morbidity in 106 consecutive patients. Ann Surg Oncol. 2007;14:1818-24 pubmed
  6. Elias D, Honore C, Ciuchendea R, Billard V, Raynard B, Lo Dico R, et al. Peritoneal pseudomyxoma: results of a systematic policy of complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. Br J Surg. 2008;95:1164-71 pubmed publisher
    ..9 level and pathological grade. CCRS is the most effective treatment for PMP, and adding HIPEC prolongs long-term survival. Further strategies should focus on improving postoperative outcome in extended PMP. ..
  7. Elias D, Souadka A, Fayard F, Mauguen A, Dumont F, Honore C, et al. Variation in the peritoneal cancer index scores between surgeons and according to when they are determined (before or after cytoreductive surgery). Eur J Surg Oncol. 2012;38:503-8 pubmed publisher
    ..The PCI is a reliable tool for measuring the extent of PC. It is easy to use and inter-surgeon concordance is high. It increases by approximately 2 before and after CRS. ..
  8. Elias D, Quenet F, Goere D. Current status and future directions in the treatment of peritoneal dissemination from colorectal carcinoma. Surg Oncol Clin N Am. 2012;21:611-23 pubmed publisher
    ..The prognostic impact of a complete resection is high, but that of HIPEC per se is more hypothetical. The presence of a few resectable liver metastases associated with PC is not a contraindication to surgery plus HIPEC. ..
  9. Elias D, Lefevre J, Chevalier J, Brouquet A, Marchal F, Classe J, et al. Complete cytoreductive surgery plus intraperitoneal chemohyperthermia with oxaliplatin for peritoneal carcinomatosis of colorectal origin. J Clin Oncol. 2009;27:681-5 pubmed publisher

More Information


  1. Elias D, Gilly F, Boutitie F, Quenet F, Bereder J, Mansvelt B, et al. Peritoneal colorectal carcinomatosis treated with surgery and perioperative intraperitoneal chemotherapy: retrospective analysis of 523 patients from a multicentric French study. J Clin Oncol. 2010;28:63-8 pubmed publisher
    ..These results should improve in the future, because the different teams involved will gain experience. This approach, when feasible, is now considered the gold standard in the French guidelines. ..
  2. Elias D, Glehen O, Pocard M, Quenet F, Goere D, Arvieux C, et al. A comparative study of complete cytoreductive surgery plus intraperitoneal chemotherapy to treat peritoneal dissemination from colon, rectum, small bowel, and nonpseudomyxoma appendix. Ann Surg. 2010;251:896-901 pubmed publisher
    ..Results were better for appendix adenocarcinoma. When feasible, this combined approach should become the gold standard treatment of PC. ..
  3. Elias D, Gilly F, Quenet F, Bereder J, Sideris L, Mansvelt B, et al. Pseudomyxoma peritonei: a French multicentric study of 301 patients treated with cytoreductive surgery and intraperitoneal chemotherapy. Eur J Surg Oncol. 2010;36:456-62 pubmed publisher
    ..To analyze a large series of patients with pseudomyxoma peritonei (PMP) treated with cytoreductive surgery associated with perioperative intraperitoneal chemotherapy (PIC) in 18 French-speaking centers...